FAM8A1 Gene
protein-coding GIFtS: 43
GCID: GC06P017600
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family with sequence similarity 8, member A1
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Aliases
for FAM8A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 8, Member A11 2 | | AHCP1 2 3 | | Autosomal Highly Conserved Protein2 3 | | Protein FAM8A12 |
Export aliases for FAM8A1 gene to outside databasesPrevious GC identifers: GC06P017658 GC06P017708 GC06P017545 |
Summaries
for FAM8A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM8A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM8A1 gene promoter:
C/EBPbeta p53 AML1a CUTL1 E4BP4 MZF-1 NF-kappaB2 Sox9 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM8A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM8A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p23 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p23FAM8A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P017600: view genomic region
(about GC identifiers)
Start:
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17,600,518 bp from pter |
End:
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17,611,950 bp from pter |
Size:
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11,433 bases |
Orientation:
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plus strand |
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Proteins
for FAM8A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA8A1_HUMAN, Q9UBU6 (See
protein sequence)Recommended Name: Protein FAM8A1 Size: 413 amino acids; 44123 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R725Explore the universe of human proteins at neXtProt for FAM8A1: NX_Q9UBU6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBU6
FAM8A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057339.1
ENSEMBL proteins: ENSP00000259963
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FAM8A1 for ontologies About GeneDecksing
FAM8A1 Antibody Products:
Assay Products for FAM8A1: |
Protein
Domains /
Families
for FAM8A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM8A1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UBU6ProtoNet protein and cluster: Q9UBU6 1 Blocks protein family: IPB010432 RDD
UniProtKB/Swiss-Prot: FA8A1_HUMAN, Q9UBU6Similarity: Contains 1 RDD domain |
Function
for FAM8A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM8A1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM8A1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM8A1 (NM_016255) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM8A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM8A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM8A1 |
|
Pathways & Interactions
for FAM8A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM8A1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FAM8A1 (ENSP000002599634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM8A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM8A1
Search CenterWatch for drugs/clinical trials and news about FAM8A1 / FA8A1
|
Transcripts
for FAM8A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM8A1 gene: NM_016255.2 Unigene Cluster for FAM8A1: Family with sequence similarity 8, member A1 Hs.95260 [show with all ESTs]Unigene Representative Sequence: NM_0162551 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000259963(uc003ncc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM8A1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM8A1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM8A1 (NM_016255) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM8A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM8A1 |
Additional cDNA sequence: AF086479.1 AF097027.1 AK074301.1 AK296393.1 AK307681.1 AK312814.1 AL050128.1 BC047881.1 2 DOTS entries: DT.211606 DT.100688696 24/182 AceView cDNA sequences (see all 182): CD244058 CB155681 BQ720425 BU753053 AI417454 BM542075 BM996027 BM712759 AW304962 AI474344 BU188115 AI249896 CB158899 AI914916 AI696410 AV720532 AV659414 BM676104 AA343954 AI285169 AI870078 AA044817 BX505712 AA719094
GeneLoc Exon Structure
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Expression
for FAM8A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM8A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGCCTGGA
About this image
See FAM8A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM8A1
SOURCE GeneReport for Unigene cluster: Hs.95260
UniProtKB/Swiss-Prot: FA8A1_HUMAN, Q9UBU6Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis
SABiosciences Custom PCR Arrays for FAM8A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM8A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM8A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM8A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM8A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM8A1 |
Orthologs
for FAM8A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM8A1 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for FAM8A1 (if available)
TreeFam Gene Tree for FAM8A1 (if available) |
Paralogs
for FAM8A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM8A1 gene
FAM8A1 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for FAM8A1 (see all 8)
PGOHUM00000242273 PGOHUM00000240979 PGOHUM00000243383 PGOHUM00000262551 PGOHUM00000236892
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Genomic Variants
for FAM8A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM8A1 (17600518 - 17611950 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM8A1
1 CNV: 4486
Human Gene Mutation Database (HGMD): FAM8A1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM8A1 |
|
Disorders
/ Diseases
for FAM8A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM8A1 for disorders About GeneDecksing
1  disease for FAM8A1: About MalaCardssmall intestine lymphoma
Export disorders for FAM8A1 gene to outside databases
|
Publications
for FAM8A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM8A1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM8A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transduction of the human gene FAM8A1 by endogenous retrovirus during primate evolution. (PubMed id 11707071)1, 2, 3 Jamain S....Bourgeron T. (2001)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- Defining human ERAD networks through an integrative mapping strategy. (PubMed id 22119785)1 Christianson J.C.... Kopito R.R. (2012)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for FAM8A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FAM8A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM8A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM8A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM8A1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FAM8A1 gene:
Search GeneIP for patents involving FAM8A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM8A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM8A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM8A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM8A1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM8A1 | | OriGene 3'-UTR Clone for FAM8A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM8A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM8A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for FAM8A1 |
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 | | | FAM8A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM8A1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM8A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM8A1 |
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