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Aliases for FAM78B Gene

Aliases for FAM78B Gene

  • Family With Sequence Similarity 78 Member B 2 3 5
  • Family With Sequence Similarity 78, Member B 2

External Ids for FAM78B Gene

Previous GeneCards Identifiers for FAM78B Gene

  • GC01M162772
  • GC01M164293
  • GC01M164305
  • GC01M166027
  • GC01M137286

Summaries for FAM78B Gene

GeneCards Summary for FAM78B Gene

FAM78B (Family With Sequence Similarity 78 Member B) is a Protein Coding gene. An important paralog of this gene is FAM78A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM78B Gene

Genomics for FAM78B Gene

Regulatory Elements for FAM78B Gene

Enhancers for FAM78B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM78B on UCSC Golden Path with GeneCards custom track

Promoters for FAM78B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM78B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM78B Gene

166,057,426 bp from pter
166,166,969 bp from pter
109,544 bases
Minus strand

Genomic View for FAM78B Gene

Genes around FAM78B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM78B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM78B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM78B Gene

Proteins for FAM78B Gene

  • Protein details for FAM78B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM78B
    Protein Accession:
    Secondary Accessions:
    • B7Z693

    Protein attributes for FAM78B Gene

    261 amino acids
    Molecular mass:
    29835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM78B Gene

Post-translational modifications for FAM78B Gene

No Post-translational modifications

Other Protein References for FAM78B Gene

No data available for DME Specific Peptides for FAM78B Gene

Domains & Families for FAM78B Gene

Protein Domains for FAM78B Gene


Suggested Antigen Peptide Sequences for FAM78B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM78 family.
  • Belongs to the FAM78 family.
genes like me logo Genes that share domains with FAM78B: view

No data available for Gene Families for FAM78B Gene

Function for FAM78B Gene

genes like me logo Genes that share phenotypes with FAM78B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM78B Gene

Localization for FAM78B Gene

Subcellular locations from

Jensen Localization Image for FAM78B Gene COMPARTMENTS Subcellular localization image for FAM78B gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM78B Gene

Pathways & Interactions for FAM78B Gene

SuperPathways for FAM78B Gene

No Data Available

Interacting Proteins for FAM78B Gene

Gene Ontology (GO) - Biological Process for FAM78B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM78B Gene

Drugs & Compounds for FAM78B Gene

No Compound Related Data Available

Transcripts for FAM78B Gene

Unigene Clusters for FAM78B Gene

Family with sequence similarity 78, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM78B Gene

No ASD Table

Relevant External Links for FAM78B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM78B Gene

mRNA expression in normal human tissues for FAM78B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FAM78B Gene:


SOURCE GeneReport for Unigene cluster for FAM78B Gene:

genes like me logo Genes that share expression patterns with FAM78B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM78B Gene

Orthologs for FAM78B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM78B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM78B 34
  • 96.68 (n)
  • 100 (a)
FAM78B 35
  • 93 (a)
(Canis familiaris)
Mammalia FAM78B 34
  • 97.32 (n)
  • 100 (a)
FAM78B 35
  • 100 (a)
(Mus musculus)
Mammalia Fam78b 34
  • 96.04 (n)
  • 100 (a)
Fam78b 16
Fam78b 35
  • 100 (a)
(Pan troglodytes)
Mammalia FAM78B 34
  • 99.74 (n)
  • 100 (a)
FAM78B 35
  • 100 (a)
(Monodelphis domestica)
Mammalia FAM78B 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia FAM78B 35
  • 78 (a)
(Gallus gallus)
Aves FAM78B 34
  • 83.14 (n)
  • 89.66 (a)
FAM78B 35
  • 89 (a)
(Anolis carolinensis)
Reptilia FAM78B 35
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam78b 34
  • 82.38 (n)
  • 92.72 (a)
(Danio rerio)
Actinopterygii fam78bb 34
  • 75.35 (n)
  • 82.76 (a)
FAM78B (1 of 2) 35
  • 82 (a)
FP102157.1 35
  • 74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
Species where no ortholog for FAM78B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM78B Gene

Gene Tree for FAM78B (if available)
Gene Tree for FAM78B (if available)

Paralogs for FAM78B Gene

Paralogs for FAM78B Gene

(1) SIMAP similar genes for FAM78B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM78B: view

Variants for FAM78B Gene

Sequence variations from dbSNP and Humsavar for FAM78B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2008 -- 166,060,888(+) AAACT(A/G)AAATA intron-variant
rs715421 -- 166,152,529(-) AGAGA(A/G)GGAGT intron-variant
rs731264 -- 166,130,684(+) ACTTA(C/G/T)TAATT intron-variant
rs919674 -- 166,123,802(-) CATGG(C/T)GTGTT intron-variant
rs919675 -- 166,123,467(-) ATTAG(G/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM78B Gene

Variant ID Type Subtype PubMed ID
esv2719162 CNV deletion 23290073
nsv1112220 CNV deletion 24896259
nsv1127041 CNV deletion 24896259
nsv1136101 CNV deletion 24896259
nsv475739 CNV novel sequence insertion 20440878
nsv955475 CNV deletion 24416366

Variation tolerance for FAM78B Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM78B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM78B Gene

Disorders for FAM78B Gene

Relevant External Links for FAM78B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM78B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM78B Gene

Publications for FAM78B Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 65
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for FAM78B Gene

Sources for FAM78B Gene