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Aliases for FAM83C Gene

Aliases for FAM83C Gene

  • Family With Sequence Similarity 83, Member C 2 3
  • C20orf128 3 4
  • Chromosome 20 Open Reading Frame 128 2
  • EC 6.3.5.3 63
  • DJ614O4.7 3
  • EC 1.6.5 63

External Ids for FAM83C Gene

Previous HGNC Symbols for FAM83C Gene

  • C20orf128

Previous GeneCards Identifiers for FAM83C Gene

  • GC20M033337
  • GC20M033874
  • GC20M030650
  • GC20M033875
  • GC20M033878
  • GC20M033882
  • GC20M033886

Summaries for FAM83C Gene

GeneCards Summary for FAM83C Gene

FAM83C (Family With Sequence Similarity 83, Member C) is a Protein Coding gene. An important paralog of this gene is FAM83D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83C Gene

Genomics for FAM83C Gene

Regulatory Elements for FAM83C Gene

Transcription factor binding sites by QIAGEN in the FAM83C gene promoter:

Genomic Location for FAM83C Gene

Chromosome:
20
Start:
35,285,731 bp from pter
End:
35,292,422 bp from pter
Size:
6,692 bases
Orientation:
Minus strand

Genomic View for FAM83C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM83C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83C Gene

Proteins for FAM83C Gene

  • Protein details for FAM83C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQN1-FA83C_HUMAN
    Recommended name:
    Protein FAM83C
    Protein Accession:
    Q9BQN1
    Secondary Accessions:
    • Q14D67
    • Q5JWN6
    • Q8N276

    Protein attributes for FAM83C Gene

    Size:
    747 amino acids
    Molecular mass:
    81078 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03594.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM83C Gene

Proteomics data for FAM83C Gene at MOPED

Selected DME Specific Peptides for FAM83C Gene

Post-translational modifications for FAM83C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83C Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FAM83C Gene

Protein Domains for FAM83C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM83C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQN1

UniProtKB/Swiss-Prot:

FA83C_HUMAN :
  • Belongs to the FAM83 family.
Family:
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83C: view

No data available for Gene Families for FAM83C Gene

Function for FAM83C Gene

Enzyme Numbers (IUBMB) for FAM83C Gene

Gene Ontology (GO) - Molecular Function for FAM83C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 24736947
genes like me logo Genes that share ontologies with FAM83C: view

Phenotypes for FAM83C Gene

genes like me logo Genes that share phenotypes with FAM83C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM83C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83C Gene

Localization for FAM83C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM83C Gene

Pathways & Interactions for FAM83C Gene

SuperPathways for FAM83C Gene

No Data Available

Interacting Proteins for FAM83C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363529%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9BQN1-FA83C_HUMAN ENSP00000363529 for FAM83C Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FAM83C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM83C Gene

Drugs & Compounds for FAM83C Gene

No Compound Related Data Available

Transcripts for FAM83C Gene

mRNA/cDNA for FAM83C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM83C Gene

Family with sequence similarity 83, member C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM83C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83C Gene

No ASD Table

Relevant External Links for FAM83C Gene

GeneLoc Exon Structure for
FAM83C
ECgene alternative splicing isoforms for
FAM83C

Expression for FAM83C Gene

mRNA expression in normal human tissues for FAM83C Gene

mRNA differential expression in normal tissues according to GTEx for FAM83C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.4), Skin - Not Sun Exposed (Suprapubic) (x14.7), Esophagus - Mucosa (x12.5), and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for FAM83C Gene

This gene is overexpressed in Heart (50.7) and Adipocyte (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM83C Gene



SOURCE GeneReport for Unigene cluster for FAM83C Gene Hs.592149

genes like me logo Genes that share expression patterns with FAM83C: view

Protein tissue co-expression partners for FAM83C Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM83C Gene

Orthologs for FAM83C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM83C 35
  • 84.34 (n)
  • 80.27 (a)
FAM83C 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM83C 35
  • 84.97 (n)
  • 81.88 (a)
FAM83C 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam83c 35
  • 81.76 (n)
  • 79.75 (a)
Fam83c 16
Fam83c 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM83C 35
  • 99.2 (n)
  • 99.06 (a)
FAM83C 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam83c 35
  • 81.65 (n)
  • 79.78 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM83C 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM83C 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM83C 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR388068.1 36
  • 39 (a)
OneToOne
Species with no ortholog for FAM83C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83C Gene

ENSEMBL:
Gene Tree for FAM83C (if available)
TreeFam:
Gene Tree for FAM83C (if available)

Paralogs for FAM83C Gene

Paralogs for FAM83C Gene

genes like me logo Genes that share paralogs with FAM83C: view

Variants for FAM83C Gene

Sequence variations from dbSNP and Humsavar for FAM83C Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1538206 -- 35,288,164(+) TGGGC(A/T)CATGG intron-variant
rs2425049 - 35,286,917(+) GTGCC(C/T)GTCTG missense, reference
rs2425050 -- 35,291,675(+) GCCAG(A/G)GGTGC intron-variant
rs2425051 -- 35,292,560(+) GTGCC(A/T)GGCCC upstream-variant-2KB
rs2425052 -- 35,292,926(+) CCCCC(A/C)CAACA upstream-variant-2KB

Variation tolerance for FAM83C Gene

Residual Variation Intolerance Score: 82.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM83C Gene

HapMap Linkage Disequilibrium report
FAM83C
Human Gene Mutation Database (HGMD)
FAM83C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM83C Gene

Disorders for FAM83C Gene

Relevant External Links for FAM83C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM83C
genes like me logo Genes that share disorders with FAM83C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83C Gene

Publications for FAM83C Gene

  1. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. (PMID: 24736947) Cipriano R. … Jackson M.W. (Mol. Cancer Res. 2014) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for FAM83C Gene

Sources for FAM83C Gene

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