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Aliases for FAM89A Gene

Aliases for FAM89A Gene

  • Family With Sequence Similarity 89 Member A 2 3 5
  • C1orf153 3 4
  • Family With Sequence Similarity 89, Member A 2
  • Chromosome 1 Open Reading Frame 153 2
  • Protein FAM89A 3

External Ids for FAM89A Gene

Previous HGNC Symbols for FAM89A Gene

  • C1orf153

Previous GeneCards Identifiers for FAM89A Gene

  • GC01M227463
  • GC01M229221
  • GC01M231154
  • GC01M201638

Summaries for FAM89A Gene

GeneCards Summary for FAM89A Gene

FAM89A (Family With Sequence Similarity 89 Member A) is a Protein Coding gene. An important paralog of this gene is FAM89B.

Additional gene information for FAM89A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89A Gene

Genomics for FAM89A Gene

GeneHancer (GH) Regulatory Elements for FAM89A Gene

Promoters and enhancers for FAM89A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I231037 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.6 +0.7 748 4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 KLF13 SP3 FAM89A C1orf131 COG2 ARV1 SPRTN LOC644006
GH01I230862 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.1 +173.6 173610 7.6 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 KLF13 C1orf198 LOC101927604 C1orf131 FAM89A ENSG00000225656
GH01I231210 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.8 -171.7 -171687 2 ARID4B SIN3A ZNF2 IRF4 ZNF48 GLIS2 ZNF213 ELK1 ARID2 ZNF143 C1orf131 COG2 GNPAT FAM89A LOC644006 MIR1182 LOC101927604 C1orf198 SPRTN LOC149373
GH01I230971 Enhancer 0.9 Ensembl ENCODE 14.9 +67.4 67375 2.2 HDAC1 MEIS2 ATF1 LEF1 TEAD4 EBF1 BATF GATA3 POLR2A ATF7 C1orf131 FAM89A ARV1 COG2 TTC13 C1orf198 GC01P230904
GH01I230976 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 5.8 +61.6 61622 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TTC13 ARV1 C1orf131 EXOC8 FAM89A LOC101927604 SPRTN GC01P230904
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM89A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM89A gene promoter:

Genomic Locations for FAM89A Gene

Genomic Locations for FAM89A Gene
21,292 bases
Minus strand

Genomic View for FAM89A Gene

Genes around FAM89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM89A Gene

Proteins for FAM89A Gene

  • Protein details for FAM89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM89A
    Protein Accession:

    Protein attributes for FAM89A Gene

    184 amino acids
    Molecular mass:
    19569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM89A Gene

Post-translational modifications for FAM89A Gene

No Post-translational modifications

Other Protein References for FAM89A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM89A Gene

Domains & Families for FAM89A Gene

Gene Families for FAM89A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM89A Gene


Suggested Antigen Peptide Sequences for FAM89A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM89 family.
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89A: view

Function for FAM89A Gene

Phenotypes From GWAS Catalog for FAM89A Gene

Phenotypes for FAM89A Gene

genes like me logo Genes that share phenotypes with FAM89A: view

Animal Model Products

miRNA for FAM89A Gene

miRTarBase miRNAs that target FAM89A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89A Gene

Localization for FAM89A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM89A gene
Compartment Confidence
mitochondrion 2
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM89A Gene

Pathways & Interactions for FAM89A Gene

SuperPathways for FAM89A Gene

No Data Available

Interacting Proteins for FAM89A Gene

Gene Ontology (GO) - Biological Process for FAM89A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM89A Gene

Drugs & Compounds for FAM89A Gene

No Compound Related Data Available

Transcripts for FAM89A Gene

mRNA/cDNA for FAM89A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(109) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM89A Gene

Family with sequence similarity 89, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89A Gene

No ASD Table

Relevant External Links for FAM89A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM89A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM89A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM89A Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.5) and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for FAM89A Gene

This gene is overexpressed in Pancreas (54.2), Adrenal (8.1), and Placenta (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM89A Gene

Protein tissue co-expression partners for FAM89A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM89A Gene:


SOURCE GeneReport for Unigene cluster for FAM89A Gene:

genes like me logo Genes that share expression patterns with FAM89A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89A Gene

Orthologs for FAM89A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM89A 33
  • 99.82 (n)
ptr-mir-1182 34
  • 99 (a)
(Canis familiaris)
Mammalia FAM89A 34 33
  • 88.26 (n)
(Bos Taurus)
Mammalia FAM89A 33 34
  • 87.69 (n)
(Mus musculus)
Mammalia Fam89a 33 16 34
  • 85.74 (n)
(Rattus norvegicus)
Mammalia Fam89a 33
  • 85.23 (n)
(Monodelphis domestica)
Mammalia FAM89A 34
  • 74 (a)
(Anolis carolinensis)
Reptilia FAM89A 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam89a 33
  • 65.38 (n)
(Danio rerio)
Actinopterygii fam89a 33 34
  • 68.85 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14120 33
Species where no ortholog for FAM89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89A Gene

Gene Tree for FAM89A (if available)
Gene Tree for FAM89A (if available)

Paralogs for FAM89A Gene

Paralogs for FAM89A Gene

(1) SIMAP similar genes for FAM89A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM89A: view

Variants for FAM89A Gene

Sequence variations from dbSNP and Humsavar for FAM89A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000167847 -- 231,026,206(-) C/T intron_variant
rs1000278930 -- 231,037,726(-) C/T intron_variant
rs1000323767 -- 231,026,852(-) G/A intron_variant
rs1000364900 -- 231,032,205(-) T/C intron_variant
rs1000551751 -- 231,024,794(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM89A Gene

Variant ID Type Subtype PubMed ID
esv3589093 CNV gain 21293372
nsv1000488 CNV gain 25217958
nsv1011066 CNV gain 25217958
nsv1068593 CNV deletion 25765185
nsv1121792 CNV deletion 24896259
nsv945366 CNV duplication 23825009

Variation tolerance for FAM89A Gene

Gene Damage Index Score: 1.01; 20.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89A Gene

Disorders for FAM89A Gene

Additional Disease Information for FAM89A

No disorders were found for FAM89A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89A Gene

Publications for FAM89A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. (PMID: 24954085) Della-Morte D … Dong C (Journal of the neurological sciences 2014) 3 58

Products for FAM89A Gene

Sources for FAM89A Gene

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