FAM83A Gene
protein-coding GIFtS: 41
GCID: GC08P124194
|
|
family with sequence similarity 83, member A
| |
Aliases
for FAM83A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 83, Member A1 2 | | MGC141281 | | BJ-TSA-91 2 | | Protein FAM83A2 | | Tumor Antigen BJ-TSA-92 3 | | TSGP3 | | Tumor-Specific Gene Expressed In Prostate Protein2 3 | | |
Export aliases for FAM83A gene to outside databasesPrevious GC identifers: GC08P124261 GC08P119520 |
Summaries
for FAM83A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM83A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM83A gene promoter:
Spz1 RP58 CUTL1 POU3F2 GATA-1 YY1 ZID Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM83A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM83A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13FAM83A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P124194: view genomic region
(about GC identifiers)
Start:
|
124,191,200 bp from pter |
End:
|
124,222,318 bp from pter |
Size:
|
31,119 bases |
Orientation:
|
plus strand |
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Proteins
for FAM83A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA83A_HUMAN, Q86UY5 (See
protein sequence)Recommended Name: Protein FAM83A Size: 434 amino acids; 47458 Da
Sequence caution: Sequence=BAC05299.1; Type=Erroneous initiation;
Secondary accessions: Q71HL2 Q8N7I1 Q96I47Alternative splicing: 3 isoforms: Q86UY5-1 Q86UY5-2 Q86UY5-3 Explore the universe of human proteins at neXtProt for FAM83A: NX_Q86UY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UY5
FAM83A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_116288.2 NP_996889.1
ENSEMBL proteins: ENSP00000428876 ENSP00000427979 ENSP00000276699 ENSP00000440565 ENSP00000445218 ENSP00000323034
Human Recombinant Protein Products:
FAM83A Antibody Products:
Assay Products for FAM83A: |
Protein
Domains /
Families
for FAM83A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM83A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86UY5ProtoNet protein and cluster: Q86UY5 1 Blocks protein family: IPB012461 Protein of unknown function DUF1669
UniProtKB/Swiss-Prot: FA83A_HUMAN, Q86UY5Similarity: Belongs to the FAM83 family |
Function
for FAM83A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM83A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM83A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM83A (NM_207006) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM83A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM83A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM83A |
1 GenomeRNAi human phenotype for FAM83A:
|
Pathways & Interactions
for FAM83A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM83A
|
Drugs & Compounds
for FAM83A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM83A
Search CenterWatch for drugs/clinical trials and news about FAM83A / FA83A
|
Transcripts
for FAM83A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM83A gene (2 alternative transcripts): NM_032899.4 NM_207006.1 Unigene Cluster for FAM83A: Family with sequence similarity 83, member A Hs.379821 [show with all ESTs]Unigene Representative Sequence: DQ28032310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000523819 ENST00000518448(uc003ypv.3 uc003ypx.3 uc003ypy.3 uc003ypw.3 uc003ypz.3)
ENST00000520541 ENST00000523412 ENST00000522648 ENST00000276699 ENST00000521468
ENST00000546351 ENST00000536633 ENST00000318462
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM83A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM83A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM83A (NM_207006) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM83A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM83A |
Additional cDNA sequence: AF497803.1 AK095301.1 AK098407.1 BC007828.2 BC052300.1 DQ280322.1 DQ280323.1 7 DOTS entries: DT.97796830 DT.99968209 DT.102825862 DT.441253 DT.91984990 DT.121472802 DT.99968931 24/93 AceView cDNA sequences (see all 93): BU727254 BM686276 BM709495 NM_207006 BQ956178 BQ935658 BI255553 BQ954905 BQ942849 AK098407 BU153347 BC052300 AW080300 BF836846 BM689064 BM662599 BQ941786 BC007828 AI590662 AW296226 BU502563 AI969223 NM_032899 AA128399
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM83A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM83A
|
Expression
for FAM83A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM83A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCAACAAAG
About this image
See FAM83A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM83A
SOURCE GeneReport for Unigene cluster: Hs.379821
SABiosciences Custom PCR Arrays for FAM83A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM83A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM83A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM83A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM83A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM83A |
Orthologs
for FAM83A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM83A gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM83A1 |
family with sequence similarity 83, member A |
62.58(n)
56.6(a) |
|
770521 XM_001233860.2 XP_001233861.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM83A6 |
-- |
57(a) |
1 ↔ 1 |
GL343581.1(444694-454731) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC689602 |
hypothetical protein MGC68960 |
73.98(n) |
|
BC057736.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7999831 |
protein FAM83A-like |
54.1(n)
46.2(a) |
|
799983 XM_001340240.3 XP_001340276.3 |
ENSEMBL Gene Tree for FAM83A (if available)
TreeFam Gene Tree for FAM83A (if available) |
Paralogs
for FAM83A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM83A gene
- FAM83C2 FAM83H2 FAM83G2 FAM83E2 FAM83D2 FAM83B2 FAM83F2
1 SIMAP similar gene for FAM83A using alignment to 1 protein entry: FA83A_HUMAN:FAM83H
FAM83A for paralogs About GeneDecksing
|
Genomic Variants
for FAM83A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM83A (124191200 - 124222318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM83A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM83A |
|
Disorders
/ Diseases
for FAM83A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM83A for disorders About GeneDecksing
2  diseases for FAM83A: About MalaCardsprostatitis lung cancer
Export disorders for FAM83A gene to outside databases
|
Publications
for FAM83A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM83A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM83A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- FAM83A confers EGFR-TKI resistance in breast cancer ce lls and in mice. (PubMed id 22886303)1 Lee S.Y....Bissell M.J. (2012)
- Detection of circulating cancer cells in lung cancer patients with a panel of marker genes. (PubMed id 18514066)1 Liu L....Yin Y.H. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
- BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer. (PubMed id 16354590)1 Li Y....Chen W. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for FAM83A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM83A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM83A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM83A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM83A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM83A gene:
Search GeneIP for patents involving FAM83A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM83A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM83A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM83A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM83A | | | OriGene Protein Over-expression Lysate for FAM83A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM83A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM83A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM83A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM83A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM83A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM83A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM83A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM83A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM83A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM83A |
| |
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| | | | Search Tocris compounds for FAM83A |
| |  |  |  |  | | | | |
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 |
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 | | | FAM83A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM83A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM83A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM83A |
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