Aliases for FAM83C Gene
Aliases for FAM83C Gene
External Ids for FAM83C Gene
- HGNC: 16121
- Entrez Gene: 128876
- Ensembl: ENSG00000125998
- UniProtKB: Q9BQN1
Previous HGNC Symbols for FAM83C Gene
- C20orf128
Previous GeneCards Identifiers for FAM83C Gene
- GC20M033337
- GC20M033874
- GC20M030650
- GC20M033875
- GC20M033878
- GC20M033882
- GC20M033886
Summaries for FAM83C Gene
-
This gene encodes a member of the family with sequence similarity 83 protein family. The encoded protein may be involved in regulating MAPK signaling in cancer cells. [provided by RefSeq, Mar 2017]
GeneCards Summary for FAM83C Gene
FAM83C (Family With Sequence Similarity 83 Member C) is a Protein Coding gene. An important paralog of this gene is FAM83A.
UniProtKB/Swiss-Prot for FAM83C Gene
-
May play a role in MAPK signaling.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83C Gene
Genomics for FAM83C Gene
Regulatory Elements for FAM83C Gene
Enhancers for FAM83C Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM83C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM83C gene promoter:
Regulatory Element Products
Genomic Location for FAM83C Gene
- Chromosome:
- 20
- Start:
- 35,285,731 bp from pter
- End:
- 35,292,422 bp from pter
- Size:
- 6,692 bases
- Orientation:
- Minus strand
Genomic View for FAM83C Gene
Genes around FAM83C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.22 by Ensembl
- 20q11.22 by Entrez Gene
- 20q11.22 by HGNC
FAM83C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM83C Gene
Proteins for FAM83C Gene
-
Protein details for FAM83C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQN1-FA83C_HUMAN
- Recommended name:
- Protein FAM83C
- Protein Accession:
- Q9BQN1
- Q14D67
- Q5JWN6
- Q8N276
Protein attributes for FAM83C Gene
- Size:
- 747 amino acids
- Molecular mass:
- 81078 Da
- Quaternary structure:
-
- May interact with RAF1.
- SequenceCaution:
-
- Sequence=BAC03594.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for FAM83C Gene
Selected DME Specific Peptides for FAM83C Gene
- Q9BQN1:
-
- RGAPALS
- PVYLLLA
Post-translational modifications for FAM83C Gene
Other Protein References for FAM83C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FAM83C
-
Abcam antibodies for FAM83C
- Invitrogen Antibodies for FAM83C
- Search GeneTex for Antibodies for FAM83C
-
Santa Cruz Biotechnology (SCBT) Antibodies for FAM83C
Protein Products
-
OriGene Purified Proteins for FAM83C
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM83C
- Origene Custom Protein Services for FAM83C
- Novus Biologicals proteins for FAM83C
- Search GeneTex for Proteins for FAM83C
Assay Products
Domains & Families for FAM83C Gene
Protein Domains for FAM83C Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM83C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BQN1- Family:
-
- Belongs to the FAM83 family.
No data available for Gene Families for FAM83C Gene
Function for FAM83C Gene
Molecular function for FAM83C Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in MAPK signaling.
Enzyme Numbers (IUBMB) for FAM83C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019901 | protein kinase binding | IPI | 24736947 |
Phenotypes for FAM83C Gene
- GenomeRNAi human phenotypes for FAM83C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM83C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM83C gene
- Search ViGene Biosciences for FAM83C
CRISPR Products
-
OriGene CRISPR knockouts for FAM83C
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM83C
- GenScript: Design CRISPR guide RNA sequences for FAM83C
miRNA for FAM83C Gene
- miRTarBase miRNAs that target FAM83C
-
- hsa-mir-6867-5p (MIRT483218)
- hsa-mir-3682-3p (MIRT483219)
- hsa-mir-1272 (MIRT483220)
- hsa-mir-580-5p (MIRT483221)
- hsa-mir-545-3p (MIRT499159)
- hsa-mir-451b (MIRT499160)
- hsa-mir-512-5p (MIRT499161)
- hsa-mir-574-5p (MIRT528254)
- hsa-mir-4455 (MIRT528255)
- hsa-mir-4664-3p (MIRT573829)
- hsa-mir-1180-3p (MIRT573830)
- hsa-mir-4497 (MIRT573831)
- hsa-mir-6807-5p (MIRT628660)
- hsa-mir-526b-5p (MIRT628661)
- hsa-mir-3177-5p (MIRT628662)
- hsa-mir-1233-3p (MIRT628663)
- hsa-mir-1225-3p (MIRT628664)
- hsa-mir-4801 (MIRT628665)
- hsa-mir-4731-3p (MIRT628666)
- hsa-mir-3650 (MIRT640735)
miRNA Products
- Search ViGene Biosciences for FAM83C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM83C
- Browse OriGene Inhibitory RNA Products For FAM83C
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM83C gene
Clone Products
-
OriGene ORF clones in human for FAM83C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM83C
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM83C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM83C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM83C gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83C Gene
Localization for FAM83C Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM83C Gene
Pathways & Interactions for FAM83C Gene
No Data Available
Interacting Proteins for FAM83C Gene
No data available for Pathways by source and SIGNOR curated interactions for FAM83C Gene
Transcripts for FAM83C Gene
mRNA/cDNA for FAM83C Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM83C Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM83C
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM83C
- GenScript: Design CRISPR guide RNA sequences for FAM83C
miRNA Products
- Search ViGene Biosciences for FAM83C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM83C
- Browse OriGene Inhibitory RNA Products For FAM83C
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM83C gene
Clone Products
-
OriGene ORF clones in human for FAM83C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FAM83C Gene
mRNA differential expression in normal tissues according to GTEx for FAM83C Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.4), Skin - Not Sun Exposed (Suprapubic) (x14.7), Esophagus - Mucosa (x12.5), and Vagina (x4.9).
This gene is overexpressed in Heart (50.7) and Adipocyte (15.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM83C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FAM83C Gene:
FAM83CSOURCE GeneReport for Unigene cluster for FAM83C Gene:
Hs.592149Primer Products
-
OriGene qPCR primer pairs for FAM83C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM83C Gene
Orthologs for FAM83C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM83C 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM83C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM83C 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam83c 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam83c 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM83C 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM83C 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FAM83C 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CR388068.1 35 |
|
OneToOne |
- Species where no ortholog for FAM83C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM83C Gene
Variants for FAM83C Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs193920940 | Uncertain significance | 35,287,916(-) | GGGCC(A/G)CATCG | reference, missense | |
| rs1000003474 | -- | 35,292,898(+) | CAAAC(A/G)CCGAT | upstream-variant-2KB | |
| rs1000150706 | -- | 35,286,300(+) | CTCTA(C/T)AGGCC | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000354933 | -- | 35,293,074(+) | CTGCC(A/G)CTCTC | upstream-variant-2KB | |
| rs1000752082 | -- | 35,288,775(+) | CTGCC(C/T)CTGGT | intron-variant |
Residual Variation Intolerance Score:
82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.59;
86.17% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM83C Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83C Gene
Disorders for FAM83C Gene
Relevant External Links for FAM83C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM83C
No disorders were found for FAM83C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83C Gene
Publications for FAM83C Gene
- Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. (PMID: 24736947) Cipriano R. … Jackson M.W. (Mol. Cancer Res. 2014) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 3 64
Products for FAM83C Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Cell Culture Products
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for FAM83C
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- OriGene qPCR primer pairs for FAM83C
- OriGene CRISPR knockouts for FAM83C
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- GenScript: Next-day shipping cDNA ORF clone for FAM83C in any vector
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- GenScript: Design CRISPR guide RNA sequences for FAM83C
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- Novus Biologicals Antibodies for FAM83C
- Novus Biologicals proteins for FAM83C
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FAM83C gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM83C gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM83C gene
- Search ViGene Biosciences for FAM83C
- Santa Cruz Biotechnology (SCBT) Antibodies for FAM83C
- Search Santa Cruz Biotechnology (SCBT) for FAM83C siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FAM83C
- Horizon Cell Lines for FAM83C
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM83C
- VectorBuilder custom plasmid, inducible vectors for FAM83C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM83C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM83C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer