Aliases for FAM89B Gene
Aliases for FAM89B Gene
External Ids for FAM89B Gene
- HGNC: 16708
- Entrez Gene: 23625
- Ensembl: ENSG00000176973
- OMIM: 616128
- UniProtKB: Q8N5H3
Previous GeneCards Identifiers for FAM89B Gene
- GC11P065097
- GC11P065339
- GC11P061667
Summaries for FAM89B Gene
GeneCards Summary for FAM89B Gene
FAM89B (Family With Sequence Similarity 89 Member B) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.
UniProtKB/Swiss-Prot for FAM89B Gene
-
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89B Gene
Genomics for FAM89B Gene
Regulatory Elements for FAM89B Gene
Enhancers for FAM89B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G065636 | 1.6 | FANTOM5 ENCODE dbSUPER | 11.3 | +68.3 | 68334 | 8.2 | HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A YBX1 ZNF143 | SIPA1 KCNK7 RNASEH2C MAP3K11 EHBP1L1 TIGD3 FAM89B SSSCA1 CFL1 SNX32 |
| GH11G065811 | 1 | Ensembl ENCODE | 10.1 | +239.9 | 239858 | 2.0 | CTCF PKNOX1 ATF1 AGO1 ZNF223 CEBPG EBF1 BCL11B NCOR1 POLR2A | SNX32 CTSW MAP3K11 OVOL1-AS1 OVOL1 AP5B1 CFL1 PCNX3 CCDC85B FIBP |
| GH11G065609 | 1.7 | FANTOM5 ENCODE dbSUPER | 3.6 | +41.7 | 41650 | 8.5 | CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 | MAP3K11 SIPA1 RNASEH2C CTSF LOC105369352 EIF1AD MRPL11 ZFPL1 SNX32 CTSW |
| GH11G065567 | 1.7 | FANTOM5 ENCODE dbSUPER | 0.7 | +1.3 | 1326 | 12.0 | MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 | NEAT1 KCNK7 EHBP1L1 TIGD3 MAP3K11 PCNX3 CDC42EP2 RNASEH2C TSGA10IP RELA |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM89B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM89B gene promoter:
Regulatory Element Products
Genomic Location for FAM89B Gene
- Chromosome:
- 11
- Start:
- 65,572,349 bp from pter
- End:
- 65,574,198 bp from pter
- Size:
- 1,850 bases
- Orientation:
- Plus strand
Genomic View for FAM89B Gene
Genes around FAM89B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
FAM89B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM89B Gene
Proteins for FAM89B Gene
-
Protein details for FAM89B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5H3-FA89B_HUMAN
- Recommended name:
- Protein FAM89B
- Protein Accession:
- Q8N5H3
- E9PB01
- E9PL72
- Q6PJ27
Protein attributes for FAM89B Gene
- Size:
- 189 amino acids
- Molecular mass:
- 20147 Da
- Quaternary structure:
-
- Interacts with SKI.
Protein Expression for FAM89B Gene
Post-translational modifications for FAM89B Gene
Other Protein References for FAM89B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM89B
- Novus Biologicals Antibodies for FAM89B
- Invitrogen Antibodies for FAM89B
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Protein Products
-
OriGene Purified Proteins for FAM89B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM89B
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- Search GeneTex for Proteins for FAM89B
No data available for DME Specific Peptides for FAM89B Gene
Domains & Families for FAM89B Gene
Suggested Antigen Peptide Sequences for FAM89B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N5H3- Family:
-
- Belongs to the FAM89 family.
No data available for Gene Families for FAM89B Gene
Function for FAM89B Gene
Molecular function for FAM89B Gene
- UniProtKB/Swiss-Prot Function:
- Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001222 | transcription corepressor binding | ISS | -- |
Phenotypes for FAM89B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM89B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM89B gene
- Search ViGene Biosciences for FAM89B
CRISPR Products
-
OriGene CRISPR knockouts for FAM89B
-
Applied Biological Materials CRISPR for FAM89B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM89B
- GenScript: Design CRISPR guide RNA sequences for FAM89B
miRNA for FAM89B Gene
- miRTarBase miRNAs that target FAM89B
miRNA Products
- Search ViGene Biosciences for FAM89B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM89B
- Browse OriGene Inhibitory RNA Products For FAM89B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM89B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FAM89B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM89B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for FAM89B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM89B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM89B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM89B gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89B Gene
Localization for FAM89B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FAM89B Gene
- Isoform 3: Cytoplasm.
- Isoform 1: Cell surface.
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0009986 | cell surface | IEA | -- |
Pathways & Interactions for FAM89B Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IEA,ISS | -- |
| GO:0060392 | negative regulation of SMAD protein import into nucleus | IEA,ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for FAM89B Gene
Transcripts for FAM89B Gene
mRNA/cDNA for FAM89B Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (429) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM89B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM89B
-
Applied Biological Materials CRISPR for FAM89B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM89B
- GenScript: Design CRISPR guide RNA sequences for FAM89B
miRNA Products
- Search ViGene Biosciences for FAM89B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM89B
- Browse OriGene Inhibitory RNA Products For FAM89B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM89B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FAM89B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM89B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | ||||||||||
| SP3: | - | - |
Expression for FAM89B Gene
This gene is overexpressed in Heart (28.8), Peripheral blood mononuclear cells (22.9), and Fetal Brain (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM89B Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM89B Gene:
FAM89BSOURCE GeneReport for Unigene cluster for FAM89B Gene:
Hs.731854Evidence on tissue expression from TISSUES for FAM89B Gene
- Lung(4.4)
- Nervous system(4.3)
- Liver(4.2)
- Muscle(2.8)
- Pancreas(2.4)
Primer Products
-
OriGene qPCR primer pairs for FAM89B
-
OriGene qPCR primer pairs and template standards for FAM89B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89B Gene
Orthologs for FAM89B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM89B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MGC140823 35 |
|
OneToOne | |
| FAM89B 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | FAM89B 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam89b 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam89b 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.7511 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53407 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100151239 34 |
|
||
| fam89b 35 |
|
OneToOne | |||
| Dr.18883 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3539 34 |
|
- Species where no ortholog for FAM89B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM89B Gene
(1) SIMAP similar genes for FAM89B Gene using alignment to 1 proteins:
Variants for FAM89B Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000708681 | -- | 65,573,301(+) | TCCAG(-/GGGGC)GGGGC | intron-variant | |
| rs1001342869 | -- | 65,570,438(+) | AGCGG(A/C)GGGCG | upstream-variant-2KB | |
| rs1001877977 | -- | 65,573,746(+) | CCTCA(C/G)CTCAC | utr-variant-3-prime | |
| rs1001940599 | -- | 65,574,159(+) | CTCCA(A/G)GGCGC | upstream-variant-2KB, utr-variant-3-prime | |
| rs1003738204 | -- | 65,572,311(+) | GGCGG(C/G)GCGCG | downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1969n54 | CNV | loss | 21841781 |
| nsv1069595 | CNV | deletion | 25765185 |
| nsv1069596 | CNV | deletion | 25765185 |
| nsv1126297 | CNV | deletion | 24896259 |
| nsv951018 | CNV | deletion | 24416366 |
Gene Damage Index Score:
0.53;
11.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM89B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM89B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89B Gene
Disorders for FAM89B Gene
Relevant External Links for FAM89B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM89B
No disorders were found for FAM89B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89B Gene
Publications for FAM89B Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Identification of human homologues of the mouse mammary tumor virus receptor. (PMID: 11958456) Stewart A.F. (Arch. Virol. 2002) 3 22 64
- Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PMID: 10512749) Sakuma-Takagi M. … Kurihara T. (Biochem. Biophys. Res. Commun. 1999) 2 3 64
- A novel membrane protein is a mouse mammary tumor virus receptor. (PMID: 9525630) Golovkina T.V. … Ross S.R. (J. Virol. 1998) 2 3 64
- Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
Products for FAM89B Gene
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- Custom Antibody ServicesOriGene Antibodies for FAM89B
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- OriGene qPCR primer pairs and template standards for FAM89B
- OriGene qPCR primer pairs for FAM89B
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- GenScript: Design CRISPR guide RNA sequences for FAM89B
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- Novus Biologicals Antibodies for FAM89B
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for FAM89B
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- Search GeneTex for Antibodies for FAM89B
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- ViGene Biosciences adenoviral particle packaged cDNA for FAM89B gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM89B gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM89B gene
- Search ViGene Biosciences for FAM89B
- Horizon Cell Lines for FAM89B
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM89B
- VectorBuilder custom plasmid, inducible vectors for FAM89B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM89B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM89B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio