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Aliases for FAM86B1 Gene

Aliases for FAM86B1 Gene

  • Family With Sequence Similarity 86, Member B1 2 3
  • EC 2.1.1.- 4

External Ids for FAM86B1 Gene

Previous GeneCards Identifiers for FAM86B1 Gene

  • GC08M012079
  • GC08M012039

Summaries for FAM86B1 Gene

GeneCards Summary for FAM86B1 Gene

FAM86B1 (Family With Sequence Similarity 86, Member B1) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is FAM86B2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B1 Gene

Genomics for FAM86B1 Gene

Regulatory Elements for FAM86B1 Gene

Genomic Location for FAM86B1 Gene

12,182,096 bp from pter
12,194,149 bp from pter
12,054 bases
Minus strand

Genomic View for FAM86B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM86B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B1 Gene

Proteins for FAM86B1 Gene

  • Protein details for FAM86B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative protein N-methyltransferase FAM86B1
    Protein Accession:

    Protein attributes for FAM86B1 Gene

    296 amino acids
    Molecular mass:
    32865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM86B1 Gene


neXtProt entry for FAM86B1 Gene

Proteomics data for FAM86B1 Gene at MOPED

Post-translational modifications for FAM86B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM86B1 Gene

Domains & Families for FAM86B1 Gene

Protein Domains for FAM86B1 Gene

Suggested Antigen Peptide Sequences for FAM86B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B1: view

No data available for Gene Families for FAM86B1 Gene

Function for FAM86B1 Gene

Enzyme Numbers (IUBMB) for FAM86B1 Gene

Gene Ontology (GO) - Molecular Function for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B1 Gene

Localization for FAM86B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM86B1 Gene

Pathways & Interactions for FAM86B1 Gene

SuperPathways for FAM86B1 Gene

No Data Available

Interacting Proteins for FAM86B1 Gene

Gene Ontology (GO) - Biological Process for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86B1 Gene

Drugs & Compounds for FAM86B1 Gene

No Compound Related Data Available

Transcripts for FAM86B1 Gene

Unigene Clusters for FAM86B1 Gene

Family with sequence similarity 86, member B1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM86B1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -

Relevant External Links for FAM86B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM86B1 Gene

mRNA expression in normal human tissues for FAM86B1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86B1 Gene

SOURCE GeneReport for Unigene cluster for FAM86B1 Gene Hs.675799

genes like me logo Genes that share expression patterns with FAM86B1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM86B1 Gene

Orthologs for FAM86B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM86A 36
  • 65 (a)
(Canis familiaris)
Mammalia -- 36
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
(Mus musculus)
Mammalia Fam86 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Pan troglodytes)
Mammalia -- 36
  • 81 (a)
(Gallus gallus)
Aves FAM86A 36
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
(Danio rerio)
Actinopterygii fam86a 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7889 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea R08D7.4 36
  • 20 (a)
Species with no ortholog for FAM86B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86B1 Gene

Gene Tree for FAM86B1 (if available)
Gene Tree for FAM86B1 (if available)

Paralogs for FAM86B1 Gene

Paralogs for FAM86B1 Gene Pseudogenes for FAM86B1 Gene

genes like me logo Genes that share paralogs with FAM86B1: view

Variants for FAM86B1 Gene

Sequence variations from dbSNP and Humsavar for FAM86B1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2684073 -- 12,183,032(+) CTGCC(A/G)TGTTC utr-variant-3-prime, nc-transcript-variant
rs2698909 -- 12,182,132(+) TTATT(C/T)ACAAA utr-variant-3-prime, nc-transcript-variant
rs62494568 -- 12,181,810(+) ATAAA(C/T)GATGC downstream-variant-500B
rs62494570 -- 12,182,393(+) TTGGA(A/G)GTGGA utr-variant-3-prime, nc-transcript-variant
rs62494571 -- 12,182,628(+) GCTAA(A/G)CCAGT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM86B1 Gene

Variant ID Type Subtype PubMed ID
nsv516685 CNV Gain+Loss 19592680
nsv428195 CNV Gain 18775914
dgv2199e1 CNV Complex 17122850
dgv2200e1 CNV Complex 17122850
esv2736614 CNV Deletion 23290073
essv15113 CNV CNV 17122850
dgv27n31 CNV Duplication 19718026
dgv1270e199 CNV Deletion 23128226
esv22986 CNV Gain+Loss 19812545
dgv244e55 CNV Gain 17911159
nsv890374 CNV Gain 21882294
nsv8288 CNV Gain+Loss 18304495
dgv2203e1 CNV Complex 17122850
dgv2204e1 CNV Complex 17122850

Variation tolerance for FAM86B1 Gene

Gene Damage Index Score: 4.56; 65.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM86B1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B1 Gene

Disorders for FAM86B1 Gene

Relevant External Links for FAM86B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM86B1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86B1 Gene

Publications for FAM86B1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for FAM86B1 Gene

Sources for FAM86B1 Gene

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