FAM89B Gene
protein-coding GIFtS: 41
GCID: GC11P065339
|
|
family with sequence similarity 89, member B
| |
Aliases
for FAM89B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 89, Member B1 2 | | MTVR12 | | Mammary Tumor Virus Receptor Homolog 12 | | Protein FAM89B2 |
Export aliases for FAM89B gene to outside databasesPrevious GC identifers: GC11P065097 GC11P061667 |
Summaries
for FAM89B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2from the nucleus to the cytoplasm in response to TGF-beta (By similarity)
|
Genomic Views
for FAM89B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM89B gene promoter:
Spz1 E2F-1 E2F p53 NRSF form 1 FOXO3 Nkx2-5 NRSF form 2 C/EBPalpha GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM89B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM89B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q23FAM89B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065339: view genomic region
(about GC identifiers)
Start:
|
65,339,820 bp from pter |
End:
|
65,341,669 bp from pter |
Size:
|
1,850 bases |
Orientation:
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plus strand |
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Proteins
for FAM89B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3 (See
protein sequence)Recommended Name: Protein FAM89B Size: 189 amino acids; 20147 Da
Subunit: Interacts with SKI (By similarity)
Subcellular location: Isoform 3: Cytoplasm (By similarity)
Subcellular location: Isoform 1: Cell surface (By similarity)
Secondary accessions: E9PB01 E9PL72 Q6PJ27Alternative splicing: 4 isoforms: Q8N5H3-3 Q8N5H3-1 Q8N5H3-2 Q8N5H3-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM89B: NX_Q8N5H3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5H3
FAM89B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001092254.1 NP_001092255.1 NP_690045.1
ENSEMBL proteins: ENSP00000314829 ENSP00000402439 ENSP00000431459
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FAM89B for ontologies About GeneDecksing
FAM89B Antibody Products:
Assay Products for FAM89B: |
Protein
Domains /
Families
for FAM89B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM89B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N5H3ProtoNet protein and cluster: Q8N5H3 UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3Similarity: Belongs to the FAM89 family |
Function
for FAM89B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2from the nucleus to the cytoplasm in response to TGF-beta (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM89B (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM89B (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FAM89B (NM_152832) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM89B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM89B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001222 | transcription corepressor binding |
ISS | -- |
FAM89B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FAM89B:
|
Pathways & Interactions
for FAM89B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM89B
1 Interacting protein for FAM89B (Q8N5H33) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
ISS | -- | | GO:0060392 | negative regulation of SMAD protein import into nucleus |
ISS | -- |
FAM89B for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM89B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM89B
Search CenterWatch for drugs/clinical trials and news about FAM89B / FA89B
|
Transcripts
for FAM89B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM89B gene (3 alternative transcripts): NM_001098784.1 NM_001098785.1 NM_152832.2 Unigene Cluster for FAM89B: Family with sequence similarity 89, member B Hs.731854 [show with all ESTs]Unigene Representative Sequence: BC0239913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316409(uc001oem.2 uc001oen.2 uc001oel.2) ENST00000449319
ENST00000530349
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM89B (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM89B (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FAM89B (NM_152832) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM89B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM89B |
Additional cDNA sequence: AF052151.1 BC023991.2 BC032373.1 3 DOTS entries: DT.100038097 DT.447144 DT.120737182 24/429 AceView cDNA sequences (see all 429): BM468381 BM127932 AI050809 BF568149 BU952053 BC014791 AI968474 AI367075 AW615007 CK819125 BQ773834 AF052151 AI214414 CR615607 H68581 AI669222 D80508 BU726508 AJ712654 CB121478 BE394215 AI244226 AI264016 BM128255
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for FAM89B
|
Expression
for FAM89B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM89B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGCACCCC
About this image
See FAM89B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM89B
SOURCE GeneReport for Unigene cluster: Hs.731854
SABiosciences Custom PCR Arrays for FAM89B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM89B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM89B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM89B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM89B |
Orthologs
for FAM89B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM89B gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC534072 |
similar to Sjogren's syndrome/scleroderma autoantigen more |
69.38(n) |
|
BC043979.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.188832 |
Transcribed sequence with weak similarity to protein more |
79.14(n) |
|
CK356398.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG310386CG344416 |
-- |
6(a)15(a) |
many ↔ manymany ↔ many |
3R(25702781-25728953) 2L(8524999-8528505) |
ENSEMBL Gene Tree for FAM89B (if available)
TreeFam Gene Tree for FAM89B (if available) |
Paralogs
for FAM89B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM89B gene
- FAM89A2
1 SIMAP similar gene for FAM89B using alignment to 1 protein entry: FA89B_HUMAN:FAM89A
FAM89B for paralogs About GeneDecksing
|
Genomic Variants
for FAM89B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM89B (65339820 - 65341669 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM89B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM89B |
|
Disorders
/ Diseases
for FAM89B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM89B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM89B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM89B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PubMed id 10512749)1, 3 Sakuma-Takagi M....Kurihara T. (1999)
- A novel membrane protein is a mouse mammary tumor virus receptor. (PubMed id 9525630)1, 3 Golovkina T.V....Ross S.R. (1998)
- Identification of human homologues of the mouse mammary tumor virus receptor. (PubMed id 11958456)1, 9 Stewart A.F. (2002)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
|
External Searches for FAM89B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM89B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM89B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM89B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM89B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM89B gene:
Search GeneIP for patents involving FAM89B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM89B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM89B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM89B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM89B | | | OriGene Protein Over-expression Lysate for FAM89B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM89B | | OriGene 3'-UTR Clone for FAM89B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM89B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM89B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM89B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM89B | | OriGene Custom Protein Services for FAM89B | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM89B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM89B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM89B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM89B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM89B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM89B |
| |
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| |  |  |  |  | | | | |
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 | | | FAM89B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FAM89B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM89B |
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