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FAM89B Gene(Protein Coding)

Family With Sequence Similarity 89 Member B

GCID:
GC11P065572
GIFtS:
43
Genes Participants
UDN Logo

Aliases for FAM89B Gene

Aliases for FAM89B Gene

  • Family With Sequence Similarity 89 Member B 2 3 5
  • Family With Sequence Similarity 89, Member B 2
  • Mammary Tumor Virus Receptor Homolog 1 3
  • Leucine Repeat Adaptor Protein 25 3
  • Protein FAM89B 3
  • LRAP25 3
  • MTVR1 3
  • MTVR 3

External Ids for FAM89B Gene

Previous GeneCards Identifiers for FAM89B Gene

  • GC11P065097
  • GC11P065339
  • GC11P061667

Summaries for FAM89B Gene

GeneCards Summary for FAM89B Gene

FAM89B (Family With Sequence Similarity 89 Member B) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor binding. An important paralog of this gene is MIR1182.

UniProtKB/Swiss-Prot for FAM89B Gene

  • Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89B Gene

Genomics for FAM89B Gene

Products:

  1. Regulatory Element

Regulatory Elements for FAM89B Gene

Enhancers for FAM89B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065636 1.3 FANTOM5 ENCODE 11.3 +68.3 68334 8.2 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 GLIS2 ZNF207 SIPA1 KCNK7 RNASEH2C MAP3K11 EHBP1L1 TIGD3 FAM89B SSSCA1 CFL1 SNX32
GH11F065811 0.9 Ensembl ENCODE 10.2 +239.9 239858 2.0 PKNOX1 NR2F1 ZNF223 CEBPB EBF1 BCL11B NCOR1 SMARCA4 POLR2A BCL11A SNX32 CTSW MAP3K11 OVOL1-AS1 OVOL1 AP5B1 CFL1 PCNX3 CCDC85B FIBP
GH11F065609 1.5 FANTOM5 ENCODE 3.6 +41.7 41650 8.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MAP3K11 MRPL11 SIPA1 RNASEH2C CD248 CTSF NEAT1 LOC105369352 FAU EIF1AD
GH11F065567 1.5 FANTOM5 ENCODE 0.8 +1.3 1326 12.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC NEAT1 MRPL11 KCNK7 CD248 EHBP1L1 TIGD3 MAP3K11 CTSW PCNX3 CDC42EP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM89B on UCSC Golden Path with GeneCards custom track

Promoters for FAM89B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769295 451 1201 HDGF SIN3A RAD21 ZNF654 SP3 ZBTB2 ZEB2 REST SP1 ZFP69B
ENSR00001769296 1351 201 HIC1 ZFP69B POLR2A ZBTB8A REST

Transcription factor binding sites by QIAGEN in the FAM89B gene promoter:

Genomic Location for FAM89B Gene

Chromosome:
11
Start:
65,572,349 bp from pter
End:
65,574,198 bp from pter
Size:
1,850 bases
Orientation:
Plus strand

Genomic View for FAM89B Gene

Genes around FAM89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM89B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FAM89B Gene

Proteins for FAM89B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FAM89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5H3-FA89B_HUMAN
    Recommended name:
    Protein FAM89B
    Protein Accession:
    Q8N5H3
    Secondary Accessions:
    • E9PB01
    • E9PL72
    • Q6PJ27

    Protein attributes for FAM89B Gene

    Size:
    189 amino acids
    Molecular mass:
    20147 Da
    Quaternary structure:
    • Interacts with SKI.

    Alternative splice isoforms for FAM89B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM89B Gene

Protein Expression for FAM89B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FAM89B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM89B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM89B Gene

Domains & Families for FAM89B Gene

Protein Domains for FAM89B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5H3

UniProtKB/Swiss-Prot:

FA89B_HUMAN :
  • Belongs to the FAM89 family.
Family:
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89B: view

No data available for Gene Families for FAM89B Gene

Function for FAM89B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FAM89B Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.

Gene Ontology (GO) - Molecular Function for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001222 transcription corepressor binding ISS --
genes like me logo Genes that share ontologies with FAM89B: view
genes like me logo Genes that share phenotypes with FAM89B: view

Animal Model Products

miRNA for FAM89B Gene

miRTarBase miRNAs that target FAM89B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89B Gene

Localization for FAM89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM89B Gene

Isoform 3: Cytoplasm.
Isoform 1: Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM89B gene
Compartment Confidence
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with FAM89B: view

Pathways & Interactions for FAM89B Gene

SuperPathways for FAM89B Gene

PathCards logo More details on SuperPathways for FAM89B
No Data Available

Interacting Proteins for FAM89B Gene

Selected Interacting proteins: Q8N5H3-FA89B_HUMAN for FAM89B Gene via IID

Symbol External ID(s) Details
MOV10
SEPT8

Gene Ontology (GO) - Biological Process for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA,ISS --
GO:0060392 negative regulation of SMAD protein import into nucleus IEA,ISS --
genes like me logo Genes that share ontologies with FAM89B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM89B Gene

Drugs & Compounds for FAM89B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FAM89B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FAM89B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(429) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM89B Gene

Family with sequence similarity 89, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e
SP1:
SP2: -
SP3: - -

Relevant External Links for FAM89B Gene

GeneLoc Exon Structure for
FAM89B
ECgene alternative splicing isoforms for
FAM89B

Expression for FAM89B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM89B Gene

mRNA expression in normal human tissues for FAM89B Gene
mRNA expression by BioGPS for FAM89B Gene

Protein differential expression in normal tissues from HIPED for FAM89B Gene

This gene is overexpressed in Heart (28.8), Peripheral blood mononuclear cells (22.9), and Fetal Brain (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM89B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM89B Gene:

FAM89B

SOURCE GeneReport for Unigene cluster for FAM89B Gene:

Hs.731854
genes like me logo Genes that share expression patterns with FAM89B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM89B Gene

Orthologs for FAM89B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FAM89B 34 35
  • 97 (n)
cow
(Bos Taurus)
 Mammalia MGC140823 35
  • 94 (a)
 OneToOne
FAM89B 34
  • 88.89 (n)
dog
(Canis familiaris)
 Mammalia FAM89B 34 35
  • 88.36 (n)
mouse
(Mus musculus)
 Mammalia Fam89b 34 16 35
  • 88.36 (n)
rat
(Rattus norvegicus)
 Mammalia Fam89b 34
  • 87.3 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.7511 34
African clawed frog
(Xenopus laevis)
 Amphibia MGC53407 34
zebrafish
(Danio rerio)
 Actinopterygii LOC100151239 34
  • 61.45 (n)
fam89b 35
  • 53 (a)
 OneToOne
Dr.18883 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3539 34
Species where no ortholog for FAM89B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89B Gene

ENSEMBL:
Gene Tree for FAM89B (if available)
TreeFam:
Gene Tree for FAM89B (if available)

Paralogs for FAM89B Gene

Paralogs for FAM89B Gene

(1) SIMAP similar genes for FAM89B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM89B: view

Variants for FAM89B Gene

Sequence variations from dbSNP and Humsavar for FAM89B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1046376 -- 65,570,695(+) CGGCT(A/C)ATGGG upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs10896017 -- 65,572,664(+) CGGCC(C/T)CGGCC utr-variant-5-prime
rs111357827 -- 65,570,971(+) TCCCG(C/G)TAAGA upstream-variant-2KB, splice-donor-variant
rs111757605 -- 65,572,661(+) CGCCG(C/G)CCCCG utr-variant-5-prime
rs111925308 -- 65,573,727(+) TGCGC(A/C/G)TTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM89B Gene

Variant ID Type Subtype PubMed ID
nsv951018 CNV deletion 24416366
nsv1126297 CNV deletion 24896259
nsv1069596 CNV deletion 25765185
nsv1069595 CNV deletion 25765185
dgv1969n54 CNV loss 21841781

Variation tolerance for FAM89B Gene

Gene Damage Index Score: 0.53; 11.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM89B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM89B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89B Gene

Disorders for FAM89B Gene

Relevant External Links for FAM89B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM89B

No disorders were found for FAM89B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89B Gene

Publications for FAM89B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Identification of human homologues of the mouse mammary tumor virus receptor. (PMID: 11958456) Stewart A.F. (Arch. Virol. 2002) 3 22 64
  3. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PMID: 10512749) Sakuma-Takagi M. … Kurihara T. (Biochem. Biophys. Res. Commun. 1999) 2 3 64
  4. A novel membrane protein is a mouse mammary tumor virus receptor. (PMID: 9525630) Golovkina T.V. … Ross S.R. (J. Virol. 1998) 2 3 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for FAM89B Gene

Sources for FAM89B Gene

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