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Aliases for FAM84B Gene

Aliases for FAM84B Gene

  • Family With Sequence Similarity 84 Member B 2 3 5
  • Breast Cancer Membrane-Associated Protein 101 2 3
  • Breast Cancer Membrane Protein 101 3 4
  • Neurological/Sensory 2 2 3
  • BCMP101 3 4
  • NSE2 3 4
  • Family With Sequence Similarity 84, Member B 2
  • Protein FAM84B 3
  • Protein NSE2 4

External Ids for FAM84B Gene

Previous GeneCards Identifiers for FAM84B Gene

  • GC08M127634
  • GC08M122881
  • GC08M127564
  • GC08M126612
  • GC08M126614
  • GC08M126616
  • GC08M126625
  • GC08M126646

Summaries for FAM84B Gene

GeneCards Summary for FAM84B Gene

FAM84B (Family With Sequence Similarity 84 Member B) is a Protein Coding gene. Diseases associated with FAM84B include Prostate Cancer Susceptibility. An important paralog of this gene is FAM84A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM84B Gene

Genomics for FAM84B Gene

Regulatory Elements for FAM84B Gene

Enhancers for FAM84B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G126432 1.4 FANTOM5 Ensembl ENCODE 56 +123.7 123672 3.6 TBP PKNOX1 NFIB BRCA1 RFX5 RCOR1 FOS SMARCC1 USF2 CEBPB FAM84B LOC105375751 ENSG00000253427 LOC101927657
GH08G126824 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -268.4 -268444 5.7 TBP PKNOX1 BRCA1 RAD21 YY1 RFX5 GATA2 ZNF143 RCOR1 FOS FAM84B CASC11 MYC GC08P126836 RNU11-4P
GH08G126578 1.2 Ensembl ENCODE dbSUPER 12 -21.5 -21494 2.1 PKNOX1 RFX1 TEAD4 DPF2 BMI1 EP300 CTBP1 BCL11A CTBP2 KDM1A FAM84B LOC105375751 ENSG00000253543 PIR61718
GH08G126648 0.3 FANTOM5 42.5 -90.6 -90557 0.4 FAM84B GC08P126672 ENSG00000253543
GH08G126582 0.9 ENCODE dbSUPER 12 -24.8 -24777 1.4 ATF1 JUN DPF2 MNT ATF2 MTA3 GATA3 JUND ATF3 CREB1 FAM84B LOC105375751 ENSG00000253543 GC08P126672
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM84B on UCSC Golden Path with GeneCards custom track

Promoters for FAM84B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000230422 1078 3201 HNRNPUL1 FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZBTB7B

Genomic Location for FAM84B Gene

Chromosome:
8
Start:
126,552,438 bp from pter
End:
126,558,478 bp from pter
Size:
6,041 bases
Orientation:
Minus strand

Genomic View for FAM84B Gene

Genes around FAM84B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM84B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM84B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM84B Gene

Proteins for FAM84B Gene

  • Protein details for FAM84B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN1-FA84B_HUMAN
    Recommended name:
    Protein FAM84B
    Protein Accession:
    Q96KN1

    Protein attributes for FAM84B Gene

    Size:
    310 amino acids
    Molecular mass:
    34474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM84B Gene

Post-translational modifications for FAM84B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM84B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM84B Gene

Domains & Families for FAM84B Gene

Protein Domains for FAM84B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM84B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KN1

UniProtKB/Swiss-Prot:

FA84B_HUMAN :
  • Belongs to the FAM84 family.
Family:
  • Belongs to the FAM84 family.
genes like me logo Genes that share domains with FAM84B: view

No data available for Gene Families for FAM84B Gene

Function for FAM84B Gene

Gene Ontology (GO) - Molecular Function for FAM84B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12477722
genes like me logo Genes that share ontologies with FAM84B: view
genes like me logo Genes that share phenotypes with FAM84B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM84B Gene

Localization for FAM84B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM84B gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM84B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12477722
GO:0005886 plasma membrane IDA 12477722
genes like me logo Genes that share ontologies with FAM84B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM84B Gene

Pathways & Interactions for FAM84B Gene

SuperPathways for FAM84B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM84B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM84B Gene

Drugs & Compounds for FAM84B Gene

No Compound Related Data Available

Transcripts for FAM84B Gene

mRNA/cDNA for FAM84B Gene

Unigene Clusters for FAM84B Gene

Family with sequence similarity 84, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM84B Gene

No ASD Table

Relevant External Links for FAM84B Gene

GeneLoc Exon Structure for
FAM84B
ECgene alternative splicing isoforms for
FAM84B

Expression for FAM84B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM84B Gene

Protein differential expression in normal tissues from HIPED for FAM84B Gene

This gene is overexpressed in Salivary gland (27.3), Stomach (9.9), and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM84B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM84B Gene:

FAM84B

SOURCE GeneReport for Unigene cluster for FAM84B Gene:

Hs.741352

mRNA Expression by UniProt/SwissProt for FAM84B Gene:

Q96KN1-FA84B_HUMAN
Tissue specificity: Expressed in esophageal squamous cell carcinomas.

Evidence on tissue expression from TISSUES for FAM84B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FAM84B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM84B Gene

Orthologs for FAM84B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM84B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM84B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia FAM84B 34 35
  • 93.16 (n)
cow
(Bos Taurus)
Mammalia FAM84B 34 35
  • 89.74 (n)
mouse
(Mus musculus)
Mammalia Fam84b 34 16 35
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Fam84b 34
  • 86.13 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM84B 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM84B 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM84B 34 35
  • 77.86 (n)
lizard
(Anolis carolinensis)
Reptilia FAM84B 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733578 34
  • 73.02 (n)
zebrafish
(Danio rerio)
Actinopterygii fam84b 34 35
  • 67.18 (n)
FAM84B (2 of 2) 35
  • 61 (a)
OneToMany
Species where no ortholog for FAM84B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM84B Gene

ENSEMBL:
Gene Tree for FAM84B (if available)
TreeFam:
Gene Tree for FAM84B (if available)

Paralogs for FAM84B Gene

Paralogs for FAM84B Gene

(1) SIMAP similar genes for FAM84B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM84B: view

Variants for FAM84B Gene

Sequence variations from dbSNP and Humsavar for FAM84B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000135662 -- 126,552,183(+) TTTTT(G/T)CATGG downstream-variant-500B
rs1000238845 -- 126,557,169(+) GATCG(C/T)AGGGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000287982 -- 126,556,702(+) CTGCA(A/G)CCGGT nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000505314 -- 126,551,940(+) GCACC(C/T)AGTGG downstream-variant-500B
rs1001581450 -- 126,558,659(+) CTTGC(C/T)TTCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM84B Gene

Variant ID Type Subtype PubMed ID
esv2737545 CNV deletion 23290073
nsv499795 OTHER inversion 21111241
nsv7419 OTHER inversion 18451855

Variation tolerance for FAM84B Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM84B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM84B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM84B Gene

Disorders for FAM84B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM84B Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM84B

Genetic Association Database (GAD)
FAM84B
Human Genome Epidemiology (HuGE) Navigator
FAM84B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM84B
genes like me logo Genes that share disorders with FAM84B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM84B Gene

Publications for FAM84B Gene

  1. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. (PMID: 20158306) White K.L. … Goode E.L. (Twin Res Hum Genet 2010) 3 46 64
  2. Evaluation of the 8q24 prostate cancer risk locus and MYC expression. (PMID: 19549893) Pomerantz M.M. … Freedman M.L. (Cancer Res. 2009) 3 46 64
  3. Negative implication of C-MYC as an amplification target in esophageal cancer. (PMID: 16490593) Huang X.-P. … Liang Q.-W. (Cancer Genet. Cytogenet. 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PMID: 12477722) Adam P.J. … Terrett J.A. (J. Biol. Chem. 2003) 2 3 64

Products for FAM84B Gene

Sources for FAM84B Gene

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