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Aliases for FAM89A Gene

Aliases for FAM89A Gene

  • Family With Sequence Similarity 89 Member A 2 3 5
  • C1orf153 3 4
  • Family With Sequence Similarity 89, Member A 2
  • Chromosome 1 Open Reading Frame 153 2
  • Protein FAM89A 3

External Ids for FAM89A Gene

Previous HGNC Symbols for FAM89A Gene

  • C1orf153

Previous GeneCards Identifiers for FAM89A Gene

  • GC01M227463
  • GC01M229221
  • GC01M231154
  • GC01M201638

Summaries for FAM89A Gene

GeneCards Summary for FAM89A Gene

FAM89A (Family With Sequence Similarity 89 Member A) is a Protein Coding gene. An important paralog of this gene is FAM89B.

Additional gene information for FAM89A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89A Gene

Genomics for FAM89A Gene

Regulatory Elements for FAM89A Gene

Enhancers for FAM89A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H231210 1.6 FANTOM5 Ensembl ENCODE 10.8 -171.7 -171688 1 ARID4B SIN3A ZNF2 GLIS2 ELK1 ZNF143 ATF7 RUNX3 SP3 ZC3H11A GNPAT C1orf131 FAM89A MIR1182 LOC644006 LOC101927604 C1orf198 COG2 SPRTN LOC149373
GH01H230971 1 Ensembl ENCODE 14.9 +67.4 67375 2 HDAC1 LEF1 ATF1 BATF GATA3 POLR2A ATF7 NFE2 ETV6 RUNX3 C1orf131 FAM89A ARV1 COG2 TTC13 C1orf198 GC01P230904
GH01H230862 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.1 +173.6 173610 7 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 REST SMARCB1 LOC101927604 C1orf198 C1orf131 FAM89A ENSG00000225656
GH01H231037 1.1 ENCODE 10.6 +0.7 748 4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 SP3 REST ZNF592 ZFP41 C1orf131 COG2 ARV1 SPRTN FAM89A LOC644006
GH01H231200 1 ENCODE 10.7 -160.3 -160269 0 PKNOX1 ATF1 ARNT FEZF1 TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 FAM89A LOC644006 MIR1182 LOC149373 GNPAT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM89A on UCSC Golden Path with GeneCards custom track

Promoters for FAM89A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021676 349 1401 HDGF ARNT SIN3A ZNF2 SP3 REST ZNF592 ZFP41 ZNF610 SMARCA4

Genomic Location for FAM89A Gene

231,018,958 bp from pter
231,040,249 bp from pter
21,292 bases
Minus strand

Genomic View for FAM89A Gene

Genes around FAM89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM89A Gene

Proteins for FAM89A Gene

  • Protein details for FAM89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM89A
    Protein Accession:

    Protein attributes for FAM89A Gene

    184 amino acids
    Molecular mass:
    19569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM89A Gene

Post-translational modifications for FAM89A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM89A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM89A Gene

Domains & Families for FAM89A Gene

Gene Families for FAM89A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM89A Gene


Suggested Antigen Peptide Sequences for FAM89A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM89 family.
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89A: view

Function for FAM89A Gene

Phenotypes From GWAS Catalog for FAM89A Gene

Phenotypes for FAM89A Gene

genes like me logo Genes that share phenotypes with FAM89A: view

Animal Model Products

CRISPR Products

miRNA for FAM89A Gene

miRTarBase miRNAs that target FAM89A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM89A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89A Gene

Localization for FAM89A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM89A gene
Compartment Confidence
mitochondrion 2
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM89A Gene

Pathways & Interactions for FAM89A Gene

SuperPathways for FAM89A Gene

No Data Available

Interacting Proteins for FAM89A Gene

Gene Ontology (GO) - Biological Process for FAM89A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM89A Gene

Drugs & Compounds for FAM89A Gene

No Compound Related Data Available

Transcripts for FAM89A Gene

mRNA/cDNA for FAM89A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(109) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM89A Gene

Family with sequence similarity 89, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM89A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89A Gene

No ASD Table

Relevant External Links for FAM89A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM89A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM89A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM89A Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.5) and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for FAM89A Gene

This gene is overexpressed in Pancreas (54.2), Adrenal (8.1), and Placenta (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM89A Gene

Protein tissue co-expression partners for FAM89A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM89A Gene:


SOURCE GeneReport for Unigene cluster for FAM89A Gene:

genes like me logo Genes that share expression patterns with FAM89A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89A Gene

Orthologs for FAM89A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM89A 33
  • 99.82 (n)
ptr-mir-1182 34
  • 99 (a)
(Canis familiaris)
Mammalia FAM89A 33 34
  • 88.26 (n)
(Bos Taurus)
Mammalia FAM89A 33 34
  • 87.69 (n)
(Mus musculus)
Mammalia Fam89a 33 16 34
  • 85.74 (n)
(Rattus norvegicus)
Mammalia Fam89a 33
  • 85.23 (n)
(Monodelphis domestica)
Mammalia FAM89A 34
  • 74 (a)
(Anolis carolinensis)
Reptilia FAM89A 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam89a 33
  • 65.38 (n)
(Danio rerio)
Actinopterygii fam89a 33 34
  • 68.85 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14120 33
Species where no ortholog for FAM89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89A Gene

Gene Tree for FAM89A (if available)
Gene Tree for FAM89A (if available)

Paralogs for FAM89A Gene

Paralogs for FAM89A Gene

(1) SIMAP similar genes for FAM89A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM89A: view

Variants for FAM89A Gene

Sequence variations from dbSNP and Humsavar for FAM89A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000167847 -- 231,026,206(+) AAGCG(C/T)CCCAT intron-variant
rs1000278930 -- 231,037,726(+) TGGCG(C/T)ACTCC intron-variant
rs1000323767 -- 231,026,852(+) TAATC(A/G)AGAAA intron-variant
rs1000364900 -- 231,032,205(+) AAACA(C/T)ATTTT intron-variant
rs1000551751 -- 231,024,794(+) TGGCC(C/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM89A Gene

Variant ID Type Subtype PubMed ID
esv3589093 CNV gain 21293372
nsv1000488 CNV gain 25217958
nsv1011066 CNV gain 25217958
nsv1068593 CNV deletion 25765185
nsv1121792 CNV deletion 24896259
nsv945366 CNV duplication 23825009

Variation tolerance for FAM89A Gene

Gene Damage Index Score: 1.01; 20.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89A Gene

Disorders for FAM89A Gene

Relevant External Links for FAM89A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM89A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89A Gene

Publications for FAM89A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for FAM89A Gene

Sources for FAM89A Gene

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