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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM84A Gene

protein-coding   GIFtS: 40
GCID: GC02P014773

family with sequence similarity 84, member A
 Explore 1 disease affiliated with
FAM84A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM84A    

Aliases
for FAM84A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 84, Member A1 2     PP115172
NSE11 2 3     Neurological/Sensory 12
Neurologic Sensory Protein 12 3     Protein FAM84A2
FLJ353921     

External Ids:    HGNC: 207431   Entrez Gene: 1513542   Ensembl: ENSG000001629817   OMIM: 6112345   UniProtKB: Q96KN43   

Export aliases for FAM84A gene to outside databases

Previous GC identifers: GC02P014724 GC02P014623


Summaries
for FAM84A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM84A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM84A gene promoter:
         Max1   NF-1   AP-1   GCNF   CUTL1   MEF-2A   GCNF-1   aMEF-2   GCNF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM84A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM84A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM84A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3   Ensembl cytogenetic band:  2p24.3   HGNC cytogenetic band: 2p24.3

FAM84A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM84A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P014773:  view genomic region     (about GC identifiers)

Start:
 14,772,810 bp from pter      End:
 14,790,933 bp from pter
Size:
 18,124 bases      Orientation:
 plus strand

Proteins
for FAM84A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FA84A_HUMAN, Q96KN4 (See protein sequence)
Recommended Name: Protein FAM84A  
Size: 292 amino acids; 32491 Da
Secondary accessions: A6NP76 Q86UZ2 Q8NAH7 Q8TAM5
Alternative splicing: 2 isoforms:  Q96KN4-1   Q96KN4-2   

Explore the universe of human proteins at neXtProt for FAM84A: NX_Q96KN4

Post-translational modifications:

  • Isoform 2 is phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96KN4

    • FAM84A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_660158.2  
    ENSEMBL proteins: 
     ENSP00000295092   ENSP00000330681  

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    Uscn ELISAs and CLIAs for FAM84A

    Protein Domains /
    Families
    for FAM84A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FAM84A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007053 LRAT-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96KN4

    ProtoNet protein and cluster: Q96KN4

    UniProtKB/Swiss-Prot: FA84A_HUMAN, Q96KN4
    Similarity: Belongs to the FAM84 family


    Function
    for FAM84A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM84A (see all 99):
    hsa-miR-579 hsa-miR-520f hsa-miR-193a-3p hsa-miR-642a hsa-miR-1258 hsa-miR-3653 hsa-miR-489 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FAM84A 3' UTR sequence
    Inhib. RNA
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    Pathways & Interactions
    for FAM84A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM84A

    Drugs & Compounds
    for FAM84A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM84A
    Search CenterWatch for drugs/clinical trials and news about FAM84A / FA84A 

    Transcripts
    for FAM84A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAM84A gene: 
    NM_145175.2  

    Unigene Cluster for FAM84A:

    Family with sequence similarity 84, member A
    Hs.260855  [show with all ESTs]
    Unigene Representative Sequence: NM_145175
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295092(uc002rbz.2) ENST00000331243 ENST00000497769 ENST00000464947


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    hsa-miR-579 hsa-miR-520f hsa-miR-193a-3p hsa-miR-642a hsa-miR-1258 hsa-miR-3653 hsa-miR-489 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FAM84A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FAM84A
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM84A
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF086407.1 AF370404.1 AJ417080.1 AK025063.1 AK092654.1 AK314463.1 AL137343.1 BC029933.1 
    BC052284.1 

    8 DOTS entries:

    DT.445353  DT.414984  DT.100019262  DT.408926  DT.97836090  DT.100763934  DT.95375329  DT.100783621 

    24/178 AceView cDNA sequences (see all 178):

    AA612573 AA513346 AI814488 BF064042 AK092654 AI763317 NM_145175 BC052284 
    BF063776 AI435604 F09452 Z39461 CD671628 F11803 AX747656 AA580399 
    AA364902 AA916725 F02788 F06514 F08506 AA327631 AJ417080 AA933622 

    GeneLoc Exon Structure


    Expression
    for FAM84A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM84A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACCATTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM84A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See FAM84A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM84A

    SOURCE GeneReport for Unigene cluster: Hs.260855
        SABiosciences Custom PCR Arrays for FAM84A
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM84A

    Orthologs
    for FAM84A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FAM84A gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FAM84A1 family with sequence similarity 84, member A 81.21(n)
    84.4(a)    		   421946  XM_419958.3  XP_419958.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FAM84A6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 1(145258003-145258920)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BG552019.12   -- 73.12(n)    BG552019.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc637242 hypothetical protein MGC63724 79.57(n)   393590  BC056807.1 


    ENSEMBL Gene Tree for FAM84A (if available)
    TreeFam Gene Tree for FAM84A (if available) 

    Paralogs
    for FAM84A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM84A gene
    FAM84B2  
    1 SIMAP similar gene for FAM84A using alignment to 1 protein entry:     FA84A_HUMAN:
    FAM84B

    FAM84A for paralogs           About GeneDecksing



    Genomic Variants
    for FAM84A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 NCBI SNPs in FAM84A are shown (see all 115)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1887667711,2
    		--14770813(+) TCAAAC/TGCTGA 1 -- us2k10--------
    rs1469321291,2
    		--14770892(+) CTGAAA/GTCCAG 1 -- us2k10--------
    rs1380661821,2
    		--14771080(+) AATAGC/TCAAAT 1 -- us2k10--------
    rs1927734401,2
    		--14771095(+) AAAAAC/GATTTA 1 -- us2k10--------
    rs739147641,2
    		C,F,--14771122(+) ACCGAT/CGGTCA 1 -- us2k14Minor allele frequency- C:0.30WA CSA 124
    rs621316701,2
    		C,--14771124(+) CGATGG/ATCATT 1 -- us2k13Minor allele frequency- A:0.03NA WA 240
    rs25716121,2
    		C,F,O,H,--14771144(-) TGCTGG/AAAAAA 1 -- us2k115Minor allele frequency- A:0.10NS EA NA WA 1630
    rs1844059851,2
    		--14771145(+) TTTTCC/TAGCAA 1 -- us2k10--------
    rs1143311701,2
    		F,--14771317(+) TGTAAC/TCTTGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1893394891,2
    		--14771545(+) TTTACC/TCTTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM84A (14772810 - 14790933 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FAM84A: --

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    Disorders / Diseases
    for FAM84A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FAM84A for disorders           About GeneDecksing

    OMIM gene information: 611234    OMIM disorders: --

    1 disease for FAM84A:    About MalaCards
    colon cancer


    Export disorders for FAM84A gene to outside databases

    Publications
    for FAM84A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM84A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM84A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    5. Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. (PubMed id 18667531)1 Pebernard S....Boddy M.N. (2008)
    6. A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. (PubMed id 16820875)1 Kobayashi T....Nakamura Y. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for FAM84A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM84A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 151354 HGNC: 20743 AceView: NSE1.1 Ensembl:ENSG00000162981 euGenes: HUgn151354
    ECgene: FAM84A H-InvDB: FAM84A

    Other Databases showing FAM84A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM84A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM84A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM84A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM84A gene:
    Search GeneIP for patents involving FAM84A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM84A gene

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    Advanced Cell Diagnostics
    About This Section

     
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