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Aliases for FAM83F Gene

Aliases for FAM83F Gene

  • Family With Sequence Similarity 83 Member F 2 3 5
  • Family With Sequence Similarity 83, Member F 2

External Ids for FAM83F Gene

Previous GeneCards Identifiers for FAM83F Gene

  • GC22P038716
  • GC22P040390
  • GC22P023353

Summaries for FAM83F Gene

GeneCards Summary for FAM83F Gene

FAM83F (Family With Sequence Similarity 83 Member F) is a Protein Coding gene. An important paralog of this gene is FAM83G.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83F Gene

Genomics for FAM83F Gene

Regulatory Elements for FAM83F Gene

Enhancers for FAM83F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G039958 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -34.3 -34304 4.5 HDGF ATF1 CREB3L1 ARNT TCF12 ZNF121 ZNF766 FOS PAF1 JUNB FAM83F GRAP2 ENTHD1 CACNA1I MIEF1 TNRC6B ENSG00000225528 GC22P039976
GH22G039946 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -45.0 -45020 7.7 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 GRAP2 SNORD83B ENTHD1 FAM83F ENSG00000272834 TNRC6B ENSG00000225528
GH22G039994 1.5 Ensembl ENCODE dbSUPER 14.3 +3.7 3666 8.4 PKNOX1 ATF1 ARNT BRCA1 TCF12 ZNF766 GATA2 ELK1 FOS DEK FAM83F CACNA1I GC22M041227
GH22G039956 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -37.7 -37665 0.6 HDAC1 HDGF TBL1XR1 ZNF143 RCOR1 RELB ETV6 IKZF2 CREM CBFB GRAP2 ENTHD1 FAM83F TNRC6B MIEF1 ENSG00000225528
GH22G039965 1.2 ENCODE dbSUPER 15.7 -27.5 -27501 3.3 PKNOX1 ATF1 TCF12 ZNF766 GATA2 FOS PAF1 JUNB REST ZNF592 FAM83F ENSG00000225528 MIEF1 GC22P039976
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM83F on UCSC Golden Path with GeneCards custom track

Promoters for FAM83F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146424 51 401 RNF2 POLR2A ZFX EZH2

Genomic Location for FAM83F Gene

39,994,949 bp from pter
40,043,529 bp from pter
48,581 bases
Plus strand

Genomic View for FAM83F Gene

Genes around FAM83F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM83F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM83F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83F Gene

Proteins for FAM83F Gene

  • Protein details for FAM83F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM83F
    Protein Accession:
    Secondary Accessions:
    • Q96FD6

    Protein attributes for FAM83F Gene

    500 amino acids
    Molecular mass:
    55486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM83F Gene


neXtProt entry for FAM83F Gene

Post-translational modifications for FAM83F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM83F Gene

Domains & Families for FAM83F Gene

Protein Domains for FAM83F Gene

Suggested Antigen Peptide Sequences for FAM83F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM83 family.
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83F: view

No data available for Gene Families for FAM83F Gene

Function for FAM83F Gene

genes like me logo Genes that share phenotypes with FAM83F: view

Animal Model Products

CRISPR Products

miRNA for FAM83F Gene

miRTarBase miRNAs that target FAM83F

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83F Gene

Localization for FAM83F Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM83F gene
Compartment Confidence
nucleus 2
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM83F Gene

Pathways & Interactions for FAM83F Gene

SuperPathways for FAM83F Gene

No Data Available

Interacting Proteins for FAM83F Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: Q8NEG4-FA83F_HUMAN ENSP00000330432 for FAM83F Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM83F Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM83F Gene

Drugs & Compounds for FAM83F Gene

No Compound Related Data Available

Transcripts for FAM83F Gene

mRNA/cDNA for FAM83F Gene

Unigene Clusters for FAM83F Gene

Family with sequence similarity 83, member F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP2: - - -

Relevant External Links for FAM83F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM83F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM83F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM83F Gene

This gene is overexpressed in Testis (x12.3), Esophagus - Mucosa (x5.6), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for FAM83F Gene

This gene is overexpressed in Cerebrospinal fluid (27.6), Platelet (22.3), Pancreas (7.9), and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM83F Gene

Protein tissue co-expression partners for FAM83F Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM83F Gene:


SOURCE GeneReport for Unigene cluster for FAM83F Gene:

genes like me logo Genes that share expression patterns with FAM83F: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM83F Gene

Orthologs for FAM83F Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM83F 34 35
  • 99.4 (n)
(Bos Taurus)
Mammalia FAM83F 34 35
  • 86.51 (n)
(Canis familiaris)
Mammalia FAM83F 34 35
  • 85.33 (n)
(Mus musculus)
Mammalia Fam83f 34 16 35
  • 83.44 (n)
(Rattus norvegicus)
Mammalia Fam83f 34
  • 83.27 (n)
(Ornithorhynchus anatinus)
Mammalia FAM83F 35
  • 77 (a)
(Monodelphis domestica)
Mammalia FAM83F 35
  • 62 (a)
(Gallus gallus)
Aves FAM83F 34 35
  • 64.79 (n)
(Anolis carolinensis)
Reptilia FAM83F 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83f 34
  • 62.05 (n)
(Danio rerio)
Actinopterygii si:dkey-165i8.3 34
  • 58.5 (n)
fam83fb 35
  • 36 (a)
FAM83F (2 of 2) 35
  • 32 (a)
Species where no ortholog for FAM83F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83F Gene

Gene Tree for FAM83F (if available)
Gene Tree for FAM83F (if available)

Paralogs for FAM83F Gene

Paralogs for FAM83F Gene

(2) SIMAP similar genes for FAM83F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM83F: view

Variants for FAM83F Gene

Sequence variations from dbSNP and Humsavar for FAM83F Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_038136 A breast cancer sample
rs1000084727 -- 40,028,595(+) CCTCC(A/G)GAGGT intron-variant
rs1000185687 -- 40,027,681(+) TGTCC(A/G)GGGCT intron-variant
rs1000261142 -- 40,025,398(+) TGGAC(A/G)ACAGA intron-variant
rs1000277988 -- 40,017,145(+) CAGAG(A/C)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM83F Gene

Variant ID Type Subtype PubMed ID
esv2452848 CNV insertion 19546169
esv2676686 CNV deletion 23128226
esv3375117 CNV duplication 20981092
esv3647769 CNV loss 21293372
esv3647771 CNV loss 21293372
nsv1109469 CNV deletion 24896259
nsv829229 CNV loss 20364138
nsv834201 CNV gain 17160897
nsv955160 CNV deletion 24416366

Variation tolerance for FAM83F Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.58; 88.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM83F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83F Gene

Disorders for FAM83F Gene

Relevant External Links for FAM83F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM83F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83F Gene

Publications for FAM83F Gene

  1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PMID: 17342744) Dall'Era M.A. … Liu A.Y. (Prostate 2007) 3 64

Products for FAM83F Gene

Sources for FAM83F Gene

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