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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM81A Gene

protein-coding GIFtS: 40
GCID: GC15P059664

family with sequence similarity 81, member A

Search for FAM81A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 81, Member A¹ ²
MGC26690¹
Protein FAM81A²

External Ids:	HGNC: 28379¹	Entrez Gene: 145773²	Ensembl: ENSG00000157470⁷	UniProtKB: Q8TBF8³

Export aliases for FAM81A gene to outside databases

Previous GC identifers: GC15P057518 GC15P059730 GC15P036552

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM81A gene promoter:
Nkx3-1 Nkx3-1 v4 Sox5 MyoD Olf-1 Nkx3-1 v1 Nkx3-1 v2 FOXO4 Nkx3-1 v3 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM81A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM81A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM81A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22.2

FAM81A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM81A gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P059664: view genomic region (about GC identifiers)

Start:	59,664,892 bp from pter	End:	59,815,751 bp from pter
Size:	150,860 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA81A_HUMAN, Q8TBF8 (See protein sequence)

Recommended Name: Protein FAM81A

Size: 368 amino acids; 42392 Da

Caution: It is uncertain whether Met-1 or Met-4 is the initiator

Sequence caution: Sequence=AAH22537.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for FAM81A: NX_Q8TBF8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TBF8

FAM81A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689663.2

ENSEMBL proteins:

ENSP00000453918 ENSP00000452962 ENSP00000288228 ENSP00000453582 ENSP00000452902

ENSP00000452853 ENSP00000453296 ENSP00000453864 ENSP00000453784 ENSP00000453769

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8TBF8

UniProtKB/Swiss-Prot: FA81A_HUMAN, Q8TBF8

Similarity: Belongs to the FAM81 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM81A
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM81A (see all 59):
		hsa-miR-429 hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-548l hsa-miR-9 hsa-miR-424

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM81A

1 Interacting protein for FAM81A (Q8TBF8³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG4	P78352³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM81A
Search CenterWatch for drugs/clinical trials and news about FAM81A / FA81A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM81A gene:

NM_152450.2

Unigene Cluster for FAM81A:

Family with sequence similarity 81, member A

Hs.531168 [show with all ESTs]

Unigene Representative Sequence: NM_152450

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000558348 ENST00000560394 ENST00000288228(uc002agc.2) ENST00000559628

ENST00000558513(uc010uha.2) ENST00000557914 ENST00000560474 ENST00000557895

ENST00000560022 ENST00000560087 ENST00000560074 ENST00000560118 ENST00000558900

ENST00000560123 ENST00000561361

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		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM81A (see all 59):
		hsa-miR-429 hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-548l hsa-miR-9 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: FAM81A 3' UTR sequence

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Additional cDNA sequence:

AK299220.1 AK307975.1 AL110257.1 BC022537.1

8 DOTS entries:

DT.313003 DT.75152894 DT.100728135 DT.121060147 DT.95363673 DT.70104918 DT.75193298 DT.91987740

24/75 AceView cDNA sequences (see all 75):

F04086 AA730039 AA764763 AI187211 BX094345 Z40929 BM969263 BE327042

F10721 Z45202 AI417773 F07830 AI918875 AA687227 BE468266 AW572236

AI695092 BX110015 BI913729 BE869450 NM_152450 BX460169 AW295249 T06990

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FAM81A (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15
SP1:							-		-		-		-		-		-										-								-
SP2:															-		-										-								-
SP3:							-		-		-		-		-		-										-
SP4:							-		-				-		-		-										-
SP5:							-		-		-		-		-		-				-						-

ECgene alternative splicing isoforms for FAM81A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM81A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTTCCTT

About this image

FAM81A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM81A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM81A

SOURCE GeneReport for Unigene cluster: Hs.531168

SABiosciences Custom PCR Arrays for FAM81A

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM81A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM81A gene from 2/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM81A¹	family with sequence similarity 81, member A	72.22(n) 70.28(a)		415396 XM_413781.3 XP_413781.3
lizard (Anolis carolinensis)	Reptilia	FAM81A⁶	--	60(a)	1 ↔ 1	GL343573.1(122246-127317)

ENSEMBL Gene Tree for FAM81A (if available)
TreeFam Gene Tree for FAM81A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM81A gene

FAM81B²

1 SIMAP similar gene for FAM81A using alignment to 10 protein entries: FA81A_HUMAN (see all proteins):

FAM81B

FAM81A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138952159^1,2		--	59728462(+)	`TTCAGC/TTTTGA`	1	--	us2k¹		0	--	--	--	--
rs11631469^1,2	C,F,A,H,	--	59728483(+)	`TAAGAA/GGGCAC`	1	--	us2k¹ tfbs³		22		NS EA NA CSA WA	2342
rs142175018^1,2		--	59728636(+)	`GGGTAA/GAGTAA`	1	--	us2k¹		0	--	--	--	--
rs189020679^1,2		--	59728658(+)	`AGAAAC/GAAGAC`	1	--	us2k¹		0	--	--	--	--
rs144645414^1,2		--	59728868(+)	`AGAGTC/GACAGT`	1	--	us2k¹		0	--	--	--	--
rs181851742^1,2		--	59728940(+)	`GGCAGA/TGGGAA`	1	--	us2k¹		0	--	--	--	--
rs117627749^1,2	F,	--	59729153(+)	`TCTTCA/CCCATT`	1	--	us2k¹		1		EA	120
rs74017794^1,2	C,	--	59729246(+)	`TAGCGC/GTTTGT`	1	--	us2k¹		2		WA	120
rs12908434^1,2	C,F,H,	--	59729257(+)	`GGAAGG/TTATTA`	1	--	us2k¹		18		NS EA NA WA CSA	1219
rs187042885^1,2		--	59729285(+)	`GGAAAC/TAGTCG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM81A (59664892 - 59815751 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM81A
1 CNV: 72256

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM81A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM81A)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 145773	HGNC: 28379	AceView: MGC26690	Ensembl:ENSG00000157470	euGenes: HUgn145773
ECgene: FAM81A	H-InvDB: FAM81A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM81A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM81A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM81A gene:
Search GeneIP for patents involving FAM81A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Hot genes Disease genes FAM81A gene at Home site.

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FAM81A Gene

family with sequence similarity 81, member A

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FAM81A Gene

family with sequence similarity 81, member A

Aliasesfor FAM81A gene

Summariesfor FAM81A gene

Genomic Viewsfor FAM81A gene

Proteinsfor FAM81A gene

Protein Domains /Familiesfor FAM81A gene

Functionfor FAM81A gene

Pathways & Interactionsfor FAM81A gene

Drugs & Compoundsfor FAM81A gene

Transcriptsfor FAM81A gene

Expression for FAM81A gene

Orthologsfor FAM81A gene

Paralogsfor FAM81A gene

Genomic Variantsfor FAM81A gene

Disorders / Diseasesfor FAM81A gene

Publicationsfor FAM81A gene

External Searches for FAM81A gene

Genome Databases showing FAM81A gene

Other Databases showing FAM81A gene

Specialized Databases showing FAM81A gene

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Productsfor FAM81A gene

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Aliases
for FAM81A gene

Summaries
for FAM81A gene

Genomic Views
for FAM81A gene

Proteins
for FAM81A gene

Protein Domains /
Families
for FAM81A gene

Function
for FAM81A gene

Pathways & Interactions
for FAM81A gene

Drugs & Compounds
for FAM81A gene

Transcripts
for FAM81A gene

Expression
for FAM81A gene

Orthologs
for FAM81A gene

Paralogs
for FAM81A gene

Genomic Variants
for FAM81A gene

Disorders / Diseases
for FAM81A gene

Publications
for FAM81A gene

Intellectual Property
for FAM81A gene

Products
for FAM81A gene