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Aliases for FAM83A Gene

Aliases for FAM83A Gene

  • Family With Sequence Similarity 83, Member A 2 3
  • Tumor-Specific Gene Expressed In Prostate Protein 3 4
  • Tumor Antigen BJ-TSA-9 3 4
  • BJ-TSA-9 3
  • TSGP 4

External Ids for FAM83A Gene

Previous GeneCards Identifiers for FAM83A Gene

  • GC08P124261
  • GC08P124194
  • GC08P119520

Summaries for FAM83A Gene

GeneCards Summary for FAM83A Gene

FAM83A (Family With Sequence Similarity 83, Member A) is a Protein Coding gene. An important paralog of this gene is FAM83D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83A Gene

Genomics for FAM83A Gene

Regulatory Elements for FAM83A Gene

Genomic Location for FAM83A Gene

Chromosome:
8
Start:
123,178,960 bp from pter
End:
123,210,079 bp from pter
Size:
31,120 bases
Orientation:
Plus strand

Genomic View for FAM83A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM83A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83A Gene

Proteins for FAM83A Gene

  • Protein details for FAM83A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UY5-FA83A_HUMAN
    Recommended name:
    Protein FAM83A
    Protein Accession:
    Q86UY5
    Secondary Accessions:
    • Q71HL2
    • Q8N7I1
    • Q96I47

    Protein attributes for FAM83A Gene

    Size:
    434 amino acids
    Molecular mass:
    47458 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAM83A Gene

    Alternative splice isoforms for FAM83A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM83A Gene

Proteomics data for FAM83A Gene at MOPED

Post-translational modifications for FAM83A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83A Gene

No data available for DME Specific Peptides for FAM83A Gene

Domains & Families for FAM83A Gene

Protein Domains for FAM83A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM83A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UY5

UniProtKB/Swiss-Prot:

FA83A_HUMAN :
  • Belongs to the FAM83 family.
Family:
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83A: view

No data available for Gene Families for FAM83A Gene

Function for FAM83A Gene

Gene Ontology (GO) - Molecular Function for FAM83A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IPI 22886303
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IDA 22886303
genes like me logo Genes that share ontologies with FAM83A: view

Phenotypes for FAM83A Gene

genes like me logo Genes that share phenotypes with FAM83A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83A Gene

Localization for FAM83A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM83A Gene

Pathways & Interactions for FAM83A Gene

SuperPathways for FAM83A Gene

No Data Available

Interacting Proteins for FAM83A Gene

Selected Interacting proteins: Q86UY5-FA83A_HUMAN for FAM83A Gene via UniProtKB

Gene Ontology (GO) - Biological Process for FAM83A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IDA 22886303
GO:0008283 cell proliferation IMP 22886303
genes like me logo Genes that share ontologies with FAM83A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM83A Gene

Drugs & Compounds for FAM83A Gene

No Compound Related Data Available

Transcripts for FAM83A Gene

Unigene Clusters for FAM83A Gene

Family with sequence similarity 83, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for FAM83A Gene

GeneLoc Exon Structure for
FAM83A
ECgene alternative splicing isoforms for
FAM83A

Expression for FAM83A Gene

mRNA expression in normal human tissues for FAM83A Gene

mRNA differential expression in normal tissues according to GTEx for FAM83A Gene

This gene is overexpressed in Esophagus - Mucosa (x27.4), Vagina (x10.4), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for FAM83A Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM83A Gene



SOURCE GeneReport for Unigene cluster for FAM83A Gene Hs.379821

genes like me logo Genes that share expression patterns with FAM83A: view

Protein tissue co-expression partners for FAM83A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM83A Gene

Orthologs for FAM83A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM83A 35
  • 85.53 (n)
  • 84.3 (a)
FAM83A 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM83A 35
  • 85.84 (n)
  • 84.53 (a)
FAM83A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam83a 35
  • 81.68 (n)
  • 81.99 (a)
Fam83a 16
Fam83a 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM83A 35
  • 99.54 (n)
  • 99.08 (a)
FAM83A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam83a 35
  • 82.06 (n)
  • 81.29 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM83A 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM83A 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM83A 35
  • 62.63 (n)
  • 56.9 (a)
FAM83A 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM83A 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83a 35
  • 57.82 (n)
  • 51.17 (a)
Str.11910 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68960 35
zebrafish
(Danio rerio)
Actinopterygii LOC799983 35
  • 56.87 (n)
  • 48.31 (a)
FAM83A 36
  • 39 (a)
OneToOne
Species with no ortholog for FAM83A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83A Gene

ENSEMBL:
Gene Tree for FAM83A (if available)
TreeFam:
Gene Tree for FAM83A (if available)

Paralogs for FAM83A Gene

Paralogs for FAM83A Gene

genes like me logo Genes that share paralogs with FAM83A: view

Variants for FAM83A Gene

Sequence variations from dbSNP and Humsavar for FAM83A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs884738 -- 123,186,249(-) ATTTG(G/T)GTGCA intron-variant
rs896681 -- 123,185,793(-) TAAAA(C/T)TGTGA intron-variant
rs1349685 -- 123,184,690(-) CCTGG(C/T)GCTGG intron-variant
rs1621182 -- 123,178,475(+) TCAGC(A/G)CTGCA upstream-variant-2KB
rs1670171 -- 123,187,200(-) ACATC(C/T)CCAAG intron-variant

Variation tolerance for FAM83A Gene

Residual Variation Intolerance Score: 93.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM83A Gene

HapMap Linkage Disequilibrium report
FAM83A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM83A Gene

Disorders for FAM83A Gene

Relevant External Links for FAM83A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM83A
genes like me logo Genes that share disorders with FAM83A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83A Gene

Publications for FAM83A Gene

  1. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. (PMID: 22886303) Lee S.Y. … Bissell M.J. (J. Clin. Invest. 2012) 2 67
  2. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 67
  3. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. (PMID: 24736947) Cipriano R. … Jackson M.W. (Mol. Cancer Res. 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis. (PMID: 24578125) Olden M. … Devuyst O. (J. Am. Soc. Nephrol. 2014) 67

Products for FAM83A Gene

Sources for FAM83A Gene

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