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Aliases for FAM81B Gene

Aliases for FAM81B Gene

  • Family With Sequence Similarity 81 Member B 2 3 5
  • Family With Sequence Similarity 81, Member B 2

External Ids for FAM81B Gene

Previous GeneCards Identifiers for FAM81B Gene

  • GC05P094753
  • GC05P089917

Summaries for FAM81B Gene

GeneCards Summary for FAM81B Gene

FAM81B (Family With Sequence Similarity 81 Member B) is a Protein Coding gene. An important paralog of this gene is FAM81A.

Additional gene information for FAM81B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM81B Gene

Genomics for FAM81B Gene

Regulatory Elements for FAM81B Gene

Enhancers for FAM81B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H095445 0.5 ENCODE 11.1 +61.9 61921 2.3 FOSL1 CEBPB EBF1 CEBPG EP300 TTC37 FAM81B RNU6-308P LOC100420911 GC05P095460
GH05H095471 0.4 ENCODE 11.6 +87.2 87195 1.3 ZFHX2 TTC37 RNU6-308P FAM81B GC05P095462
GH05H095358 0.4 ENCODE 11.3 -25.8 -25839 0.8 PKNOX1 FAM81B MCTP1
GH05H095285 0.8 ENCODE 0.1 -99.7 -99711 0 CTCF KLF1 ZNF777 SUZ12 KLF17 ZIC2 GLIS2 ZBTB48 PATZ1 ZBTB20 MCTP1 FAM81B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM81B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM81B Gene

Genomic Locations for FAM81B Gene
65,653 bases
Plus strand

Genomic View for FAM81B Gene

Genes around FAM81B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM81B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM81B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM81B Gene

Proteins for FAM81B Gene

  • Protein details for FAM81B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM81B
    Protein Accession:

    Protein attributes for FAM81B Gene

    452 amino acids
    Molecular mass:
    52032 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71646.1; Type=Frameshift; Positions=24; Evidence={ECO:0000305};

neXtProt entry for FAM81B Gene

Post-translational modifications for FAM81B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM81B Gene

Domains & Families for FAM81B Gene

Gene Families for FAM81B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM81B Gene


Suggested Antigen Peptide Sequences for FAM81B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM81 family.
  • Belongs to the FAM81 family.
genes like me logo Genes that share domains with FAM81B: view

Function for FAM81B Gene

Gene Ontology (GO) - Molecular Function for FAM81B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM81B: view
genes like me logo Genes that share phenotypes with FAM81B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM81B Gene

Localization for FAM81B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM81B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM81B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with FAM81B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FAM81B Gene

Pathways & Interactions for FAM81B Gene

SuperPathways for FAM81B Gene

No Data Available

Interacting Proteins for FAM81B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000283357 Q96LP2-FA81B_HUMAN for FAM81B Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for FAM81B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM81B Gene

Drugs & Compounds for FAM81B Gene

No Compound Related Data Available

Transcripts for FAM81B Gene

Unigene Clusters for FAM81B Gene

Family with sequence similarity 81, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM81B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: -

Relevant External Links for FAM81B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM81B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM81B Gene

mRNA differential expression in normal tissues according to GTEx for FAM81B Gene

This gene is overexpressed in Testis (x31.9).

Protein differential expression in normal tissues from HIPED for FAM81B Gene

This gene is overexpressed in Fetal ovary (42.2), Fetal heart (14.3), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM81B Gene

Protein tissue co-expression partners for FAM81B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM81B Gene:


SOURCE GeneReport for Unigene cluster for FAM81B Gene:


Evidence on tissue expression from TISSUES for FAM81B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM81B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM81B Gene

Orthologs for FAM81B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM81B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM81B 33 34
  • 99.41 (n)
(Canis familiaris)
Mammalia FAM81B 33 34
  • 88.94 (n)
(Bos Taurus)
Mammalia FAM81B 33 34
  • 85.88 (n)
(Mus musculus)
Mammalia Fam81b 33 16
  • 83.41 (n)
(Rattus norvegicus)
Mammalia Fam81b 33
  • 83.01 (n)
(Monodelphis domestica)
Mammalia FAM81B 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia FAM81B 34
  • 55 (a)
(Gallus gallus)
Aves FAM81B 33 34
  • 60.73 (n)
(Anolis carolinensis)
Reptilia FAM81B 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam81b 33
  • 60.13 (n)
(Danio rerio)
Actinopterygii LOC101886959 33
  • 50 (n)
FAM81B 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for FAM81B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM81B Gene

Gene Tree for FAM81B (if available)
Gene Tree for FAM81B (if available)

Paralogs for FAM81B Gene

Paralogs for FAM81B Gene

(1) SIMAP similar genes for FAM81B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM81B: view

Variants for FAM81B Gene

Sequence variations from dbSNP and Humsavar for FAM81B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000034155 -- 95,447,668(+) AAAGG(G/T)TCATA intron-variant
rs1000064194 -- 95,441,995(+) ATAAG(A/G)AAAGA intron-variant
rs1000078137 -- 95,444,465(+) GAGCC(A/G)ATGGA intron-variant
rs1000096208 -- 95,396,668(+) GGAAA(C/T)AGAGT intron-variant
rs1000125304 -- 95,398,441(+) AAATA(A/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM81B Gene

Variant ID Type Subtype PubMed ID
nsv598954 CNV loss 21841781
esv3605831 CNV loss 21293372
esv2634786 CNV insertion 19546169

Variation tolerance for FAM81B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM81B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM81B Gene

Disorders for FAM81B Gene

Relevant External Links for FAM81B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM81B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM81B Gene

Publications for FAM81B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60

Products for FAM81B Gene

Sources for FAM81B Gene

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