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FAM86C1 Gene

protein-coding   GIFtS: 36
GCID: GC11P071500

Family With Sequence Similarity 86, Member C1

(Previous names: family with sequence similarity 86, member C)
(Previous symbol: FAM86C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 86, Member C11 2
FAM86C1 2 3
Family With Sequence Similarity 86, Member C1 2
Protein FAM86C12
Protein FAM86C3

External Ids:    HGNC: 255611   Entrez Gene: 551992   Ensembl: ENSG000001584837   UniProtKB: Q9NVL13   

Export aliases for FAM86C1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM86C1 Gene:
FAM86C1 (family with sequence similarity 86, member C1) is a protein-coding gene. An important paralog of this gene is FAM86A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM86C1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM86C1 promoter sequence
   Search Chromatin IP Primers for FAM86C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM86C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

FAM86C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM86C1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071500:  view genomic region     (about GC identifiers)

Start:
71,498,556 bp from pter      End:
71,512,282 bp from pter
Size:
13,727 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA86C_HUMAN, Q9NVL1 (See protein sequence)
Recommended Name: Protein FAM86C1  
Size: 165 amino acids; 18454 Da
Subunit: Interacts with FAM86A
Secondary accessions: Q8N5D3
Alternative splicing: 3 isoforms:  Q9NVL1-1   Q9NVL1-2   Q9NVL1-3   

Explore the universe of human proteins at neXtProt for FAM86C1: NX_Q9NVL1

Explore proteomics data for FAM86C1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM86C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001093123.1  NP_060642.2  NP_689776.1  

    ENSEMBL proteins: 
     ENSP00000325662   ENSP00000432416   ENSP00000423511   ENSP00000352182   ENSP00000391329  
     ENSP00000436598  

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    antibodies-online proteins for FAM86C1 (2 products) 

     
    Search antibodies-online for peptides for FAM86C1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NVL1

    UniProtKB/Swiss-Prot: FA86C_HUMAN, Q9NVL1
    Similarity: Belongs to the FAM86 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM86C1

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM86C1
    Interactions:

        Search GeneGlobe Interaction Network for FAM86C1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FAM86C1 (Q9NVL12, 3 ENSP000003521824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216732, 3, ENSP000003685724MINT-68192 I2D: score=5 STRING: ENSP00000368572
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM86C1 (FA86C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM86C1 gene (3 alternative transcripts): 
    NM_001099653.1  NM_018172.2  NM_152563.2  

    Unigene Cluster for FAM86C1:

    Family with sequence similarity 86, member C1
    Hs.567527  [show with all ESTs]
    Unigene Representative Sequence: NM_018172
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346333(uc009ysr.3 uc001oqw.4 uc009yss.3 uc010rqq.2)
    ENST00000526393 ENST00000510443 ENST00000359244(uc001oqv.4) ENST00000426628
    ENST00000528685
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    3 qRT-PCR Assays for microRNAs that regulate FAM86C1:
    hsa-miR-1255a hsa-miR-3143 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidFAM86C1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM86C1
      QuantiFast Probe-based Assays in human, mouse, rat FAM86C1

    Additional mRNA sequence: 

    AK001523.1 AK130709.1 AK293221.1 AK311428.1 AK311518.1 AK311675.1 AK315454.1 BC032519.1 

    8 DOTS entries:

    DT.100039028  DT.86994913  DT.100039034  DT.120705994  DT.95277946  DT.100802969  DT.40109072  DT.91969689 

    Selected AceView cDNA sequences (see all 42):

    BM793838 BM451472 BQ921333 BU160080 BU179083 BM797131 BQ960450 AU129712 
    AK001523 BX641966 BU528509 NM_152563 AK130709 NM_018172 BX641967 BC032519 
    AI591187 BG747631 BU528060 BU682159 AI348002 BX279664 CN481152 BV179789 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM86C1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:              -                     
    SP2:                                    


    ECgene alternative splicing isoforms for FAM86C1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM86C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM86C1 Expression
    About this image

    FAM86C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM86C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567527
        Custom PCR Arrays for FAM86C1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM86C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM86C1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FAM86A6
    Gallus gallus family with sequence similarity 86, ...
    17(a)
    1 → many
    14(13389142-13393572) ENSGALG00000002044
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    18(a)
    1 → many
    GL343402.1(678506-686747)
    zebrafish
    (Danio rerio)
    Actinopterygii fam86a6
    family with sequence similarity 86, member A
    15(a)
    1 → many
    3(29020729-29023875) ENSDARG00000054950
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78896
    --
    8(a)
    1 → many
    X(19137666-19139255)
    worm
    (Caenorhabditis elegans)
    Secernentea R08D7.46
    Protein R08D7.4, isoform a
    7(a)
    1 → many
    III(8971892-8973949) WBGene00011144
            Species with no ortholog for FAM86C1

    ENSEMBL Gene Tree for FAM86C1 (if available)
    TreeFam Gene Tree for FAM86C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM86C1 gene
    FAM86A2  FAM86B12  FAM86B22  
    4 SIMAP similar genes for FAM86C1 using alignment to 3 protein entries:     FA86C_HUMAN (see all proteins):
    FAM86A    FAM86B1    FAM86C2P    FAM86B2

    Find genes that share paralogs with FAM86C1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FAM86C1
    PGOHUM00000250300 PGOHUM00000258226


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM86C1 (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612854331,2
    --71496580(+) CAACAC/TCTCAG 3 -- us2k10--------
    rs1396997621,2
    C--71496774(+) AATTCC/TCCTCT 3 -- us2k10--------
    rs93264641,2
    C,F,A--71496812(+) AGTGCT/CTCTCA 3 -- us2k1 tfbs33Minor allele frequency- C:0.25NA 8
    rs93264651,2
    C,A--71496878(+) CTTAAC/AAAATT 3 -- us2k11Minor allele frequency- A:0.00NA 2
    rs93264661,2
    C,F,A--71496890(+) GCTCTT/CGGGAC 3 -- us2k13Minor allele frequency- C:0.25NA 8
    rs1829898071,2
    --71496894(+) TCGGGA/TCTCTT 3 -- us2k10--------
    rs1879562201,2
    --71497076(+) CTGACC/TCCACG 3 -- us2k10--------
    rs1909243331,2
    --71497142(+) TCCCTC/GCAAGA 3 -- us2k10--------
    rs1496577911,2
    --71497210(+) CACTAC/TTGTAC 3 -- us2k10--------
    rs1823162941,2
    --71497318(+) GTTACA/GTATCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM86C1 (71498556 - 71512282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FAM86C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744758CNV Deletion23290073
    dgv223e199CNV Deletion23128226
    dgv1220n71CNV Loss21882294
    esv25167CNV Gain19812545
    nsv897903CNV Gain21882294
    dgv1219n71CNV Gain21882294
    nsv482161CNV Gain20164927
    nsv832205CNV Gain17160897
    nsv428262CNV Gain+Loss18775914
    dgv396e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM86C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM86C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55199 HGNC: 25561 AceView: FLJ10661 Ensembl:ENSG00000158483 euGenes: HUgn55199
    ECgene: FAM86C1 H-InvDB: FAM86C1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM86C1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM86C1 gene:
    Search GeneIP for patents involving FAM86C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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      Search antibodies-online for antibodies for FAM86C1
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     antibodies-online proteins for FAM86C1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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