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Aliases for FAM8A1 Gene

Aliases for FAM8A1 Gene

  • Family With Sequence Similarity 8, Member A1 2 3
  • Autosomal Highly Conserved Protein 3 4
  • AHCP 3 4

External Ids for FAM8A1 Gene

Previous GeneCards Identifiers for FAM8A1 Gene

  • GC06P017658
  • GC06P017708
  • GC06P017545

Summaries for FAM8A1 Gene

GeneCards Summary for FAM8A1 Gene

FAM8A1 (Family With Sequence Similarity 8, Member A1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM8A1 Gene

Genomics for FAM8A1 Gene

Regulatory Elements for FAM8A1 Gene

Genomic Location for FAM8A1 Gene

Chromosome:
6
Start:
17,600,287 bp from pter
End:
17,611,719 bp from pter
Size:
11,433 bases
Orientation:
Plus strand

Genomic View for FAM8A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM8A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM8A1 Gene

Proteins for FAM8A1 Gene

  • Protein details for FAM8A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU6-FA8A1_HUMAN
    Recommended name:
    Protein FAM8A1
    Protein Accession:
    Q9UBU6
    Secondary Accessions:
    • B2R725

    Protein attributes for FAM8A1 Gene

    Size:
    413 amino acids
    Molecular mass:
    44123 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM8A1 Gene

Proteomics data for FAM8A1 Gene at MOPED

Post-translational modifications for FAM8A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM8A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM8A1 Gene

Domains & Families for FAM8A1 Gene

Protein Domains for FAM8A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM8A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBU6

UniProtKB/Swiss-Prot:

FA8A1_HUMAN :
  • Contains 1 RDD domain.
Domain:
  • Contains 1 RDD domain.
genes like me logo Genes that share domains with FAM8A1: view

No data available for Gene Families for FAM8A1 Gene

Function for FAM8A1 Gene

genes like me logo Genes that share phenotypes with FAM8A1: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM8A1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM8A1 Gene

Localization for FAM8A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM8A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM8A1 Gene COMPARTMENTS Subcellular localization image for FAM8A1 gene
Compartment Confidence
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for FAM8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM8A1: view

Pathways & Interactions for FAM8A1 Gene

SuperPathways for FAM8A1 Gene

No Data Available

Interacting Proteins for FAM8A1 Gene

Gene Ontology (GO) - Biological Process for FAM8A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM8A1 Gene

Drugs & Compounds for FAM8A1 Gene

No Compound Related Data Available

Transcripts for FAM8A1 Gene

mRNA/cDNA for FAM8A1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(182) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM8A1 Gene

Family with sequence similarity 8, member A1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM8A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM8A1 Gene

No ASD Table

Relevant External Links for FAM8A1 Gene

GeneLoc Exon Structure for
FAM8A1
ECgene alternative splicing isoforms for
FAM8A1

Expression for FAM8A1 Gene

mRNA expression in normal human tissues for FAM8A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM8A1 Gene

This gene is overexpressed in Adrenal (35.1) and Testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM8A1 Gene



SOURCE GeneReport for Unigene cluster for FAM8A1 Gene Hs.95260

mRNA Expression by UniProt/SwissProt for FAM8A1 Gene

Q9UBU6-FA8A1_HUMAN
Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis.
genes like me logo Genes that share expression patterns with FAM8A1: view

Protein tissue co-expression partners for FAM8A1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM8A1 Gene

Orthologs for FAM8A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM8A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM8A1 35
  • 87.19 (n)
  • 82.48 (a)
FAM8A1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM8A1 35
  • 85.08 (n)
  • 79.58 (a)
FAM8A1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C78339 35
  • 82.65 (n)
  • 81.12 (a)
C78339 16
C78339 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM8A1 35
  • 99.51 (n)
  • 99.51 (a)
FAM8A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam8a1 35
  • 84.51 (n)
  • 82.51 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM8A1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM8A1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM8A1 35
  • 73.14 (n)
  • 74.67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam8a1 35
  • 67.51 (n)
  • 68.23 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
LOC100537042 35
  • 61.82 (n)
  • 58.16 (a)
fam8a1 36
  • 49 (a)
OneToMany
FAM8A1 (2 of 3) 36
  • 54 (a)
OneToMany
FAM8A1 (3 of 3) 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8237 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for FAM8A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM8A1 Gene

ENSEMBL:
Gene Tree for FAM8A1 (if available)
TreeFam:
Gene Tree for FAM8A1 (if available)

Paralogs for FAM8A1 Gene

genes like me logo Genes that share paralogs with FAM8A1: view

No data available for Paralogs for FAM8A1 Gene

Variants for FAM8A1 Gene

Sequence variations from dbSNP and Humsavar for FAM8A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1012470 -- 17,607,405(-) gaggt(G/T)gttag intron-variant
rs1055111 -- 17,609,859(+) TTTCT(G/T)TGACG utr-variant-3-prime
rs1063675 -- 17,611,071(+) CCAAC(G/T)GAACT utr-variant-3-prime
rs1969830 -- 17,606,182(+) CAGTA(C/T)ACATT intron-variant
rs1986139 -- 17,606,512(+) GATCA(C/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM8A1 Gene

Variant ID Type Subtype PubMed ID
nsv516012 CNV Gain+Loss 19592680
nsv883455 CNV Gain 21882294
nsv883456 CNV Gain 21882294
nsv883457 CNV Gain 21882294
nsv883458 CNV Gain 21882294
nsv830596 CNV Gain 17160897
esv2731633 CNV Deletion 23290073

Variation tolerance for FAM8A1 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM8A1 Gene

HapMap Linkage Disequilibrium report
FAM8A1
Human Gene Mutation Database (HGMD)
FAM8A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM8A1 Gene

Disorders for FAM8A1 Gene

Relevant External Links for FAM8A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM8A1
genes like me logo Genes that share disorders with FAM8A1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM8A1 Gene

Publications for FAM8A1 Gene

  1. Transduction of the human gene FAM8A1 by endogenous retrovirus during primate evolution. (PMID: 11707071) Jamain S. … Bourgeron T. (Genomics 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 67
  5. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 67

Products for FAM8A1 Gene

Sources for FAM8A1 Gene

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