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Aliases for FAM84A Gene

Aliases for FAM84A Gene

  • Family With Sequence Similarity 84 Member A 2 3 5
  • Neurologic Sensory Protein 1 3 4
  • Neurological/Sensory 1 2 3
  • NSE1 3 4
  • Family With Sequence Similarity 84, Member A 2
  • Protein FAM84A 3
  • PP11517 3

External Ids for FAM84A Gene

Previous GeneCards Identifiers for FAM84A Gene

  • GC02P014724
  • GC02P014773

Summaries for FAM84A Gene

GeneCards Summary for FAM84A Gene

FAM84A (Family With Sequence Similarity 84 Member A) is a Protein Coding gene. An important paralog of this gene is FAM84B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM84A Gene

Genomics for FAM84A Gene

Regulatory Elements for FAM84A Gene

Enhancers for FAM84A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G014296 0.5 ENCODE 14.2 -335.1 -335148 1.1 CTBP1 GATA3 DPF2 FAM84A RNU6-1288P GC02P014286 GC02P014362
GH02G014287 0.6 ENCODE 10.1 -344.5 -344513 0.8 ZNF579 CTCF CTBP1 RFX1 SMC3 DPF2 RAD21 FAM84A GC02P014286 GC02P014362
GH02G014423 0.7 ENCODE 7.6 -208.0 -208047 3.2 MTA2 NR2F1 BACH1 JUNB BMI1 DPF2 ATF2 TBX21 ARID3A IKZF1 FAM84A LINC00276 ENSG00000237261
GH02G014134 0.5 ENCODE 10.5 -497.9 -497894 0.7 ATF2 PRDM1 MAFK FAM84A GC02P014156 GC02P013975
GH02G015359 1 Ensembl ENCODE 4.3 +727.5 727533 2.1 BCOR SOX13 ZNF146 FOXA2 JUN ZMYM3 CEBPG ZNF384 DNMT3B RARA NBAS FAM84A GC02M015398 GC02M015275
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM84A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM84A Gene

Chromosome:
2
Start:
14,632,686 bp from pter
End:
14,650,814 bp from pter
Size:
18,129 bases
Orientation:
Plus strand

Genomic View for FAM84A Gene

Genes around FAM84A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM84A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM84A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM84A Gene

Proteins for FAM84A Gene

  • Protein details for FAM84A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN4-FA84A_HUMAN
    Recommended name:
    Protein FAM84A
    Protein Accession:
    Q96KN4
    Secondary Accessions:
    • A6NP76
    • Q86UZ2
    • Q8NAH7
    • Q8TAM5

    Protein attributes for FAM84A Gene

    Size:
    292 amino acids
    Molecular mass:
    32491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM84A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM84A Gene

Post-translational modifications for FAM84A Gene

Other Protein References for FAM84A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM84A Gene

Domains & Families for FAM84A Gene

Protein Domains for FAM84A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM84A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KN4

UniProtKB/Swiss-Prot:

FA84A_HUMAN :
  • Belongs to the FAM84 family.
Family:
  • Belongs to the FAM84 family.
genes like me logo Genes that share domains with FAM84A: view

No data available for Gene Families for FAM84A Gene

Function for FAM84A Gene

Phenotypes for FAM84A Gene

GenomeRNAi human phenotypes for FAM84A:
genes like me logo Genes that share phenotypes with FAM84A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM84A Gene

Localization for FAM84A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM84A gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM84A Gene

Pathways & Interactions for FAM84A Gene

SuperPathways for FAM84A Gene

No Data Available

Interacting Proteins for FAM84A Gene

Gene Ontology (GO) - Biological Process for FAM84A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM84A Gene

Drugs & Compounds for FAM84A Gene

No Compound Related Data Available

Transcripts for FAM84A Gene

Unigene Clusters for FAM84A Gene

Family with sequence similarity 84, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM84A Gene

No ASD Table

Relevant External Links for FAM84A Gene

GeneLoc Exon Structure for
FAM84A
ECgene alternative splicing isoforms for
FAM84A

Expression for FAM84A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM84A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM84A Gene

This gene is overexpressed in Esophagus - Mucosa (x5.7) and Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for FAM84A Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM84A Gene



Protein tissue co-expression partners for FAM84A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM84A Gene:

FAM84A

SOURCE GeneReport for Unigene cluster for FAM84A Gene:

Hs.260855

Evidence on tissue expression from TISSUES for FAM84A Gene

  • Nervous system(4.4)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with FAM84A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM84A Gene

Orthologs for FAM84A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM84A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM84A 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia FAM84A 34 35
  • 95.09 (n)
cow
(Bos Taurus)
Mammalia FAM84A 34 35
  • 93.61 (n)
mouse
(Mus musculus)
Mammalia Fam84a 34 16 35
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Fam84a 34
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM84A 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM84A 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM84A 34 35
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia FAM84A 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam84a 34
  • 68.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fam84a 34 35
  • 69.1 (n)
zgc63724 34
Species where no ortholog for FAM84A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM84A Gene

ENSEMBL:
Gene Tree for FAM84A (if available)
TreeFam:
Gene Tree for FAM84A (if available)

Paralogs for FAM84A Gene

Paralogs for FAM84A Gene

(1) SIMAP similar genes for FAM84A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM84A: view

Variants for FAM84A Gene

Sequence variations from dbSNP and Humsavar for FAM84A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000211790 -- 14,647,940(+) GCATT(A/G)TCCTC intron-variant
rs1000215319 -- 14,639,235(+) TAAAG(C/T)TAACA intron-variant, utr-variant-3-prime
rs1000305008 -- 14,648,350(+) ATTTG(C/T)CACGA intron-variant
rs1000307819 -- 14,632,573(+) AAAGC(A/G)CACAG upstream-variant-2KB
rs1000383205 -- 14,632,771(+) GCGCA(G/T)ACCTG nc-transcript-variant, utr-variant-5-prime

Variation tolerance for FAM84A Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM84A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM84A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM84A Gene

Disorders for FAM84A Gene

Relevant External Links for FAM84A

Genetic Association Database (GAD)
FAM84A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM84A

No disorders were found for FAM84A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM84A Gene

Publications for FAM84A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 64
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64

Products for FAM84A Gene

Sources for FAM84A Gene

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