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Aliases for FAM86B2 Gene

Aliases for FAM86B2 Gene

  • Family With Sequence Similarity 86 Member B2 2 3 5
  • Family With Sequence Similarity 86, Member B2 2
  • EC 2.1.1.- 4

External Ids for FAM86B2 Gene

Previous GeneCards Identifiers for FAM86B2 Gene

  • GC08U900647
  • GC08M012330
  • GC08M012283
  • GC08M012285
  • GC08M012290
  • GC08M012299

Summaries for FAM86B2 Gene

GeneCards Summary for FAM86B2 Gene

FAM86B2 (Family With Sequence Similarity 86 Member B2) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is EEF2KMT.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B2 Gene

Genomics for FAM86B2 Gene

Regulatory Elements for FAM86B2 Gene

Enhancers for FAM86B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F011799 1.1 Ensembl ENCODE 12.1 +631.6 631596 11.2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 FDFT1 FAM85A DEFB135 LINC00208 ZNF705D LINC00529 ENSG00000249316 ZNF705CP OR7E10P NEIL2
GH08F012525 0.4 Ensembl 10 -89.5 -89484 1.4 ZNF585B CEBPB ENPP7P12 ENPP7P6 RPS3AP34 FAM86B2
GH08F013270 0.9 Ensembl ENCODE 9.9 -837.4 -837396 7.6 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ZNF263 RPS3AP34 LOC101930149 ENPP7P6 ENSG00000255122 FAM86B2 DLC1 GC08M013255
GH08F011994 0.2 ENCODE 6 +441.0 441021 1.1 ELF3 MLX ARID4B DMAP1 ZSCAN9 RAD21 RARA ZNF366 FOS CREM LOC105379241 FAM86B2 LOC100421446 DEFB135
GH08F013245 1 Ensembl ENCODE 5 -811.0 -810963 2.8 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 GATA2 REST PPARG ZNF518A RPS3AP34 FAM66A DLC1 FAM86B2 GC08M013255 GC08M013094
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM86B2 on UCSC Golden Path with GeneCards custom track

Promoters for FAM86B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001898651 -483 3000 SP1 SP3 SMARCA4 ZNF366 GLIS1 ZNF143 ZBTB20 ZXDB

Genomic Location for FAM86B2 Gene

12,425,614 bp from pter
12,436,417 bp from pter
10,804 bases
Minus strand

Genomic View for FAM86B2 Gene

Genes around FAM86B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B2 Gene

Proteins for FAM86B2 Gene

  • Protein details for FAM86B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative protein N-methyltransferase FAM86B2
    Protein Accession:

    Protein attributes for FAM86B2 Gene

    330 amino acids
    Molecular mass:
    36771 Da
    Quaternary structure:
    • Interacts with EEF2KMT.

neXtProt entry for FAM86B2 Gene

Post-translational modifications for FAM86B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM86B2 Gene

Domains & Families for FAM86B2 Gene

Protein Domains for FAM86B2 Gene

Suggested Antigen Peptide Sequences for FAM86B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B2: view

No data available for Gene Families for FAM86B2 Gene

Function for FAM86B2 Gene

Enzyme Numbers (IUBMB) for FAM86B2 Gene

Gene Ontology (GO) - Molecular Function for FAM86B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FAM86B2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B2 Gene

Localization for FAM86B2 Gene

Subcellular locations from

Jensen Localization Image for FAM86B2 Gene COMPARTMENTS Subcellular localization image for FAM86B2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86B2 Gene

Pathways & Interactions for FAM86B2 Gene

SuperPathways for FAM86B2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM86B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86B2: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86B2 Gene

Transcripts for FAM86B2 Gene

mRNA/cDNA for FAM86B2 Gene

(14) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM86B2 Gene

Family with sequence similarity 86, member B2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B2 Gene

No ASD Table

Relevant External Links for FAM86B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM86B2 Gene

mRNA expression in normal human tissues for FAM86B2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86B2 Gene

Protein tissue co-expression partners for FAM86B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM86B2 Gene:


SOURCE GeneReport for Unigene cluster for FAM86B2 Gene:

genes like me logo Genes that share expression patterns with FAM86B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM86B2 Gene

Orthologs for FAM86B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC454371 34
  • 94.41 (n)
-- 35
  • 90 (a)
(Bos Taurus)
Mammalia FAM86A 35
  • 72 (a)
(Mus musculus)
Mammalia Fam86 35
  • 69 (a)
(Canis familiaris)
Mammalia -- 35
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
(Gallus gallus)
Aves FAM86A 35
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
(Danio rerio)
Actinopterygii fam86a 35
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7889 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea R08D7.4 35
  • 22 (a)
Species where no ortholog for FAM86B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86B2 Gene

Gene Tree for FAM86B2 (if available)
Gene Tree for FAM86B2 (if available)

Paralogs for FAM86B2 Gene

Paralogs for FAM86B2 Gene

(4) SIMAP similar genes for FAM86B2 Gene using alignment to 4 proteins: Pseudogenes for FAM86B2 Gene

genes like me logo Genes that share paralogs with FAM86B2: view

Variants for FAM86B2 Gene

Sequence variations from dbSNP and Humsavar for FAM86B2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1058038 -- 12,437,519(+) TGTCA(C/G)CAAAC nc-transcript-variant, upstream-variant-2KB
rs111308966 -- 12,437,742(+) GCAGG(A/G)GGAGT intron-variant, upstream-variant-2KB
rs111880691 -- 12,434,875(+) ACTTC(C/T)CCCCA intron-variant
rs112372149 -- 12,434,895(+) TTCAC(C/T)ATTTC intron-variant
rs112377950 -- 12,424,683(+) AGTTT(C/T)CAGAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM86B2 Gene

Variant ID Type Subtype PubMed ID
dgv1270e199 CNV deletion 23128226
dgv140n17 CNV loss 16327808
dgv154e203 CNV gain+loss 21179565
dgv244e55 CNV gain 17911159
dgv245e55 CNV gain 17911159
dgv246e55 CNV gain 17911159
dgv263n111 CNV deletion 26073780
dgv264n111 CNV duplication 26073780
dgv7015n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7017n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7019n100 CNV gain 25217958
dgv7020n100 CNV loss 25217958
dgv7021n100 CNV loss 25217958
dgv7025n100 CNV gain 25217958
dgv7026n100 CNV gain+loss 25217958
dgv7032n100 CNV gain 25217958
dgv7033n100 CNV gain 25217958
dgv7035n100 CNV loss 25217958
dgv7036n100 CNV gain 25217958
dgv7037n100 CNV loss 25217958
dgv7039n100 CNV gain+loss 25217958
dgv7040n100 CNV gain 25217958
dgv7047n100 CNV gain+loss 25217958
dgv7048n100 CNV loss 25217958
dgv7049n100 CNV gain 25217958
dgv7050n100 CNV gain+loss 25217958
dgv7051n100 CNV gain 25217958
dgv7052n100 CNV gain+loss 25217958
dgv7053n100 CNV loss 25217958
dgv7054n100 CNV gain 25217958
dgv7055n100 CNV gain+loss 25217958
dgv7056n100 CNV gain 25217958
dgv7057n100 CNV loss 25217958
dgv7058n100 CNV loss 25217958
dgv7060n100 CNV loss 25217958
dgv7064n100 CNV loss 25217958
dgv7065n100 CNV gain+loss 25217958
dgv7068n100 CNV gain+loss 25217958
dgv7069n100 CNV loss 25217958
dgv7070n100 CNV gain+loss 25217958
dgv7071n100 CNV gain 25217958
dgv7072n100 CNV loss 25217958
esv25198 CNV gain+loss 19812545
esv2736614 CNV deletion 23290073
esv2759593 CNV gain+loss 17122850
esv3891341 CNV gain 25118596
nsv1020906 CNV loss 25217958
nsv1032173 CNV loss 25217958
nsv1032729 CNV gain+loss 25217958
nsv1032964 CNV gain 25217958
nsv1034659 CNV loss 25217958
nsv1115782 CNV duplication 24896259
nsv428195 CNV gain 18775914
nsv469553 CNV loss 16826518
nsv471463 CNV gain 19718026
nsv471652 CNV gain+loss 15918152
nsv482121 CNV gain 20164927
nsv516685 CNV gain+loss 19592680
nsv821657 CNV loss 15273396
nsv8288 CNV gain+loss 18304495
nsv831234 CNV loss 17160897
nsv831235 CNV loss 17160897
nsv831236 CNV loss 17160897
nsv951106 CNV deletion 24416366
nsv971288 CNV duplication 23825009

Variation tolerance for FAM86B2 Gene

Gene Damage Index Score: 7.90; 83.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM86B2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B2 Gene

Disorders for FAM86B2 Gene

Relevant External Links for FAM86B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM86B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86B2 Gene

Publications for FAM86B2 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  2. Personalized copy number and segmental duplication maps using next-generation sequencing. (PMID: 19718026) Alkan C. … Eichler E.E. (Nat. Genet. 2009) 3 64
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64

Products for FAM86B2 Gene

Sources for FAM86B2 Gene

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