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Aliases for FAM81B Gene

Aliases for FAM81B Gene

  • Family With Sequence Similarity 81 Member B 2 3 5
  • Family With Sequence Similarity 81, Member B 2

External Ids for FAM81B Gene

Previous GeneCards Identifiers for FAM81B Gene

  • GC05P094753
  • GC05P089917

Summaries for FAM81B Gene

GeneCards Summary for FAM81B Gene

FAM81B (Family With Sequence Similarity 81 Member B) is a Protein Coding gene. An important paralog of this gene is FAM81A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM81B Gene

Genomics for FAM81B Gene

Regulatory Elements for FAM81B Gene

Enhancers for FAM81B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM81B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM81B Gene

95,384,802 bp from pter
95,450,454 bp from pter
65,653 bases
Plus strand

Genomic View for FAM81B Gene

Genes around FAM81B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM81B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM81B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM81B Gene

Proteins for FAM81B Gene

  • Protein details for FAM81B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM81B
    Protein Accession:

    Protein attributes for FAM81B Gene

    452 amino acids
    Molecular mass:
    52032 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71646.1; Type=Frameshift; Positions=24; Evidence={ECO:0000305};

neXtProt entry for FAM81B Gene

Proteomics data for FAM81B Gene at MOPED

Post-translational modifications for FAM81B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM81B Gene

No data available for DME Specific Peptides for FAM81B Gene

Domains & Families for FAM81B Gene

Protein Domains for FAM81B Gene


Suggested Antigen Peptide Sequences for FAM81B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM81 family.
  • Belongs to the FAM81 family.
genes like me logo Genes that share domains with FAM81B: view

No data available for Gene Families for FAM81B Gene

Function for FAM81B Gene

genes like me logo Genes that share phenotypes with FAM81B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM81B Gene

Localization for FAM81B Gene

Subcellular locations from

Jensen Localization Image for FAM81B Gene COMPARTMENTS Subcellular localization image for FAM81B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM81B Gene

Pathways & Interactions for FAM81B Gene

SuperPathways for FAM81B Gene

No Data Available

Interacting Proteins for FAM81B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000283357 Q96LP2-FA81B_HUMAN for FAM81B Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM81B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM81B Gene

Drugs & Compounds for FAM81B Gene

No Compound Related Data Available

Transcripts for FAM81B Gene

Unigene Clusters for FAM81B Gene

Family with sequence similarity 81, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM81B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: -

Relevant External Links for FAM81B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM81B Gene

mRNA expression in normal human tissues for FAM81B Gene

mRNA differential expression in normal tissues according to GTEx for FAM81B Gene

This gene is overexpressed in Testis (x31.9).

Protein differential expression in normal tissues from HIPED for FAM81B Gene

This gene is overexpressed in Fetal ovary (42.2), Fetal heart (14.3), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM81B Gene

SOURCE GeneReport for Unigene cluster for FAM81B Gene Hs.276287

genes like me logo Genes that share expression patterns with FAM81B: view

Protein tissue co-expression partners for FAM81B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM81B Gene

Orthologs for FAM81B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM81B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM81B 35
  • 85.88 (n)
  • 78.93 (a)
FAM81B 36
  • 79 (a)
(Canis familiaris)
Mammalia FAM81B 35
  • 88.94 (n)
  • 85.25 (a)
FAM81B 36
  • 83 (a)
(Mus musculus)
Mammalia Fam81b 35
  • 83.41 (n)
  • 79.37 (a)
Fam81b 16
(Pan troglodytes)
Mammalia FAM81B 35
  • 99.41 (n)
  • 98.67 (a)
FAM81B 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam81b 35
  • 83.01 (n)
  • 79.95 (a)
(Monodelphis domestica)
Mammalia FAM81B 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia FAM81B 36
  • 55 (a)
(Gallus gallus)
Aves FAM81B 35
  • 60.73 (n)
  • 48.94 (a)
FAM81B 36
  • 43 (a)
(Anolis carolinensis)
Reptilia FAM81B 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam81b 35
  • 60.13 (n)
  • 46.59 (a)
(Danio rerio)
Actinopterygii LOC101886959 35
  • 50 (n)
  • 37.5 (a)
FAM81B 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for FAM81B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM81B Gene

Gene Tree for FAM81B (if available)
Gene Tree for FAM81B (if available)

Paralogs for FAM81B Gene

Paralogs for FAM81B Gene

(1) SIMAP similar genes for FAM81B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM81B: view

Variants for FAM81B Gene

Sequence variations from dbSNP and Humsavar for FAM81B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042271 - 95,414,101(+) GCTTT(C/G)GAAAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11555275 - 95,420,306(+) AAGAG(C/T)TCGAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1541797 - 95,428,662(-) TTTGC(C/T)GGTGC nc-transcript-variant, reference, missense
rs6878669 - 95,436,836(+) CCAGT(C/G/T)CTGAG nc-transcript-variant, reference, missense
rs33893 -- 95,394,065(-) AGCCA(C/T)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM81B Gene

Variant ID Type Subtype PubMed ID
esv2634786 CNV Insertion 19546169
nsv882388 CNV Loss 21882294

Variation tolerance for FAM81B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM81B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM81B Gene

Disorders for FAM81B Gene

Relevant External Links for FAM81B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM81B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM81B Gene

Publications for FAM81B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FAM81B Gene

Sources for FAM81B Gene