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Aliases for FAM81A Gene

Aliases for FAM81A Gene

  • Family With Sequence Similarity 81 Member A 2 3 5
  • Family With Sequence Similarity 81, Member A 2

External Ids for FAM81A Gene

Previous GeneCards Identifiers for FAM81A Gene

  • GC15P057518
  • GC15P059730
  • GC15P036552
  • GC15P059664

Summaries for FAM81A Gene

GeneCards Summary for FAM81A Gene

FAM81A (Family With Sequence Similarity 81 Member A) is a Protein Coding gene. An important paralog of this gene is FAM81B.

Additional gene information for FAM81A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM81A Gene

Genomics for FAM81A Gene

Regulatory Elements for FAM81A Gene

Enhancers for FAM81A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H059492 1 Ensembl ENCODE 26.2 +120.4 120408 0.6 CTCF ZNF2 RAD21 RELA TEAD3 SLC30A9 GATA3 GATAD1 SMC3 ZNF143 FAM81A MIR2116 MYO1E GC15M059526 ENSG00000200252
GH15H059409 1.5 FANTOM5 Ensembl ENCODE 14.8 +39.1 39105 3.7 PKNOX1 FOXA2 ARID4B YBX1 ZNF143 ATF7 RUNX3 SP5 JUNB NFIL3 FAM81A MYO1E LOC100132644 ENSG00000200252 GC15M059526
GH15H059270 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -93.8 -93758 16.3 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 BRCA1 GTF3C2 SLC30A9 GLIS2 MYO1E SLTM FAM81A PIGHP1 RNF111 RPS3AP6 MIR2116 ENSG00000259250 GCNT3 GC15M059271
GH15H059173 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -196.4 -196372 5.2 CTCF TFAP4 PKNOX1 SIN3A CEBPG RAD21 TEAD3 ZFHX2 POLR2A EGR1 LDHAL6B FAM81A MYO1E RNF111 ADAM10 MIR2116
GH15H059406 1.1 FANTOM5 Ensembl ENCODE 14.7 +34.5 34508 2.4 POLR2A EED RUNX3 CREM MYO1E FAM81A LOC100132644 LOC100421765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM81A on UCSC Golden Path with GeneCards custom track

Promoters for FAM81A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077340 -293 2801 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 GLIS2

Genomic Locations for FAM81A Gene

Genomic Locations for FAM81A Gene
chr15:59,372,693-59,523,552
(GRCh38/hg38)
Size:
150,860 bases
Orientation:
Plus strand
chr15:59,664,892-59,815,751
(GRCh37/hg19)

Genomic View for FAM81A Gene

Genes around FAM81A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM81A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM81A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM81A Gene

Proteins for FAM81A Gene

  • Protein details for FAM81A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF8-FA81A_HUMAN
    Recommended name:
    Protein FAM81A
    Protein Accession:
    Q8TBF8

    Protein attributes for FAM81A Gene

    Size:
    368 amino acids
    Molecular mass:
    42392 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22537.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM81A Gene

Post-translational modifications for FAM81A Gene

  • Ubiquitination at isoforms=119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM81A Gene

Domains & Families for FAM81A Gene

Gene Families for FAM81A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM81A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM81A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBF8

UniProtKB/Swiss-Prot:

FA81A_HUMAN :
  • Belongs to the FAM81 family.
Family:
  • Belongs to the FAM81 family.
genes like me logo Genes that share domains with FAM81A: view

Function for FAM81A Gene

Phenotypes From GWAS Catalog for FAM81A Gene

Phenotypes for FAM81A Gene

GenomeRNAi human phenotypes for FAM81A:
genes like me logo Genes that share phenotypes with FAM81A: view

miRNA for FAM81A Gene

miRTarBase miRNAs that target FAM81A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM81A Gene

Localization for FAM81A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM81A gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM81A Gene

Pathways & Interactions for FAM81A Gene

SuperPathways for FAM81A Gene

No Data Available

Interacting Proteins for FAM81A Gene

Selected Interacting proteins: Q8TBF8-FA81A_HUMAN for FAM81A Gene via IID

Symbol External ID(s) Details
DLG4
UBC

Gene Ontology (GO) - Biological Process for FAM81A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM81A Gene

Drugs & Compounds for FAM81A Gene

No Compound Related Data Available

Transcripts for FAM81A Gene

Unigene Clusters for FAM81A Gene

Family with sequence similarity 81, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM81A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9: - - - - - -
SP10: -

Relevant External Links for FAM81A Gene

GeneLoc Exon Structure for
FAM81A
ECgene alternative splicing isoforms for
FAM81A

Expression for FAM81A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM81A Gene

mRNA differential expression in normal tissues according to GTEx for FAM81A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.8), Brain - Anterior cingulate cortex (BA24) (x8.0), Brain - Cortex (x7.9), Brain - Hippocampus (x4.7), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for FAM81A Gene

This gene is overexpressed in Bone (20.3), Uterus (16.9), Colon (7.3), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM81A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM81A Gene:

FAM81A

SOURCE GeneReport for Unigene cluster for FAM81A Gene:

Hs.531168

Evidence on tissue expression from TISSUES for FAM81A Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with FAM81A: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM81A Gene

Orthologs for FAM81A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM81A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM81A 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia FAM81A 33 34
  • 91.8 (n)
cow
(Bos Taurus)
Mammalia FAM81A 33 34
  • 90.7 (n)
rat
(Rattus norvegicus)
Mammalia Fam81a 33
  • 87.91 (n)
mouse
(Mus musculus)
Mammalia Fam81a 33 16 34
  • 87.82 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM81A 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM81A 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM81A 33 34
  • 72.21 (n)
lizard
(Anolis carolinensis)
Reptilia FAM81A 34
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for FAM81A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM81A Gene

ENSEMBL:
Gene Tree for FAM81A (if available)
TreeFam:
Gene Tree for FAM81A (if available)

Paralogs for FAM81A Gene

Paralogs for FAM81A Gene

(1) SIMAP similar genes for FAM81A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with FAM81A: view

Variants for FAM81A Gene

Sequence variations from dbSNP and Humsavar for FAM81A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000008030 -- 59,460,277(+) ACCCA(C/T)ATCTA intron-variant
rs1000046344 -- 59,523,706(+) TCTGA(C/T)GACTG downstream-variant-500B
rs1000084667 -- 59,471,549(+) CGTCA(A/G)ACTCC intron-variant
rs1000097258 -- 59,452,255(+) GATCC(A/G)TGATT intron-variant
rs1000129653 -- 59,452,057(+) AATTT(C/G)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM81A Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER inversion 18451855
nsv569604 CNV loss 21841781
nsv527307 CNV gain 19592680
nsv1552 CNV insertion 18451855
nsv1134454 CNV deletion 24896259
esv3636642 CNV loss 21293372
esv27356 CNV gain 19812545

Variation tolerance for FAM81A Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM81A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM81A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM81A Gene

Disorders for FAM81A Gene

Relevant External Links for FAM81A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM81A

No disorders were found for FAM81A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM81A Gene

Publications for FAM81A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60
  3. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. (PMID: 24962325) Kapoor M … Goate A (Drug and alcohol dependence 2014) 3 60
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 60
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 3 60

Products for FAM81A Gene

Sources for FAM81A Gene

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