Aliases for FAM84B Gene
Aliases for FAM84B Gene
External Ids for FAM84B Gene
- HGNC: 24166
- Entrez Gene: 157638
- Ensembl: ENSG00000168672
- OMIM: 609483
- UniProtKB: Q96KN1
Previous GeneCards Identifiers for FAM84B Gene
- GC08M127634
- GC08M122881
- GC08M127564
- GC08M126612
- GC08M126614
- GC08M126616
- GC08M126625
- GC08M126646
Summaries for FAM84B Gene
GeneCards Summary for FAM84B Gene
FAM84B (Family With Sequence Similarity 84 Member B) is a Protein Coding gene. Diseases associated with FAM84B include Prostate Cancer Susceptibility. An important paralog of this gene is FAM84A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM84B Gene
Genomics for FAM84B Gene
Regulatory Elements for FAM84B Gene
Enhancers for FAM84B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G126432 | 1.4 | FANTOM5 Ensembl ENCODE | 56 | +123.7 | 123672 | 3.6 | TBP PKNOX1 NFIB BRCA1 RFX5 RCOR1 FOS SMARCC1 USF2 CEBPB | FAM84B LOC105375751 ENSG00000253427 LOC101927657 |
| GH08G126824 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 17.1 | -268.4 | -268444 | 5.7 | TBP PKNOX1 BRCA1 RAD21 YY1 RFX5 GATA2 ZNF143 RCOR1 FOS | FAM84B CASC11 MYC GC08P126836 RNU11-4P |
| GH08G126578 | 1.2 | Ensembl ENCODE dbSUPER | 12 | -21.5 | -21494 | 2.1 | PKNOX1 RFX1 TEAD4 DPF2 BMI1 EP300 CTBP1 BCL11A CTBP2 KDM1A | LOC105375751 FAM84B ENSG00000253543 PIR61718 |
| GH08G126648 | 0.3 | FANTOM5 | 42.5 | -90.6 | -90557 | 0.4 | FAM84B GC08P126672 ENSG00000253543 | |
| GH08G126582 | 0.9 | ENCODE dbSUPER | 12 | -24.8 | -24777 | 1.4 | ATF1 JUN DPF2 MNT ATF2 MTA3 GATA3 JUND ATF3 CREB1 | FAM84B LOC105375751 ENSG00000253543 GC08P126672 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM84B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM84B gene promoter:
Regulatory Element Products
Genomic Location for FAM84B Gene
- Chromosome:
- 8
- Start:
- 126,552,438 bp from pter
- End:
- 126,558,478 bp from pter
- Size:
- 6,041 bases
- Orientation:
- Minus strand
Genomic View for FAM84B Gene
Genes around FAM84B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.21 by Ensembl
- 8q24.21 by Entrez Gene
- 8q24.21 by HGNC
FAM84B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM84B Gene
Proteins for FAM84B Gene
-
Protein details for FAM84B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96KN1-FA84B_HUMAN
- Recommended name:
- Protein FAM84B
- Protein Accession:
- Q96KN1
Protein attributes for FAM84B Gene
- Size:
- 310 amino acids
- Molecular mass:
- 34474 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM84B Gene
Post-translational modifications for FAM84B Gene
Other Protein References for FAM84B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FAM84B
-
Abcam antibodies for FAM84B
- Invitrogen Antibodies for FAM84B
- GeneTex FAM84B antibody for FAM84B
Protein Products
-
OriGene Purified Proteins for FAM84B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM84B
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- ProSpec Recombinant Proteins for FAM84B
- Search GeneTex for Proteins for FAM84B
-
Abcam proteins for FAM84B
Assay Products
No data available for DME Specific Peptides for FAM84B Gene
Domains & Families for FAM84B Gene
Protein Domains for FAM84B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM84B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96KN1- Family:
-
- Belongs to the FAM84 family.
No data available for Gene Families for FAM84B Gene
Function for FAM84B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12477722 |
Phenotypes for FAM84B Gene
- GenomeRNAi human phenotypes for FAM84B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM84B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM84B gene
- Search ViGene Biosciences for FAM84B
CRISPR Products
-
OriGene CRISPR knockouts for FAM84B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM84B
- GenScript: Design CRISPR guide RNA sequences for FAM84B
miRNA for FAM84B Gene
- miRTarBase miRNAs that target FAM84B
-
- hsa-mir-335-5p (MIRT016822)
- hsa-let-7b-5p (MIRT052286)
- hsa-mir-513b-5p (MIRT443583)
- hsa-mir-4662a-5p (MIRT443584)
- hsa-mir-125b-2-3p (MIRT443585)
- hsa-mir-4457 (MIRT443586)
- hsa-mir-3651 (MIRT443588)
- hsa-mir-513a-5p (MIRT502480)
- hsa-mir-4277 (MIRT502481)
- hsa-mir-139-5p (MIRT502482)
- hsa-mir-3168 (MIRT502483)
- hsa-mir-4760-3p (MIRT502484)
- hsa-mir-27a-3p (MIRT502485)
- hsa-mir-128-3p (MIRT502486)
- hsa-mir-3681-3p (MIRT502487)
- hsa-mir-27b-3p (MIRT502488)
- hsa-mir-216a-3p (MIRT502489)
- hsa-mir-101-3p (MIRT502490)
- hsa-mir-187-5p (MIRT537456)
- hsa-mir-1283 (MIRT537457)
- hsa-mir-5584-3p (MIRT537458)
- hsa-mir-8066 (MIRT537459)
- hsa-mir-224-5p (MIRT537460)
- hsa-mir-548l (MIRT537461)
- hsa-mir-548n (MIRT537462)
- hsa-mir-548e-5p (MIRT537463)
- hsa-mir-6875-3p (MIRT537464)
- hsa-mir-4320 (MIRT537465)
- hsa-mir-5191 (MIRT537466)
- hsa-mir-6753-5p (MIRT537467)
- hsa-mir-6840-3p (MIRT537468)
- hsa-mir-1911-3p (MIRT537469)
- hsa-mir-664b-3p (MIRT642099)
- hsa-mir-579-3p (MIRT642100)
- hsa-mir-5696 (MIRT642101)
- hsa-mir-6853-3p (MIRT642102)
- hsa-mir-146b-3p (MIRT642103)
- hsa-mir-5000-5p (MIRT642104)
- hsa-mir-6779-3p (MIRT642105)
- hsa-mir-7-2-3p (MIRT711062)
- hsa-mir-7-1-3p (MIRT711063)
miRNA Products
- Search ViGene Biosciences for FAM84B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM84B
- Browse OriGene Inhibitory RNA Products For FAM84B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM84B gene
Clone Products
-
OriGene ORF clones in human for FAM84B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM84B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM84B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM84B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM84B gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM84B Gene
Localization for FAM84B Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 12477722 |
| GO:0005886 | plasma membrane | IDA | 12477722 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM84B Gene
Pathways & Interactions for FAM84B Gene
No Data Available
Interacting Proteins for FAM84B Gene
Selected Interacting proteins:
ENSP00000302578
Q96KN1-FA84B_HUMAN
for FAM84B Gene via
STRING
IID
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for FAM84B Gene
Transcripts for FAM84B Gene
mRNA/cDNA for FAM84B Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM84B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM84B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM84B
- GenScript: Design CRISPR guide RNA sequences for FAM84B
miRNA Products
- Search ViGene Biosciences for FAM84B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM84B
- Browse OriGene Inhibitory RNA Products For FAM84B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM84B gene
Clone Products
-
OriGene ORF clones in human for FAM84B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FAM84B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Ureteric Bud
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Brain (Nervous System)
This gene is overexpressed in Salivary gland (27.3), Stomach (9.9), and Breast (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM84B Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM84B Gene:
FAM84BSOURCE GeneReport for Unigene cluster for FAM84B Gene:
Hs.741352mRNA Expression by UniProt/SwissProt for FAM84B Gene:
Q96KN1-FA84B_HUMAN
Tissue specificity:
Expressed in esophageal squamous cell carcinomas.
Evidence on tissue expression from TISSUES for FAM84B Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for FAM84B
-
OriGene qPCR primer pairs for FAM84B
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM84B Gene
Orthologs for FAM84B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM84B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM84B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM84B 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam84b 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam84b 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM84B 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM84B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM84B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FAM84B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101733578 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam84b 34 35 |
|
||
| FAM84B (2 of 2) 35 |
|
OneToMany |
- Species where no ortholog for FAM84B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM84B Gene
(1) SIMAP similar genes for FAM84B Gene using alignment to 1 proteins:
Variants for FAM84B Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000135662 | -- | 126,552,183(+) | TTTTT(G/T)CATGG | downstream-variant-500B | |
| rs1000238845 | -- | 126,557,169(+) | GATCG(C/T)AGGGC | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs1000287982 | -- | 126,556,702(+) | CTGCA(A/G)CCGGT | nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon | |
| rs1000505314 | -- | 126,551,940(+) | GCACC(C/T)AGTGG | downstream-variant-500B | |
| rs1001581450 | -- | 126,558,659(+) | CTTGC(C/T)TTCCG | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.08;
50.79% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM84B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM84B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM84B Gene
Disorders for FAM84B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer susceptibility |
|
|
Search FAM84B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FAM84B
No data available for UniProtKB/Swiss-Prot and Genatlas for FAM84B Gene
Publications for FAM84B Gene
- Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. (PMID: 20158306) White K.L. … Goode E.L. (Twin Res Hum Genet 2010) 3 46 64
- Evaluation of the 8q24 prostate cancer risk locus and MYC expression. (PMID: 19549893) Pomerantz M.M. … Freedman M.L. (Cancer Res. 2009) 3 46 64
- Negative implication of C-MYC as an amplification target in esophageal cancer. (PMID: 16490593) Huang X.-P. … Liang Q.-W. (Cancer Genet. Cytogenet. 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PMID: 12477722) Adam P.J. … Terrett J.A. (J. Biol. Chem. 2003) 2 3 64
Products for FAM84B Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- OriGene qPCR primer pairs and template standards for FAM84B
- OriGene qPCR primer pairs for FAM84B
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FAM84B in any vector
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- GenScript: Design CRISPR guide RNA sequences for FAM84B
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- Novus Biologicals Antibodies for FAM84B
- Novus Biologicals proteins and lysates for FAM84B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FAM84B
- Abcam proteins for FAM84B
- Search for Assays for FAM84B at Abcam
- Find your target
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- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM84B
- VectorBuilder custom plasmid, inducible vectors for FAM84B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM84B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM84B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer