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Aliases for FAM78A Gene

Aliases for FAM78A Gene

  • Family With Sequence Similarity 78, Member A 2 3
  • C9orf59 3 4
  • Chromosome 9 Open Reading Frame 59 2
  • Protein FAM78A 3

External Ids for FAM78A Gene

Previous HGNC Symbols for FAM78A Gene

  • C9orf59

Previous GeneCards Identifiers for FAM78A Gene

  • GC09M131165
  • GC09M133123
  • GC09M134133
  • GC09M103624

Summaries for FAM78A Gene

GeneCards Summary for FAM78A Gene

FAM78A (Family With Sequence Similarity 78, Member A) is a Protein Coding gene. An important paralog of this gene is FAM78B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM78A Gene

Genomics for FAM78A Gene

Regulatory Elements for FAM78A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM78A Gene

131,258,076 bp from pter
131,276,547 bp from pter
18,472 bases
Minus strand

Genomic View for FAM78A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM78A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM78A Gene

Proteins for FAM78A Gene

  • Protein details for FAM78A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM78A
    Protein Accession:
    Secondary Accessions:
    • Q86VQ9
    • Q9H7P4

    Protein attributes for FAM78A Gene

    283 amino acids
    Molecular mass:
    31968 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH49388.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM78A Gene

Proteomics data for FAM78A Gene at MOPED

Post-translational modifications for FAM78A Gene

Other Protein References for FAM78A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FAM78A Gene

Domains for FAM78A Gene

Protein Domains for FAM78A Gene


Suggested Antigen Peptide Sequences for FAM78A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM78 family.
  • Belongs to the FAM78 family.
genes like me logo Genes that share domains with FAM78A: view

No data available for Gene Families for FAM78A Gene

Function for FAM78A Gene

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM78A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM78A Gene

Localization for FAM78A Gene

Subcellular locations from

Jensen Localization Image for FAM78A Gene COMPARTMENTS Subcellular localization image for FAM78A gene
Compartment Confidence
cytoskeleton 2
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM78A Gene

Pathways for FAM78A Gene

SuperPathways for FAM78A Gene

No Data Available

Interacting Proteins for FAM78A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361345 for FAM78A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM78A Gene


No data available for Pathways by source for FAM78A Gene

Transcripts for FAM78A Gene

Unigene Clusters for FAM78A Gene

Family with sequence similarity 78, member A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM78A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM78A Gene

No ASD Table

Relevant External Links for FAM78A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM78A Gene

mRNA expression in normal human tissues for FAM78A Gene

mRNA differential expression in normal tissues according to GTEx for FAM78A Gene

This gene is overexpressed in Whole Blood (7.0), Heart - Atrial Appendage (5.7), Heart - Left Ventricle (4.6), and Spleen (4.5).

Protein differential expression in normal tissues for FAM78A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.4) and CD8 Tcells (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM78A Gene

SOURCE GeneReport for Unigene cluster for FAM78A Gene Hs.143878

genes like me logo Genes that share expressions with FAM78A: view

Expression partners for FAM78A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM78A Gene

Orthologs for FAM78A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM78A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM78A 35
  • 92.89 (n)
  • 94.49 (a)
C9ORF59 36
  • 80 (a)
(Canis familiaris)
Mammalia FAM78A 35
  • 92.58 (n)
  • 97.17 (a)
FAM78A 36
  • 97 (a)
(Mus musculus)
Mammalia Fam78a 35
  • 92.34 (n)
  • 97.17 (a)
Fam78a 16
Fam78a 36
  • 97 (a)
(Pan troglodytes)
Mammalia FAM78A 35
  • 99.18 (n)
  • 99.65 (a)
FAM78A 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Fam78a 35
  • 91.05 (n)
  • 97.17 (a)
(Monodelphis domestica)
Mammalia FAM78A 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FAM78A 36
  • 85 (a)
(Gallus gallus)
Aves FAM78A 35
  • 83.9 (n)
  • 86.31 (a)
FAM78A 36
  • 86 (a)
(Anolis carolinensis)
Reptilia FAM78A 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam78a 35
  • 73.76 (n)
  • 74.9 (a)
(Danio rerio)
Actinopterygii Dr.16888 35
fam78ab 35
  • 74.43 (n)
  • 71.76 (a)
fam78aa 36
  • 64 (a)
fam78ab 36
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for FAM78A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM78A Gene

Gene Tree for FAM78A (if available)
Gene Tree for FAM78A (if available)

Paralogs for FAM78A Gene

Paralogs for FAM78A Gene

(8) SIMAP similar genes for FAM78A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM78A: view

Variants for FAM78A Gene

Sequence variations from dbSNP and Humsavar for FAM78A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs352951 -- 131,261,290(-) TCGGA(C/T)GGGGT synonymous-codon, reference
rs352952 -- 131,261,128(-) ACCAA(C/T)ATCTA synonymous-codon, reference
rs352953 -- 131,259,378(-) AGAGC(A/G)ACAGG utr-variant-3-prime
rs352954 -- 131,259,327(-) TCCCT(C/T)GGTCC utr-variant-3-prime
rs352955 -- 131,258,336(-) TGCTC(A/T)TGTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM78A Gene

Variant ID Type Subtype PubMed ID
dgv8310n71 CNV Loss 21882294
nsv831739 CNV Loss 17160897
dgv8311n71 CNV Loss 21882294
nsv893979 CNV Loss 21882294
nsv509327 CNV Insertion 20534489
nsv893983 CNV Loss 21882294
esv2660985 CNV Deletion 23128226
nsv893984 CNV Gain 21882294
dgv8312n71 CNV Loss 21882294
nsv893987 CNV Loss 21882294
nsv466602 CNV Loss 19166990
nsv893988 CNV Gain 21882294
nsv825126 CNV Gain 20364138

Relevant External Links for FAM78A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM78A Gene

Disorders for FAM78A Gene

No disorders were found for FAM78A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM78A Gene

Publications for FAM78A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM78A Gene

Sources for FAM78A Gene

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