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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM89B Gene

protein-coding GIFtS: 43
GCID: GC11P065339

Family With Sequence Similarity 89, Member B

2 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Family With Sequence Similarity 89, Member B¹ ²
MTVR1²
Mammary Tumor Virus Receptor Homolog 1²
Protein FAM89B²

External Ids:	HGNC: 16708¹	Entrez Gene: 23625²	Ensembl: ENSG00000176973⁷	UniProtKB: Q8N5H3³

Export aliases for FAM89B gene to outside databases

Previous GC identifers: GC11P065097 GC11P061667

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM89B Gene:

FAM89B (family with sequence similarity 89, member B) is a protein-coding gene. Diseases associated with FAM89B include sjogren's syndrome, and scleroderma. GO annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.

UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3

Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2

from the nucleus to the cytoplasm in response to TGF-beta (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.2 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM89B gene promoter:
Spz1 E2F-1 E2F p53 NRSF form 1 FOXO3 Nkx2-5 NRSF form 2 C/EBPalpha GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM89B promoter sequence

Search SABiosciences Chromatin IP Primers for FAM89B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM89B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q23

FAM89B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM89B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065339: view genomic region (about GC identifiers)

Start:	65,339,820 bp from pter	End:	65,341,669 bp from pter
Size:	1,850 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3 (See protein sequence)

Recommended Name: Protein FAM89B

Size: 189 amino acids; 20147 Da

Subunit: Interacts with SKI (By similarity)

Subcellular location: Isoform 3: Cytoplasm (By similarity)

Subcellular location: Isoform 1: Cell surface (By similarity)

Secondary accessions: E9PB01 E9PL72 Q6PJ27

Alternative splicing: 4 isoforms: Q8N5H3-3 Q8N5H3-1 Q8N5H3-2 Q8N5H3-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM89B: NX_Q8N5H3

Explore proteomics data for FAM89B at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N5H3

FAM89B Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001092254.1 NP_001092255.1 NP_690045.1

ENSEMBL proteins:

ENSP00000314829 ENSP00000402439 ENSP00000431459

Human Recombinant Protein Products for FAM89B:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0009986	cell surface	IEA	--

FAM89B for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR026654 FAM89

Graphical View of Domain Structure for InterPro Entry Q8N5H3

ProtoNet protein and cluster: Q8N5H3

UniProtKB/Swiss-Prot: FA89B_HUMAN, Q8N5H3

Similarity: Belongs to the FAM89 family

FAM89B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FA89B_HUMAN, Q8N5H3

Function: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2

from the nucleus to the cytoplasm in response to TGF-beta (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001222	transcription corepressor binding	ISS	--
GO:0005515	protein binding	--	--

FAM89B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for FAM89B:

Decreased melanin production

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM89B

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM89B

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		hsa-miR-22 hsa-miR-4303 hsa-miR-646
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM89B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM89B

1 Interacting protein for FAM89B (Q8N5H3³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT8	Q92599³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISS	--
GO:0060392	negative regulation of SMAD protein import into nucleus	ISS	--

FAM89B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse Tocris compounds for FAM89B (FA89B)

Search CenterWatch for drugs/clinical trials and news about FAM89B / FA89B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM89B gene (3 alternative transcripts):

NM_001098784.1 NM_001098785.1 NM_152832.2

Unigene Cluster for FAM89B:

Family with sequence similarity 89, member B

Hs.731854 [show with all ESTs]

Unigene Representative Sequence: BC023991

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316409(uc001oem.2 uc001oen.2 uc001oel.2) ENST00000449319

ENST00000530349

miRNA Products:
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		hsa-miR-22 hsa-miR-4303 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: FAM89B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional mRNA sequence:

AF052151.1 BC023991.2 BC032373.1

4 DOTS entries:

DT.100038097 DT.447144 DT.120737182 DT.100773817

24/429 AceView cDNA sequences (see all 429):

BM468381 BM127932 CR610230 AI214414 AF052151 BQ672827 CR615607 H68581

CB121478 AJ712654 AI669222 CB138486 AI083960 CB137711 CB135184 AI872507

F20427 BF928812 BM788839 AI277698 T34020 BM128255 CA426777 CB130083

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e
SP1:
SP2:			-
SP3:			-		-

ECgene alternative splicing isoforms for FAM89B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM89B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTGCACCCC

About this image

See FAM89B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM89B

SOURCE GeneReport for Unigene cluster: Hs.731854

SABiosciences Custom PCR Arrays for FAM89B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM89B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM89B gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Fam89b^{1 , 5}	family with sequence similarity 89, member B^{1, 5}	88.36(n)¹ 96.3(a)¹	19 (4.34 cM)⁵ 17826¹ NM_181452.2¹ NP_852117.2¹ 5728087⁵
African clawed frog (Xenopus laevis)	Amphibia	MGC53407²	similar to Sjogren's syndrome/scleroderma autoantigen more	69.38(n)	BC043979.1
zebrafish (Danio rerio)	Actinopterygii	Dr.18883²	Transcribed sequence with weak similarity to protein more	79.14(n)	CK356398.1

ENSEMBL Gene Tree for FAM89B (if available)
TreeFam Gene Tree for FAM89B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM89B gene

FAM89A²

1 SIMAP similar gene for FAM89B using alignment to 1 protein entry: FA89B_HUMAN:

FAM89A

FAM89B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181226303^1,2		--	65339890(+)	`TGAGTA/GGATGT`	3	--	ut5¹		0	--	--	--	--
rs10896017^1,2	C,F	--	65340135(+)	`CGGCCC/TCGGCC`	3	--	ut5¹ ese³		1		EA	120
rs186744049^1,2		--	65340754(+)	`TGGGCG/TGGGGC`	3	--	int¹		0	--	--	--	--
rs141694006^1,2	C	--	65341056(+)	`TGCCCC/GAGACG`	5	Q E	mis¹ ut3¹		1		NA	4538
rs190686076^1,2	C	--	65341192(+)	`GGAGCC/TTGCGC`	3	--	ut3¹		0	--	--	--	--
rs111925308^1,2	C	--	65341198(+)	`TGCGCA/C/GTTCCC`	6	--	ut3¹		1		CSA	1
rs182976740^1,2		--	65341252(+)	`AGAGGC/TGAAAC`	3	--	ut3¹		0	--	--	--	--
rs80283068^1,2	C,F	--	65341273(+)	`TTTCTC/TCTGTC`	3	--	ut3¹		1		NA	120
rs187637845^1,2		--	65341439(+)	`GATTGA/GGATGA`	3	--	ut3¹		0	--	--	--	--
rs201502824^1,2	--	--	65341025(+)	`AGCCTG/ACCTCC`	5	/L	syn¹ ut3¹		1		EU	1311

HapMap Linkage Disequilibrium report for FAM89B (65339820 - 65341669 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/12 variations for FAM89B (see all 12): About this table

Variant ID	Type	Subtype	PubMed ID
nsv897723	CNV	Loss	21882294
dgv1175n71	CNV	Loss	21882294
nsv897739	CNV	Loss	21882294
dgv1180n71	CNV	Loss	21882294
nsv897736	CNV	Loss	21882294
nsv897730	CNV	Loss	21882294
dgv1176n71	CNV	Loss	21882294
dgv1181n71	CNV	Loss	21882294
dgv1179n71	CNV	Loss	21882294
nsv897718	CNV	Loss	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM89B for disorders About GeneDecksing

2 diseases for FAM89B: About MalaCards

sjogren's syndrome scleroderma

Export disorders for FAM89B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM89B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM89B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PubMed id 10512749)^{1, 3} Sakuma-Takagi M....Kurihara T. (1999)
A novel membrane protein is a mouse mammary tumor virus receptor. (PubMed id 9525630)^{1, 3} Golovkina T.V....Ross S.R. (1998)
Identification of human homologues of the mouse mammary tumor virus receptor. (PubMed id 11958456)^{1, 9} Stewart A.F. (2002)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)¹ Yu W.... Gibbs R.A. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23625	HGNC: 16708	AceView: SSSCA1andMTVR1	Ensembl:ENSG00000176973	euGenes: HUgn23625
ECgene: FAM89B	H-InvDB: FAM89B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM89B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM89B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM89B gene:
Search GeneIP for patents involving FAM89B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM89B gene at Home site.

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FAM89B Gene

Family With Sequence Similarity 89, Member B

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for FAM89B gene

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for FAM89B gene

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FAM89B Gene

Family With Sequence Similarity 89, Member B

Aliasesfor FAM89B gene

Summariesfor FAM89B gene

Genomic Viewsfor FAM89B gene

Proteinsfor FAM89B gene

Protein Domains /Familiesfor FAM89B gene

Functionfor FAM89B gene

Pathways & Interactionsfor FAM89B gene

Drugs & Compoundsfor FAM89B gene

Transcriptsfor FAM89B gene

Expression for FAM89B gene

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for FAM89B gene

Summaries
for FAM89B gene

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for FAM89B gene

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for FAM89B gene

Protein Domains /
Families
for FAM89B gene

Function
for FAM89B gene

Pathways & Interactions
for FAM89B gene

Drugs & Compounds
for FAM89B gene

Transcripts
for FAM89B gene

Expression
for FAM89B gene

Orthologs
for FAM89B gene

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for FAM89B gene

Genomic Variants
for FAM89B gene

Disorders / Diseases
for FAM89B gene

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for FAM89B gene

Intellectual Property
for FAM89B gene

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for FAM89B gene