Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM81A Gene

Aliases for FAM81A Gene

  • Family With Sequence Similarity 81, Member A 2 3

External Ids for FAM81A Gene

Previous GeneCards Identifiers for FAM81A Gene

  • GC15P057518
  • GC15P059730
  • GC15P036552
  • GC15P059664

Summaries for FAM81A Gene

GeneCards Summary for FAM81A Gene

FAM81A (Family With Sequence Similarity 81, Member A) is a Protein Coding gene. An important paralog of this gene is FAM81B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM81A Gene

Genomics for FAM81A Gene

Regulatory Elements for FAM81A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM81A Gene

59,372,693 bp from pter
59,523,552 bp from pter
150,860 bases
Plus strand

Genomic View for FAM81A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM81A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM81A Gene

Proteins for FAM81A Gene

  • Protein details for FAM81A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM81A
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FAM81A Gene

    368 amino acids
    Molecular mass:
    42392 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22537.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM81A Gene

Proteomics data for FAM81A Gene at MOPED

Post-translational modifications for FAM81A Gene

  • Ubiquitination at Lys119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM81A Gene

Domains for FAM81A Gene

Protein Domains for FAM81A Gene


Suggested Antigen Peptide Sequences for FAM81A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM81 family.
  • Belongs to the FAM81 family.
genes like me logo Genes that share domains with FAM81A: view

No data available for Gene Families for FAM81A Gene

Function for FAM81A Gene

Animal Model Products

CRISPR Products

miRNA for FAM81A Gene

miRTarBase miRNAs that target FAM81A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM81A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM81A Gene

Localization for FAM81A Gene

Subcellular locations from

Jensen Localization Image for FAM81A Gene COMPARTMENTS Subcellular localization image for FAM81A gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM81A Gene

Pathways for FAM81A Gene

SuperPathways for FAM81A Gene

No Data Available

Interacting Proteins for FAM81A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000288228 Q8TBF8-FA81A_HUMAN for FAM81A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM81A Gene


No data available for Pathways by source for FAM81A Gene

Transcripts for FAM81A Gene

Unigene Clusters for FAM81A Gene

Family with sequence similarity 81, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM81A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM81A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9: - - - - - -
SP10: -

Relevant External Links for FAM81A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM81A Gene

mRNA expression in normal human tissues for FAM81A Gene

mRNA differential expression in normal tissues according to GTEx for FAM81A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.8), Brain - Anterior cingulate cortex (BA24) (8.0), Brain - Cortex (7.9), Brain - Hippocampus (4.7), and Brain - Amygdala (4.0).

Protein differential expression in normal tissues for FAM81A Gene

This gene is overexpressed in Bone (20.3), Uterus (16.9), Colon (7.3), and Ovary (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM81A Gene

SOURCE GeneReport for Unigene cluster for FAM81A Gene Hs.531168

genes like me logo Genes that share expressions with FAM81A: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for FAM81A Gene

Orthologs for FAM81A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM81A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM81A 35
  • 90.7 (n)
  • 94.2 (a)
FAM81A 36
  • 94 (a)
(Canis familiaris)
Mammalia FAM81A 35
  • 91.8 (n)
  • 93.37 (a)
FAM81A 36
  • 93 (a)
(Mus musculus)
Mammalia Fam81a 35
  • 87.82 (n)
  • 93.13 (a)
Fam81a 16
Fam81a 36
  • 93 (a)
(Pan troglodytes)
Mammalia FAM81A 35
  • 99.64 (n)
  • 100 (a)
FAM81A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam81a 35
  • 87.91 (n)
  • 94.23 (a)
(Monodelphis domestica)
Mammalia FAM81A 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia FAM81A 36
  • 81 (a)
(Gallus gallus)
Aves FAM81A 35
  • 72.21 (n)
  • 70.36 (a)
FAM81A 36
  • 66 (a)
(Anolis carolinensis)
Reptilia FAM81A 36
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for FAM81A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM81A Gene

Gene Tree for FAM81A (if available)
Gene Tree for FAM81A (if available)

Paralogs for FAM81A Gene

Paralogs for FAM81A Gene

(1) SIMAP similar genes for FAM81A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with FAM81A: view

Variants for FAM81A Gene

Sequence variations from dbSNP and Humsavar for FAM81A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs744416 -- 59,415,547(+) CTTCT(C/G)Tcatg intron-variant
rs900829 -- 59,416,410(+) AGTCA(A/G)CTGCC intron-variant
rs923012 -- 59,411,192(+) GATCA(A/G)GGAGG intron-variant
rs960025 -- 59,410,794(-) TGCAC(A/T)ATAGC intron-variant
rs960026 -- 59,410,657(-) TTTCA(A/C)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM81A Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv527307 CNV Gain 19592680
dgv2391n71 CNV Gain 21882294
nsv904278 CNV Gain 21882294
esv27356 CNV Gain 19812545
nsv1552 CNV Insertion 18451855
nsv904279 CNV Gain 21882294

Relevant External Links for FAM81A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM81A Gene

Disorders for FAM81A Gene

No disorders were found for FAM81A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM81A Gene

Publications for FAM81A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. (PMID: 24962325) Kapoor M. … Goate A. (Drug Alcohol Depend 2014) 3

Products for FAM81A Gene

Sources for FAM81A Gene

Back to Top