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FAM89B Gene(Protein Coding)

Family With Sequence Similarity 89 Member B

GCID:
GC11P065572
GIFtS:
43
Genes Participants
UDN Logo

Aliases for FAM89B Gene

Aliases for FAM89B Gene

  • Family With Sequence Similarity 89 Member B 2 3 5
  • Family With Sequence Similarity 89, Member B 2 3
  • Mammary Tumor Virus Receptor Homolog 1 3
  • Leucine Repeat Adaptor Protein 25 3
  • LRAP25 3
  • MTVR1 3
  • MTVR 3

External Ids for FAM89B Gene

Previous GeneCards Identifiers for FAM89B Gene

  • GC11P065097
  • GC11P065339
  • GC11P061667

Summaries for FAM89B Gene

GeneCards Summary for FAM89B Gene

FAM89B (Family With Sequence Similarity 89 Member B) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.

UniProtKB/Swiss-Prot for FAM89B Gene

  • Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89B Gene

Genomics for FAM89B Gene

Products:

  1. Regulatory Element

Regulatory Elements for FAM89B Gene

Enhancers for FAM89B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM89B on UCSC Golden Path with GeneCards custom track

Promoters for FAM89B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM89B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FAM89B gene promoter:

Genomic Location for FAM89B Gene

Chromosome:
11
Start:
65,572,349 bp from pter
End:
65,574,198 bp from pter
Size:
1,850 bases
Orientation:
Plus strand

Genomic View for FAM89B Gene

Genes around FAM89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM89B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FAM89B Gene

Proteins for FAM89B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FAM89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5H3-FA89B_HUMAN
    Recommended name:
    Protein FAM89B
    Protein Accession:
    Q8N5H3
    Secondary Accessions:
    • E9PB01
    • E9PL72
    • Q6PJ27

    Protein attributes for FAM89B Gene

    Size:
    189 amino acids
    Molecular mass:
    20147 Da
    Quaternary structure:
    • Interacts with SKI.

    Alternative splice isoforms for FAM89B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM89B Gene

Proteomics data for FAM89B Gene at MOPED

Protein Expression for FAM89B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FAM89B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM89B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM89B Gene

Domains & Families for FAM89B Gene

Protein Domains for FAM89B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5H3

UniProtKB/Swiss-Prot:

FA89B_HUMAN :
  • Belongs to the FAM89 family.
Family:
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89B: view

No data available for Gene Families for FAM89B Gene

Function for FAM89B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FAM89B Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.

Gene Ontology (GO) - Molecular Function for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001222 transcription corepressor binding ISS --
genes like me logo Genes that share ontologies with FAM89B: view

Phenotypes for FAM89B Gene

GenomeRNAi human phenotypes for FAM89B:
genes like me logo Genes that share phenotypes with FAM89B: view

Animal Model Products

CRISPR Products

miRNA for FAM89B Gene

miRTarBase miRNAs that target FAM89B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89B Gene

Localization for FAM89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM89B Gene

Isoform 3: Cytoplasm.
Isoform 1: Cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM89B Gene COMPARTMENTS Subcellular localization image for FAM89B gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FAM89B Gene

Pathways & Interactions for FAM89B Gene

SuperPathways for FAM89B Gene

PathCards logoMore details on SuperPathways for FAM89B
No Data Available

Interacting Proteins for FAM89B Gene

Selected Interacting proteins: Q8N5H3-FA89B_HUMAN for FAM89B Gene via I2D

Symbol External ID(s) Details
SEPT8

Gene Ontology (GO) - Biological Process for FAM89B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM89B Gene

Drugs & Compounds for FAM89B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FAM89B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FAM89B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(429) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM89B Gene

Family with sequence similarity 89, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e
SP1:
SP2: -
SP3: - -

Relevant External Links for FAM89B Gene

GeneLoc Exon Structure for
FAM89B
ECgene alternative splicing isoforms for
FAM89B

Expression for FAM89B Gene

Products:

  1. Primer

mRNA expression in normal human tissues for FAM89B Gene

mRNA expression in normal human tissues for FAM89B Gene
mRNA expression by BioGPS for FAM89B Gene

Protein differential expression in normal tissues from HIPED for FAM89B Gene

This gene is overexpressed in Heart (28.8), Peripheral blood mononuclear cells (22.9), and Fetal Brain (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM89B Gene



SOURCE GeneReport for Unigene cluster for FAM89B Gene Hs.731854

genes like me logo Genes that share expression patterns with FAM89B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM89B Gene

Orthologs for FAM89B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia FAM89B 35
  • 88.89 (n)
  • 96.3 (a)
MGC140823 36
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FAM89B 35
  • 88.36 (n)
  • 95.77 (a)
FAM89B 36
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fam89b 35
  • 88.36 (n)
  • 96.3 (a)
Fam89b 16
Fam89b 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia FAM89B 35
  • 97 (n)
  • 96.3 (a)
FAM89B 36
  • 64 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Fam89b 35
  • 87.3 (n)
  • 96.3 (a)
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.7511 35
African clawed frog
(Xenopus laevis)
 Amphibia MGC53407 35
zebrafish
(Danio rerio)
 Actinopterygii Dr.18883 35
LOC100151239 35
  • 61.45 (n)
  • 54.22 (a)
fam89b 36
  • 53 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3539 35
Species with no ortholog for FAM89B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89B Gene

ENSEMBL:
Gene Tree for FAM89B (if available)
TreeFam:
Gene Tree for FAM89B (if available)

Paralogs for FAM89B Gene

Paralogs for FAM89B Gene

(1) SIMAP similar genes for FAM89B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM89B: view

Variants for FAM89B Gene

Sequence variations from dbSNP and Humsavar for FAM89B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112380292 -- 65,573,734(+) TCCCC(A/C)CTACC utr-variant-3-prime
rs112836159 -- 65,572,972(+) GGGTG(A/G)GCGCC intron-variant
rs113308199 -- 65,573,026(+) TGGGA(A/C)AGGCG intron-variant
rs190686076 -- 65,573,721(+) GGAGC(C/T)TGCGC utr-variant-3-prime
rs144434621 -- 65,573,521(+) GGCCT(A/G)TCTGA reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM89B Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv897723 CNV Loss 21882294
nsv897730 CNV Loss 21882294
dgv1179n71 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
dgv1181n71 CNV Loss 21882294
dgv1182n71 CNV Loss 21882294
nsv897739 CNV Loss 21882294

Variation tolerance for FAM89B Gene

Gene Damage Index Score: 0.53; 11.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM89B Gene

Disorders for FAM89B Gene

Relevant External Links for FAM89B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM89B

No disorders were found for FAM89B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89B Gene

Publications for FAM89B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Identification of human homologues of the mouse mammary tumor virus receptor. (PMID: 11958456) Stewart A.F. (Arch. Virol. 2002) 3 23
  3. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PMID: 10512749) Sakuma-Takagi M. … Kurihara T. (Biochem. Biophys. Res. Commun. 1999) 2 3
  4. A novel membrane protein is a mouse mammary tumor virus receptor. (PMID: 9525630) Golovkina T.V. … Ross S.R. (J. Virol. 1998) 2 3
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3

Products for FAM89B Gene

Sources for FAM89B Gene

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