Aliases for FAM86B2 Gene
Aliases for FAM86B2 Gene
External Ids for FAM86B2 Gene
- HGNC: 32222
- Entrez Gene: 653333
- Ensembl: ENSG00000145002
- OMIM: 616123
- UniProtKB: P0C5J1
Previous GeneCards Identifiers for FAM86B2 Gene
- GC08U900647
- GC08M012330
- GC08M012283
- GC08M012285
- GC08M012290
- GC08M012299
Summaries for FAM86B2 Gene
GeneCards Summary for FAM86B2 Gene
FAM86B2 (Family With Sequence Similarity 86 Member B2) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is EEF2KMT.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B2 Gene
Genomics for FAM86B2 Gene
Regulatory Elements for FAM86B2 Gene
Enhancers for FAM86B2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G011799 | 1.4 | ENCODE dbSUPER | 12.1 | +631.6 | 631596 | 11.2 | HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 | FDFT1 FAM85A NEIL2 CTSB FAM86B2 PINX1 LOC105379241 BLK ENSG00000255122 RPS3AP34 |
| GH08G013245 | 1.5 | Ensembl ENCODE dbSUPER | 5 | -811.0 | -810963 | 2.8 | PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 TCF12 GATA2 REST PPARG | FAM66A DLC1 RPS3AP34 FAM86B2 GC08M013255 GC08M013094 |
| GH08G011994 | 0.9 | ENCODE | 6 | +441.0 | 441021 | 1.1 | FOXA2 MLX ARID4B DMAP1 FOS SP5 NFYC MXD4 MIER2 ZNF518A | LOC105379241 FAM86B2 LOC100421446 DEFB135 |
| GH08G012435 | 0.6 | ENCODE | 0.7 | -0.1 | -52 | 1.0 | SP1 EGR1 GLIS1 NRF1 ZNF143 MNT ZBTB26 | FAM86B2 LOC100506990 |
| GH08G012430 | 0.2 | Ensembl | 0.4 | +5.4 | 5417 | 0.4 | FAM86B2 GC08M012424 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM86B2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM86B2 gene promoter:
Regulatory Element Products
Genomic Location for FAM86B2 Gene
- Chromosome:
- 8
- Start:
- 12,425,614 bp from pter
- End:
- 12,436,417 bp from pter
- Size:
- 10,804 bases
- Orientation:
- Minus strand
Genomic View for FAM86B2 Gene
Genes around FAM86B2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p23.1 by Ensembl
- 8p23.1 by Entrez Gene
- 8p23.1 by HGNC
FAM86B2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM86B2 Gene
Proteins for FAM86B2 Gene
-
Protein details for FAM86B2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C5J1-F86B2_HUMAN
- Recommended name:
- Putative protein N-methyltransferase FAM86B2
- Protein Accession:
- P0C5J1
Protein attributes for FAM86B2 Gene
- Size:
- 330 amino acids
- Molecular mass:
- 36771 Da
- Quaternary structure:
-
- Interacts with EEF2KMT.
Protein Expression for FAM86B2 Gene
Post-translational modifications for FAM86B2 Gene
Other Protein References for FAM86B2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for FAM86B2
Protein Products
-
OriGene Purified Proteins for FAM86B2
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM86B2
- Origene Custom Protein Services for FAM86B2
- Search GeneTex for Proteins for FAM86B2
Assay Products
No data available for DME Specific Peptides for FAM86B2 Gene
Domains & Families for FAM86B2 Gene
Gene Families for FAM86B2 Gene
Protein Domains for FAM86B2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM86B2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0C5J1UniProtKB/Swiss-Prot:
F86B2_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
Function for FAM86B2 Gene
Enzyme Numbers (IUBMB) for FAM86B2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM86B2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86B2 gene
- Search ViGene Biosciences for FAM86B2
CRISPR Products
-
OriGene CRISPR knockouts for FAM86B2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM86B2
- GenScript: Design CRISPR guide RNA sequences for FAM86B2
miRNA Products
- Search ViGene Biosciences for FAM86B2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM86B2
- Browse OriGene Inhibitory RNA Products For FAM86B2
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86B2 gene
Clone Products
-
OriGene ORF clones in human for FAM86B2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
Horizon Cell Lines for FAM86B2
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM86B2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM86B2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86B2 gene
Flow Cytometry Products
No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B2 Gene
Localization for FAM86B2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86B2 Gene
Pathways & Interactions for FAM86B2 Gene
No Data Available
Interacting Proteins for FAM86B2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032259 | methylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FAM86B2 Gene
Transcripts for FAM86B2 Gene
mRNA/cDNA for FAM86B2 Gene
- (14) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM86B2 Gene
- Family with sequence similarity 86, member B2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FAM86B2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM86B2
- GenScript: Design CRISPR guide RNA sequences for FAM86B2
miRNA Products
- Search ViGene Biosciences for FAM86B2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM86B2
- Browse OriGene Inhibitory RNA Products For FAM86B2
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM86B2 gene
Clone Products
-
OriGene ORF clones in human for FAM86B2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for FAM86B2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86B2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FAM86B2 Gene:
FAM86B2SOURCE GeneReport for Unigene cluster for FAM86B2 Gene:
Hs.458413Primer Products
-
OriGene qPCR primer pairs for FAM86B2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86B2 Gene
Orthologs for FAM86B2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC454371 34 |
|
||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | FAM86A 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Fam86 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | FAM86A 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | fam86a 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG7889 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | R08D7.4 35 |
|
OneToMany |
- Species where no ortholog for FAM86B2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for FAM86B2 Gene
(4) SIMAP similar genes for FAM86B2 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for FAM86B2 Gene
Variants for FAM86B2 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002748380 | -- | 12,425,274(+) | AGTAC(A/T)CCTCA | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1003084492 | -- | 12,424,271(+) | TAATA(A/C)ATCAT | downstream-variant-500B | |
| rs1003673537 | -- | 12,432,333(+) | ATAAG(C/T)CGTTT | intron-variant, upstream-variant-2KB | |
| rs1004151967 | -- | 12,433,052(+) | GATGG(G/T)TTTTT | intron-variant | |
| rs1005092809 | -- | 12,438,122(+) | TAAGA(A/G)AGGGG | intron-variant, upstream-variant-2KB |
Gene Damage Index Score:
7.90;
83.78% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM86B2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B2 Gene
Disorders for FAM86B2 Gene
Relevant External Links for FAM86B2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM86B2
No disorders were found for FAM86B2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86B2 Gene
Publications for FAM86B2 Gene
- A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
- Personalized copy number and segmental duplication maps using next-generation sequencing. (PMID: 19718026) Alkan C. … Eichler E.E. (Nat. Genet. 2009) 3 64
- DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
Products for FAM86B2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FAM86B2
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM86B2
- Origene Custom Protein Services for FAM86B2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM86B2
- Browse OriGene Inhibitory RNA Products For FAM86B2
- OriGene qPCR primer pairs for FAM86B2
- OriGene CRISPR knockouts for FAM86B2
- OriGene ORF clones in human for FAM86B2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FAM86B2
- GenScript: Next-day shipping cDNA ORF clone for FAM86B2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FAM86B2
- GenScript Custom Assay Services for FAM86B2
- GenScript Custom overexpressing Cell Line Services for FAM86B2
- GenScript: Design CRISPR guide RNA sequences for FAM86B2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FAM86B2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FAM86B2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM86B2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM86B2 gene
- Search ViGene Biosciences for FAM86B2
- Horizon Cell Lines for FAM86B2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM86B2
- VectorBuilder custom plasmid, inducible vectors for FAM86B2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM86B2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM86B2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer