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FAM89B Gene

protein-coding GIFtS: 41
GCID: GC11P065339

Family With Sequence Similarity 89, Member B

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Family With Sequence Similarity 89, Member B¹ ²
MTVR1²
Mammary Tumor Virus Receptor Homolog 1²
Protein FAM89B²

External Ids:	HGNC: 16708¹	Entrez Gene: 23625²	Ensembl: ENSG00000176973⁷	UniProtKB: Q8N5H3³

Export aliases for FAM89B gene to outside databases

Previous GC identifers: GC11P065097 GC11P061667

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM89B Gene:

FAM89B (family with sequence similarity 89, member B) is a protein-coding gene. GO annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.

UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3

Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of

SMAD2 from the nucleus to the cytoplasm in response to TGF-beta (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Regulatory transcription factor binding sites in the FAM89B gene promoter:
Spz1 E2F-1 E2F p53 NRSF form 1 FOXO3 Nkx2-5 NRSF form 2 C/EBPalpha GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM89B promoter sequence

Search Chromatin IP Primers for FAM89B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM89B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q23

FAM89B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM89B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065339: view genomic region (about GC identifiers)

Start:	65,339,820 bp from pter	End:	65,341,669 bp from pter
Size:	1,850 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3 (See protein sequence)

Recommended Name: Protein FAM89B

Size: 189 amino acids; 20147 Da

Subunit: Interacts with SKI (By similarity)

Secondary accessions: E9PB01 E9PL72 Q6PJ27

Alternative splicing: 4 isoforms: Q8N5H3-3 Q8N5H3-1 Q8N5H3-2 Q8N5H3-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM89B: NX_Q8N5H3

Explore proteomics data for FAM89B at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See FAM89B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001092254.1 NP_001092255.1 NP_690045.1

ENSEMBL proteins:

ENSP00000314829 ENSP00000402439 ENSP00000431459

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR026654 FAM89

Graphical View of Domain Structure for InterPro Entry Q8N5H3

ProtoNet protein and cluster: Q8N5H3

UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3

Similarity: Belongs to the FAM89 family

Find genes that share domains with FAM89B About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FA89B_HUMAN, Q8N5H3

Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of

SMAD2 from the nucleus to the cytoplasm in response to TGF-beta (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001222	transcription corepressor binding	ISS	--
GO:0005515	protein binding	--	--

Find genes that share ontologies with FAM89B About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for FAM89B:

Decreased melanin production

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for FAM89B

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

FA89B_HUMAN, Q8N5H3: Isoform 3: Cytoplasm (By similarity)

FA89B_HUMAN, Q8N5H3: Isoform 1: Cell surface (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	1
extracellular	1
mitochondrion	1
nucleus	1
peroxisome	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0009986	cell surface	IEA	--

Find genes that share ontologies with FAM89B About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for FAM89B
Interactions:

Search GeneGlobe Interaction Network for FAM89B

1 Interacting protein for FAM89B (Q8N5H3³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT8	Q92599³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISS	--
GO:0060392	negative regulation of SMAD protein import into nucleus	ISS	--

Find genes that share ontologies with FAM89B About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for FAM89B (FA89B)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for FAM89B gene (3 alternative transcripts):

NM_001098784.1 NM_001098785.1 NM_152832.2

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316409(uc001oem.2 uc001oen.2 uc001oel.2) ENST00000449319

ENST00000530349

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Selected AceView cDNA sequences (see all 429):

BM127932 CR610230 AI214414 AF052151 AI050809 AI125339 BC014791 BM128003

AI189581 AI367075 AI968474 AI271516 BU625777 AA236870 AA313202 AI991293

CB148370 AI494494 BG740803 AI123851 CR612503 BX379528 BQ879514 AW275991

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e
SP1:
SP2:			-
SP3:			-		-

ECgene alternative splicing isoforms for FAM89B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM89B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTGCACCCC

About this image

FAM89B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FAM89B Protein Expression

Custom PCR Arrays for FAM89B

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM89B gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Fam89b^{1 , 5}	family with sequence similarity 89, member B^{1, 5}	88.36(n)¹ 96.3(a)¹	19 (4.34 cM)⁵ 17826¹ NM_181452.2¹ NP_852117.2¹ 5728087⁵
African clawed frog (Xenopus laevis)	Amphibia	MGC53407²	similar to Sjogren's syndrome/scleroderma autoantigen more	69.38(n)	BC043979.1
zebrafish (Danio rerio)	Actinopterygii	Dr.18883²	Transcribed sequence with weak similarity to protein more	79.14(n)	CK356398.1

ENSEMBL Gene Tree for FAM89B (if available)
TreeFam Gene Tree for FAM89B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for FAM89B gene

FAM89A²

1 SIMAP similar gene for FAM89B using alignment to 1 protein entry: FA89B_HUMAN:

FAM89A

Find genes that share paralogs with FAM89B About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181226303^1,2		--	65339890(+)	`TGAGTA/GGATGT`	3	--	ut5¹		0	--	--	--	--
rs10896017^1,2	C,F	--	65340135(+)	`CGGCCC/TCGGCC`	3	--	ut5¹ ese³		1		EA	120
rs186744049^1,2		--	65340754(+)	`TGGGCG/TGGGGC`	3	--	int¹		0	--	--	--	--
rs141694006^1,2	C	--	65341056(+)	`TGCCCC/GAGACG`	5	Q E	mis¹ ut3¹		1		NA	4538
rs190686076^1,2	C	--	65341192(+)	`GGAGCC/TTGCGC`	3	--	ut3¹		0	--	--	--	--
rs111925308^1,2	C	--	65341198(+)	`TGCGCA/C/GTTCCC`	6	--	ut3¹		1		CSA	1
rs182976740^1,2		--	65341252(+)	`AGAGGC/TGAAAC`	3	--	ut3¹		0	--	--	--	--
rs80283068^1,2	C,F	--	65341273(+)	`TTTCTC/TCTGTC`	3	--	ut3¹		1		NA	120
rs187637845^1,2		--	65341439(+)	`GATTGA/GGATGA`	3	--	ut3¹		0	--	--	--	--
rs201502824^1,2	--	--	65341025(+)	`AGCCTG/ACCTCC`	5	/L	syn¹ ut3¹		1		EU	1311

HapMap Linkage Disequilibrium report for FAM89B (65339820 - 65341669 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for FAM89B (see all 12): About this table

Variant ID	Type	Subtype	PubMed ID
nsv897723	CNV	Loss	21882294
dgv1175n71	CNV	Loss	21882294
nsv897739	CNV	Loss	21882294
dgv1180n71	CNV	Loss	21882294
nsv897736	CNV	Loss	21882294
nsv897730	CNV	Loss	21882294
dgv1176n71	CNV	Loss	21882294
dgv1181n71	CNV	Loss	21882294
dgv1179n71	CNV	Loss	21882294
nsv897718	CNV	Loss	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM89B gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with FAM89B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PubMed id 10512749)^{1, 3} Sakuma-Takagi M....Kurihara T. (Biochem. Biophys. Res. Commun. 1999)
A novel membrane protein is a mouse mammary tumor virus receptor. (PubMed id 9525630)^{1, 3} Golovkina T.V....Ross S.R. (J. Virol. 1998)
Identification of human homologues of the mouse mammary tumor virus receptor. (PubMed id 11958456)^{1, 9} Stewart A.F. (Arch. Virol. 2002)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (Sci. Signal. 2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (Nature 2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)¹ Yu W.... Gibbs R.A. (Genome Res. 1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)¹ Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23625	HGNC: 16708	AceView: SSSCA1andMTVR1	Ensembl:ENSG00000176973	euGenes: HUgn23625
ECgene: FAM89B	H-InvDB: FAM89B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM89B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM89B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM89B gene:
Search GeneIP for patents involving FAM89B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


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FAM89B Gene

Family With Sequence Similarity 89, Member B

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for FAM89B gene

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FAM89B Human Recombinant Protein Products:

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GeneCards Suite

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Export list of displayed genes

FAM89B Gene

Family With Sequence Similarity 89, Member B

Aliasesfor FAM89B gene

Summariesfor FAM89B gene

Genomic Viewsfor FAM89B gene

Proteinsfor FAM89B gene

FAM89B Human Recombinant Protein Products:

FAM89B Antibody Products:

FAM89B Assay Products:

Domains /Familiesfor FAM89B gene

Functionfor FAM89B gene

Localizationfor FAM89B gene

Pathways & Interactionsfor FAM89B gene

Drugs & Compoundsfor FAM89B gene

Transcriptsfor FAM89B gene

Expression for FAM89B gene

Orthologsfor FAM89B gene

Paralogsfor FAM89B gene

Genomic Variantsfor FAM89B gene

Disorders / Diseasesfor FAM89B gene

Publicationsfor FAM89B gene

External Searches for FAM89B gene

Genome Databases showing FAM89B gene

Other Databases showing FAM89B gene

Specialized Databases showing FAM89B gene

Intellectual Propertyfor FAM89B gene

Productsfor FAM89B gene

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Aliases
for FAM89B gene

Summaries
for FAM89B gene

Genomic Views
for FAM89B gene

Proteins
for FAM89B gene

Domains /
Families
for FAM89B gene

Function
for FAM89B gene

Localization
for FAM89B gene

Pathways & Interactions
for FAM89B gene

Drugs & Compounds
for FAM89B gene

Transcripts
for FAM89B gene

Expression
for FAM89B gene

Orthologs
for FAM89B gene

Paralogs
for FAM89B gene

Genomic Variants
for FAM89B gene

Disorders / Diseases
for FAM89B gene

Publications
for FAM89B gene

Intellectual Property
for FAM89B gene

Products
for FAM89B gene