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Aliases for FAM92A Gene

Aliases for FAM92A Gene

  • Family With Sequence Similarity 92 Member A 2 3 5
  • Family With Sequence Similarity 92 Member A1 2 3
  • FAM92A1 3 4
  • Family With Sequence Similarity 92, Member A1 2
  • Protein FAM92A1 3
  • Protein FAM92A 3

External Ids for FAM92A Gene

Previous HGNC Symbols for FAM92A Gene

  • FAM92A1

Summaries for FAM92A Gene

GeneCards Summary for FAM92A Gene

FAM92A (Family With Sequence Similarity 92 Member A) is a Protein Coding gene. An important paralog of this gene is FAM92B.

UniProtKB/Swiss-Prot for FAM92A Gene

  • May play a role in ciliogenesis (PubMed:27528616). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).

Additional gene information for FAM92A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM92A Gene

Genomics for FAM92A Gene

Regulatory Elements for FAM92A Gene

Enhancers for FAM92A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H093956 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +260.4 260359 4 CTCF TFAP4 FOXA2 TBL1XR1 JUN RAD21 GATA3 ZNF143 SMC3 RUNX3 LINC00535 FAM92A LOC105375645 RBM12B PDP1 ENSG00000253722 GEM RPL34P18 ENSG00000275386
GH08H093915 1.3 ENCODE dbSUPER 11 +218.8 218800 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 SP3 SP5 PDP1 FAM92A LINC00535 ENSG00000253854 ENSG00000264448 PSMA2P2
GH08H093843 1.3 Ensembl ENCODE dbSUPER 10.1 +147.5 147507 4 MAX FEZF1 CEBPG RFX5 POLR2A ZSCAN5C FOS PRDM10 ATF7 KLF8 LOC105375645 FAM92A LINC00535 ENSG00000264448 ENSG00000254057 PIR34125
GH08H093900 1.2 Ensembl ENCODE dbSUPER 10.1 +205.3 205307 6 PKNOX1 TBL1XR1 JUN FOXK2 POLR2A FOS PRDM10 ATF7 RUNX3 MAFK PDP1 LINC00535 FAM92A FSBP LOC105375646 GC08M093861
GH08H093943 1.1 Ensembl ENCODE dbSUPER 9.9 +245.6 245633 2 STAT1 JUN EBF1 JUND GATA3 GLIS1 FOS ZFX WT1 LINC00535 FAM92A PDP1 PSMA2P2 PIR51498
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM92A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM92A Gene

Chromosome:
8
Start:
93,698,561 bp from pter
End:
93,731,527 bp from pter
Size:
32,967 bases
Orientation:
Plus strand

Genomic View for FAM92A Gene

Genes around FAM92A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM92A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM92A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM92A Gene

Proteins for FAM92A Gene

  • Protein details for FAM92A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1XBS5-FA92A_HUMAN
    Recommended name:
    Protein FAM92A
    Protein Accession:
    A1XBS5
    Secondary Accessions:
    • A1XBS4
    • Q32ND3
    • Q6AHW7
    • Q8N8R1
    • Q96L09

    Protein attributes for FAM92A Gene

    Size:
    289 amino acids
    Molecular mass:
    33431 Da
    Quaternary structure:
    • Homodimer (via BAR-like domain) (PubMed:27528616). Heterodimer with FAM92B (via BAR-like domains) (PubMed:27528616). Interacts (via BAR-like domain) with CBY1; this interaction is required for targeting FAM92A to centriole (PubMed:27528616).
    SequenceCaution:
    • Sequence=AAH14598.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI08708.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM92A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM92A Gene

Post-translational modifications for FAM92A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM92A Gene

Domains & Families for FAM92A Gene

Gene Families for FAM92A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM92A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM92A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1XBS5

UniProtKB/Swiss-Prot:

FA92A_HUMAN :
  • The BAR-like domain displays limited similarity to other BAR domains.
  • Belongs to the FAM92 family.
Domain:
  • The BAR-like domain displays limited similarity to other BAR domains.
Family:
  • Belongs to the FAM92 family.
genes like me logo Genes that share domains with FAM92A: view

Function for FAM92A Gene

Molecular function for FAM92A Gene

UniProtKB/Swiss-Prot Function:
May play a role in ciliogenesis (PubMed:27528616). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).

Phenotypes From GWAS Catalog for FAM92A Gene

Gene Ontology (GO) - Molecular Function for FAM92A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM92A: view

Phenotypes for FAM92A Gene

genes like me logo Genes that share phenotypes with FAM92A: view

Animal Models for FAM92A Gene

MGI Knock Outs for FAM92A:

Animal Model Products

CRISPR Products

miRNA for FAM92A Gene

miRTarBase miRNAs that target FAM92A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM92A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM92A Gene

Localization for FAM92A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM92A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Weak punctate vesicular distribution throughout the cytoplasm (PubMed:27528616). Localizes at the distal end of mother centrioles (PubMed:27528616). Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). {ECO:0000269 PubMed:27528616}.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM92A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM92A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 27528616
GO:0005814 centriole IDA,IEA 27528616
GO:0005856 cytoskeleton IEA --
GO:0036064 ciliary basal body IEA --
genes like me logo Genes that share ontologies with FAM92A: view

Pathways & Interactions for FAM92A Gene

SuperPathways for FAM92A Gene

No Data Available

Interacting Proteins for FAM92A Gene

Gene Ontology (GO) - Biological Process for FAM92A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IMP 27528616
genes like me logo Genes that share ontologies with FAM92A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM92A Gene

Drugs & Compounds for FAM92A Gene

No Compound Related Data Available

Transcripts for FAM92A Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM92A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM92A Gene

No ASD Table

Relevant External Links for FAM92A Gene

GeneLoc Exon Structure for
FAM92A
ECgene alternative splicing isoforms for
FAM92A

Expression for FAM92A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM92A Gene:

FAM92A

Evidence on tissue expression from TISSUES for FAM92A Gene

  • Blood(5)
  • Nervous system(4.4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM92A Gene

Orthologs for FAM92A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM92A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM92A1 34 33
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM92A1 34 34 33
  • 90 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam92a1 33
  • 87.65 (n)
mouse
(Mus musculus)
Mammalia Fam92a 16 34 33
  • 86.91 (n)
dog
(Canis familiaris)
Mammalia FAM92A1 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM92A1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM92A1 34 33
  • 77.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM92A1 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam92a1 33
  • 71.95 (n)
Str.4426 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11471 33
zebrafish
(Danio rerio)
Actinopterygii fam92a1 34 33
  • 67.16 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6405 34 33
  • 44.75 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009881 33
  • 42.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11121 34
  • 37 (a)
OneToMany
Species where no ortholog for FAM92A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM92A Gene

ENSEMBL:
Gene Tree for FAM92A (if available)
TreeFam:
Gene Tree for FAM92A (if available)

Paralogs for FAM92A Gene

Paralogs for FAM92A Gene

Pseudogenes.org Pseudogenes for FAM92A Gene

genes like me logo Genes that share paralogs with FAM92A: view

Variants for FAM92A Gene

Sequence variations from dbSNP and Humsavar for FAM92A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000012792 -- 93,731,513(+) ATCAA(A/C)TTTAC utr-variant-3-prime
rs1000162151 -- 93,715,353(+) AGTAG(C/T)TGACA intron-variant
rs1000342649 -- 93,720,525(+) AAACA(C/T)TACAG intron-variant
rs1000400155 -- 93,727,126(+) ACAAA(A/G)GCAGG intron-variant, utr-variant-3-prime
rs1000514042 -- 93,714,296(+) TTTTT(A/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM92A Gene

Variant ID Type Subtype PubMed ID
esv3543858 CNV deletion 23714750
nsv1022473 CNV loss 25217958
nsv528872 CNV loss 19592680
nsv831399 CNV loss 17160897

Variation tolerance for FAM92A Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM92A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM92A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM92A Gene

Disorders for FAM92A Gene

Relevant External Links for FAM92A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM92A

No disorders were found for FAM92A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM92A Gene

Publications for FAM92A Gene

  1. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. (PMID: 27528616) Li FQ … Takemaru KI (Molecular and cellular biology 2016) 2 3 4 60
  2. Identification and characterization of two novel variants of the DUF1208 protein FAM92A1. (PMID: 17646714) Ruan XZ … Wei YQ (Molecules and cells 2007) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The Tumor-promoting Effects of FAM92A1-289 in Cervical Carcinoma Cells. (PMID: 27798880) Gui H … Ruan XZ (Anticancer research 2016) 3 60

Products for FAM92A Gene

Sources for FAM92A Gene

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