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Aliases for FAM86B2 Gene

Aliases for FAM86B2 Gene

  • Family With Sequence Similarity 86 Member B2 2 3 5
  • Family With Sequence Similarity 86, Member B2 2
  • EC 2.1.1.- 4

External Ids for FAM86B2 Gene

Previous GeneCards Identifiers for FAM86B2 Gene

  • GC08U900647
  • GC08M012330
  • GC08M012283
  • GC08M012285
  • GC08M012290
  • GC08M012299

Summaries for FAM86B2 Gene

GeneCards Summary for FAM86B2 Gene

FAM86B2 (Family With Sequence Similarity 86 Member B2) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is FAM86C1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B2 Gene

Genomics for FAM86B2 Gene

Regulatory Elements for FAM86B2 Gene

Enhancers for FAM86B2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM86B2 on UCSC Golden Path with GeneCards custom track

Promoters for FAM86B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM86B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM86B2 Gene

Chromosome:
8
Start:
12,425,614 bp from pter
End:
12,436,417 bp from pter
Size:
10,804 bases
Orientation:
Minus strand

Genomic View for FAM86B2 Gene

Genes around FAM86B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B2 Gene

Proteins for FAM86B2 Gene

  • Protein details for FAM86B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C5J1-F86B2_HUMAN
    Recommended name:
    Putative protein N-methyltransferase FAM86B2
    Protein Accession:
    P0C5J1

    Protein attributes for FAM86B2 Gene

    Size:
    330 amino acids
    Molecular mass:
    36771 Da
    Quaternary structure:
    • Interacts with EEF2KMT.

neXtProt entry for FAM86B2 Gene

Proteomics data for FAM86B2 Gene at MOPED

Post-translational modifications for FAM86B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM86B2 Gene

No data available for DME Specific Peptides for FAM86B2 Gene

Domains & Families for FAM86B2 Gene

Protein Domains for FAM86B2 Gene

Suggested Antigen Peptide Sequences for FAM86B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C5J1

UniProtKB/Swiss-Prot:

F86B2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B2: view

No data available for Gene Families for FAM86B2 Gene

Function for FAM86B2 Gene

Enzyme Numbers (IUBMB) for FAM86B2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B2 Gene

Localization for FAM86B2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM86B2 Gene COMPARTMENTS Subcellular localization image for FAM86B2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86B2 Gene

Pathways & Interactions for FAM86B2 Gene

SuperPathways for FAM86B2 Gene

No Data Available

Interacting Proteins for FAM86B2 Gene

Gene Ontology (GO) - Biological Process for FAM86B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM86B2 Gene

Drugs & Compounds for FAM86B2 Gene

No Compound Related Data Available

Transcripts for FAM86B2 Gene

mRNA/cDNA for FAM86B2 Gene

(12) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM86B2 Gene

Family with sequence similarity 86, member B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B2 Gene

No ASD Table

Relevant External Links for FAM86B2 Gene

GeneLoc Exon Structure for
FAM86B2
ECgene alternative splicing isoforms for
FAM86B2

Expression for FAM86B2 Gene

mRNA expression in normal human tissues for FAM86B2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86B2 Gene



SOURCE GeneReport for Unigene cluster for FAM86B2 Gene Hs.458413

genes like me logo Genes that share expression patterns with FAM86B2: view

Protein tissue co-expression partners for FAM86B2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM86B2 Gene

Orthologs for FAM86B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454371 35
  • 94.41 (n)
  • 89.6 (a)
-- 36
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM86A 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam86 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM86A 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam86a 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7889 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.4 36
  • 22 (a)
OneToMany
Species with no ortholog for FAM86B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86B2 Gene

ENSEMBL:
Gene Tree for FAM86B2 (if available)
TreeFam:
Gene Tree for FAM86B2 (if available)

Paralogs for FAM86B2 Gene

Paralogs for FAM86B2 Gene

(4) SIMAP similar genes for FAM86B2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM86B2: view

Variants for FAM86B2 Gene

Sequence variations from dbSNP and Humsavar for FAM86B2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_036617 -
VAR_036618 -
rs2037422 -- 12,431,508(+) caaca(C/T)agtga intron-variant, upstream-variant-2KB
rs2684087 -- 12,430,017(+) ccacc(C/T)gcctt intron-variant
rs2684088 -- 12,432,107(+) GAAAG(A/C)ACCAG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM86B2 Gene

Variant ID Type Subtype PubMed ID
nsv516685 CNV Gain+Loss 19592680
nsv428195 CNV Gain 18775914
dgv2199e1 CNV Complex 17122850
dgv2200e1 CNV Complex 17122850
esv2736614 CNV Deletion 23290073
dgv1270e199 CNV Deletion 23128226
dgv244e55 CNV Gain 17911159
nsv890374 CNV Gain 21882294
nsv8288 CNV Gain+Loss 18304495
dgv2203e1 CNV Complex 17122850
dgv2204e1 CNV Complex 17122850
nsv821657 CNV Loss 15273396
esv25198 CNV Gain+Loss 19812545
nsv831234 CNV Loss 17160897
dgv2207e1 CNV Complex 17122850
nsv469553 CNV Loss 16826518
nsv471652 CNV Gain+Loss 15918152
nsv890381 CNV Gain 21882294
dgv7706n71 CNV Gain 21882294
dgv2209e1 CNV Complex 17122850
dgv245e55 CNV Gain 17911159
dgv2210e1 CNV Complex 17122850
dgv246e55 CNV Gain 17911159
nsv831235 CNV Loss 17160897
dgv140n17 CNV Loss 16327808
nsv890387 CNV Gain 21882294
nsv831236 CNV Loss 17160897
nsv471463 CNV Duplication 19718026
nsv482121 CNV Gain 20164927

Variation tolerance for FAM86B2 Gene

Gene Damage Index Score: 7.90; 83.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM86B2 Gene

Human Gene Mutation Database (HGMD)
FAM86B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B2 Gene

Disorders for FAM86B2 Gene

Relevant External Links for FAM86B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM86B2

No disorders were found for FAM86B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86B2 Gene

Publications for FAM86B2 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 67
  2. Personalized copy number and segmental duplication maps using next-generation sequencing. (PMID: 19718026) Alkan C. … Eichler E.E. (Nat. Genet. 2009) 3

Products for FAM86B2 Gene

Sources for FAM86B2 Gene

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