Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM86B1 Gene

Aliases for FAM86B1 Gene

  • Family With Sequence Similarity 86, Member B1 2 3
  • EC 2.1.1.- 4

External Ids for FAM86B1 Gene

Previous GeneCards Identifiers for FAM86B1 Gene

  • GC08M012079
  • GC08M012039

Summaries for FAM86B1 Gene

GeneCards Summary for FAM86B1 Gene

FAM86B1 (Family With Sequence Similarity 86, Member B1) is a Protein Coding gene. An important paralog of this gene is FAM86B2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B1 Gene

Genomics for FAM86B1 Gene

Regulatory Elements for FAM86B1 Gene

Genomic Location for FAM86B1 Gene

Start:
12,182,096 bp from pter
End:
12,194,133 bp from pter
Size:
12,038 bases
Orientation:
Minus strand

Genomic View for FAM86B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM86B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B1 Gene

Proteins for FAM86B1 Gene

  • Protein details for FAM86B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7N1-F86B1_HUMAN
    Recommended name:
    Putative protein N-methyltransferase FAM86B1
    Protein Accession:
    Q8N7N1
    Secondary Accessions:

    Protein attributes for FAM86B1 Gene

    Size:
    296 amino acids
    Molecular mass:
    32865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM86B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM86B1 Gene

Proteomics data for FAM86B1 Gene at MOPED

Post-translational modifications for FAM86B1 Gene

  • Ubiquitination at Lys37 and Lys143
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM86B1 Gene

Domains for FAM86B1 Gene

Protein Domains for FAM86B1 Gene

Suggested Antigen Peptide Sequences for FAM86B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7N1

UniProtKB/Swiss-Prot:

F86B1_HUMAN :
  • Q8N7N1
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B1: view

No data available for Gene Families for FAM86B1 Gene

Function for FAM86B1 Gene

Enzyme Numbers (IUBMB) for FAM86B1 Gene

Gene Ontology (GO) - Molecular Function for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM86B1 Gene

Localization for FAM86B1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM86B1 Gene COMPARTMENTS Subcellular localization image for FAM86B1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86B1 Gene

Pathways for FAM86B1 Gene

SuperPathways for FAM86B1 Gene

No Data Available

Interacting Proteins for FAM86B1 Gene

Gene Ontology (GO) - Biological Process for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

No data available for Pathways by source for FAM86B1 Gene

Transcripts for FAM86B1 Gene

Unigene Clusters for FAM86B1 Gene

Family with sequence similarity 86, member B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for FAM86B1 Gene

GeneLoc Exon Structure for
FAM86B1
ECgene alternative splicing isoforms for
FAM86B1

Expression for FAM86B1 Gene

mRNA expression in normal human tissues for FAM86B1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM86B1 Gene

SOURCE GeneReport for Unigene cluster for FAM86B1 Gene Hs.675799

genes like me logo Genes that share expressions with FAM86B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM86B1 Gene

Orthologs for FAM86B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM86A 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam86 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM86A 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam86a 36
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7889 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.4 36
  • 20 (a)
OneToMany
Species with no ortholog for FAM86B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86B1 Gene

ENSEMBL:
Gene Tree for FAM86B1 (if available)
TreeFam:
Gene Tree for FAM86B1 (if available)

Paralogs for FAM86B1 Gene

Paralogs for FAM86B1 Gene

Pseudogenes.org Pseudogenes for FAM86B1 Gene

genes like me logo Genes that share paralogs with FAM86B1: view

Variants for FAM86B1 Gene

Sequence variations from dbSNP and Humsavar for FAM86B1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2684085 -- 12,186,819(+) GTGAC(C/T)GAGCC reference, synonymous-codon, nc-transcript-variant, missense
rs2719503 -- 12,190,964(+) AACTC(A/G)GAGCA intron-variant
rs2719504 -- 12,191,465(+) GCATC(C/T)ACCAA intron-variant
rs62494589 -- 12,188,438(+) AAAAT(A/T)ATTCC intron-variant, upstream-variant-2KB
rs62494590 -- 12,189,445(+) AGAGA(C/T)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM86B1 Gene

Variant ID Type Subtype PubMed ID
nsv516685 CNV Gain+Loss 19592680
nsv428195 CNV Gain 18775914
dgv2199e1 CNV Complex 17122850
dgv2200e1 CNV Complex 17122850
esv2736614 CNV Deletion 23290073
essv15113 CNV CNV 17122850
dgv27n31 CNV Duplication 19718026
dgv1270e199 CNV Deletion 23128226
esv22986 CNV Gain+Loss 19812545
dgv244e55 CNV Gain 17911159
nsv890374 CNV Gain 21882294
nsv8288 CNV Gain+Loss 18304495
dgv2203e1 CNV Complex 17122850
dgv2204e1 CNV Complex 17122850

Relevant External Links for FAM86B1 Gene

HapMap Linkage Disequilibrium report
FAM86B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B1 Gene

Disorders for FAM86B1 Gene

No disorders were found for FAM86B1 Gene.

No data available for UniProtKB/Swiss-Prot for FAM86B1 Gene

Publications for FAM86B1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3

Products for FAM86B1 Gene

Sources for FAM86B1 Gene

Back to Top

Content