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Aliases for FAM83B Gene

Aliases for FAM83B Gene

  • Family With Sequence Similarity 83, Member B 2 3
  • C6orf143 3 4
  • Chromosome 6 Open Reading Frame 143 2
  • Protein FAM83B 3

External Ids for FAM83B Gene

Previous HGNC Symbols for FAM83B Gene

  • C6orf143

Previous GeneCards Identifiers for FAM83B Gene

  • GC06P054820
  • GC06P054711
  • GC06P054545

Summaries for FAM83B Gene

GeneCards Summary for FAM83B Gene

FAM83B (Family With Sequence Similarity 83, Member B) is a Protein Coding gene. An important paralog of this gene is FAM83D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83B Gene

Genomics for FAM83B Gene

Regulatory Elements for FAM83B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM83B Gene

54,846,687 bp from pter
54,945,099 bp from pter
98,413 bases
Plus strand

Genomic View for FAM83B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM83B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83B Gene

Proteins for FAM83B Gene

  • Protein details for FAM83B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM83B
    Protein Accession:
    Secondary Accessions:
    • Q2M1P3
    • Q96DQ2

    Protein attributes for FAM83B Gene

    1011 amino acids
    Molecular mass:
    114799 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM83B Gene

Proteomics data for FAM83B Gene at MOPED

Post-translational modifications for FAM83B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM83B Gene

Domains for FAM83B Gene

Protein Domains for FAM83B Gene


Suggested Antigen Peptide Sequences for FAM83B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM83 family.
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83B: view

No data available for Gene Families for FAM83B Gene

Function for FAM83B Gene

Phenotypes for FAM83B Gene

genes like me logo Genes that share phenotypes with FAM83B: view

Animal Model Products

CRISPR Products

miRNA for FAM83B Gene

miRTarBase miRNAs that target FAM83B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM83B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83B Gene

Localization for FAM83B Gene

Subcellular locations from

Jensen Localization Image for FAM83B Gene COMPARTMENTS Subcellular localization image for FAM83B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM83B Gene

Pathways for FAM83B Gene

SuperPathways for FAM83B Gene

No Data Available

Interacting Proteins for FAM83B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000304078 for FAM83B Gene via STRING

Gene Ontology (GO) - Biological Process for FAM83B Gene


No data available for Pathways by source for FAM83B Gene

Transcripts for FAM83B Gene

mRNA/cDNA for FAM83B Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM83B Gene

Family with sequence similarity 83, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM83B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83B Gene

No ASD Table

Relevant External Links for FAM83B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM83B Gene

mRNA expression in normal human tissues for FAM83B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM83B Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.6), Skin - Sun Exposed (Lower leg) (10.6), Esophagus - Mucosa (8.5), and Vagina (4.8).

Protein differential expression in normal tissues for FAM83B Gene

This gene is overexpressed in Placenta (54.0) and Islet of Langerhans (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM83B Gene

SOURCE GeneReport for Unigene cluster for FAM83B Gene Hs.152423

genes like me logo Genes that share expressions with FAM83B: view

Expression partners for FAM83B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM83B Gene

Orthologs for FAM83B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM83B 35
  • 85.05 (n)
  • 84.18 (a)
FAM83B 36
  • 84 (a)
(Canis familiaris)
Mammalia FAM83B 35
  • 89.44 (n)
  • 89.01 (a)
FAM83B 36
  • 89 (a)
(Mus musculus)
Mammalia Fam83b 35
  • 82.2 (n)
  • 81.5 (a)
Fam83b 16
Fam83b 36
  • 81 (a)
(Pan troglodytes)
Mammalia FAM83B 35
  • 99.44 (n)
  • 99.21 (a)
FAM83B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam83b 35
  • 81.89 (n)
  • 82.22 (a)
(Monodelphis domestica)
Mammalia FAM83B 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FAM83B 36
  • 75 (a)
(Gallus gallus)
Aves FAM83B 35
  • 70.76 (n)
  • 67.37 (a)
FAM83B 36
  • 65 (a)
(Anolis carolinensis)
Reptilia FAM83B 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83b 35
  • 62.13 (n)
  • 56.44 (a)
(Danio rerio)
Actinopterygii fam83b 35
  • 51.1 (n)
  • 42.84 (a)
fam83b 36
  • 37 (a)
Species with no ortholog for FAM83B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83B Gene

Gene Tree for FAM83B (if available)
Gene Tree for FAM83B (if available)

Paralogs for FAM83B Gene

Paralogs for FAM83B Gene

genes like me logo Genes that share paralogs with FAM83B: view

Variants for FAM83B Gene

Sequence variations from dbSNP and Humsavar for FAM83B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs148109 -- 54,894,428(+) ATATG(A/G)TACGC intron-variant
rs171224 -- 54,942,208(-) CAAAT(A/C)ATGTG utr-variant-3-prime
rs171225 -- 54,912,849(-) CTTCT(C/T)TTGGA intron-variant
rs171226 -- 54,908,276(-) ATAAA(A/G)AAATA intron-variant
rs181155 -- 54,887,895(-) ACTAT(A/G)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM83B Gene

Variant ID Type Subtype PubMed ID
nsv885900 CNV Gain 21882294
esv269420 CNV Insertion 20981092
esv2732102 CNV Deletion 23290073
nsv5308 CNV Insertion 18451855
esv2675172 CNV Deletion 23128226
esv2732103 CNV Deletion 23290073
esv271389 CNV Insertion 20981092
esv2678553 CNV Deletion 23128226
esv2732104 CNV Deletion 23290073

Relevant External Links for FAM83B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83B Gene

Disorders for FAM83B Gene

Relevant External Links for FAM83B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FAM83B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM83B Gene

Publications for FAM83B Gene

  1. FAM83B mediates EGFR- and RAS-driven oncogenic transformation. (PMID: 22886302) Cipriano R. … Jackson M.W. (J. Clin. Invest. 2012) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for FAM83B Gene

Sources for FAM83B Gene

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