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Aliases for FAM86C1 Gene

Aliases for FAM86C1 Gene

  • Family With Sequence Similarity 86 Member C1 2 3 5
  • Family With Sequence Similarity 86, Member C 2 3
  • FAM86C 3 4
  • Family With Sequence Similarity 86, Member C1 2
  • Protein FAM86C1 3
  • Protein FAM86C 4
  • EC 2.1.1.- 4

External Ids for FAM86C1 Gene

Previous HGNC Symbols for FAM86C1 Gene

  • FAM86C

Previous GeneCards Identifiers for FAM86C1 Gene

  • GC11P071500

Summaries for FAM86C1 Gene

GeneCards Summary for FAM86C1 Gene

FAM86C1 (Family With Sequence Similarity 86 Member C1) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is EEF2KMT.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86C1 Gene

Genomics for FAM86C1 Gene

Regulatory Elements for FAM86C1 Gene

Enhancers for FAM86C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G071785 1 ENCODE 72.2 -0.4 -443 4.0 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 FAM86C1 LOC105379409
GH11G071781 0.9 FANTOM5 ENCODE 67.9 -5.3 -5315 1.7 RNF2 MAFG DPF2 ARID1B ZNF316 HDAC2 IKZF1 NFE2 KDM1A HNF4A FAM86C1 LOC105379409 ENPP7P8
GH11G071749 0.7 ENCODE 53.8 -38.1 -38072 0.6 CTCF TAL1 FOSL1 TCF12 NCOR1 NR2F6 ZSCAN29 SMARCE1 MTA2 NR2F1 FAM86C1 LOC105379409 ENPP7P8
GH11G072098 1.4 ENCODE dbSUPER 26.2 +314.3 314300 6.0 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 FAM86C1 LRTOMT NUMA1 OR7E128P ENSG00000204971 LAMTOR1
GH11G071813 0.8 ENCODE 44.2 +26.5 26476 1.0 ELF3 RB1 SIN3A RAD21 GLIS2 ZNF143 ZNF654 REST GATAD2B KAT8 FAM86C1 ALG1L9P ENSG00000248671
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM86C1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM86C1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041611 -210 2201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2

Genomic Location for FAM86C1 Gene

Chromosome:
11
Start:
71,787,510 bp from pter
End:
71,801,236 bp from pter
Size:
13,727 bases
Orientation:
Plus strand

Genomic View for FAM86C1 Gene

Genes around FAM86C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86C1 Gene

Proteins for FAM86C1 Gene

  • Protein details for FAM86C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVL1-FA86C_HUMAN
    Recommended name:
    Protein FAM86C1
    Protein Accession:
    Q9NVL1
    Secondary Accessions:
    • Q8N5D3

    Protein attributes for FAM86C1 Gene

    Size:
    165 amino acids
    Molecular mass:
    18454 Da
    Quaternary structure:
    • Interacts with EEF2KMT.

    Alternative splice isoforms for FAM86C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM86C1 Gene

Post-translational modifications for FAM86C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM86C1 Gene

No data available for DME Specific Peptides for FAM86C1 Gene

Domains & Families for FAM86C1 Gene

Protein Domains for FAM86C1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM86C1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVL1

UniProtKB/Swiss-Prot:

FA86C_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86C1: view

No data available for Gene Families for FAM86C1 Gene

Function for FAM86C1 Gene

Enzyme Numbers (IUBMB) for FAM86C1 Gene

Gene Ontology (GO) - Molecular Function for FAM86C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FAM86C1: view

Phenotypes for FAM86C1 Gene

GenomeRNAi human phenotypes for FAM86C1:
genes like me logo Genes that share phenotypes with FAM86C1: view

Animal Model Products

CRISPR Products

miRNA for FAM86C1 Gene

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM86C1 Gene

Localization for FAM86C1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM86C1 gene
Compartment Confidence
extracellular 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86C1 Gene

Pathways & Interactions for FAM86C1 Gene

SuperPathways for FAM86C1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM86C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86C1: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86C1 Gene

Drugs & Compounds for FAM86C1 Gene

No Compound Related Data Available

Transcripts for FAM86C1 Gene

Unigene Clusters for FAM86C1 Gene

Family with sequence similarity 86, member C1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86C1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for FAM86C1 Gene

GeneLoc Exon Structure for
FAM86C1
ECgene alternative splicing isoforms for
FAM86C1

Expression for FAM86C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM86C1 Gene

Protein differential expression in normal tissues from HIPED for FAM86C1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86C1 Gene



Protein tissue co-expression partners for FAM86C1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM86C1 Gene:

FAM86C1

SOURCE GeneReport for Unigene cluster for FAM86C1 Gene:

Hs.567527

Evidence on tissue expression from TISSUES for FAM86C1 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with FAM86C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86C1 Gene

Orthologs for FAM86C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM86A 34
  • 93.77 (n)
FAM86C1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM86A 35
  • 24 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam86 35
  • 23 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 21 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 17 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 9 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM86A 35
  • 17 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam86a 35
  • 15 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7889 35
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.4 35
  • 7 (a)
OneToMany
Species where no ortholog for FAM86C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86C1 Gene

ENSEMBL:
Gene Tree for FAM86C1 (if available)
TreeFam:
Gene Tree for FAM86C1 (if available)

Paralogs for FAM86C1 Gene

Paralogs for FAM86C1 Gene

(4) SIMAP similar genes for FAM86C1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM86C1 Gene

genes like me logo Genes that share paralogs with FAM86C1: view

Variants for FAM86C1 Gene

Sequence variations from dbSNP and Humsavar for FAM86C1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000153538 -- 71,794,974(+) CCATC(C/G/T)GCAAG intron-variant, nc-transcript-variant
rs1000264057 -- 71,789,238(+) GAACA(C/G)GCCAG intron-variant
rs1000315864 -- 71,789,056(+) CCCCA(A/G)AGAGG intron-variant
rs1000601503 -- 71,790,092(+) TCTAG(A/G)GAAAG intron-variant
rs1000652127 -- 71,789,958(+) TTCAA(A/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM86C1 Gene

Variant ID Type Subtype PubMed ID
dgv1222n100 CNV gain 25217958
dgv1223n100 CNV gain 25217958
dgv1224n100 CNV gain 25217958
dgv223e199 CNV deletion 23128226
esv25167 CNV gain 19812545
esv2744758 CNV deletion 23290073
esv2759836 CNV gain+loss 17122850
esv2761682 CNV gain 21179565
esv3892025 CNV gain 25118596
nsv1045511 CNV loss 25217958
nsv1127207 CNV deletion 24896259
nsv428262 CNV gain+loss 18775914
nsv482161 CNV gain 20164927
nsv832205 CNV gain 17160897
nsv951036 CNV deletion 24416366
nsv972041 CNV duplication 23825009

Variation tolerance for FAM86C1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.73; 97.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM86C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM86C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86C1 Gene

Disorders for FAM86C1 Gene

Relevant External Links for FAM86C1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM86C1

No disorders were found for FAM86C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86C1 Gene

Publications for FAM86C1 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for FAM86C1 Gene

Sources for FAM86C1 Gene

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