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FAM81B Gene

protein-coding   GIFtS: 45
GCID: GC05P094753

Family With Sequence Similarity 81, Member B

  Search for FAM81B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 81, Member B1 2
Protein FAM81B2

External Ids:    HGNC: 263351   Entrez Gene: 1536432   Ensembl: ENSG000001533477   UniProtKB: Q96LP23   

Export aliases for FAM81B gene to outside databases

Previous GC identifer: GC05P089917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM81B Gene:
FAM81B (family with sequence similarity 81, member B) is a protein-coding gene. An important paralog of this gene is FAM81A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM81B gene promoter:
         Pbx1a   AML1a   GATA-3   ATF-2   CUTL1   GATA-1   GATA-2   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM81B promoter sequence
   Search Chromatin IP Primers for FAM81B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM81B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

FAM81B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM81B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P094753:  view genomic region     (about GC identifiers)

Start:
94,727,048 bp from pter      End:
94,786,158 bp from pter
Size:
59,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA81B_HUMAN, Q96LP2 (See protein sequence)
Recommended Name: Protein FAM81B  
Size: 452 amino acids; 52032 Da
Caution: It is uncertain whether Met-1 or Met-39 is the initiator. Met-1 does not seem to exist in orthologs
Sequence caution: Sequence=AAH34772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB71646.1; Type=Frameshift; Positions=24;

Explore the universe of human proteins at neXtProt for FAM81B: NX_Q96LP2

Explore proteomics data for FAM81B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM81B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689761.2  
    ENSEMBL proteins: 
     ENSP00000283357   ENSP00000423648   ENSP00000423016   ENSP00000424883   ENSP00000423296  
     ENSP00000421181   ENSP00000422946  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96LP2

    UniProtKB/Swiss-Prot: FA81B_HUMAN, Q96LP2
    Similarity: Belongs to the FAM81 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM81B:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM81B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM81B
    Interactions:

        Search GeneGlobe Interaction Network for FAM81B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM81B (FA81B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM81B gene: 
    NM_152548.2  

    Unigene Cluster for FAM81B:

    Family with sequence similarity 81, member B
    Hs.276287  [show with all ESTs]
    Unigene Representative Sequence: BC034772
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283357(uc003kla.1) ENST00000513529 ENST00000507832(uc010jbe.1)
    ENST00000506418 ENST00000503361 ENST00000510458 ENST00000503099 ENST00000512365
    ENST00000513110
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    Additional mRNA sequence: 

    AK058062.1 AK310245.1 BC034772.1 

    6 DOTS entries:

    DT.40126853  DT.99989463  DT.95134714  DT.95134713  DT.100780541  DT.99986999 

    Selected AceView cDNA sequences (see all 67):

    BU854411 BX111320 AA939120 BQ271590 BU950197 AK058062 BG723858 BP370080 
    BG191229 CD358339 BM972754 AI809846 BG198373 BP368951 BI828491 BP369579 
    NM_152548 BQ428777 BM560335 BG211373 AI769413 BP368816 BC034772 CD512755 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM81B (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                -     -     -                       -                                             
    SP2:                                -     -     -                                                                     
    SP3:                                -     -     -                 -     -                                             
    SP4:                                -     -     -     -                 -                                             
    SP5:                                -     -     -     -                 -                                             


    ECgene alternative splicing isoforms for FAM81B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM81B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTCTCAG
    FAM81B Expression
    About this image

    FAM81B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM81B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.276287
        Custom PCR Arrays for FAM81B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM81B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM81B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam81b1 , 5 family with sequence similarity 81, member B1, 5 83.41(n)1
    79.37(a)1
      13 (40.96 cM)5
    2387261  XM_006517506.11  XP_006517569.11 
     762016945 
    chicken
    (Gallus gallus)
    Aves FAM81B1 family with sequence similarity 81, member B 60.73(n)
    48.94(a)
      431568  XM_429122.4  XP_429122.4 
    lizard
    (Anolis carolinensis)
    Reptilia FAM81B6
    family with sequence similarity 81, member B
    47(a)
    1 ↔ 1
    2(25806218-25827765)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam81b1 family with sequence similarity 81, member B 60.13(n)
    46.59(a)
      100498576  XM_002933438.2  XP_002933484.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018869591 protein FAM81B-like 50(n)
    37.5(a)
      101886959  XM_005165537.1  XP_005165594.1 


    ENSEMBL Gene Tree for FAM81B (if available)
    TreeFam Gene Tree for FAM81B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM81B gene
    FAM81A2  
    1 SIMAP similar gene for FAM81B using alignment to 7 protein entries:     FA81B_HUMAN (see all proteins):
    FAM81A

    Find genes that share paralogs with FAM81B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM81B (see all 1223)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141345161,2
    C,F--94725187(+) ACATAG/ACAAGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1818801,2
    C,F,H--94725223(-) agtttC/Atctct 1 -- us2k122Minor allele frequency- A:0.14NS EA NA WA CSA 2118
    rs1440801331,2
    --94725260(+) AGCCCA/TCTCCT 1 -- us2k10--------
    rs1808229961,2
    --94725429(+) AGGCCA/GAGGTG 1 -- us2k10--------
    rs1852032121,2
    --94725452(+) GGTCAA/GGAAAT 1 -- us2k10--------
    rs1900160531,2
    --94725478(+) TAACAC/TGATGA 1 -- us2k10--------
    rs1812708241,2
    --94725613(+) GCCAAC/GATCGC 1 -- us2k10--------
    rs1857340951,2
    --94725856(+) AAATAC/TCATGG 1 -- us2k10--------
    rs1410429081,2
    C--94725919(+) GTTAAA/GTCTAG 1 -- us2k10--------
    rs1447764121,2
    C--94726029(+) GCACCA/GCCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM81B (94727048 - 94786158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM81B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2634786CNV Insertion19546169
    nsv882388CNV Loss21882294

    Human Gene Mutation Database (HGMD): FAM81B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM81B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM81B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM81B           About GenesLikeMe

    Genetic Association Database (GAD): FAM81B
    Human Genome Epidemiology (HuGE) Navigator: FAM81B (1 document)

    Export disorders for FAM81B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM81B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM81B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153643 HGNC: 26335 AceView: FLJ25333 Ensembl:ENSG00000153347 euGenes: HUgn153643
    ECgene: FAM81B H-InvDB: FAM81B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM81B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM81B gene:
    Search GeneIP for patents involving FAM81B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FAM81B   OriGene Custom Protein Services for FAM81B  

     
     
     Block miRNA regulation of human, mouse, rat FAM81B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FAM81B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM81B Predesigned siRNA for gene silencing in human, mouse, rat FAM81B
     QuantiFast Probe-based Assays in human, mouse, rat FAM81B QuantiTect SYBR Green Assays in human, mouse, rat FAM81B
     Custom PCR Arrays for FAM81B Search Chromatin IP Primers for FAM81B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM81B  Search GeneGlobe Interaction Network for FAM81B
     Regulatory tfbs in FAM81B promoter
     GenScript Custom Purified and Recombinant Proteins Services for FAM81B GenScript cDNA clones with any tag delivered in your preferred vector for FAM81B
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     Search for Antibodies & Assays

     Search Tocris compounds for FAM81B (FA81B)
     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for FAM81B
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     SwitchGear 3'UTR luciferase reporter plasmids for FAM81B
     SwitchGear Promoter luciferase reporter plasmids for FAM81B
     ThermoFisher Antibodies for FAM81B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM81B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM81B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM81B
     LSBio Antibodies in human, mouse, rat for FAM81B
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     Search Addgene for plasmids for FAM81B
      Search eBioscience for proteins for FAM81B
      Search eBioscience for elisas for FAM81B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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