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Aliases for FAM83G Gene

Aliases for FAM83G Gene

  • Family With Sequence Similarity 83 Member G 2 3 5
  • Protein Associated With SMAD1 2 3 4
  • Family With Sequence Similarity 83, Member G 2 3
  • PAWS1 3 4

External Ids for FAM83G Gene

Previous GeneCards Identifiers for FAM83G Gene

  • GC17M018818
  • GC17M018816
  • GC17M018872
  • GC17M018440

Summaries for FAM83G Gene

GeneCards Summary for FAM83G Gene

FAM83G (Family With Sequence Similarity 83 Member G) is a Protein Coding gene. An important paralog of this gene is FAM83B.

UniProtKB/Swiss-Prot for FAM83G Gene

  • May regulate the bone morphogenetic proteins (BMP) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83G Gene

Genomics for FAM83G Gene

Regulatory Elements for FAM83G Gene

Promoters for FAM83G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM83G on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM83G Gene

Chromosome:
17
Start:
18,968,789 bp from pter
End:
19,004,804 bp from pter
Size:
36,016 bases
Orientation:
Minus strand

Genomic View for FAM83G Gene

Genes around FAM83G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM83G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM83G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83G Gene

Proteins for FAM83G Gene

  • Protein details for FAM83G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND36-FA83G_HUMAN
    Recommended name:
    Protein FAM83G
    Protein Accession:
    A6ND36
    Secondary Accessions:
    • Q3KQZ4
    • Q6ZW60

    Protein attributes for FAM83G Gene

    Size:
    823 amino acids
    Molecular mass:
    90835 Da
    Quaternary structure:
    • Found in a macromolecular complex with SMAD1. Interacts with SMAD1 (via MH2 domain); in a SMAD4-independent manner.

    Alternative splice isoforms for FAM83G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM83G Gene

Proteomics data for FAM83G Gene at MOPED

Post-translational modifications for FAM83G Gene

  • BMP signaling induces the phosphorylation of PAWS1 by BMPR1A at Ser-610, Ser-614 and Ser-616. In response to BMP phosphorylation at Ser-610 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM83G Gene

Domains & Families for FAM83G Gene

Protein Domains for FAM83G Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM83G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6ND36

UniProtKB/Swiss-Prot:

FA83G_HUMAN :
  • Belongs to the FAM83 family.
Family:
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83G: view

No data available for Gene Families for FAM83G Gene

Function for FAM83G Gene

Molecular function for FAM83G Gene

UniProtKB/Swiss-Prot Function:
May regulate the bone morphogenetic proteins (BMP) pathway.
genes like me logo Genes that share phenotypes with FAM83G: view

Animal Models for FAM83G Gene

MGI Knock Outs for FAM83G:

Animal Model Products

CRISPR Products

miRNA for FAM83G Gene

miRTarBase miRNAs that target FAM83G

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM83G Gene

Localization for FAM83G Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM83G Gene

Cytoplasm, cytosol. Nucleus. Note=Detected predominantly in cytosolic. Upon BMP stimulation, a small portion of PAWS1 is detected in the nucleus. {ECO:0000269 PubMed:24554596}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM83G Gene COMPARTMENTS Subcellular localization image for FAM83G gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FAM83G Gene

Pathways & Interactions for FAM83G Gene

SuperPathways for FAM83G Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM83G Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM83G Gene

Drugs & Compounds for FAM83G Gene

No Compound Related Data Available

Transcripts for FAM83G Gene

mRNA/cDNA for FAM83G Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM83G Gene

Family with sequence similarity 83, member G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83G Gene

No ASD Table

Relevant External Links for FAM83G Gene

GeneLoc Exon Structure for
FAM83G
ECgene alternative splicing isoforms for
FAM83G

Expression for FAM83G Gene

mRNA expression in normal human tissues for FAM83G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM83G Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.7), Esophagus - Mucosa (x7.1), and Skin - Not Sun Exposed (Suprapubic) (x7.0).

Protein differential expression in normal tissues from HIPED for FAM83G Gene

This gene is overexpressed in Adipocyte (34.8), Heart (17.7), Esophagus (8.0), and Liver (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM83G Gene



SOURCE GeneReport for Unigene cluster for FAM83G Gene Hs.710727

genes like me logo Genes that share expression patterns with FAM83G: view

Protein tissue co-expression partners for FAM83G Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM83G Gene

Orthologs for FAM83G Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM83G 35
  • 84.28 (n)
  • 82.35 (a)
FAM83G 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM83G 35
  • 84.66 (n)
  • 83.8 (a)
FAM83G 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam83g 35
  • 82.92 (n)
  • 81.16 (a)
Fam83g 16
Fam83g 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM83G 35
  • 99.31 (n)
  • 99.03 (a)
FAM83G 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam83g 35
  • 82.45 (n)
  • 81.18 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM83G 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM83G 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM83G 35
  • 78.67 (n)
  • 79.87 (a)
FAM83G 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM83G 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83g 35
  • 63.39 (n)
  • 60.06 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM83G (1 of 2) 36
  • 44 (a)
OneToMany
FAM83G (2 of 2) 36
  • 19 (a)
OneToMany
Species with no ortholog for FAM83G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83G Gene

ENSEMBL:
Gene Tree for FAM83G (if available)
TreeFam:
Gene Tree for FAM83G (if available)

Paralogs for FAM83G Gene

Paralogs for FAM83G Gene

(2) SIMAP similar genes for FAM83G Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FAM83G Gene

genes like me logo Genes that share paralogs with FAM83G: view

Variants for FAM83G Gene

Sequence variations from dbSNP and Humsavar for FAM83G Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_053903 -
VAR_075713 -
VAR_075714 -

Structural Variations from Database of Genomic Variants (DGV) for FAM83G Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv523721 CNV Gain 19592680
nsv833390 CNV Loss 17160897
nsv907783 CNV Gain 21882294
dgv3080n71 CNV Gain 21882294
nsv833391 CNV Loss 17160897
esv33572 CNV Gain 17666407
nsv907786 CNV Gain 21882294
nsv457699 CNV Gain 19166990
nsv428336 CNV Gain+Loss 18775914
dgv933e1 CNV Complex 17122850
dgv3081n71 CNV Gain 21882294
nsv470581 CNV Gain 18288195
nsv907789 CNV Loss 21882294
dgv3082n71 CNV Loss 21882294
nsv907795 CNV Loss 21882294

Variation tolerance for FAM83G Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM83G Gene

HapMap Linkage Disequilibrium report
FAM83G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83G Gene

Disorders for FAM83G Gene

Relevant External Links for FAM83G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM83G

No disorders were found for FAM83G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83G Gene

Publications for FAM83G Gene

  1. Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling. (PMID: 24554596) Vogt J. … Sapkota G.P. (Open Biol 2014) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PMID: 19531213) Havrylov S. … Redowicz M.J. (Proteome Sci 2009) 3

Products for FAM83G Gene

Sources for FAM83G Gene

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