Aliases for FAM89B Gene
Aliases for FAM89B Gene
External Ids for FAM89B Gene
- HGNC: 16708
- Entrez Gene: 23625
- Ensembl: ENSG00000176973
- OMIM: 616128
- UniProtKB: Q8N5H3
Previous GeneCards Identifiers for FAM89B Gene
- GC11P065097
- GC11P065339
- GC11P061667
Summaries for FAM89B Gene
GeneCards Summary for FAM89B Gene
FAM89B (Family With Sequence Similarity 89 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.
UniProtKB/Swiss-Prot for FAM89B Gene
-
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Additional gene information for FAM89B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89B Gene
Genomics for FAM89B Gene
GeneHancer (GH) Regulatory Elements for FAM89B Gene
Promoters and enhancers for FAM89B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FAM89B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FAM89B gene promoter:
Regulatory Element Products
Genomic Locations for FAM89B Gene
Genomic Locations for FAM89B Gene
- chr11:65,572,349-65,574,198
- (GRCh38/hg38)
- Size:
- 1,850 bases
- Orientation:
- Plus strand
- chr11:65,339,820-65,341,669
- (GRCh37/hg19)
Genomic View for FAM89B Gene
Genes around FAM89B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
FAM89B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM89B Gene
Proteins for FAM89B Gene
-
Protein details for FAM89B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5H3-LRA25_HUMAN
- Recommended name:
- Leucine repeat adapter protein 25
- Protein Accession:
- Q8N5H3
- E9PB01
- E9PL72
- Q6PJ27
Protein attributes for FAM89B Gene
- Size:
- 189 amino acids
- Molecular mass:
- 20147 Da
- Quaternary structure:
-
- Interacts with SKI. Interacts (via LRR repeat) with CDC42BPA (via AGC-kinase C-terminal domain), CDC42BPB (via AGC-kinase C-terminal domain) and LIMK1 (via LIM zinc-binding domains). Forms a tripartite complex with CDC42BPA, CDC42BPB and LIMK1.
Protein Expression for FAM89B Gene
Post-translational modifications for FAM89B Gene
No Post-translational modifications
Other Protein References for FAM89B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM89B
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Protein Products
-
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-
Abcam proteins for FAM89B
Assay Products
No data available for DME Specific Peptides for FAM89B Gene
Domains & Families for FAM89B Gene
Gene Families for FAM89B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FAM89B Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM89B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N5H3- Family:
-
- Belongs to the FAM89 family.
Function for FAM89B Gene
Molecular function for FAM89B Gene
- UniProtKB/Swiss-Prot Function:
- Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Phenotypes From GWAS Catalog for FAM89B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001222 | transcription corepressor binding | ISS | -- |
Phenotypes for FAM89B Gene
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM89B gene
-
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CRISPR Products
-
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- Applied Biological Materials CRISPR for FAM89B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM89B
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miRNA for FAM89B Gene
- miRTarBase miRNAs that target FAM89B
miRNA Products
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Inhibitory RNA Products
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Clone Products
-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FAM89B gene related products
- orf clones - Search results for available FAM89B gene related products
- Applied Biological Materials Clones for FAM89B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FAM89B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM89B gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89B Gene
Localization for FAM89B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FAM89B Gene
- Isoform 3: Cytoplasm. Cell projection, lamellipodium. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000250 UniProtKB:Q9QUI1}.
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0030027 | lamellipodium | ISS | -- |
| GO:0042995 | cell projection | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM89B Gene
Pathways & Interactions for FAM89B Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030010 | establishment of cell polarity | ISS,IEA | -- |
| GO:0030335 | positive regulation of cell migration | ISS,IEA | -- |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IEA,ISS | -- |
| GO:0060392 | negative regulation of SMAD protein import into nucleus | IEA,ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for FAM89B Gene
Transcripts for FAM89B Gene
mRNA/cDNA for FAM89B Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (429) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM89B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM89B
- genomics-online: gRNA clones - Search results for available FAM89B gene related products
- Applied Biological Materials CRISPR for FAM89B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM89B
- GenScript: Design CRISPR guide RNA sequences for FAM89B
miRNA Products
- Search ViGene Biosciences for FAM89B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FAM89B
- Browse OriGene Inhibitory RNA Products For FAM89B
- genomics-online: shRNA clones - Search results for available FAM89B gene related products
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Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for FAM89B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM89B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FAM89B gene related products
- orf clones - Search results for available FAM89B gene related products
- Applied Biological Materials Clones for FAM89B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | ||||||||||
| SP3: | - | - |
Expression for FAM89B Gene
This gene is overexpressed in Heart (28.8), Peripheral blood mononuclear cells (22.9), and Fetal Brain (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM89B Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM89B Gene:
FAM89BSOURCE GeneReport for Unigene cluster for FAM89B Gene:
Hs.731854Evidence on tissue expression from TISSUES for FAM89B Gene
- Lung(4.4)
- Nervous system(4.3)
- Liver(4.2)
- Muscle(2.8)
- Pancreas(2.4)
Primer Products
-
OriGene qPCR primer pairs for FAM89B
-
OriGene qPCR primer pairs and template standards for FAM89B
- genomics-online: primer clones - Search results for available FAM89B gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89B Gene
Orthologs for FAM89B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM89B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MGC140823 34 |
|
OneToOne | |
| FAM89B 33 |
|
||||
| mouse (Mus musculus) |
Mammalia | Fam89b 33 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM89B 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fam89b 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.7511 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53407 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100151239 33 |
|
||
| fam89b 34 |
|
OneToOne | |||
| Dr.18883 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3539 33 |
|
- Species where no ortholog for FAM89B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM89B Gene
(1) SIMAP similar genes for FAM89B Gene using alignment to 1 proteins:
Variants for FAM89B Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000708681 | -- | 65,573,301(+) | GGGGCGGGGC/GGGGC | intron_variant | |
| rs1001342869 | -- | 65,570,438(+) | A/C | upstream_transcript_variant | |
| rs1001877977 | -- | 65,573,746(+) | C/G | 3_prime_UTR_variant | |
| rs1001940599 | -- | 65,574,159(+) | G/A | 3_prime_UTR_variant | |
| rs1003738204 | -- | 65,572,311(+) | G/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1969n54 | CNV | loss | 21841781 |
| nsv1069595 | CNV | deletion | 25765185 |
| nsv1069596 | CNV | deletion | 25765185 |
| nsv1126297 | CNV | deletion | 24896259 |
| nsv951018 | CNV | deletion | 24416366 |
Gene Damage Index Score:
0.53;
11.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FAM89B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM89B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89B Gene
Disorders for FAM89B Gene
Additional Disease Information for FAM89B
No disorders were found for FAM89B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89B Gene
Publications for FAM89B Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification of human homologues of the mouse mammary tumor virus receptor. (PMID: 11958456) Stewart AF (Archives of virology 2002) 3 22 58
- Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PMID: 10512749) Sakuma-Takagi M … Kurihara T (Biochemical and biophysical research communications 1999) 2 3 58
- A novel membrane protein is a mouse mammary tumor virus receptor. (PMID: 9525630) Golovkina TV … Ross SR (Journal of virology 1998) 2 3 58
- Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
Products for FAM89B Gene
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- Invitrogen Antibodies for FAM89B
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- VectorBuilder custom plasmid, inducible vectors for FAM89B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM89B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available FAM89B related products ranked by validation data
- antibodies-online: Search results for available FAM89B related products ranked by validation data
- antibodies-online: Search results for available FAM89B related products ranked by validation data
- Search GeneTex for Antibodies for FAM89B
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- ViGene Biosciences adenoviral particle packaged cDNA for FAM89B gene
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- Search ViGene Biosciences for FAM89B
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- genomics-online: cdna clones - Search results for available FAM89B gene related products
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Sources for FAM89B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
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- (155) genomics-online
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- (157) EPDnew