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Aliases for FAM84B Gene

Aliases for FAM84B Gene

  • Family With Sequence Similarity 84 Member B 2 3 5
  • Breast Cancer Membrane-Associated Protein 101 2 3
  • Family With Sequence Similarity 84, Member B 2 3
  • Breast Cancer Membrane Protein 101 3 4
  • Neurological/Sensory 2 2 3
  • BCMP101 3 4
  • NSE2 3 4
  • Protein NSE2 4

External Ids for FAM84B Gene

Previous GeneCards Identifiers for FAM84B Gene

  • GC08M127634
  • GC08M122881
  • GC08M127564
  • GC08M126612
  • GC08M126614

Summaries for FAM84B Gene

GeneCards Summary for FAM84B Gene

FAM84B (Family With Sequence Similarity 84 Member B) is a Protein Coding gene. An important paralog of this gene is FAM84A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM84B Gene

Genomics for FAM84B Gene

Regulatory Elements for FAM84B Gene

Promoters for FAM84B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM84B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM84B Gene

Chromosome:
8
Start:
126,552,438 bp from pter
End:
126,558,478 bp from pter
Size:
6,041 bases
Orientation:
Minus strand

Genomic View for FAM84B Gene

Genes around FAM84B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM84B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM84B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM84B Gene

Proteins for FAM84B Gene

  • Protein details for FAM84B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN1-FA84B_HUMAN
    Recommended name:
    Protein FAM84B
    Protein Accession:
    Q96KN1

    Protein attributes for FAM84B Gene

    Size:
    310 amino acids
    Molecular mass:
    34474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM84B Gene

Proteomics data for FAM84B Gene at MOPED

Post-translational modifications for FAM84B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM84B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM84B Gene

Domains & Families for FAM84B Gene

Protein Domains for FAM84B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM84B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KN1

UniProtKB/Swiss-Prot:

FA84B_HUMAN :
  • Belongs to the FAM84 family.
Family:
  • Belongs to the FAM84 family.
genes like me logo Genes that share domains with FAM84B: view

No data available for Gene Families for FAM84B Gene

Function for FAM84B Gene

genes like me logo Genes that share phenotypes with FAM84B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM84B Gene

Localization for FAM84B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM84B Gene COMPARTMENTS Subcellular localization image for FAM84B gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM84B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12477722
genes like me logo Genes that share ontologies with FAM84B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM84B Gene

Pathways & Interactions for FAM84B Gene

SuperPathways for FAM84B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM84B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM84B Gene

Drugs & Compounds for FAM84B Gene

No Compound Related Data Available

Transcripts for FAM84B Gene

mRNA/cDNA for FAM84B Gene

Unigene Clusters for FAM84B Gene

Family with sequence similarity 84, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM84B Gene

No ASD Table

Relevant External Links for FAM84B Gene

GeneLoc Exon Structure for
FAM84B
ECgene alternative splicing isoforms for
FAM84B

Expression for FAM84B Gene

mRNA expression in normal human tissues for FAM84B Gene

Protein differential expression in normal tissues from HIPED for FAM84B Gene

This gene is overexpressed in Salivary gland (27.3), Stomach (9.9), and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM84B Gene



SOURCE GeneReport for Unigene cluster for FAM84B Gene Hs.741352

mRNA Expression by UniProt/SwissProt for FAM84B Gene

Q96KN1-FA84B_HUMAN
Tissue specificity: Expressed in esophageal squamous cell carcinomas.
genes like me logo Genes that share expression patterns with FAM84B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM84B Gene

Orthologs for FAM84B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM84B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM84B 35
  • 100 (n)
  • 100 (a)
FAM84B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM84B 36
  • 92 (a)
OneToOne
FAM84B 35
  • 89.74 (n)
  • 93.71 (a)
dog
(Canis familiaris)
Mammalia FAM84B 35
  • 93.16 (n)
  • 94.02 (a)
FAM84B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam84b 16
Fam84b 35
  • 86.88 (n)
  • 92.58 (a)
Fam84b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM84B 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM84B 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam84b 35
  • 86.13 (n)
  • 92.58 (a)
chicken
(Gallus gallus)
Aves FAM84B 35
  • 77.86 (n)
  • 79.34 (a)
FAM84B 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM84B 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733578 35
  • 73.02 (n)
  • 68.13 (a)
zebrafish
(Danio rerio)
Actinopterygii fam84b 36
  • 65 (a)
OneToMany
FAM84B (2 of 2) 36
  • 61 (a)
OneToMany
fam84b 35
  • 67.18 (n)
  • 67.05 (a)
Species with no ortholog for FAM84B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM84B Gene

ENSEMBL:
Gene Tree for FAM84B (if available)
TreeFam:
Gene Tree for FAM84B (if available)

Paralogs for FAM84B Gene

Paralogs for FAM84B Gene

(1) SIMAP similar genes for FAM84B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM84B: view

Variants for FAM84B Gene

Sequence variations from dbSNP and Humsavar for FAM84B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs9643213 -- 126,555,284(+) TCAGC(C/G)TAAGA intron-variant, utr-variant-3-prime
rs16901511 -- 126,553,028(+) ATAGC(A/G)TACGT nc-transcript-variant, utr-variant-3-prime
rs74519505 -- 126,554,446(+) CTGTG(A/G)GAGTA intron-variant, utr-variant-3-prime
rs78338944 -- 126,554,445(+) GCTGT(A/G)AGAGT intron-variant, utr-variant-3-prime
rs77693027 -- 126,554,418(+) TCCAT(C/G)AGCAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM84B Gene

Variant ID Type Subtype PubMed ID
esv2737545 CNV Deletion 23290073
nsv7419 OTHER Inversion 18451855
nsv499795 OTHER Inversion 21111241

Variation tolerance for FAM84B Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM84B Gene

HapMap Linkage Disequilibrium report
FAM84B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM84B Gene

Disorders for FAM84B Gene

Relevant External Links for FAM84B

Genetic Association Database (GAD)
FAM84B
Human Genome Epidemiology (HuGE) Navigator
FAM84B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM84B

No disorders were found for FAM84B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM84B Gene

Publications for FAM84B Gene

  1. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. (PMID: 20158306) White K.L. … Goode E.L. (Twin Res Hum Genet 2010) 3 48 67
  2. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PMID: 12477722) Adam P.J. … Terrett J.A. (J. Biol. Chem. 2003) 2 3
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FAM84B Gene

Sources for FAM84B Gene

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