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Aliases for FAM89B Gene

Aliases for FAM89B Gene

  • Family With Sequence Similarity 89, Member B 2 3
  • Mammary Tumor Virus Receptor Homolog 1 3
  • Leucine Repeat Adaptor Protein 25 3
  • Protein FAM89B 3
  • LRAP25 3
  • MTVR1 3
  • MTVR 3

External Ids for FAM89B Gene

Previous GeneCards Identifiers for FAM89B Gene

  • GC11P065097
  • GC11P065339
  • GC11P061667

Summaries for FAM89B Gene

GeneCards Summary for FAM89B Gene

FAM89B (Family With Sequence Similarity 89, Member B) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.

UniProtKB/Swiss-Prot for FAM89B Gene

  • Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89B Gene

Genomics for FAM89B Gene

Regulatory Elements for FAM89B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM89B Gene

65,572,349 bp from pter
65,574,198 bp from pter
1,850 bases
Plus strand

Genomic View for FAM89B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM89B Gene

Proteins for FAM89B Gene

  • Protein details for FAM89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM89B
    Protein Accession:
    Secondary Accessions:
    • E9PB01
    • E9PL72
    • Q6PJ27

    Protein attributes for FAM89B Gene

    189 amino acids
    Molecular mass:
    20147 Da
    Quaternary structure:
    • Interacts with SKI.

    Alternative splice isoforms for FAM89B Gene


neXtProt entry for FAM89B Gene

Proteomics data for FAM89B Gene at MOPED

Post-translational modifications for FAM89B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM89B Gene

No data available for DME Specific Peptides for FAM89B Gene

Domains for FAM89B Gene

Protein Domains for FAM89B Gene


Suggested Antigen Peptide Sequences for FAM89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N5H3
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89B: view

No data available for Gene Families for FAM89B Gene

Function for FAM89B Gene

Molecular function for FAM89B Gene

UniProtKB/Swiss-Prot Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.

Gene Ontology (GO) - Molecular Function for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001222 transcription corepressor binding ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FAM89B: view

Phenotypes for FAM89B Gene

GenomeRNAi human phenotypes for FAM89B:
genes like me logo Genes that share phenotypes with FAM89B: view

Animal Model Products

CRISPR Products

miRNA for FAM89B Gene

miRTarBase miRNAs that target FAM89B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM89B Gene

Localization for FAM89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM89B Gene

Isoform 3: Cytoplasm.
Isoform 1: Cell surface.

Subcellular locations from

Jensen Localization Image for FAM89B Gene COMPARTMENTS Subcellular localization image for FAM89B gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with FAM89B: view

Pathways for FAM89B Gene

SuperPathways for FAM89B Gene

No Data Available

Interacting Proteins for FAM89B Gene

Selected Interacting proteins: Q8N5H3-FA89B_HUMAN for FAM89B Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS --
GO:0060392 negative regulation of SMAD protein import into nucleus ISS --
genes like me logo Genes that share ontologies with FAM89B: view

No data available for Pathways by source for FAM89B Gene

Transcripts for FAM89B Gene

mRNA/cDNA for FAM89B Gene

Unigene Clusters for FAM89B Gene

Family with sequence similarity 89, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM89B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e
SP2: -
SP3: - -

Relevant External Links for FAM89B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM89B Gene

mRNA expression in normal human tissues for FAM89B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM89B Gene

SOURCE GeneReport for Unigene cluster for FAM89B Gene Hs.731854

genes like me logo Genes that share expressions with FAM89B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM89B Gene

Orthologs for FAM89B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM89B 35
  • 97 (n)
  • 96.3 (a)
FAM89B 36
  • 64 (a)
(Bos Taurus)
Mammalia FAM89B 35
  • 88.89 (n)
  • 96.3 (a)
MGC140823 36
  • 94 (a)
(Canis familiaris)
Mammalia FAM89B 35
  • 88.36 (n)
  • 95.77 (a)
FAM89B 36
  • 95 (a)
(Mus musculus)
Mammalia Fam89b 35
  • 88.36 (n)
  • 96.3 (a)
Fam89b 16
Fam89b 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam89b 35
  • 87.3 (n)
  • 96.3 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53407 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7511 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3539 35
(Danio rerio)
Actinopterygii Dr.18883 35
fam89b 36
  • 53 (a)
LOC100151239 35
  • 61.45 (n)
  • 54.22 (a)
Species with no ortholog for FAM89B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89B Gene

Gene Tree for FAM89B (if available)
Gene Tree for FAM89B (if available)

Paralogs for FAM89B Gene

Paralogs for FAM89B Gene

Selected SIMAP similar genes for FAM89B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM89B: view

Variants for FAM89B Gene

Sequence variations from dbSNP and Humsavar for FAM89B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10896017 -- 65,572,664(+) CGGCC(C/T)CGGCC utr-variant-5-prime
rs80283068 -- 65,573,802(+) TTTCT(C/T)CTGTC utr-variant-3-prime
rs111757605 -- 65,572,661(+) CGCCG(C/G)CCCCG utr-variant-5-prime
rs111925308 -- 65,573,727(+) TGCGC(A/C/G)TTCCC utr-variant-3-prime
rs112380292 -- 65,573,734(+) TCCCC(A/C)CTACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM89B Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv897723 CNV Loss 21882294
nsv897730 CNV Loss 21882294
dgv1179n71 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
dgv1181n71 CNV Loss 21882294
dgv1182n71 CNV Loss 21882294
nsv897739 CNV Loss 21882294

Relevant External Links for FAM89B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89B Gene

Disorders for FAM89B Gene

No disorders were found for FAM89B Gene.

No data available for UniProtKB/Swiss-Prot for FAM89B Gene

Publications for FAM89B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification of human homologues of the mouse mammary tumor virus receptor. (PMID: 11958456) Stewart A.F. (Arch. Virol. 2002) 3 23
  3. A novel membrane protein is a mouse mammary tumor virus receptor. (PMID: 9525630) Golovkina T.V. … Ross S.R. (J. Virol. 1998) 2 3
  4. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PMID: 10512749) Sakuma-Takagi M. … Kurihara T. (Biochem. Biophys. Res. Commun. 1999) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM89B Gene

Sources for FAM89B Gene

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