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Aliases for FAM83E Gene

Aliases for FAM83E Gene

  • Family With Sequence Similarity 83, Member E 2 3

External Ids for FAM83E Gene

Previous GeneCards Identifiers for FAM83E Gene

  • GC19M053796
  • GC19M049103
  • GC19M045482

Summaries for FAM83E Gene

GeneCards Summary for FAM83E Gene

FAM83E (Family With Sequence Similarity 83, Member E) is a Protein Coding gene. An important paralog of this gene is FAM83D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83E Gene

Genomics for FAM83E Gene

Regulatory Elements for FAM83E Gene

Genomic Location for FAM83E Gene

Start:
48,600,600 bp from pter
End:
48,614,854 bp from pter
Size:
14,255 bases
Orientation:
Minus strand

Genomic View for FAM83E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM83E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83E Gene

Proteins for FAM83E Gene

  • Protein details for FAM83E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2I3-FA83E_HUMAN
    Recommended name:
    Protein FAM83E
    Protein Accession:
    Q2M2I3
    Secondary Accessions:
    • Q9NXK1

    Protein attributes for FAM83E Gene

    Size:
    478 amino acids
    Molecular mass:
    51780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM83E Gene

Proteomics data for FAM83E Gene at MOPED

Post-translational modifications for FAM83E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM83E Gene

Domains for FAM83E Gene

Protein Domains for FAM83E Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM83E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M2I3

UniProtKB/Swiss-Prot:

FA83E_HUMAN :
  • Q2M2I3
Family:
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83E: view

No data available for Gene Families for FAM83E Gene

Function for FAM83E Gene

Phenotypes for FAM83E Gene

GenomeRNAi human phenotypes for FAM83E:
genes like me logo Genes that share phenotypes with FAM83E: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM83E Gene

Localization for FAM83E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM83E Gene COMPARTMENTS Subcellular localization image for FAM83E gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM83E Gene

Pathways for FAM83E Gene

SuperPathways for FAM83E Gene

No Data Available

Interacting Proteins for FAM83E Gene

Gene Ontology (GO) - Biological Process for FAM83E Gene

None

No data available for Pathways by source for FAM83E Gene

Transcripts for FAM83E Gene

mRNA/cDNA for FAM83E Gene

Unigene Clusters for FAM83E Gene

Family with sequence similarity 83, member E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83E Gene

No ASD Table

Relevant External Links for FAM83E Gene

GeneLoc Exon Structure for
FAM83E
ECgene alternative splicing isoforms for
FAM83E

Expression for FAM83E Gene

mRNA expression in normal human tissues for FAM83E Gene

mRNA differential expression in normal tissues according to GTEx for FAM83E Gene

This gene is overexpressed in Colon - Transverse (16.3), Small Intestine - Terminal Ileum (7.1), Minor Salivary Gland (6.6), and Stomach (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM83E Gene

SOURCE GeneReport for Unigene cluster for FAM83E Gene Hs.165803

genes like me logo Genes that share expressions with FAM83E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM83E Gene

Orthologs for FAM83E Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM83E 35
  • 99.3 (n)
  • 99.58 (a)
FAM83E 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM83E 35
  • 83.44 (n)
  • 79.87 (a)
FAM83E 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM83E 35
  • 82.7 (n)
  • 81.3 (a)
FAM83E 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam83e 35
  • 76.06 (n)
  • 73.76 (a)
Fam83e 16
Fam83e 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM83E 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM83E 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam83e 35
  • 75.34 (n)
  • 74.19 (a)
lizard
(Anolis carolinensis)
Reptilia FAM83E 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83e 35
  • 55.59 (n)
  • 51.25 (a)
zebrafish
(Danio rerio)
Actinopterygii CR762484.3 36
  • 22 (a)
OneToOne
Species with no ortholog for FAM83E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83E Gene

ENSEMBL:
Gene Tree for FAM83E (if available)
TreeFam:
Gene Tree for FAM83E (if available)

Paralogs for FAM83E Gene

Paralogs for FAM83E Gene

Selected SIMAP similar genes for FAM83E Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM83E: view

Variants for FAM83E Gene

Sequence variations from dbSNP and Humsavar for FAM83E Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs368654 -- 48,613,298(+) TATAG(A/G)AAGCC synonymous-codon, reference
rs374886 -- 48,613,990(+) CAGTC(A/G)CAGTA upstream-variant-2KB, utr-variant-5-prime
rs376524 -- 48,613,181(+) CCCTG(A/G)ACCTC synonymous-codon, reference
rs378333 -- 48,600,262(-) GCAGC(A/G)GATCC downstream-variant-500B
rs390881 -- 48,601,482(-) tggcc(A/G)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM83E Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912228 CNV Loss 21882294
nsv138413 CNV Loss 16902084
nsv912234 CNV Loss 21882294

Relevant External Links for FAM83E Gene

HapMap Linkage Disequilibrium report
FAM83E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83E Gene

Disorders for FAM83E Gene

Relevant External Links for FAM83E

Genetic Association Database (GAD)
FAM83E
Human Genome Epidemiology (HuGE) Navigator
FAM83E
genes like me logo Genes that share disorders with FAM83E: view

No data available for UniProtKB/Swiss-Prot for FAM83E Gene

Publications for FAM83E Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3
  3. Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. (PMID: 24941225) Liang Y. … Peng T. (PLoS ONE 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for FAM83E Gene

Sources for FAM83E Gene

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