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FAM86B2 Gene

protein-coding   GIFtS: 33
GCID: GC08M012299          (predicted)

Family With Sequence Similarity 86, Member B2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 86, Member B21 2
Protein FAM86B22

External Ids:    HGNC: 322221   Entrez Gene: 6533332   Ensembl: ENSG000001450027   UniProtKB: P0C5J13   

Export aliases for FAM86B2 gene to outside databases

Previous GC identifers: GC08U900647 GC08M012330 GC08M012283 GC08M012285 GC08M012290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM86B2 Gene:
FAM86B2 (family with sequence similarity 86, member B2) is a protein-coding gene. An important paralog of this gene is FAM86A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM86B2 gene promoter:
         AML1a   Pax-5   HNF-4alpha2   AP-4   LCR-F1   NF-kappaB   HNF-4alpha1   RORalpha1   STAT3   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM86B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM86B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

FAM86B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM86B2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M012299:  view genomic region     (about GC identifiers)

Start:
12,282,913 bp from pter      End:
12,293,915 bp from pter
Size:
11,003 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F86B2_HUMAN, P0C5J1 (See protein sequence)
Recommended Name: Protein FAM86B2  
Size: 330 amino acids; 36771 Da
Subunit: Interacts with FAM86A

Explore the universe of human proteins at neXtProt for FAM86B2: NX_P0C5J1

Explore proteomics data for FAM86B2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys37, Lys177

  • See FAM86B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001131082.1  
    ENSEMBL proteins: 
     ENSP00000432491   ENSP00000436338   ENSP00000262365   ENSP00000283479   ENSP00000377318  
     ENSP00000311330  

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    antibodies-online kits for FAM86B2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019410 Nicotinamide_N-MeTfrase-like

    Graphical View of Domain Structure for InterPro Entry P0C5J1

    ProtoNet protein and cluster: P0C5J1

    UniProtKB/Swiss-Prot: F86B2_HUMAN, P0C5J1
    Similarity: Belongs to the FAM86 family


    Find genes that share domains with FAM86B2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM86B2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM86B2
    Interactions:

        Search GeneGlobe Interaction Network for FAM86B2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM86B2 (ENSP000002623654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM86B2 (F86B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM86B2 gene: 
    NM_001137610.1  

    Unigene Cluster for FAM86B2:

    Family with sequence similarity 86, member B2
    Hs.458413  [show with all ESTs]
    Unigene Representative Sequence: NM_001137610
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527331 ENST00000532480 ENST00000262365(uc003wvq.4 uc003wvt.4 uc010lsn.3 uc010lsl.3)
    ENST00000351291(uc003wvr.4) ENST00000393715(uc011kxt.2 uc011kxu.2)
    ENST00000309608(uc003wvu.4 uc010lso.3)
    miRNA
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM86B2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM86B2
      QuantiFast Probe-based Assays in human, mouse, rat FAM86B2

    Additional mRNA sequence: 

    AK291001.1 AK297741.1 AK298940.1 AK309984.1 

    10 DOTS entries:

    DT.121493884  DT.121493883  DT.121493969  DT.121493980  DT.75109099  DT.100039035  DT.102834484  DT.40109072 
    DT.95277934  DT.99964932 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM86B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTCTAG
    FAM86B2 Expression
    About this image

    FAM86B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM86B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458413
        Custom PCR Arrays for FAM86B2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM86B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM86B2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FAM86A6
    Gallus gallus family with sequence similarity 86, ...
    50(a)
    1 → many
    14(13389142-13393572)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    53(a)
    1 → many
    GL343402.1(678506-686747)
    zebrafish
    (Danio rerio)
    Actinopterygii fam86a6
    family with sequence similarity 86, member A
    45(a)
    1 → many
    3(29020729-29023875) ENSDARG00000054950
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78896
    --
    25(a)
    1 → many
    X(19137666-19139255)
    worm
    (Caenorhabditis elegans)
    Secernentea R08D7.46
    Protein R08D7.4, isoform a
    22(a)
    1 → many
    III(8971892-8973949) WBGene00011144
            Species with no ortholog for FAM86B2

    ENSEMBL Gene Tree for FAM86B2 (if available)
    TreeFam Gene Tree for FAM86B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM86B2 gene
    FAM86KP  FAM86A2  FAM86B12  FAM86C12  
    4 SIMAP similar genes for FAM86B2 using alignment to 4 protein entries:     F86B2_HUMAN (see all proteins):
    FAM86A    FAM86B1    FAM86C1    FAM86C2P

    Find genes that share paralogs with FAM86B2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for FAM86B2 (see all 11)
    PGOHUM00000242120 PGOHUM00000257839 PGOHUM00000239317 PGOHUM00000250246 PGOHUM00000250257


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM86B2 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010239381,2
    C--12282637(+) TGGTGC/TCACCT 1 -- ds50010--------
    rs3690826561,2
    C--12282652(+) GAATG-/CCCGGG 1 -- ds50010--------
    rs18149981,2
    --12285943(+) CTCCAA/CCAACA 1 -- int10--------
    rs1481617261,2
    C--12286307(+) GAGGAC/TCCGGC 2 I V mis10--------
    rs2005882681,2
    F--12540885(+) CCATCC/TCGGCC 2 Q syn11Minor allele frequency- T:0.02EU 243
    rs1442590201,2
    C--12541019(+) GGTTCC/GGAGGC 1 -- int10--------
    rs2022314061,2
    C--12541245(+) GCCAG-/CTTCTGT 1 -- int10--------
    rs1397635281,2
    C--12541295(+) CTATGG/TGTGCT 1 -- int10--------
    rs2015978641,2
    C,F--12542521(+) TCGGGC/GCCATG 1 -- int11Minor allele frequency- G:0.34EU 365
    rs1479361211,2
    C,F--12542550(+) GGGGGC/TTCACC 1 -- int11Minor allele frequency- T:0.38EU 382

    HapMap Linkage Disequilibrium report for FAM86B2 (12282913 - 12293915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM86B2 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1270e199CNV Deletion23128226
    esv2736614CNV Deletion23290073
    nsv471463CNV Duplication19718026
    nsv831236CNV Loss17160897
    nsv469553CNV Loss16826518
    nsv831235CNV Loss17160897
    dgv140n17CNV Loss16327808
    nsv831234CNV Loss17160897
    nsv821657CNV Loss15273396
    dgv245e55CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FAM86B2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM86B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM86B2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM86B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    3. Personalized copy number and segmental duplication maps using next-generation sequencing. (PubMed id 19718026)1 Alkan C....Eichler E.E. (Nat. Genet. 2009)
    4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653333 HGNC: 32222 Ensembl:ENSG00000145002 euGenes: HUgn653333 ECgene: FAM86B2
    H-InvDB: FAM86B2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM86B2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM86B2 gene:
    Search GeneIP for patents involving FAM86B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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