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FAM81B Gene(Protein Coding)

Family With Sequence Similarity 81 Member B

GCID:
GC05P095391
GIFtS:
45
Genes Participants
UDN Logo

Aliases for FAM81B Gene

Aliases for FAM81B Gene

  • Family With Sequence Similarity 81 Member B 2 3 5
  • Family With Sequence Similarity 81, Member B 2

External Ids for FAM81B Gene

Previous GeneCards Identifiers for FAM81B Gene

  • GC05P094753
  • GC05P089917

Summaries for FAM81B Gene

GeneCards Summary for FAM81B Gene

FAM81B (Family With Sequence Similarity 81 Member B) is a Protein Coding gene. An important paralog of this gene is FAM81A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM81B Gene

Genomics for FAM81B Gene

Products:

  1. Regulatory Element

Regulatory Elements for FAM81B Gene

Enhancers for FAM81B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G095445 0.6 ENCODE 11.1 +61.9 61921 2.3 FOSL1 CEBPB FEZF1 CEBPG EBF1 EP300 TTC37 FAM81B RNU6-308P LOC100420911 GC05P095460
GH05G095471 0.4 ENCODE 11.6 +87.2 87195 1.3 CTCF ZFHX2 TTC37 RNU6-308P FAM81B GC05P095462
GH05G095358 0.4 ENCODE 11.3 -25.8 -25839 0.8 PKNOX1 FAM81B MCTP1
GH05G095285 0.8 ENCODE 0.1 -99.7 -99711 0.0 KLF1 ZNF777 SUZ12 FUS KLF17 ZIC2 GLIS2 ZBTB48 PATZ1 ZBTB20 MCTP1 FAM81B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM81B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FAM81B gene promoter:

Genomic Location for FAM81B Gene

Chromosome:
5
Start:
95,384,802 bp from pter
End:
95,450,454 bp from pter
Size:
65,653 bases
Orientation:
Plus strand

Genomic View for FAM81B Gene

Genes around FAM81B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM81B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM81B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FAM81B Gene

Proteins for FAM81B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FAM81B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LP2-FA81B_HUMAN
    Recommended name:
    Protein FAM81B
    Protein Accession:
    Q96LP2

    Protein attributes for FAM81B Gene

    Size:
    452 amino acids
    Molecular mass:
    52032 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71646.1; Type=Frameshift; Positions=24; Evidence={ECO:0000305};

neXtProt entry for FAM81B Gene

Protein Expression for FAM81B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FAM81B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM81B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM81B Gene

Domains & Families for FAM81B Gene

Protein Domains for FAM81B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM81B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LP2

UniProtKB/Swiss-Prot:

FA81B_HUMAN :
  • Belongs to the FAM81 family.
Family:
  • Belongs to the FAM81 family.
genes like me logo Genes that share domains with FAM81B: view

No data available for Gene Families for FAM81B Gene

Function for FAM81B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for FAM81B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM81B: view
genes like me logo Genes that share phenotypes with FAM81B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM81B Gene

Localization for FAM81B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM81B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM81B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with FAM81B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM81B Gene

Pathways & Interactions for FAM81B Gene

SuperPathways for FAM81B Gene

PathCards logo More details on SuperPathways for FAM81B
No Data Available

Interacting Proteins for FAM81B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283357%0d%0a9606.ENSP00000257700%0d%0a
Selected Interacting proteins: Q96LP2-FA81B_HUMAN ENSP00000283357 for FAM81B Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM81B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM81B Gene

Drugs & Compounds for FAM81B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FAM81B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FAM81B Gene

(9) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM81B Gene

Family with sequence similarity 81, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM81B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: -
SP7:

Relevant External Links for FAM81B Gene

GeneLoc Exon Structure for
FAM81B
ECgene alternative splicing isoforms for
FAM81B

Expression for FAM81B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM81B Gene

mRNA expression in normal human tissues for FAM81B Gene
mRNA expression by BioGPS for FAM81B GenemRNA expression by GTEx for FAM81B Gene

mRNA differential expression in normal tissues according to GTEx for FAM81B Gene

This gene is overexpressed in Testis (x31.9).

Protein differential expression in normal tissues from HIPED for FAM81B Gene

This gene is overexpressed in Fetal ovary (42.2), Fetal heart (14.3), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM81B Gene



Protein tissue co-expression partners for FAM81B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM81B Gene:

FAM81B

SOURCE GeneReport for Unigene cluster for FAM81B Gene:

Hs.276287

Evidence on tissue expression from TISSUES for FAM81B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM81B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM81B Gene

Orthologs for FAM81B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM81B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FAM81B 34 35
  • 99.41 (n)
dog
(Canis familiaris)
 Mammalia FAM81B 34 35
  • 88.94 (n)
cow
(Bos Taurus)
 Mammalia FAM81B 34 35
  • 85.88 (n)
mouse
(Mus musculus)
 Mammalia Fam81b 34 16
  • 83.41 (n)
rat
(Rattus norvegicus)
 Mammalia Fam81b 34
  • 83.01 (n)
oppossum
(Monodelphis domestica)
 Mammalia FAM81B 35
  • 55 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FAM81B 35
  • 55 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FAM81B 34 35
  • 60.73 (n)
lizard
(Anolis carolinensis)
 Reptilia FAM81B 35
  • 47 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fam81b 34
  • 60.13 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC101886959 34
  • 50 (n)
FAM81B 35
  • 37 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 24 (a)
 OneToMany
Species where no ortholog for FAM81B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM81B Gene

ENSEMBL:
Gene Tree for FAM81B (if available)
TreeFam:
Gene Tree for FAM81B (if available)

Paralogs for FAM81B Gene

Paralogs for FAM81B Gene

(1) SIMAP similar genes for FAM81B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM81B: view

Variants for FAM81B Gene

Sequence variations from dbSNP and Humsavar for FAM81B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000034155 -- 95,447,668(+) AAAGG(G/T)TCATA intron-variant
rs1000064194 -- 95,441,995(+) ATAAG(A/G)AAAGA intron-variant
rs1000078137 -- 95,444,465(+) GAGCC(A/G)ATGGA intron-variant
rs1000096208 -- 95,396,668(+) GGAAA(C/T)AGAGT intron-variant
rs1000125304 -- 95,398,441(+) AAATA(A/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM81B Gene

Variant ID Type Subtype PubMed ID
esv2634786 CNV insertion 19546169
esv3605831 CNV loss 21293372
nsv598954 CNV loss 21841781

Variation tolerance for FAM81B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM81B Gene

Human Gene Mutation Database (HGMD)
FAM81B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM81B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM81B Gene

Disorders for FAM81B Gene

Relevant External Links for FAM81B

Genetic Association Database (GAD)
FAM81B
Human Genome Epidemiology (HuGE) Navigator
FAM81B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM81B

No disorders were found for FAM81B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM81B Gene

Publications for FAM81B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64

Products for FAM81B Gene

Sources for FAM81B Gene

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