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Aliases for FAM83A Gene

Aliases for FAM83A Gene

  • Family With Sequence Similarity 83 Member A 2 3 5
  • Tumor-Specific Gene Expressed In Prostate Protein 3 4
  • Tumor Antigen BJ-TSA-9 3 4
  • Family With Sequence Similarity 83, Member A 2
  • Protein FAM83A 3
  • BJ-TSA-9 3
  • TSGP 4

External Ids for FAM83A Gene

Previous GeneCards Identifiers for FAM83A Gene

  • GC08P124261
  • GC08P124194
  • GC08P119520

Summaries for FAM83A Gene

GeneCards Summary for FAM83A Gene

FAM83A (Family With Sequence Similarity 83 Member A) is a Protein Coding gene. An important paralog of this gene is FAM83C.

UniProtKB/Swiss-Prot for FAM83A Gene

  • Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83A Gene

Genomics for FAM83A Gene

Regulatory Elements for FAM83A Gene

Enhancers for FAM83A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G123181 1.6 Ensembl ENCODE dbSUPER 14 +4.4 4399 4.5 HDGF PKNOX1 ARNT AGO1 SIN3A YBX1 ZBTB7B YY1 ZNF766 CBX5 FAM83A-AS1 FAM83A WDYHV1 ENSG00000253258 ENSG00000253410
GH08G123148 1.1 ENCODE dbSUPER 19.3 -29.7 -29677 1.4 INSM2 TCF12 FOS CREM ZBTB2 JUNB ZEB2 REST MTA1 SMARCA4 FAM83A FAM83A-AS1 ENSG00000221461 ENSG00000253258 DERL1 TBC1D31 ENSG00000238901 ENSG00000253607 RNU6-875P MIR548AA1
GH08G123155 1.7 Ensembl ENCODE dbSUPER 10.9 -21.4 -21449 3.8 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 PPARGC1A SSRP1 DERL1 FAM83A FAM83A-AS1 TRM-CAT1-1
GH08G123178 1.4 Ensembl ENCODE dbSUPER 12.7 +0.5 466 2.7 PKNOX1 ATF1 TCF12 ZNF766 GATA2 CAVIN1 NCOA1 ZNF592 MBD2 SMARCA4 FAM83A FAM83A-AS1 WDYHV1 ENSG00000221461 GC08M123182
GH08G123160 1.4 Ensembl ENCODE dbSUPER 10.7 -18.0 -17987 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 RAD21 RFX5 ZNF207 ZNF143 FAM83A FAM83A-AS1 TRM-CAT1-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM83A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM83A Gene

Chromosome:
8
Start:
123,178,960 bp from pter
End:
123,210,079 bp from pter
Size:
31,120 bases
Orientation:
Plus strand

Genomic View for FAM83A Gene

Genes around FAM83A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM83A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM83A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83A Gene

Proteins for FAM83A Gene

  • Protein details for FAM83A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UY5-FA83A_HUMAN
    Recommended name:
    Protein FAM83A
    Protein Accession:
    Q86UY5
    Secondary Accessions:
    • Q71HL2
    • Q8N7I1
    • Q96I47

    Protein attributes for FAM83A Gene

    Size:
    434 amino acids
    Molecular mass:
    47458 Da
    Quaternary structure:
    • Interacts with the regulatory subunit p85 of PI3-kinase; increased by EGFR activation (PubMed:22886303). Interacts with RAF1; increased by EGFR activation it activates RAF1 (PubMed:22886303, PubMed:24736947).
    SequenceCaution:
    • Sequence=BAC05299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAM83A Gene

    Alternative splice isoforms for FAM83A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM83A Gene

Post-translational modifications for FAM83A Gene

No data available for DME Specific Peptides for FAM83A Gene

Domains & Families for FAM83A Gene

Protein Domains for FAM83A Gene

Suggested Antigen Peptide Sequences for FAM83A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UY5

UniProtKB/Swiss-Prot:

FA83A_HUMAN :
  • Belongs to the FAM83 family.
Family:
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83A: view

No data available for Gene Families for FAM83A Gene

Function for FAM83A Gene

Molecular function for FAM83A Gene

UniProtKB/Swiss-Prot Function:
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.

Gene Ontology (GO) - Molecular Function for FAM83A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IPI 22886303
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IDA 22886303
genes like me logo Genes that share ontologies with FAM83A: view
genes like me logo Genes that share phenotypes with FAM83A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83A Gene

Localization for FAM83A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM83A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM83A gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM83A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FAM83A: view

Pathways & Interactions for FAM83A Gene

SuperPathways for FAM83A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM83A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IDA 22886303
GO:0008283 cell proliferation IMP 22886303
genes like me logo Genes that share ontologies with FAM83A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM83A Gene

Drugs & Compounds for FAM83A Gene

No Compound Related Data Available

Transcripts for FAM83A Gene

Unigene Clusters for FAM83A Gene

Family with sequence similarity 83, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for FAM83A Gene

GeneLoc Exon Structure for
FAM83A
ECgene alternative splicing isoforms for
FAM83A

Expression for FAM83A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM83A Gene

mRNA differential expression in normal tissues according to GTEx for FAM83A Gene

This gene is overexpressed in Esophagus - Mucosa (x27.4), Vagina (x10.4), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for FAM83A Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM83A Gene



Protein tissue co-expression partners for FAM83A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM83A Gene:

FAM83A

SOURCE GeneReport for Unigene cluster for FAM83A Gene:

Hs.379821

Evidence on tissue expression from TISSUES for FAM83A Gene

  • Lung(4.3)
  • Pancreas(4.1)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with FAM83A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM83A Gene

Orthologs for FAM83A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM83A 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia FAM83A 34 35
  • 85.84 (n)
cow
(Bos Taurus)
Mammalia FAM83A 34 35
  • 85.53 (n)
rat
(Rattus norvegicus)
Mammalia Fam83a 34
  • 82.06 (n)
mouse
(Mus musculus)
Mammalia Fam83a 34 16 35
  • 81.68 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM83A 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM83A 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM83A 34 35
  • 62.63 (n)
lizard
(Anolis carolinensis)
Reptilia FAM83A 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83a 34
  • 57.82 (n)
Str.11910 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68960 34
zebrafish
(Danio rerio)
Actinopterygii LOC799983 34
  • 56.87 (n)
FAM83A 35
  • 39 (a)
OneToOne
Species where no ortholog for FAM83A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83A Gene

ENSEMBL:
Gene Tree for FAM83A (if available)
TreeFam:
Gene Tree for FAM83A (if available)

Paralogs for FAM83A Gene

Paralogs for FAM83A Gene

genes like me logo Genes that share paralogs with FAM83A: view

Variants for FAM83A Gene

Sequence variations from dbSNP and Humsavar for FAM83A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000136647 -- 123,205,445(+) GGGGG(G/T)GTGGG intron-variant
rs1000300310 -- 123,192,680(+) TCCTC(C/T)GGGAG intron-variant
rs1000610196 -- 123,179,809(+) GGATA(C/T)TCACC upstream-variant-2KB, utr-variant-5-prime
rs1000671024 -- 123,179,193(+) TTCAT(A/G)TGTTG upstream-variant-2KB, utr-variant-5-prime
rs1000673961 -- 123,178,548(+) AACAC(C/T)CCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM83A Gene

Variant ID Type Subtype PubMed ID
esv3412283 CNV duplication 20981092
esv3618663 CNV loss 21293372
nsv1032827 CNV gain 25217958

Variation tolerance for FAM83A Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM83A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM83A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83A Gene

Disorders for FAM83A Gene

Relevant External Links for FAM83A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM83A

No disorders were found for FAM83A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83A Gene

Publications for FAM83A Gene

  1. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. (PMID: 22886303) Lee S.Y. … Bissell M.J. (J. Clin. Invest. 2012) 2 3 4 64
  2. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. (PMID: 24736947) Cipriano R. … Jackson M.W. (Mol. Cancer Res. 2014) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64

Products for FAM83A Gene

Sources for FAM83A Gene

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