Aliases for FAM86C1 Gene
Aliases for FAM86C1 Gene
External Ids for FAM86C1 Gene
- HGNC: 25561
- Entrez Gene: 55199
- Ensembl: ENSG00000158483
- OMIM: 616124
- UniProtKB: Q9NVL1
Previous HGNC Symbols for FAM86C1 Gene
- FAM86C
Previous GeneCards Identifiers for FAM86C1 Gene
- GC11P071500
Summaries for FAM86C1 Gene
GeneCards Summary for FAM86C1 Gene
FAM86C1 (Family With Sequence Similarity 86 Member C1) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is EEF2KMT.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86C1 Gene
Genomics for FAM86C1 Gene
Regulatory Elements for FAM86C1 Gene
Enhancers for FAM86C1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G071785 | 1 | ENCODE | 72.1 | -0.4 | -443 | 4.0 | HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 | FAM86C1 LOC105379409 |
| GH11G071781 | 0.9 | FANTOM5 ENCODE | 67.9 | -5.3 | -5315 | 1.7 | RNF2 MAFG DPF2 ARID1B ZNF316 HDAC2 IKZF1 NFE2 KDM1A HNF4A | FAM86C1 LOC105379409 ENPP7P8 |
| GH11G071749 | 0.7 | ENCODE | 53.8 | -38.1 | -38072 | 0.6 | CTCF TAL1 FOSL1 TCF12 NCOR1 NR2F6 ZSCAN29 SMARCE1 MTA2 RNF2 | FAM86C1 LOC105379409 ENPP7P8 |
| GH11G072098 | 1.4 | ENCODE dbSUPER | 26.2 | +314.3 | 314300 | 6.0 | HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 | FAM86C1 LRTOMT NUMA1 OR7E128P ENSG00000204971 LAMTOR1 |
| GH11G071813 | 0.8 | ENCODE | 44.2 | +26.5 | 26476 | 1.0 | ELF3 RB1 SIN3A RAD21 GLIS2 ZNF143 ZNF654 REST GATAD2B KAT8 | FAM86C1 ALG1L9P ENSG00000248671 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM86C1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FAM86C1 Gene
- Chromosome:
- 11
- Start:
- 71,787,510 bp from pter
- End:
- 71,801,236 bp from pter
- Size:
- 13,727 bases
- Orientation:
- Plus strand
Genomic View for FAM86C1 Gene
Genes around FAM86C1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.4 by Ensembl
- 11q13.4 by Entrez Gene
- 11q13.4 by HGNC
FAM86C1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM86C1 Gene
Proteins for FAM86C1 Gene
-
Protein details for FAM86C1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NVL1-FA86C_HUMAN
- Recommended name:
- Protein FAM86C1
- Protein Accession:
- Q9NVL1
- Q8N5D3
Protein attributes for FAM86C1 Gene
- Size:
- 165 amino acids
- Molecular mass:
- 18454 Da
- Quaternary structure:
-
- Interacts with EEF2KMT.
Protein Expression for FAM86C1 Gene
Post-translational modifications for FAM86C1 Gene
Other Protein References for FAM86C1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for FAM86C1
Protein Products
-
OriGene Purified Proteins for FAM86C1
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM86C1
- Origene Custom Protein Services for FAM86C1
- Novus Biologicals lysates for FAM86C1
- Search GeneTex for Proteins for FAM86C1
Assay Products
No data available for DME Specific Peptides for FAM86C1 Gene
Domains & Families for FAM86C1 Gene
Suggested Antigen Peptide Sequences for FAM86C1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NVL1UniProtKB/Swiss-Prot:
FA86C_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
No data available for Gene Families for FAM86C1 Gene
Function for FAM86C1 Gene
Enzyme Numbers (IUBMB) for FAM86C1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for FAM86C1 Gene
- GenomeRNAi human phenotypes for FAM86C1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM86C1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86C1 gene
- Search ViGene Biosciences for FAM86C1
CRISPR Products
-
OriGene CRISPR knockouts for FAM86C1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM86C1
- GenScript: Design CRISPR guide RNA sequences for FAM86C1
miRNA for FAM86C1 Gene
- miRTarBase miRNAs that target FAM86C1
miRNA Products
- Search ViGene Biosciences for FAM86C1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM86C1
- Browse OriGene Inhibitory RNA Products For FAM86C1
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86C1 gene
Cell Line Products
-
Horizon Cell Lines for FAM86C1
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM86C1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM86C1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86C1 gene
Flow Cytometry Products
No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM86C1 Gene
Localization for FAM86C1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86C1 Gene
Pathways & Interactions for FAM86C1 Gene
No Data Available
Interacting Proteins for FAM86C1 Gene
Selected Interacting proteins:
Q9NVL1-FA86C_HUMAN
ENSP00000352182
for FAM86C1 Gene via
IID
UniProtKB
STRING
| Symbol | External ID(s) | Details |
|---|---|---|
| EEF2KMT | ||
| SAT1 | ||
| TRAF1 | ||
| BUD23 | ||
| ENSG00000267168 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032259 | methylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FAM86C1 Gene
Transcripts for FAM86C1 Gene
mRNA/cDNA for FAM86C1 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM86C1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM86C1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM86C1
- GenScript: Design CRISPR guide RNA sequences for FAM86C1
miRNA Products
- Search ViGene Biosciences for FAM86C1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM86C1
- Browse OriGene Inhibitory RNA Products For FAM86C1
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86C1 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: |
Expression for FAM86C1 Gene
This gene is overexpressed in Urine (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86C1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FAM86C1 Gene:
FAM86C1SOURCE GeneReport for Unigene cluster for FAM86C1 Gene:
Hs.567527Evidence on tissue expression from TISSUES for FAM86C1 Gene
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs for FAM86C1
-
OriGene qPCR primer pairs and template standards for FAM86C1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86C1 Gene
Orthologs for FAM86C1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM86A 34 |
|
||
| FAM86C1 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | FAM86A 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Fam86 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | FAM86A 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | fam86a 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG7889 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | R08D7.4 35 |
|
OneToMany |
- Species where no ortholog for FAM86C1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for FAM86C1 Gene
(4) SIMAP similar genes for FAM86C1 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for FAM86C1 Gene
Variants for FAM86C1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000153538 | -- | 71,794,974(+) | CCATC(C/G/T)GCAAG | intron-variant, nc-transcript-variant | |
| rs1000264057 | -- | 71,789,238(+) | GAACA(C/G)GCCAG | intron-variant | |
| rs1000315864 | -- | 71,789,056(+) | CCCCA(A/G)AGAGG | intron-variant | |
| rs1000601503 | -- | 71,790,092(+) | TCTAG(A/G)GAAAG | intron-variant | |
| rs1000652127 | -- | 71,789,958(+) | TTCAA(A/G)GAACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1222n100 | CNV | gain | 25217958 |
| dgv1223n100 | CNV | gain | 25217958 |
| dgv1224n100 | CNV | gain | 25217958 |
| dgv223e199 | CNV | deletion | 23128226 |
| esv25167 | CNV | gain | 19812545 |
| esv2744758 | CNV | deletion | 23290073 |
| esv2759836 | CNV | gain+loss | 17122850 |
| esv2761682 | CNV | gain | 21179565 |
| esv3892025 | CNV | gain | 25118596 |
| nsv1045511 | CNV | loss | 25217958 |
| nsv1127207 | CNV | deletion | 24896259 |
| nsv428262 | CNV | gain+loss | 18775914 |
| nsv482161 | CNV | gain | 20164927 |
| nsv832205 | CNV | gain | 17160897 |
| nsv951036 | CNV | deletion | 24416366 |
| nsv972041 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.73;
97.33% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM86C1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM86C1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86C1 Gene
Disorders for FAM86C1 Gene
Relevant External Links for FAM86C1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM86C1
No disorders were found for FAM86C1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86C1 Gene
Publications for FAM86C1 Gene
- A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
Products for FAM86C1 Gene
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- OriGene qPCR primer pairs and template standards for FAM86C1
- OriGene qPCR primer pairs for FAM86C1
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- Novus Biologicals lysates for FAM86C1
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- Horizon Cell Lines for FAM86C1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM86C1
- VectorBuilder custom plasmid, inducible vectors for FAM86C1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM86C1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
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- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer