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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM91A1 Gene

protein-coding   GIFtS: 47
GCID: GC08P124780

Family With Sequence Similarity 91, Member A1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 91, Member A11 2
Protein FAM91A12
Skeletal Muscle Cells Re-Entry Induced2

External Ids:    HGNC: 263061   Entrez Gene: 1577692   Ensembl: ENSG000001768537   UniProtKB: Q658Y43   

Export aliases for FAM91A1 gene to outside databases

Previous GC identifers: GC08P124860 GC08P120107


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM91A1 Gene: 
FAM91A1 (family with sequence similarity 91, member A1) is a protein-coding gene. Diseases associated with FAM91A1 include pancreatic cancer, and pancreatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM91A1 gene promoter:
         STAT1   STAT1beta   CUTL1   STAT1alpha   RORalpha2   GATA-1   POU2F1   Ik-2   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM91A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM91A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM91A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

FAM91A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM91A1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P124780:  view genomic region     (about GC identifiers)

Start:
124,780,696 bp from pter      End:
124,827,692 bp from pter
Size:
46,997 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F91A1_HUMAN, Q658Y4 (See protein sequence)
Recommended Name: Protein FAM91A1  
Size: 838 amino acids; 93909 Da
Sequence caution: Sequence=BAB85063.1; Type=Erroneous initiation;
Secondary accessions: B6YY23 Q658T5 Q8TE89

Explore the universe of human proteins at neXtProt for FAM91A1: NX_Q658Y4

Explore proteomics data for FAM91A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q658Y4

  • FAM91A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM91A1 Protein Expression
    REFSEQ proteins: NP_659400.2  
    ENSEMBL proteins: 
     ENSP00000429491   ENSP00000335082   ENSP00000429784   ENSP00000430158   ENSP00000431097  

    Human Recombinant Protein Products for FAM91A1: 
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    Assay Products for FAM91A1: 
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    Cloud-Clone Corp. CLIAs for FAM91A1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q658Y4

    UniProtKB/Swiss-Prot: F91A1_HUMAN, Q658Y4
    Similarity: Belongs to the FAM91 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM91A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM91A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM91A1 
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    SwitchGear 3'UTR luciferase reporter plasmidFAM91A1 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM91A1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM91A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FAM91A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 2
    Gastric cancer network 2


    1 BioSystems Pathway for FAM91A1
        Gastric cancer network 2


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM91A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for FAM91A1 (Q658Y43 ENSP000003350824) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1Q9H0R83I2D: score=2 
    MAP1LC3BQ9GZQ83I2D: score=1 
    MED4Q9NPJ63I2D: score=1 
    PAHP004393I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM91A1 (F91A1)

    Search CenterWatch for drugs/clinical trials and news about FAM91A1 / F91A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM91A1 gene: 
    NM_144963.2  

    Unigene Cluster for FAM91A1:

    Family with sequence similarity 91, member A1
    Hs.459174  [show with all ESTs]
    Unigene Representative Sequence: AL832999
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521166(uc011lik.1) ENST00000334705(uc003yqv.3 uc011lil.2)
    ENST00000519721 ENST00000521704 ENST00000517912 ENST00000518333 ENST00000518976
    ENST00000520246
    miRNA
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM91A1 (see all 58):
    hsa-miR-142-5p hsa-miR-15a hsa-miR-200a hsa-miR-134 hsa-miR-30d hsa-miR-219-5p hsa-miR-3916 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidFAM91A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM91A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM91A1
    Clone
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    OriGene clones in human, mouse for FAM91A1 (see all 7)
    OriGene ORF clones in mouse, rat for FAM91A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM91A1 (NM_144963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM91A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM91A1
    Sirion Biotech Customized lentivirus for stable overexpression of FAM91A1 
                         Customized lentivirus expression plasmids for stable overexpression of FAM91A1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM91A1
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM91A1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM91A1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM91A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM91A1

    Additional mRNA sequence: 

    AK074370.1 AK300603.1 AL832830.1 AL832999.1 BC030520.1 BC144630.1 DQ228141.1 

    9 DOTS entries:

    DT.100818566  DT.97768720  DT.92422857  DT.70104629  DT.95372824  DT.121481344  DT.40225130  DT.91988771 
    DT.95160693 

    24/228 AceView cDNA sequences (see all 228):

    N25189 AW778908 BU167041 CB215998 AI281168 BM469613 Z46022 BM054889 
    BM828638 NM_144963 Z41637 CA435372 AI246035 AI804888 BM857373 AL832999 
    AI701246 AA954281 CA419311 BM478807 AI741908 BU738546 AI273738 AI521060 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM91A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACAAATA
    FAM91A1 Expression
    About this image


    See FAM91A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM91A1

    SOURCE GeneReport for Unigene cluster: Hs.459174
        SABiosciences Custom PCR Arrays for FAM91A1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAM91A1
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM91A1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM91A1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM91A1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM91A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM91A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAM91A1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D15Ertd621e1 , 5 DNA segment, Chr 15, ERATO Doi 621, expressed1, 5 88.73(n)1
    94.98(a)1
      15 (24.76 cM)5
    2109981  NM_145959.31  NP_666071.21 
     584154685 
    chicken
    (Gallus gallus)
    Aves FAM91A11 family with sequence similarity 91, member A1 81.63(n)
    88.96(a)
      770621  XM_001233959.1  XP_001233960.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM91A16
    Uncharacterized protein
    87(a)
    1 ↔ 1
    4(6628794-6664681)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89252 Xenopus laevis transcribed sequence with weak similarity more 81.47(n)    BG554525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636092 hypothetical protein MGC63609 77.26(n)   393413  AY423008.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76001 CG7600 49.36(n)
    45.14(a)
      39267  NM_140196.3  NP_648453.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F33H2.21 Protein F33H2.2 51.78(n)
    46.56(a)
      173371  NM_061218.4  NP_493619.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G352201 hypothetical protein 47.74(n)
    36.51(a)
      840411  NM_103220.2  NP_174756.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g03032001 hypothetical protein 48.77(n)
    38.04(a)
      4323900  NM_001049367.1  NP_001042832.1 


    ENSEMBL Gene Tree for FAM91A1 (if available)
    TreeFam Gene Tree for FAM91A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM91A1 gene
    1 SIMAP similar gene for FAM91A1 using alignment to 6 protein entries:     F91A1_HUMAN (see all proteins):
    FAM91A2

    FAM91A1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for FAM91A1 (see all 9)
    PGOHUM00000256670 PGOHUM00000244909 PGOHUM00000244974 PGOHUM00000256882 PGOHUM00000256883


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/928 SNPs in FAM91A1 are shown (see all 928)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0674494
    ----see VAR_0674492 C Y mis40--------
    rs285131261,2
    F--125049721(+) TTTTAC/TAGTTT 1 -- us2k10--------
    rs1846628871,2
    --125049738(+) TGTCCA/TCTAAA 1 -- us2k10--------
    rs1879312681,2
    C--125049742(+) CACTAA/CACTCA 1 -- us2k10--------
    rs2000715721,2
    --125049817(+) AGGGA-/TTTTTT 1 -- us2k10--------
    rs1165021371,2
    C--125049827(+) TTAAGC/TTAAAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1918781271,2
    --125049960(+) TTGAAG/TGAACA 1 -- us2k10--------
    rs737036531,2
    C,F--125050000(+) GTTCAG/ATGAGT 1 -- us2k13Minor allele frequency- A:0.03WA NA 240
    rs588707941,2
    C,F--125050059(+) CCTTCG/AGCTCC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1843696241,2
    --125050074(+) TGGCTC/GTGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM91A1 (124780696 - 124827692 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM91A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6373CNV Loss18451855
    nsv831451CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): FAM91A1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM91A1
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM91A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for FAM91A1:    About MalaCards
    pancreatic cancer    pancreatitis


    FAM91A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM91A1

    Export disorders for FAM91A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM91A1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with FAM91A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1 Low S.K....Sakamoto H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157769 HGNC: 26306 AceView: FLJ23790 Ensembl:ENSG00000176853 euGenes: HUgn157769
    ECgene: FAM91A1 H-InvDB: FAM91A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM91A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM91A1 gene:
    Search GeneIP for patents involving FAM91A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Proteins for FAM91A1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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