Aliases for FAM78B Gene
Aliases for FAM78B Gene
External Ids for FAM78B Gene
- HGNC: 13495
- Entrez Gene: 149297
- Ensembl: ENSG00000188859
- UniProtKB: Q5VT40
Previous GeneCards Identifiers for FAM78B Gene
- GC01M162772
- GC01M164293
- GC01M164305
- GC01M166027
- GC01M137286
Summaries for FAM78B Gene
GeneCards Summary for FAM78B Gene
FAM78B (Family With Sequence Similarity 78 Member B) is a Protein Coding gene. An important paralog of this gene is FAM78A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM78B Gene
Genomics for FAM78B Gene
Regulatory Elements for FAM78B Gene
Enhancers for FAM78B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G166166 | 0.9 | ENCODE | 0.7 | -0.2 | -161 | 1.1 | TBP ARNT SIN3A DMAP1 ZBTB40 ZNF766 ZNF143 ZNF207 KLF7 THAP11 | FAM78B LOC284685 |
| GH01G166185 | 0.4 | ENCODE | 0.4 | -18.3 | -18250 | 0.2 | SMARCA4 | MIR921 FAM78B LOC284685 |
| GH01G166170 | 0.2 | ENCODE | 0.7 | -4.0 | -3970 | 0.2 | FAM78B LOC284685 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM78B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM78B gene promoter:
Regulatory Element Products
Genomic Location for FAM78B Gene
- Chromosome:
- 1
- Start:
- 166,057,426 bp from pter
- End:
- 166,166,969 bp from pter
- Size:
- 109,544 bases
- Orientation:
- Minus strand
Genomic View for FAM78B Gene
Genes around FAM78B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q24.1 by Ensembl
- 1q24.1 by Entrez Gene
- 1q24.1 by HGNC
FAM78B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM78B Gene
Proteins for FAM78B Gene
-
Protein details for FAM78B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VT40-FA78B_HUMAN
- Recommended name:
- Protein FAM78B
- Protein Accession:
- Q5VT40
- B7Z693
Protein attributes for FAM78B Gene
- Size:
- 261 amino acids
- Molecular mass:
- 29835 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for FAM78B Gene
No Post-translational modifications
Other Protein References for FAM78B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM78B
- Novus Biologicals Antibodies for FAM78B
-
Abcam antibodies for FAM78B
- Invitrogen Antibodies for FAM78B
- GeneTex FAM78B antibody for FAM78B
Protein Products
-
OriGene Purified Proteins for FAM78B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM78B
- Origene Custom Protein Services for FAM78B
- Search GeneTex for Proteins for FAM78B
Assay Products
No data available for DME Specific Peptides for FAM78B Gene
Domains & Families for FAM78B Gene
Suggested Antigen Peptide Sequences for FAM78B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5VT40- Family:
-
- Belongs to the FAM78 family.
No data available for Gene Families for FAM78B Gene
Function for FAM78B Gene
Phenotypes for FAM78B Gene
- GenomeRNAi human phenotypes for FAM78B:
-
- Increased viability
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased interferon-beta reporter expression
- Decreased viability with TRAIL
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM78B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM78B gene
- Search ViGene Biosciences for FAM78B
CRISPR Products
-
OriGene CRISPR knockouts for FAM78B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM78B
- GenScript: Design CRISPR guide RNA sequences for FAM78B
miRNA for FAM78B Gene
- miRTarBase miRNAs that target FAM78B
-
- mmu-mir-758-3p (MIRT007571)
- mmu-mir-15a-5p (MIRT011678)
- mmu-mir-362-3p (MIRT577075)
- mmu-mir-329-3p (MIRT577076)
- mmu-mir-101c (MIRT577207)
- mmu-mir-466i-3p (MIRT577208)
- mmu-mir-344f-5p (MIRT583592)
- mmu-mir-223-3p (MIRT583593)
- mmu-mir-664-3p (MIRT583594)
- mmu-mir-465b-3p (MIRT596207)
- mmu-mir-465a-3p (MIRT596208)
- mmu-mir-465c-3p (MIRT596209)
miRNA Products
- Search ViGene Biosciences for FAM78B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM78B
- Browse OriGene Inhibitory RNA Products For FAM78B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM78B gene
Clone Products
-
OriGene ORF clones in human for FAM78B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM78B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM78B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM78B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM78B gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM78B Gene
Localization for FAM78B Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM78B Gene
Transcripts for FAM78B Gene
mRNA/cDNA for FAM78B Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM78B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM78B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM78B
- GenScript: Design CRISPR guide RNA sequences for FAM78B
miRNA Products
- Search ViGene Biosciences for FAM78B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM78B
- Browse OriGene Inhibitory RNA Products For FAM78B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM78B gene
Clone Products
-
OriGene ORF clones in human for FAM78B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FAM78B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
-
Stomach (Gastrointestinal Tract)
NURSA nuclear receptor signaling pathways regulating expression of FAM78B Gene:
FAM78BSOURCE GeneReport for Unigene cluster for FAM78B Gene:
Hs.133029Evidence on tissue expression from TISSUES for FAM78B Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FAM78B
-
OriGene qPCR primer pairs for FAM78B
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM78B Gene
Orthologs for FAM78B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM78B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM78B 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM78B 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FAM78B 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam78b 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM78B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM78B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FAM78B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam78b 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | FAM78B (1 of 2) 35 |
|
OneToMany | |
| fam78bb 34 |
|
||||
| FP102157.1 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FAM78B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM78B Gene
(1) SIMAP similar genes for FAM78B Gene using alignment to 4 proteins:
Variants for FAM78B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006492 | -- | 166,162,344(+) | CTTCC(C/T)AAAGT | intron-variant | |
| rs1000015354 | -- | 166,107,824(+) | GGATG(C/G)AGGGA | intron-variant | |
| rs1000106707 | -- | 166,167,569(+) | TGTAC(A/C/G)GTATG | upstream-variant-2KB | |
| rs1000111359 | -- | 166,130,272(+) | TGGAC(A/G)TAACA | intron-variant | |
| rs1000147020 | -- | 166,113,079(+) | TCTGA(C/T)GGTCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2719162 | CNV | deletion | 23290073 |
| nsv1112220 | CNV | deletion | 24896259 |
| nsv1127041 | CNV | deletion | 24896259 |
| nsv1136101 | CNV | deletion | 24896259 |
| nsv475739 | CNV | novel sequence insertion | 20440878 |
| nsv955475 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.62;
13.36% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM78B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM78B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM78B Gene
Disorders for FAM78B Gene
Relevant External Links for FAM78B
No disorders were found for FAM78B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM78B Gene
Publications for FAM78B Gene
- Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
- Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for FAM78B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for FAM78B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FAM78B
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM78B
- Browse OriGene Inhibitory RNA Products For FAM78B
- OriGene qPCR primer pairs and template standards for FAM78B
- OriGene qPCR primer pairs for FAM78B
- OriGene CRISPR knockouts for FAM78B
- OriGene ORF clones in human for FAM78B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FAM78B in any vector
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- GenScript: Design CRISPR guide RNA sequences for FAM78B
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for FAM78B
- Novus Biologicals proteins and lysates for FAM78B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FAM78B gene
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- Search ViGene Biosciences for FAM78B
- Horizon Cell Lines for FAM78B
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM78B
- VectorBuilder custom plasmid, inducible vectors for FAM78B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM78B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM78B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer