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Aliases for FAM86B1 Gene

Aliases for FAM86B1 Gene

  • Family With Sequence Similarity 86 Member B1 2 3 5
  • Family With Sequence Similarity 86, Member B1 2
  • EC 2.1.1.- 4

External Ids for FAM86B1 Gene

Previous GeneCards Identifiers for FAM86B1 Gene

  • GC08M012079
  • GC08M012039

Summaries for FAM86B1 Gene

GeneCards Summary for FAM86B1 Gene

FAM86B1 (Family With Sequence Similarity 86 Member B1) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is FAM86B2.

Additional gene information for FAM86B1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM86B1 Gene

Genomics for FAM86B1 Gene

Regulatory Elements for FAM86B1 Gene

Enhancers for FAM86B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H011472 1.4 Ensembl ENCODE dbSUPER 13.9 +718.7 718717 5 FOXA2 PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF121 ELK1 ZNF366 SCRT2 FAM66A FAM66D FAM167A PRSS52P LOC105379241 LINC00208 ENSG00000249316 LINC00529 DEFB135 ZNF705D
GH08H011283 1.1 ENCODE 10.3 +909.4 909407 2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF302 FAM90A2P PINX1 LOC101929290 LOC100129129 FAM86B1 MTMR9 ENSG00000272505 ENSG00000280273
GH08H012014 0.8 Ensembl 6.6 +179.1 179132 2 CTCF ZNF777 RB1 ZIC2 ZFHX2 CTBP1 SCRT2 SMC3 ZNF143 ATF7 LOC105379241 DEFB131E FAM66A FAM85A FAM86B1 ENSG00000269918 NEIL2 ENSG00000270154 ENSG00000255518 ENSG00000284610
GH08H012193 0.9 ENCODE 0.7 -0.2 -234 1 HDAC1 HDGF PKNOX1 RB1 KLF17 ZEB1 ZNF121 GLIS2 EGR1 ZNF143 FAM86B1 PIR51133
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM86B1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM86B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221159 -351 2201 HDAC1 HDGF PKNOX1 RB1 KLF17 ZEB1 ZNF121 GLIS2 EGR1 KLF7

Genomic Location for FAM86B1 Gene

Chromosome:
8
Start:
12,182,096 bp from pter
End:
12,194,149 bp from pter
Size:
12,054 bases
Orientation:
Minus strand

Genomic View for FAM86B1 Gene

Genes around FAM86B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B1 Gene

Proteins for FAM86B1 Gene

  • Protein details for FAM86B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7N1-F86B1_HUMAN
    Recommended name:
    Putative protein N-methyltransferase FAM86B1
    Protein Accession:
    Q8N7N1

    Protein attributes for FAM86B1 Gene

    Size:
    296 amino acids
    Molecular mass:
    32865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM86B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM86B1 Gene

Post-translational modifications for FAM86B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM86B1 Gene

Domains & Families for FAM86B1 Gene

Gene Families for FAM86B1 Gene

Protein Domains for FAM86B1 Gene

Suggested Antigen Peptide Sequences for FAM86B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7N1

UniProtKB/Swiss-Prot:

F86B1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B1: view

Function for FAM86B1 Gene

Enzyme Numbers (IUBMB) for FAM86B1 Gene

Gene Ontology (GO) - Molecular Function for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

Phenotypes for FAM86B1 Gene

GenomeRNAi human phenotypes for FAM86B1:
genes like me logo Genes that share phenotypes with FAM86B1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM86B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B1 Gene

Localization for FAM86B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM86B1 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM86B1 Gene

Pathways & Interactions for FAM86B1 Gene

SuperPathways for FAM86B1 Gene

No Data Available

Interacting Proteins for FAM86B1 Gene

Gene Ontology (GO) - Biological Process for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86B1 Gene

Drugs & Compounds for FAM86B1 Gene

No Compound Related Data Available

Transcripts for FAM86B1 Gene

Unigene Clusters for FAM86B1 Gene

Family with sequence similarity 86, member B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM86B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for FAM86B1 Gene

GeneLoc Exon Structure for
FAM86B1
ECgene alternative splicing isoforms for
FAM86B1

Expression for FAM86B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM86B1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM86B1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM86B1 Gene:

FAM86B1

SOURCE GeneReport for Unigene cluster for FAM86B1 Gene:

Hs.675799
genes like me logo Genes that share expression patterns with FAM86B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86B1 Gene

Orthologs for FAM86B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM86A 34
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam86 34
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM86A 34
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam86a 34
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7889 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.4 34
  • 20 (a)
OneToMany
Species where no ortholog for FAM86B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM86B1 Gene

ENSEMBL:
Gene Tree for FAM86B1 (if available)
TreeFam:
Gene Tree for FAM86B1 (if available)

Paralogs for FAM86B1 Gene

Variants for FAM86B1 Gene

Sequence variations from dbSNP and Humsavar for FAM86B1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1002033453 -- 12,182,945(+) CCCCT(C/G)CTAGC nc-transcript-variant, utr-variant-3-prime
rs1002446503 -- 12,185,082(+) ACCTC(C/T)ATTTT intron-variant
rs1003063594 -- 12,193,444(+) GCAGG(-/T)TCCCC intron-variant, upstream-variant-2KB
rs1003422476 -- 12,191,778(+) TCTTA(C/G)CTTCT splice-donor-variant
rs1006664094 -- 12,187,922(+) AGACA(A/G)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM86B1 Gene

Variant ID Type Subtype PubMed ID
dgv1270e199 CNV deletion 23128226
dgv154e203 CNV gain+loss 21179565
dgv244e55 CNV gain 17911159
dgv27n31 CNV gain 19718026
dgv7015n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7017n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7019n100 CNV gain 25217958
dgv7020n100 CNV loss 25217958
dgv7021n100 CNV loss 25217958
dgv7025n100 CNV gain 25217958
dgv7026n100 CNV gain+loss 25217958
esv22986 CNV gain+loss 19812545
esv2736614 CNV deletion 23290073
esv2759593 CNV gain+loss 17122850
nsv1034132 CNV gain 25217958
nsv1077519 CNV duplication 25765185
nsv1139930 CNV duplication 24896259
nsv428195 CNV gain 18775914
nsv516685 CNV gain+loss 19592680
nsv8288 CNV gain+loss 18304495
nsv951104 CNV deletion 24416366
nsv967565 CNV duplication 23825009

Variation tolerance for FAM86B1 Gene

Gene Damage Index Score: 4.56; 65.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM86B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM86B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM86B1 Gene

Disorders for FAM86B1 Gene

Relevant External Links for FAM86B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM86B1

No disorders were found for FAM86B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM86B1 Gene

Publications for FAM86B1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60

Products for FAM86B1 Gene

Sources for FAM86B1 Gene

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