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FAM83D Gene

protein-coding   GIFtS: 41
GCID: GC20P037554

Family With Sequence Similarity 83, Member D

(Previous name: chromosome 20 open reading frame 129)
(Previous symbol: C20orf129)
  Search for FAM83D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 83, Member D1 2     CHICA2
C20orf1291 2 3     dJ616B8.32
Spindle Protein CHICA2 3     Protein FAM83D2
Chromosome 20 Open Reading Frame 1291     

External Ids:    HGNC: 161221   Entrez Gene: 816102   Ensembl: ENSG000001014477   UniProtKB: Q9H4H83   

Export aliases for FAM83D gene to outside databases

Previous GC identifers: GC20P036989 GC20P034292


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM83D Gene:
FAM83D (family with sequence similarity 83, member D) is a protein-coding gene. An important paralog of this gene is FAM83H.

UniProtKB/Swiss-Prot: FA83D_HUMAN, Q9H4H8
Function: Required for proper chromosome congression and alignment during mitosis. Required for targeting
KIF22/KID to the spindle microtubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM83D gene promoter:
         p53   Pax-5   POU3F1   E4BP4   E47   AREB6   Max   Hand1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM83D promoter sequence
   Search Chromatin IP Primers for FAM83D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM83D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

FAM83D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM83D gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037554:  view genomic region     (about GC identifiers)

Start:
37,554,955 bp from pter      End:
37,581,703 bp from pter
Size:
26,749 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FA83D_HUMAN, Q9H4H8 (See protein sequence)
Recommended Name: Protein FAM83D  
Size: 585 amino acids; 64424 Da
Subunit: Interacts with KIF22/KID
Miscellaneous: Was named CHICA (girl in Spanish) because it interacts with KID
Sequence caution: Sequence=AAH01068.2; Type=Erroneous initiation; Sequence=AAH06553.3; Type=Erroneous initiation;
Sequence=AAH53683.1; Type=Erroneous initiation; Sequence=AAH63661.1; Type=Erroneous initiation;
Sequence=AAH80188.1; Type=Erroneous initiation; Sequence=BAB71016.1; Type=Erroneous termination; Positions=262;
Note=Translated as Trp; Sequence=CAI22033.1; Type=Erroneous initiation;
Secondary accessions: B4E1I7 Q5THR2 Q68EN1 Q6P457 Q7Z6H0 Q96DF5 Q96N89 Q9BVM8
Alternative splicing: 2 isoforms:  Q9H4H8-1   Q9H4H8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM83D: NX_Q9H4H8

Explore proteomics data for FAM83D at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys149, Lys310
  • Modification sites at PhosphoSitePlus

  • See FAM83D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112181.2  
    ENSEMBL proteins: 
     ENSP00000217429  

    FAM83D Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for FAM83D
    Cloud-Clone Corp. CLIAs for FAM83D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012461 DUF1669

    Graphical View of Domain Structure for InterPro Entry Q9H4H8

    ProtoNet protein and cluster: Q9H4H8

    1 Blocks protein domain: IPB012461 Protein of unknown function DUF1669

    UniProtKB/Swiss-Prot: FA83D_HUMAN, Q9H4H8
    Similarity: Belongs to the FAM83 family


    FAM83D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA83D_HUMAN, Q9H4H8
    Function: Required for proper chromosome congression and alignment during mitosis. Required for targeting
    KIF22/KID to the spindle microtubules

    Phenotypes:
         2 GenomeRNAi human phenotypes for FAM83D:

     Increased gamma-H2AX phosphory  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM83D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM83D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM83D

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM83D:
    hsa-mir-215-5p (MIRT024511), hsa-mir-192-5p (MIRT026481), hsa-mir-124-3p (MIRT022620)

    Block miRNA regulation of human, mouse, rat FAM83D using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FAM83D:
    hsa-miR-19b hsa-miR-4255 hsa-miR-19a hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidFAM83D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM83D
    Predesigned siRNA for gene silencing in human, mouse, rat FAM83D

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FAM83D (NM_030919)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM83D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM83D

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM83D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA83D_HUMAN, Q9H4H8: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
    Note=Primarily cytoplasmic during interphase, but beginning in prophase, associates with spindle microtubules,
    with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and
    anaphase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IEA--

    FAM83D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM83D
    Interactions:

        Search GeneGlobe Interaction Network for FAM83D

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for FAM83D (Q9H4H82, 3 ENSP000002174294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1EP496742, 3MINT-8252736 I2D: score=2 
    DYNC1I1O145762, 3MINT-8254866 I2D: score=2 
    GADD45AP245222, 3MINT-8255794 I2D: score=2 
    GSK3BP498412, 3MINT-8257196 I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--

    FAM83D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM83D (FA83D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM83D gene: 
    NM_030919.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000217429(uc002xjf.3 uc002xjg.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM83D using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FAM83D:
    hsa-miR-19b hsa-miR-4255 hsa-miR-19a hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidFAM83D 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM83D
    Predesigned siRNA for gene silencing in human, mouse, rat FAM83D
    Clone
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    OriGene clones in human, mouse for FAM83D (see all 8)
    OriGene ORF clones in mouse, rat for FAM83D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM83D (NM_030919)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM83D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM83D
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM83D
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM83D
      QuantiTect SYBR Green Assays in human, mouse, rat FAM83D
      QuantiFast Probe-based Assays in human, mouse, rat FAM83D

    Selected AceView cDNA sequences (see all 353):

    NM_015568 BQ054956 BX953060 BQ057952 BQ773664 CB044475 CR610227 Z44472 
    CF135965 AA486490 AI689511 BF196542 BQ063362 BU849415 BQ008740 BG180317 
    BF970611 AW500225 AI762143 AA488678 AW575805 AI796725 AI057204 CR594147 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM83D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTACAGGT
    FAM83D Expression
    About this image

    FAM83D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM83D Protein Expression
        Custom PCR Arrays for FAM83D
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM83D
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM83D
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    QuantiFast Probe-based Assays in human, mouse, rat FAM83D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM83D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM83D gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam83d1 , 5 family with sequence similarity 83, member D1, 5 79.17(n)1
    77.8(a)1
      2 (78.73 cM)5
    718781  NM_027975.21  NP_082251.21 
     1587680935 
    chicken
    (Gallus gallus)
    Aves FAM83D1 family with sequence similarity 83, member D 69.48(n)
    63.73(a)
      419171  XM_417351.4  XP_417351.4 
    lizard
    (Anolis carolinensis)
    Reptilia FAM83D6
    family with sequence similarity 83, member D
    51(a)
    1 ↔ 1
    4(140925095-140953979)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334032 Xenopus laevis transcribed sequence with weak similarity more 72.45(n)    CA788959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam83d1 family with sequence similarity 83, member D 53.98(n)
    47.97(a)
      492689  NM_001089355.1  NP_001082824.1 


    ENSEMBL Gene Tree for FAM83D (if available)
    TreeFam Gene Tree for FAM83D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM83D gene
    FAM83H2  FAM83C2  FAM83G2  FAM83E2  FAM83A2  FAM83B2  FAM83F2  

    FAM83D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM83D
    PGOHUM00000247655


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM83D (see all 610)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558615101,2
    C--37552957(+) ACATGA/GAAGTC 1 -- us2k10--------
    rs590029751,2
    C,F--37552961(+) GGAAGT/GCCCCA 1 -- us2k13Minor allele frequency- G:0.13WA NA EA 358
    rs1427306331,2
    --37552964(+) AGTCCC/GCACAC 1 -- us2k10--------
    rs1816525131,2
    --37553044(+) ACAGCA/GGCAGG 1 -- us2k10--------
    rs1400400441,2
    --37553234(+) CTGATG/TGAAGA 1 -- us2k10--------
    rs1175133861,2
    F--37553345(+) TGTCAC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs622013941,2
    F--37553476(+) TAGGCG/ACACCA 1 -- us2k12Minor allele frequency- A:0.05NA WA 120
    rs1441429941,2
    --37553501(+) CTTTTC/GTATTT 1 -- us2k10--------
    rs1868543451,2
    --37553513(+) TTTGTA/GAAGAC 1 -- us2k10--------
    rs1451310081,2
    --37553674(+) GGGGAA/GCTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM83D (37554955 - 37581703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM83D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3374CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM83D
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM83D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM83D gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with FAM83D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of the expression of the mitosis-related gene Fam83D. (PubMed id 23205133)1, 3 Varisli L. (Oncol Lett 2012)
    2. The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. (PubMed id 18485706)1, 2 Santamaria A.... Nigg E.A. (Curr. Biol. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81610 HGNC: 16122 AceView: PPP1R16BandC20orf129 Ensembl:ENSG00000101447 euGenes: HUgn81610
    ECgene: FAM83D H-InvDB: FAM83D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM83D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM83D gene:
    Search GeneIP for patents involving FAM83D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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