FAM86B1 Gene
protein-coding GIFtS: 36
GCID: GC08M012039 (predicted)
|
|
family with sequence similarity 86, member B1
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Aliases
for FAM86B1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 86, Member B11 2 | | MGC162791 | | Protein FAM86B12 |
Export aliases for FAM86B1 gene to outside databasesPrevious GC identifer: GC08M012079 |
Summaries
for FAM86B1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM86B1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_077531.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM86B1 gene promoter:
HOXA9B HOXA9 AML1a Pax-5 HNF-4alpha2 AP-4 LCR-F1 HNF-4alpha1 RORalpha1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM86B1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM86B1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1FAM86B1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M012039: view genomic region
(about GC identifiers)
Start:
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12,035,972 bp from pter |
End:
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12,052,469 bp from pter |
Size:
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16,498 bases |
Orientation:
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minus strand |
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Proteins
for FAM86B1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F86B1_HUMAN, Q8N7N1 (See
protein sequence)Recommended Name: Protein FAM86B1 Size: 296 amino acids; 32865 DaAlternative splicing: 2 isoforms: Q8N7N1-1 Q8N7N1-2 Explore the universe of human proteins at neXtProt for FAM86B1: NX_Q8N7N1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7N1
FAM86B1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001077006.1
ENSEMBL proteins: ENSP00000432496 ENSP00000435100 ENSP00000435183 ENSP00000407067 ENSP00000432931 ENSP00000433147 ENSP00000435688 ENSP00000434799 ENSP00000433563 ENSP00000436024 ENSP00000431362 ENSP00000432250 ENSP00000433972 ENSP00000436977 ENSP00000432448 ENSP00000432790 ENSP00000435201 ENSP00000444227 ENSP00000439686 ENSP00000342610
Human Recombinant Protein Products for FAM86B1:
FAM86B1 Antibody Products:
Assay Products for FAM86B1: |
Protein
Domains /
Families
for FAM86B1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM86B1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N7N1ProtoNet protein and cluster: Q8N7N1 UniProtKB/Swiss-Prot: F86B1_HUMAN, Q8N7N1Similarity: Belongs to the FAM86 family |
Function
for FAM86B1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM86B1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM86B1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM86B1 (NM_001083537) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM86B1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM86B1 |
|
Pathways & Interactions
for FAM86B1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM86B1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM86B1 (ENSP000004070674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM86B1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM86B1
Search CenterWatch for drugs/clinical trials and news about FAM86B1 / F86B1
|
Transcripts
for FAM86B1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM86B1 gene: NM_001083537.1 Unigene Cluster for FAM86B1: Family with sequence similarity 86, member B1 Hs.675799 [show with all ESTs]Unigene Representative Sequence: NM_00108353718/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35): ENST00000533489 ENST00000525917 ENST00000529146(uc003wvf.4) ENST00000534095
ENST00000533042 ENST00000534187(uc003wvh.4 uc003wvi.4) ENST00000448228
ENST00000533852 ENST00000530385 ENST00000527437 ENST00000530289 ENST00000530066
ENST00000524484 ENST00000527300 ENST00000530299 ENST00000531343 ENST00000530508
ENST00000533710
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM86B1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM86B1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM86B1 (NM_001083537) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM86B1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM86B1 |
Additional cDNA sequence: AK308439.1 AK308513.1 BC048297.1 BC062615.1 BC085016.1 BC093808.1 BC093810.1 BC098427.1 NR_003494.1 8 DOTS entries: DT.40109072 DT.95277934 DT.95277942 DT.100039036 DT.100842166 DT.121494046 DT.75109099 DT.121494000 24/51 AceView cDNA sequences (see all 51): BQ949472 BU557028 CR622002 CR607690 CR619504 BI335060 BC048297 BC062615 BU628100 BG056431 BU156325 CA448574 AL555160 AW167540 CA420428 BU192106 BU944645 BU955849 BV202388 BE048769 BE729618 BU176438 BG680421 BI868251
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM86B1
|
Expression
for FAM86B1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM86B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTACGTTC
About this image
See FAM86B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM86B1
SOURCE GeneReport for Unigene cluster: Hs.675799
SABiosciences Custom PCR Arrays for FAM86B1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM86B1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM86B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM86B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM86B1 |
Orthologs
for FAM86B1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM86B1 gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4163926 |
hypothetical protein LOC416392 |
47(a) |
1 → many |
14(14150470-14154909) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
48(a) |
1 → many |
GL343402.1(678506-686747) |
zebrafish
(Danio rerio) |
Actinopterygii |
fam86a6 |
family with sequence similarity 86, member A |
40(a) |
1 → many |
3(29020729-29023875) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG78896 |
-- |
22(a) |
1 → many |
X(19137666-19139255) |
worm
(Caenorhabditis elegans) |
Secernentea |
R08D7.46 |
Uncharacterized protein R08D7.4 |
19(a) |
1 → many |
III(8971815-8973872) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G274006 |
S-adenosyl-L-methionine-dependent methyltransferas... |
18(a) |
1 → many |
5(9676334-9678503) |
rice
(Oryza sativa) |
Liliopsida |
-- |
GA20663-PA, putative, expressed |
21(a) |
1 → many |
5(2494958-2499418) |
ENSEMBL Gene Tree for FAM86B1 (if available)
TreeFam Gene Tree for FAM86B1 (if available) |
Paralogs
for FAM86B1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM86B1 gene
- FAM86A2 FAM86C12 FAM86B22
4 SIMAP similar genes for FAM86B1 using alignment to 16 protein entries: F86B1_HUMAN (see all proteins):FAM86A FAM86B2 FAM86C1 FAM86C2P
FAM86B1 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for FAM86B1
PGOHUM00000239316 PGOHUM00000257931 PGOHUM00000262272 PGOHUM00000257204
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Genomic Variants
for FAM86B1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM86B1 (12035972 - 12052469 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 27 variations for FAM86B1
12 CNVs: 82482 2736 82483 31428 8596 0297 70283 95259 52352 34527 70285 3720
15 Inversions: 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FAM86B1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM86B1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM86B1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM86B1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
|
External Searches for FAM86B1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM86B1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM86B1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM86B1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM86B1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM86B1 gene:
Search GeneIP for patents involving FAM86B1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM86B1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM86B1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM86B1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM86B1 | | | OriGene Protein Over-expression Lysate for FAM86B1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM86B1 | | OriGene 3'-UTR Clone for FAM86B1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM86B1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM86B1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM86B1 | | OriGene Custom Protein Services for FAM86B1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM86B1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM86B1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM86B1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM86B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM86B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM86B1 |
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| | | | Search Tocris compounds for FAM86B1 |
| |  |  |  |  | | | | |
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 | | | FAM86B1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for FAM86B1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM86B1 |
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