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Aliases for FAM86C1 Gene

Aliases for FAM86C1 Gene

  • Family With Sequence Similarity 86 Member C1 2 3 5
  • Family With Sequence Similarity 86, Member C 2 3
  • FAM86C 3 4
  • Family With Sequence Similarity 86, Member C1 2
  • Protein FAM86C1 3
  • Protein FAM86C 4
  • EC 2.1.1.- 4

External Ids for FAM86C1 Gene

Previous HGNC Symbols for FAM86C1 Gene

  • FAM86C

Previous GeneCards Identifiers for FAM86C1 Gene

  • GC11P071500

Summaries for FAM86C1 Gene

GeneCards Summary for FAM86C1 Gene

FAM86C1 (Family With Sequence Similarity 86 Member C1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is EEF2KMT.

Additional gene information for FAM86C1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86C1 Gene

Genomics for FAM86C1 Gene

GeneHancer (GH) Regulatory Elements for FAM86C1 Gene

Promoters and enhancers for FAM86C1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I071785 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 622.2 -0.4 -442 4 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 FAM86C1 LOC105379409
GH11I072098 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 34.7 +314.3 314299 6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 LAMTOR1 FAM86C1 NUMA1 LOC100128494 LRTOMT ZNF705E RNF121 IL18BP OR7E128P ENSG00000204971
GH11I071813 Promoter/Enhancer 1.3 Ensembl ENCODE 44.2 +26.3 26332 1.3 RB1 SIN3A RAD21 ZNF335 GLIS2 ARID2 ZNF143 SMARCA5 ZNF654 ZBTB11 ALG1L9P FAM86C1 ENSG00000248671 ZNF705E
GH11I071781 Enhancer 0.8 FANTOM5 ENCODE 67.9 -5.3 -5315 1.7 MAFG CBFA2T3 DPF2 ZNF316 HDAC2 IKZF1 NFE2 KDM1A HNF4A EMSY FAM86C1 LOC105379409 ENPP7P8
GH11I072430 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 +645.4 645417 4.7 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A ZNF610 ZNF585B CLPB NUMA1 LOC100128494 ZNF705E RNF121 IL18BP NADSYN1 ENSG00000248671 ARHGEF17 FAM86C1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM86C1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM86C1 Gene

Genomic Locations for FAM86C1 Gene
13,727 bases
Plus strand

Genomic View for FAM86C1 Gene

Genes around FAM86C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86C1 Gene

Proteins for FAM86C1 Gene

  • Protein details for FAM86C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM86C1
    Protein Accession:
    Secondary Accessions:
    • Q8N5D3

    Protein attributes for FAM86C1 Gene

    165 amino acids
    Molecular mass:
    18454 Da
    Quaternary structure:
    • Interacts with EEF2KMT.

    Alternative splice isoforms for FAM86C1 Gene


neXtProt entry for FAM86C1 Gene

Post-translational modifications for FAM86C1 Gene

No Post-translational modifications

Other Protein References for FAM86C1 Gene

No data available for DME Specific Peptides for FAM86C1 Gene

Domains & Families for FAM86C1 Gene

Gene Families for FAM86C1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM86C1 Gene


Suggested Antigen Peptide Sequences for FAM86C1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86C1: view

Function for FAM86C1 Gene

Enzyme Numbers (IUBMB) for FAM86C1 Gene

Phenotypes From GWAS Catalog for FAM86C1 Gene

Gene Ontology (GO) - Molecular Function for FAM86C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23349634
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FAM86C1: view

Phenotypes for FAM86C1 Gene

GenomeRNAi human phenotypes for FAM86C1:
genes like me logo Genes that share phenotypes with FAM86C1: view

miRNA for FAM86C1 Gene

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM86C1 Gene

Localization for FAM86C1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM86C1 gene
Compartment Confidence
extracellular 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM86C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA 23349634
genes like me logo Genes that share ontologies with FAM86C1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FAM86C1 Gene

Pathways & Interactions for FAM86C1 Gene

SuperPathways for FAM86C1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM86C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86C1: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86C1 Gene

Drugs & Compounds for FAM86C1 Gene

No Compound Related Data Available

Transcripts for FAM86C1 Gene

Unigene Clusters for FAM86C1 Gene

Family with sequence similarity 86, member C1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86C1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -

Relevant External Links for FAM86C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM86C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM86C1 Gene

Protein differential expression in normal tissues from HIPED for FAM86C1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86C1 Gene

Protein tissue co-expression partners for FAM86C1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM86C1 Gene:


SOURCE GeneReport for Unigene cluster for FAM86C1 Gene:


Evidence on tissue expression from TISSUES for FAM86C1 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with FAM86C1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86C1 Gene

Orthologs for FAM86C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM86A 33
  • 93.77 (n)
FAM86C1 34
  • 93 (a)
(Bos Taurus)
Mammalia FAM86A 34
  • 24 (a)
(Mus musculus)
Mammalia Fam86 34
  • 23 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 21 (a)
(Canis familiaris)
Mammalia -- 34
  • 17 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 9 (a)
(Gallus gallus)
Aves FAM86A 34
  • 17 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
(Danio rerio)
Actinopterygii fam86a 34
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7889 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea R08D7.4 34
  • 7 (a)
Species where no ortholog for FAM86C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86C1 Gene

Gene Tree for FAM86C1 (if available)
Gene Tree for FAM86C1 (if available)

Paralogs for FAM86C1 Gene

Paralogs for FAM86C1 Gene

(4) SIMAP similar genes for FAM86C1 Gene using alignment to 3 proteins: Pseudogenes for FAM86C1 Gene

genes like me logo Genes that share paralogs with FAM86C1: view

Variants for FAM86C1 Gene

Sequence variations from dbSNP and Humsavar for FAM86C1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000153538 -- 71,794,974(+) T/C/G intron_variant
rs1000264057 -- 71,789,238(+) G/C intron_variant
rs1000315864 -- 71,789,056(+) A/G intron_variant
rs1000601503 -- 71,790,092(+) G/A intron_variant
rs1000652127 -- 71,789,958(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM86C1 Gene

Variant ID Type Subtype PubMed ID
dgv1222n100 CNV gain 25217958
dgv1223n100 CNV gain 25217958
dgv1224n100 CNV gain 25217958
dgv223e199 CNV deletion 23128226
esv25167 CNV gain 19812545
esv2744758 CNV deletion 23290073
esv2759836 CNV gain+loss 17122850
esv2761682 CNV gain 21179565
esv3892025 CNV gain 25118596
nsv1045511 CNV loss 25217958
nsv1127207 CNV deletion 24896259
nsv428262 CNV gain+loss 18775914
nsv482161 CNV gain 20164927
nsv832205 CNV gain 17160897
nsv951036 CNV deletion 24416366
nsv972041 CNV duplication 23825009

Variation tolerance for FAM86C1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.73; 97.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM86C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86C1 Gene

Disorders for FAM86C1 Gene

Additional Disease Information for FAM86C1

No disorders were found for FAM86C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86C1 Gene

Publications for FAM86C1 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for FAM86C1 Gene

Sources for FAM86C1 Gene

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