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FAM86B1 Gene

protein-coding   GIFtS: 34
GCID: GC08M012039          (predicted)

Family With Sequence Similarity 86, Member B1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 86, Member B11 2
Protein FAM86B12

External Ids:    HGNC: 282681   Entrez Gene: 850022   Ensembl: ENSG000001865237   UniProtKB: Q8N7N13   

Export aliases for FAM86B1 gene to outside databases

Previous GC identifer: GC08M012079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM86B1 Gene:
FAM86B1 (family with sequence similarity 86, member B1) is a protein-coding gene. An important paralog of this gene is FAM86A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM86B1 gene promoter:
         HOXA9B   HOXA9   AML1a   Pax-5   HNF-4alpha2   AP-4   LCR-F1   HNF-4alpha1   RORalpha1   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM86B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM86B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

FAM86B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM86B1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M012039:  view genomic region     (about GC identifiers)

Start:
12,039,605 bp from pter      End:
12,051,642 bp from pter
Size:
12,038 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F86B1_HUMAN, Q8N7N1 (See protein sequence)
Recommended Name: Protein FAM86B1  
Size: 296 amino acids; 32865 Da
Alternative splicing: 2 isoforms:  Q8N7N1-1   Q8N7N1-2   

Explore the universe of human proteins at neXtProt for FAM86B1: NX_Q8N7N1

Explore proteomics data for FAM86B1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys37, Lys143
  • Modification sites at PhosphoSitePlus

  • See FAM86B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001077006.1  
    ENSEMBL proteins: 
     ENSP00000473629   ENSP00000342610   ENSP00000444227   ENSP00000473414   ENSP00000407067  
     ENSP00000432931   ENSP00000433147   ENSP00000434799   ENSP00000436024   ENSP00000431362  
     ENSP00000433972   ENSP00000432250   ENSP00000473457   ENSP00000432790   ENSP00000435201  
     ENSP00000439686  

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    antibodies-online kits for FAM86B1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019410 Nicotinamide_N-MeTfrase-like

    Graphical View of Domain Structure for InterPro Entry Q8N7N1

    ProtoNet protein and cluster: Q8N7N1

    UniProtKB/Swiss-Prot: F86B1_HUMAN, Q8N7N1
    Similarity: Belongs to the FAM86 family


    Find genes that share domains with FAM86B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM86B1

    miRNA
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    hsa-miR-3182
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM86B1
    Interactions:

        Search GeneGlobe Interaction Network for FAM86B1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM86B1 (ENSP000004070674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM86B1 (F86B1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM86B1 gene: 
    NM_001083537.1  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000529146(uc003wvf.4) ENST00000340537(uc010lsf.3 uc003wvl.4 uc011kxq.2)
    ENST00000431227(uc010lsd.3 uc010lse.3 uc010lsg.3) ENST00000534187(uc003wvh.4 uc003wvi.4)
    ENST00000448228 ENST00000533852 ENST00000530385 ENST00000527300 ENST00000530508
    ENST00000534732 ENST00000524893 ENST00000534520 ENST00000525822 ENST00000529060
    ENST00000526708 ENST00000529617 ENST00000531833 ENST00000524571
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate FAM86B1:
    hsa-miR-3182
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM86B1
      QuantiFast Probe-based Assays in human, mouse, rat FAM86B1

    Selected AceView cDNA sequences (see all 51):

    BQ949472 BU557028 CR622002 CR619504 CR607690 BC007983 CA420428 AL514700 
    BI912911 BX282235 BI333928 BE048769 CA448574 BI335060 BM798081 BM787786 
    BV202388 BU192106 BE729618 BC062615 BU944645 NM_032916 AK098138 BU955849 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                    -     -               
    SP2:                                          


    ECgene alternative splicing isoforms for FAM86B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM86B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTACGTTC
    FAM86B1 Expression
    About this image

    FAM86B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM86B1 Protein Expression
        Custom PCR Arrays for FAM86B1
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    QuantiFast Probe-based Assays in human, mouse, rat FAM86B1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM86B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM86B1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FAM86A6
    Gallus gallus family with sequence similarity 86, ...
    46(a)
    1 → many
    14(13389142-13393572)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    47(a)
    1 → many
    GL343402.1(678506-686747)
    zebrafish
    (Danio rerio)
    Actinopterygii fam86a6
    family with sequence similarity 86, member A
    40(a)
    1 → many
    3(29020729-29023875) ENSDARG00000054950
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78896
    --
    22(a)
    1 → many
    X(19137666-19139255)
    worm
    (Caenorhabditis elegans)
    Secernentea R08D7.46
    Protein R08D7.4, isoform a
    20(a)
    1 → many
    III(8971892-8973949) WBGene00011144
            Species with no ortholog for FAM86B1

    ENSEMBL Gene Tree for FAM86B1 (if available)
    TreeFam Gene Tree for FAM86B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM86B1 gene
    FAM86A2  FAM86C12  FAM86B22  
    4 SIMAP similar genes for FAM86B1 using alignment to 15 protein entries:     F86B1_HUMAN (see all proteins):
    FAM86A    FAM86C1    FAM86B2    FAM86C2P

    Find genes that share paralogs with FAM86B1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for FAM86B1
    PGOHUM00000239316 PGOHUM00000257931 PGOHUM00000262272 PGOHUM00000257204


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM86B1 (see all 136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439501431,2
    C--12039821(+) TAGAGG/TCCGGA 2 -- ut31 nc-transcript-variant0--------
    rs624945701,2
    C--12039902(+) TTGGAG/AGTGGA 2 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.00NA 12
    rs624945711,2
    C--12040137(+) GCTAAA/GCCAGT 2 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.00NA WA 4
    rs1878897551,2
    --12040141(+) AGCCAA/GTTCTG 2 -- ut31 nc-transcript-variant0--------
    rs1880187671,2
    C--12040307(+) CCTTTC/TGAGCA 2 -- ut31 nc-transcript-variant0--------
    rs2008481081,2
    C--12040541(+) CTGCCA/GTGTTC 2 -- ut31 nc-transcript-variant0--------
    rs2001034171,2
    C--12040766(+) TGGCAA/GCTGCA 2 -- ut31 nc-transcript-variant0--------
    rs2011221641,2
    C--12040786(+) GCTTTC/GTGAGG 2 -- ut31 nc-transcript-variant0--------
    rs1417876561,2
    C--12040998(+) TTGGAA/GTTTAA 2 -- ut31 nc-transcript-variant0--------
    rs2005480401,2
    C--12041140(+) TTGCCA/GTCTCC 3 T M mis11Minor allele frequency- G:0.00EU 433

    HapMap Linkage Disequilibrium report for FAM86B1 (12039605 - 12051642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM86B1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736614CNV Deletion23290073
    dgv1270e199CNV Deletion23128226
    dgv27n31CNV Duplication19718026
    nsv428195CNV Gain18775914
    nsv890374CNV Gain21882294
    dgv244e55CNV Gain17911159
    nsv516685CNV Gain+Loss19592680
    nsv8288CNV Gain+Loss18304495
    esv22986CNV Gain+Loss19812545
    essv15113CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FAM86B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM86B1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM86B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    7. Diagnostic value of rectal mucosal acetylcholinesterase levels in Hirschsprung's disease. (PubMed id 85002)1 Dale G....Scott D.J. (Lancet 1979)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85002 HGNC: 28268 AceView: MGC16279 Ensembl:ENSG00000186523 euGenes: HUgn85002
    ECgene: FAM86B1 H-InvDB: FAM86B1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM86B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM86B1 gene:
    Search GeneIP for patents involving FAM86B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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