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FAM89A Gene

protein-coding   GIFtS: 39
GCID: GC01M231154

Family With Sequence Similarity 89, Member A

(Previous name: chromosome 1 open reading frame 153)
(Previous symbol: C1orf153)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 89, Member A1 2
C1orf1531 2 3
Chromosome 1 Open Reading Frame 1531
Protein FAM89A2

External Ids:    HGNC: 250571   Entrez Gene: 3750612   Ensembl: ENSG000001821187   UniProtKB: Q96GI73   

Export aliases for FAM89A gene to outside databases

Previous GC identifers: GC01M227463 GC01M229221 GC01M201638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM89A Gene:
FAM89A (family with sequence similarity 89, member A) is a protein-coding gene. An important paralog of this gene is FAM89B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM89A gene promoter:
         Egr-3   C/EBPalpha   Gfi-1   FOXL1   CHOP-10   Egr-2   POU2F1   FOXO4   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM89A promoter sequence
   Search Chromatin IP Primers for FAM89A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM89A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

FAM89A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM89A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M231154:  view genomic region     (about GC identifiers)

Start:
231,154,704 bp from pter      End:
231,175,995 bp from pter
Size:
21,292 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA89A_HUMAN, Q96GI7 (See protein sequence)
Recommended Name: Protein FAM89A  
Size: 184 amino acids; 19569 Da

Explore the universe of human proteins at neXtProt for FAM89A: NX_Q96GI7

Explore proteomics data for FAM89A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM89A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940954.1  
    ENSEMBL proteins: 
     ENSP00000355614  

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    Search eBioscience for ELISAs for FAM89A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026654 FAM89

    Graphical View of Domain Structure for InterPro Entry Q96GI7

    ProtoNet protein and cluster: Q96GI7

    UniProtKB/Swiss-Prot: FA89A_HUMAN, Q96GI7
    Similarity: Belongs to the FAM89 family


    Find genes that share domains with FAM89A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM89A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM89A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM89A
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    hsa-mir-103a-3p (MIRT027068), hsa-mir-375 (MIRT019796), hsa-mir-128-3p (MIRT021927), hsa-mir-124-3p (MIRT022701), hsa-mir-425-5p (MIRT016649), hsa-mir-16-5p (MIRT031717)

    Block miRNA regulation of human, mouse, rat FAM89A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAM89A:
    hsa-miR-656 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidFAM89A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM89A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM89A
    Interactions:

        Search GeneGlobe Interaction Network for FAM89A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FAM89A (ENSP000003556144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA8L1ENSP000003521014STRING: ENSP00000352101
    FRMD4AENSP000003500324STRING: ENSP00000350032
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM89A (FA89A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM89A gene: 
    NM_198552.2  

    Unigene Cluster for FAM89A:

    Family with sequence similarity 89, member A
    Hs.38516  [show with all ESTs]
    Unigene Representative Sequence: NM_198552
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366654(uc001hui.2) ENST00000494111 ENST00000466258
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FAM89A:
    hsa-miR-656 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidFAM89A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM89A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM89A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM89A
    Primer
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    OriGene qPCR primer pairs and template standards for FAM89A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM89A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM89A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM89A
      QuantiFast Probe-based Assays in human, mouse, rat FAM89A

    Additional mRNA sequence: BC009447.1 

    7 DOTS entries:

    DT.113036  DT.100841916  DT.100654352  DT.439995  DT.95114153  DT.95168531  DT.99975913 

    Selected AceView cDNA sequences (see all 109):

    CR611018 AA579874 CR613855 BX956691 CR590276 AA150704 BF726202 CR617492 
    CR590053 CD366578 BQ184256 BM479160 BU176432 BX110907 CR598847 NM_198552 
    BC009447 CR590371 BG542025 BI603058 BX349099 BU164132 AA046201 BG208673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM89A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAATAGTG
    FAM89A Expression
    About this image


    FAM89A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
             HyStem+BMP4-induced SK11 cells
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced SK11 cells
    FAM89A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM89A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38516
        Custom PCR Arrays for FAM89A
    Primer
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    OriGene qPCR primer pairs and template standards for FAM89A
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    QuantiFast Probe-based Assays in human, mouse, rat FAM89A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM89A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM89A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam89a1 , 5 family with sequence similarity 89, member A1, 5 85.74(n)1
    84.94(a)1
      8 (72.81 cM)5
    696271  NM_001081120.11  NP_001074589.11 
     1247402575 
    lizard
    (Anolis carolinensis)
    Reptilia FAM89A6
    family with sequence similarity 89, member A
    76(a)
    1 ↔ 1
    1(223005064-223011119)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam89a1 family with sequence similarity 89, member A 65.38(n)
    73.72(a)
      100380112  XM_002934452.2  XP_002934498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam89a1 family with sequence similarity 89, member A 68.85(n)
    68.85(a)
      568145  XM_002665651.3  XP_002665697.3 


    ENSEMBL Gene Tree for FAM89A (if available)
    TreeFam Gene Tree for FAM89A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM89A gene
    FAM89B2  
    1 SIMAP similar gene for FAM89A using alignment to 1 protein entry:     FA89A_HUMAN:
    FAM89B

    Find genes that share paralogs with FAM89A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM89A (see all 446)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124075451,2
    F--231154230(+) TGGCTG/CACACT 1 -- int12Minor allele frequency- C:0.50CSA 4
    rs1146669891,2
    F--231154295(+) CAAGAC/TCAGCT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs107465061,2
    C,F,H--231154412(+) TGCTTG/AAACCC 1 -- int113Minor allele frequency- A:0.28NA WA CSA EA 376
    rs340849531,2
    C,F--231154599(+) TTAGTG/CGCAGA 1 -- int15Minor allele frequency- C:0.25WA NA CSA 244
    rs107798101,2
    C,F,A,H--231154618(+) CTAATT/ATTCTT 1 -- int17Minor allele frequency- A:0.14NA CSA WA EA 366
    rs1868364911,2
    --231154801(+) CTGGTC/TTGAGT 1 -- ut310--------
    rs1901796881,2
    --231154824(+) GCTTTA/CTAGCA 1 -- ut310--------
    rs1827523211,2
    --231154954(+) TCTTCA/GTATTA 1 -- ut310--------
    rs1145011791,2
    C,F--231155002(+) ATAAAA/GTTTTG 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1490907471,2
    --231155059(+) TCAGTA/GAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM89A (231154704 - 231175995 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM89A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM89A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM89A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM89A           About GenesLikeMe

    Genetic Association Database (GAD): FAM89A

    Export disorders for FAM89A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM89A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM89A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375061 HGNC: 25057 AceView: MGC15887 Ensembl:ENSG00000182118 euGenes: HUgn375061
    ECgene: FAM89A H-InvDB: FAM89A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM89A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM89A gene:
    Search GeneIP for patents involving FAM89A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for FAM89A Search Chromatin IP Primers for FAM89A
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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