Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM86B2 Gene

Aliases for FAM86B2 Gene

  • Family With Sequence Similarity 86 Member B2 2 3 5
  • Family With Sequence Similarity 86, Member B2 2
  • EC 2.1.1.- 4

External Ids for FAM86B2 Gene

Previous GeneCards Identifiers for FAM86B2 Gene

  • GC08U900647
  • GC08M012330
  • GC08M012283
  • GC08M012285
  • GC08M012290
  • GC08M012299

Summaries for FAM86B2 Gene

GeneCards Summary for FAM86B2 Gene

FAM86B2 (Family With Sequence Similarity 86 Member B2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is EEF2KMT.

Additional gene information for FAM86B2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B2 Gene

Genomics for FAM86B2 Gene

GeneHancer (GH) Regulatory Elements for FAM86B2 Gene

Promoters and enhancers for FAM86B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I012435 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.3 -284 1.8 SP3 FOXA2 NRF1 MNT ZNF335 SP1 ZNF366 EGR1 SMARCA4 GLIS1 FAM86B2 LOC100506990
GH08I012437 Promoter 0.8 Ensembl 550.8 -1.5 -1483 0.2 ZNF335 SP3 SMARCA4 ZNF366 ZXDB ZBTB20 ZBTB17 FAM86B2 LOC100506990 DEFB109E
GH08I012438 Enhancer 0.2 Ensembl 550.8 -1.9 -1884 0.2 FAM86B2 LOC100506990 DEFB109E
GH08I011799 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 +631.6 631595 11.2 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 FDFT1 PINX1 LOC101929290 NEIL2 CTSB FAM86B2 LOC105379241 BLK RPS3AP34 ENSG00000255122
GH08I013264 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -834.5 -834492 13.4 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS SP5 ENPP7P6 RPS3AP34 LOC101930149 FAM66A ENSG00000255122 FAM86B2 DLC1 GC08M013255
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM86B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM86B2 gene promoter:

Genomic Locations for FAM86B2 Gene

Genomic Locations for FAM86B2 Gene
chr8:12,425,614-12,436,417
(GRCh38/hg38)
Size:
10,804 bases
Orientation:
Minus strand
chr8:12,282,913-12,293,915
(GRCh37/hg19)

Genomic View for FAM86B2 Gene

Genes around FAM86B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B2 Gene

Proteins for FAM86B2 Gene

  • Protein details for FAM86B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C5J1-F86B2_HUMAN
    Recommended name:
    Putative protein N-methyltransferase FAM86B2
    Protein Accession:
    P0C5J1

    Protein attributes for FAM86B2 Gene

    Size:
    330 amino acids
    Molecular mass:
    36771 Da
    Quaternary structure:
    • Interacts with EEF2KMT.

neXtProt entry for FAM86B2 Gene

Post-translational modifications for FAM86B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM86B2 Gene

Domains & Families for FAM86B2 Gene

Gene Families for FAM86B2 Gene

Protein Domains for FAM86B2 Gene

Suggested Antigen Peptide Sequences for FAM86B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C5J1

UniProtKB/Swiss-Prot:

F86B2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B2: view

Function for FAM86B2 Gene

Enzyme Numbers (IUBMB) for FAM86B2 Gene

Phenotypes From GWAS Catalog for FAM86B2 Gene

Gene Ontology (GO) - Molecular Function for FAM86B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23349634
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FAM86B2: view

Clone Products

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B2 Gene

Localization for FAM86B2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM86B2 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM86B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA 23349634
genes like me logo Genes that share ontologies with FAM86B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM86B2 Gene

Pathways & Interactions for FAM86B2 Gene

SuperPathways for FAM86B2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM86B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86B2: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86B2 Gene

Drugs & Compounds for FAM86B2 Gene

No Compound Related Data Available

Transcripts for FAM86B2 Gene

mRNA/cDNA for FAM86B2 Gene

(14) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM86B2 Gene

Family with sequence similarity 86, member B2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B2 Gene

No ASD Table

Relevant External Links for FAM86B2 Gene

GeneLoc Exon Structure for
FAM86B2
ECgene alternative splicing isoforms for
FAM86B2

Expression for FAM86B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM86B2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86B2 Gene



Protein tissue co-expression partners for FAM86B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM86B2 Gene:

FAM86B2

SOURCE GeneReport for Unigene cluster for FAM86B2 Gene:

Hs.458413
genes like me logo Genes that share expression patterns with FAM86B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86B2 Gene

Orthologs for FAM86B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454371 33
  • 94.41 (n)
-- 34
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM86A 34
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam86 34
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM86A 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam86a 34
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7889 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.4 34
  • 22 (a)
OneToMany
Species where no ortholog for FAM86B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86B2 Gene

ENSEMBL:
Gene Tree for FAM86B2 (if available)
TreeFam:
Gene Tree for FAM86B2 (if available)

Paralogs for FAM86B2 Gene

Paralogs for FAM86B2 Gene

(4) SIMAP similar genes for FAM86B2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FAM86B2 Gene

genes like me logo Genes that share paralogs with FAM86B2: view

Variants for FAM86B2 Gene

Sequence variations from dbSNP and Humsavar for FAM86B2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1002748380 -- 12,425,274(-) T/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1003084492 -- 12,424,271(-) C/A downstream_transcript_variant
rs1003673537 -- 12,432,333(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1004151967 -- 12,433,052(-) G/T genic_upstream_transcript_variant, intron_variant
rs1005092809 -- 12,438,122(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM86B2 Gene

Variant ID Type Subtype PubMed ID
dgv1270e199 CNV deletion 23128226
dgv140n17 CNV loss 16327808
dgv154e203 CNV gain+loss 21179565
dgv244e55 CNV gain 17911159
dgv245e55 CNV gain 17911159
dgv246e55 CNV gain 17911159
dgv263n111 CNV deletion 26073780
dgv264n111 CNV duplication 26073780
dgv7015n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7017n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7019n100 CNV gain 25217958
dgv7020n100 CNV loss 25217958
dgv7021n100 CNV loss 25217958
dgv7025n100 CNV gain 25217958
dgv7026n100 CNV gain+loss 25217958
dgv7032n100 CNV gain 25217958
dgv7033n100 CNV gain 25217958
dgv7035n100 CNV loss 25217958
dgv7036n100 CNV gain 25217958
dgv7037n100 CNV loss 25217958
dgv7039n100 CNV gain+loss 25217958
dgv7040n100 CNV gain 25217958
dgv7047n100 CNV gain+loss 25217958
dgv7048n100 CNV loss 25217958
dgv7049n100 CNV gain 25217958
dgv7050n100 CNV gain+loss 25217958
dgv7051n100 CNV gain 25217958
dgv7052n100 CNV gain+loss 25217958
dgv7053n100 CNV loss 25217958
dgv7054n100 CNV gain 25217958
dgv7055n100 CNV gain+loss 25217958
dgv7056n100 CNV gain 25217958
dgv7057n100 CNV loss 25217958
dgv7058n100 CNV loss 25217958
dgv7060n100 CNV loss 25217958
dgv7064n100 CNV loss 25217958
dgv7065n100 CNV gain+loss 25217958
dgv7068n100 CNV gain+loss 25217958
dgv7069n100 CNV loss 25217958
dgv7070n100 CNV gain+loss 25217958
dgv7071n100 CNV gain 25217958
dgv7072n100 CNV loss 25217958
esv25198 CNV gain+loss 19812545
esv2736614 CNV deletion 23290073
esv2759593 CNV gain+loss 17122850
esv3891341 CNV gain 25118596
nsv1020906 CNV loss 25217958
nsv1032173 CNV loss 25217958
nsv1032729 CNV gain+loss 25217958
nsv1032964 CNV gain 25217958
nsv1034659 CNV loss 25217958
nsv1115782 CNV duplication 24896259
nsv428195 CNV gain 18775914
nsv469553 CNV loss 16826518
nsv471463 CNV gain 19718026
nsv471652 CNV gain+loss 15918152
nsv482121 CNV gain 20164927
nsv516685 CNV gain+loss 19592680
nsv821657 CNV loss 15273396
nsv8288 CNV gain+loss 18304495
nsv831234 CNV loss 17160897
nsv831235 CNV loss 17160897
nsv831236 CNV loss 17160897
nsv951106 CNV deletion 24416366
nsv971288 CNV duplication 23825009

Variation tolerance for FAM86B2 Gene

Gene Damage Index Score: 7.90; 83.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM86B2 Gene

Human Gene Mutation Database (HGMD)
FAM86B2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM86B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B2 Gene

Disorders for FAM86B2 Gene

Additional Disease Information for FAM86B2

No disorders were found for FAM86B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86B2 Gene

Publications for FAM86B2 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  2. Personalized copy number and segmental duplication maps using next-generation sequencing. (PMID: 19718026) Alkan C … Eichler EE (Nature genetics 2009) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for FAM86B2 Gene

Sources for FAM86B2 Gene

Content
Loading form....