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Aliases for FAM91A1 Gene

Aliases for FAM91A1 Gene

  • Family With Sequence Similarity 91 Member A1 2 3 5
  • Family With Sequence Similarity 91, Member A1 2

External Ids for FAM91A1 Gene

Previous GeneCards Identifiers for FAM91A1 Gene

  • GC08P124860
  • GC08P120107
  • GC08P124780

Summaries for FAM91A1 Gene

GeneCards Summary for FAM91A1 Gene

FAM91A1 (Family With Sequence Similarity 91 Member A1) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM91A1 Gene

Genomics for FAM91A1 Gene

Regulatory Elements for FAM91A1 Gene

Enhancers for FAM91A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F124440 1.1 Ensembl ENCODE 11.3 +672.2 672162 0.8 PKNOX1 ARID4B SIN3A DMAP1 BRCA1 RAD21 RARA SLC30A9 GATA2 ZNF366 TRMT12 NSMCE2 FAM91A1 FER1L6-AS1 ENSG00000254249 GC08P124425
GH08F124442 0.5 ENCODE 11.3 +673.7 673716 0.2 FAM91A1 ENSG00000254249 FER1L6-AS1 TRMT12 GC08P124425
GH08F123920 1.1 Ensembl ENCODE 11.2 +153.3 153285 3.1 ATF1 PKNOX1 ARNT CREB3L1 SIN3A ZNF48 ELK1 GATA2 ZNF143 FOS RNF139-AS1 FAM91A1 FER1L6 ENSG00000254000 GC08P123918
GH08F123686 0.8 FANTOM5 Ensembl ENCODE 11 -80.9 -80851 2.3 L3MBTL2 MGA FBXO32 KLHL38 ANXA13 FAM91A1 LOC105375738 ATAD2 WDYHV1 DUTP2 MIR548AA1 RNU6-875P
GH08F123718 1.3 Ensembl ENCODE 10.8 -48.5 -48505 3.4 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 PPARG FAM91A1 FBXO32 ATAD2 WDYHV1 RNU6-875P DUTP2 MIR548AA1 ENSG00000253106 LOC105375739 ANXA13
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM91A1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM91A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400698 762 3200 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 FOS

Genomic Location for FAM91A1 Gene

Chromosome:
8
Start:
123,768,439 bp from pter
End:
123,815,452 bp from pter
Size:
47,014 bases
Orientation:
Plus strand

Genomic View for FAM91A1 Gene

Genes around FAM91A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM91A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM91A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM91A1 Gene

Proteins for FAM91A1 Gene

  • Protein details for FAM91A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q658Y4-F91A1_HUMAN
    Recommended name:
    Protein FAM91A1
    Protein Accession:
    Q658Y4
    Secondary Accessions:
    • B6YY23
    • Q658T5
    • Q8TE89

    Protein attributes for FAM91A1 Gene

    Size:
    838 amino acids
    Molecular mass:
    93909 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85063.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM91A1 Gene

Post-translational modifications for FAM91A1 Gene

  • Ubiquitination at Lys 638
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM91A1 Gene

No data available for DME Specific Peptides for FAM91A1 Gene

Domains & Families for FAM91A1 Gene

Protein Domains for FAM91A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM91A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q658Y4

UniProtKB/Swiss-Prot:

F91A1_HUMAN :
  • Belongs to the FAM91 family.
Family:
  • Belongs to the FAM91 family.
genes like me logo Genes that share domains with FAM91A1: view

No data available for Gene Families for FAM91A1 Gene

Function for FAM91A1 Gene

genes like me logo Genes that share phenotypes with FAM91A1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM91A1 Gene

Localization for FAM91A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM91A1 Gene COMPARTMENTS Subcellular localization image for FAM91A1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM91A1 Gene

Pathways & Interactions for FAM91A1 Gene

SuperPathways for FAM91A1 Gene

SuperPathway Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with FAM91A1: view

Pathways by source for FAM91A1 Gene

1 BioSystems pathway for FAM91A1 Gene

Interacting Proteins for FAM91A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335082%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000262854%0d%0a
Selected Interacting proteins: Q658Y4-F91A1_HUMAN ENSP00000335082 for FAM91A1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM91A1 Gene

None

No data available for SIGNOR curated interactions for FAM91A1 Gene

Transcripts for FAM91A1 Gene

Unigene Clusters for FAM91A1 Gene

Family with sequence similarity 91, member A1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM91A1 Gene

No ASD Table

Relevant External Links for FAM91A1 Gene

GeneLoc Exon Structure for
FAM91A1
ECgene alternative splicing isoforms for
FAM91A1

Expression for FAM91A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM91A1 Gene

Protein differential expression in normal tissues from HIPED for FAM91A1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM91A1 Gene



Protein tissue co-expression partners for FAM91A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM91A1 Gene:

FAM91A1

SOURCE GeneReport for Unigene cluster for FAM91A1 Gene:

Hs.459174
genes like me logo Genes that share expression patterns with FAM91A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM91A1 Gene

Orthologs for FAM91A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM91A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM91A1 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia FAM91A1 34 35
  • 93 (n)
cow
(Bos Taurus)
Mammalia FAM91A1 34 35
  • 91.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM91A1 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM91A1 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam91a1 34
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia D15Ertd621e 34 35
  • 88.73 (n)
Fam91a1 16
chicken
(Gallus gallus)
Aves FAM91A1 34 35
  • 81.63 (n)
lizard
(Anolis carolinensis)
Reptilia FAM91A1 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam91a1 34
  • 75.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8925 34
zebrafish
(Danio rerio)
Actinopterygii fam91a1 34 35
  • 71.42 (n)
zgc63609 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002874 34
  • 48.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7600 34 35
  • 48.62 (n)
worm
(Caenorhabditis elegans)
Secernentea F33H2.2 34 35
  • 52.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G35220 34
  • 48.63 (n)
rice
(Oryza sativa)
Liliopsida Os01g0303200 34
  • 49.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
Species where no ortholog for FAM91A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM91A1 Gene

ENSEMBL:
Gene Tree for FAM91A1 (if available)
TreeFam:
Gene Tree for FAM91A1 (if available)

Paralogs for FAM91A1 Gene

(1) SIMAP similar genes for FAM91A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM91A1: view

No data available for Paralogs for FAM91A1 Gene

Variants for FAM91A1 Gene

Sequence variations from dbSNP and Humsavar for FAM91A1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10094050 -- 123,795,016(+) atgca(A/G)ctttt intron-variant
rs1045923 -- 123,814,599(+) ATCAT(G/T)AATTT nc-transcript-variant, utr-variant-3-prime
rs10505441 -- 123,777,934(+) TGAAA(A/T)TAAGC intron-variant
rs10956148 -- 123,770,100(+) GGTGC(A/G)CGCCA intron-variant
rs10956149 -- 123,807,479(+) TCTCT(A/C)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM91A1 Gene

Variant ID Type Subtype PubMed ID
nsv6373 CNV deletion 18451855
nsv831451 CNV gain+loss 17160897
nsv971699 CNV duplication 23825009

Variation tolerance for FAM91A1 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM91A1 Gene

Human Gene Mutation Database (HGMD)
FAM91A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM91A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM91A1 Gene

Disorders for FAM91A1 Gene

Relevant External Links for FAM91A1

Genetic Association Database (GAD)
FAM91A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM91A1

No disorders were found for FAM91A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM91A1 Gene

Publications for FAM91A1 Gene

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for FAM91A1 Gene

Sources for FAM91A1 Gene

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