Aliases for FAM89A Gene
Aliases for FAM89A Gene
External Ids for FAM89A Gene
- HGNC: 25057
- Entrez Gene: 375061
- Ensembl: ENSG00000182118
- UniProtKB: Q96GI7
Previous HGNC Symbols for FAM89A Gene
- C1orf153
Previous GeneCards Identifiers for FAM89A Gene
- GC01M227463
- GC01M229221
- GC01M231154
- GC01M201638
Summaries for FAM89A Gene
GeneCards Summary for FAM89A Gene
FAM89A (Family With Sequence Similarity 89 Member A) is a Protein Coding gene. An important paralog of this gene is FAM89B.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM89A Gene
Genomics for FAM89A Gene
Regulatory Elements for FAM89A Gene
Enhancers for FAM89A Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM89A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM89A gene promoter:
Regulatory Element Products
Genomic Location for FAM89A Gene
- Chromosome:
- 1
- Start:
- 231,018,958 bp from pter
- End:
- 231,040,249 bp from pter
- Size:
- 21,292 bases
- Orientation:
- Minus strand
Genomic View for FAM89A Gene
Genes around FAM89A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.2 by Ensembl
- 1q42.2 by Entrez Gene
- 1q42.2 by HGNC
FAM89A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM89A Gene
Proteins for FAM89A Gene
-
Protein details for FAM89A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96GI7-FA89A_HUMAN
- Recommended name:
- Protein FAM89A
- Protein Accession:
- Q96GI7
Protein attributes for FAM89A Gene
- Size:
- 184 amino acids
- Molecular mass:
- 19569 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM89A Gene
Post-translational modifications for FAM89A Gene
Other Protein References for FAM89A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FAM89A
- Invitrogen Antibodies for FAM89A
- Search GeneTex for Antibodies for FAM89A
Protein Products
-
OriGene Purified Proteins for FAM89A
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM89A
- Origene Custom Protein Services for FAM89A
- Novus Biologicals proteins for FAM89A
- Search GeneTex for Proteins for FAM89A
Assay Products
No data available for DME Specific Peptides for FAM89A Gene
Domains & Families for FAM89A Gene
Protein Domains for FAM89A Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM89A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96GI7- Family:
-
- Belongs to the FAM89 family.
No data available for Gene Families for FAM89A Gene
Function for FAM89A Gene
Phenotypes for FAM89A Gene
- GenomeRNAi human phenotypes for FAM89A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM89A gene
- Search ViGene Biosciences for FAM89A
CRISPR Products
-
OriGene CRISPR knockouts for FAM89A
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM89A
- GenScript: Design CRISPR guide RNA sequences for FAM89A
miRNA for FAM89A Gene
- miRTarBase miRNAs that target FAM89A
-
- hsa-mir-425-5p (MIRT016649)
- hsa-mir-375 (MIRT019796)
- hsa-mir-128-3p (MIRT021927)
- hsa-mir-124-3p (MIRT022701)
- hsa-mir-103a-3p (MIRT027068)
- hsa-mir-16-5p (MIRT031717)
- hsa-mir-4711-5p (MIRT495736)
- hsa-mir-1292-3p (MIRT495737)
- hsa-mir-7151-3p (MIRT516594)
- hsa-mir-5095 (MIRT516595)
- hsa-mir-6508-3p (MIRT516596)
- hsa-mir-4726-5p (MIRT516597)
- hsa-mir-4640-5p (MIRT516598)
- hsa-mir-6853-5p (MIRT516599)
- hsa-mir-6504-3p (MIRT516600)
- hsa-mir-4438 (MIRT516601)
- hsa-mir-1287-5p (MIRT540254)
- hsa-mir-3135b (MIRT540255)
- hsa-mir-6128 (MIRT540256)
- hsa-mir-150-5p (MIRT540257)
- hsa-mir-186-3p (MIRT540258)
- hsa-mir-520h (MIRT540259)
- hsa-mir-520g-3p (MIRT540260)
- hsa-mir-512-3p (MIRT540261)
- hsa-mir-520e (MIRT540262)
- hsa-mir-520d-3p (MIRT540263)
- hsa-mir-520c-3p (MIRT540264)
- hsa-mir-520b (MIRT540265)
- hsa-mir-520a-3p (MIRT540266)
- hsa-mir-373-3p (MIRT540267)
- hsa-mir-372-3p (MIRT540268)
- hsa-mir-302e (MIRT540269)
- hsa-mir-302d-3p (MIRT540270)
- hsa-mir-302c-3p (MIRT540271)
- hsa-mir-302b-3p (MIRT540272)
- hsa-mir-302a-3p (MIRT540273)
- hsa-mir-93-5p (MIRT540274)
- hsa-mir-526b-3p (MIRT540275)
- hsa-mir-519d-3p (MIRT540276)
- hsa-mir-20b-5p (MIRT540277)
- hsa-mir-20a-5p (MIRT540278)
- hsa-mir-17-5p (MIRT540279)
- hsa-mir-106b-5p (MIRT540280)
- hsa-mir-106a-5p (MIRT540281)
- hsa-mir-335-3p (MIRT610688)
- hsa-mir-5096 (MIRT610689)
- hsa-mir-4677-5p (MIRT610690)
- hsa-mir-22-5p (MIRT610691)
- hsa-mir-2116-5p (MIRT610692)
- hsa-mir-4272 (MIRT610693)
- hsa-mir-124-5p (MIRT614054)
- hsa-mir-5010-3p (MIRT615658)
- hsa-mir-2113 (MIRT615659)
- hsa-mir-421 (MIRT615660)
- hsa-mir-505-3p (MIRT615661)
- hsa-mir-7159-5p (MIRT615662)
- hsa-mir-6740-3p (MIRT623973)
miRNA Products
- Search ViGene Biosciences for FAM89A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM89A
- Browse OriGene Inhibitory RNA Products For FAM89A
- Search ViGene Biosciences for FAM89A
Clone Products
-
OriGene ORF clones in human for FAM89A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM89A
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM89A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM89A gene
- Search ViGene Biosciences for FAM89A
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89A Gene
Localization for FAM89A Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| nucleus | 2 |
| golgi apparatus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM89A Gene
Transcripts for FAM89A Gene
mRNA/cDNA for FAM89A Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (109) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM89A Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM89A
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM89A
- GenScript: Design CRISPR guide RNA sequences for FAM89A
miRNA Products
- Search ViGene Biosciences for FAM89A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM89A
- Browse OriGene Inhibitory RNA Products For FAM89A
- Search ViGene Biosciences for FAM89A
Clone Products
-
OriGene ORF clones in human for FAM89A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FAM89A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Cartilage (Muscoskeletal System)
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FAM89A Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x5.5) and Adipose - Subcutaneous (x4.2).
This gene is overexpressed in Pancreas (54.2), Adrenal (8.1), and Placenta (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM89A Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM89A Gene:
FAM89ASOURCE GeneReport for Unigene cluster for FAM89A Gene:
Hs.38516Primer Products
-
OriGene qPCR primer pairs for FAM89A
-
OriGene qPCR primer pairs and template standards for FAM89A
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89A Gene
Orthologs for FAM89A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM89A 34 |
|
||
| ptr-mir-1182 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | FAM89A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM89A 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam89a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam89a 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM89A 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FAM89A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam89a 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam89a 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.14120 34 |
|
- Species where no ortholog for FAM89A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM89A Gene
(1) SIMAP similar genes for FAM89A Gene using alignment to 1 proteins:
Variants for FAM89A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000167847 | -- | 231,026,206(+) | AAGCG(C/T)CCCAT | intron-variant | |
| rs1000278930 | -- | 231,037,726(+) | TGGCG(C/T)ACTCC | intron-variant | |
| rs1000323767 | -- | 231,026,852(+) | TAATC(A/G)AGAAA | intron-variant | |
| rs1000364900 | -- | 231,032,205(+) | AAACA(C/T)ATTTT | intron-variant | |
| rs1000551751 | -- | 231,024,794(+) | TGGCC(C/T)CCCAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3589093 | CNV | gain | 21293372 |
| nsv1000488 | CNV | gain | 25217958 |
| nsv1011066 | CNV | gain | 25217958 |
| nsv1068593 | CNV | deletion | 25765185 |
| nsv1121792 | CNV | deletion | 24896259 |
| nsv945366 | CNV | duplication | 23825009 |
Gene Damage Index Score:
1.01;
20.75% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM89A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM89A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89A Gene
Disorders for FAM89A Gene
Relevant External Links for FAM89A
No disorders were found for FAM89A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89A Gene
Publications for FAM89A Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. (PMID: 24954085) Della-Morte D. … Dong C. (J. Neurol. Sci. 2014) 3 64
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
Products for FAM89A Gene
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- Browse R&D Systems for biochemical assays
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- OriGene Purified Proteins for FAM89A
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM89A
- Browse OriGene Inhibitory RNA Products For FAM89A
- OriGene qPCR primer pairs and template standards for FAM89A
- OriGene qPCR primer pairs for FAM89A
- OriGene CRISPR knockouts for FAM89A
- OriGene ORF clones in human for FAM89A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FAM89A in any vector
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- GenScript: Design CRISPR guide RNA sequences for FAM89A
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
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- Novus Biologicals Antibodies for FAM89A
- Novus Biologicals proteins for FAM89A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FAM89A gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM89A gene
- Search ViGene Biosciences for FAM89A
- Horizon Cell Lines for FAM89A
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM89A
- VectorBuilder custom plasmid, inducible vectors for FAM89A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM89A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM89A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer