Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM76B Gene

Aliases for FAM76B Gene

  • Family With Sequence Similarity 76 Member B 2 3 5
  • Family With Sequence Similarity 76, Member B 2

External Ids for FAM76B Gene

Previous GeneCards Identifiers for FAM76B Gene

  • GC11M095142
  • GC11M095502
  • GC11M091567

Summaries for FAM76B Gene

GeneCards Summary for FAM76B Gene

FAM76B (Family With Sequence Similarity 76 Member B) is a Protein Coding gene. GO annotations related to this gene include NEDD8-specific protease activity. An important paralog of this gene is FAM76A.

Gene Wiki entry for FAM76B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM76B Gene

Genomics for FAM76B Gene

Regulatory Elements for FAM76B Gene

Enhancers for FAM76B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G096054 1.6 Ensembl ENCODE dbSUPER 22.2 -265.6 -265595 2.4 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 FOS FAM76B MAML2 CEP57 GC11M095989 GC11P096202
GH11G096241 2 FANTOM5 Ensembl ENCODE dbSUPER 16.7 -452.5 -452532 3.6 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF207 FOS MAML2 FAM76B CCDC82 JRKL GC11P096202 GC11M096338
GH11G095788 1.4 ENCODE dbSUPER 20.9 0.0 -8 4.4 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 CEP57 FAM76B JRKL LOC101929295 MAML2 MTMR2 GC11M095802
GH11G096337 1.7 FANTOM5 ENCODE dbSUPER 12.3 -550.1 -550057 6.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A CBX5 ZNF143 FOS DEK MAML2 FAM76B CCDC82 JRKL MIR1260B GC11M096338
GH11G095248 1.1 ENCODE dbSUPER 15.6 +541.5 541463 1.3 HDGF TBP CBX5 SCRT2 ZNF548 RELB ETV6 IKZF2 CREM CBFB FAM76B MRE11 ANKRD49 CEP57 LOC101929295 GC11M095260 SESN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM76B on UCSC Golden Path with GeneCards custom track

Promoters for FAM76B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043656 209 3201 MLX DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC TBX21 ZNF610 GLIS1

Genomic Location for FAM76B Gene

95,768,942 bp from pter
95,790,409 bp from pter
21,468 bases
Minus strand

Genomic View for FAM76B Gene

Genes around FAM76B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM76B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM76B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM76B Gene

Proteins for FAM76B Gene

  • Protein details for FAM76B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM76B
    Protein Accession:
    Secondary Accessions:
    • B2R9C2
    • Q6PIU3
    • Q8TC53

    Protein attributes for FAM76B Gene

    339 amino acids
    Molecular mass:
    38708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM76B Gene


neXtProt entry for FAM76B Gene

Post-translational modifications for FAM76B Gene

  • Ubiquitination at Lys225
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM76B Gene

Domains & Families for FAM76B Gene

Protein Domains for FAM76B Gene


Suggested Antigen Peptide Sequences for FAM76B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The polyhistidine repeat acts as a targeting signal to nuclear speckles.
  • Belongs to the FAM76 family.
  • The polyhistidine repeat acts as a targeting signal to nuclear speckles.
  • Belongs to the FAM76 family.
genes like me logo Genes that share domains with FAM76B: view

No data available for Gene Families for FAM76B Gene

Function for FAM76B Gene

Gene Ontology (GO) - Molecular Function for FAM76B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM76B: view
genes like me logo Genes that share phenotypes with FAM76B: view

Animal Model Products

CRISPR Products

miRNA for FAM76B Gene

miRTarBase miRNAs that target FAM76B

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM76B Gene

Localization for FAM76B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM76B Gene

Nucleus speckle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM76B gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM76B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016607 nuclear speck IEA,IDA 19266028
genes like me logo Genes that share ontologies with FAM76B: view

Pathways & Interactions for FAM76B Gene

SuperPathways for FAM76B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM76B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM76B Gene

Drugs & Compounds for FAM76B Gene

No Compound Related Data Available

Transcripts for FAM76B Gene

Unigene Clusters for FAM76B Gene

Family with sequence similarity 76, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM76B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - -
SP2: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: -
SP10: -

Relevant External Links for FAM76B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM76B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM76B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM76B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.7), Lung (11.9), Fetal Brain (8.8), and Lymph node (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM76B Gene

Protein tissue co-expression partners for FAM76B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM76B Gene:


SOURCE GeneReport for Unigene cluster for FAM76B Gene:


Evidence on tissue expression from TISSUES for FAM76B Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM76B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM76B Gene

Orthologs for FAM76B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM76B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM76B 34 35
  • 99.71 (n)
(Monodelphis domestica)
Mammalia FAM76B 35
  • 99 (a)
(Canis familiaris)
Mammalia FAM76B 34 35
  • 96.66 (n)
(Bos Taurus)
Mammalia FAM76B 34 35
  • 94.79 (n)
(Ornithorhynchus anatinus)
Mammalia FAM76B 35
  • 93 (a)
(Mus musculus)
Mammalia Fam76b 34 16 35
  • 91.45 (n)
(Gallus gallus)
Aves FAM76B 34 35
  • 84.57 (n)
(Anolis carolinensis)
Reptilia FAM76B 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam76b 34
  • 83.13 (n)
Str.6497 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5406 34
(Danio rerio)
Actinopterygii fam76b 34 35
  • 75.43 (n)
wufa11h02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9806 34
fruit fly
(Drosophila melanogaster)
Insecta CG4452 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea K04F10.7 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for FAM76B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM76B Gene

Gene Tree for FAM76B (if available)
Gene Tree for FAM76B (if available)

Paralogs for FAM76B Gene

Paralogs for FAM76B Gene

(1) SIMAP similar genes for FAM76B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM76B: view

Variants for FAM76B Gene

Sequence variations from dbSNP and Humsavar for FAM76B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs878854985 Uncertain significance 95,790,702(+) AGATG(A/G)CGGCG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000024325 -- 95,773,529(+) AGACA(C/T)GTTGG intron-variant
rs1000116560 -- 95,785,659(+) GAATT(A/G)TCACA intron-variant
rs1000246363 -- 95,770,932(+) ACATT(G/T)TACCT nc-transcript-variant, utr-variant-3-prime
rs1000416925 -- 95,789,934(+) TCAGC(G/T)CGCGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM76B Gene

Variant ID Type Subtype PubMed ID
nsv832235 CNV gain 17160897

Variation tolerance for FAM76B Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM76B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM76B Gene

Disorders for FAM76B Gene

Relevant External Links for FAM76B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM76B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM76B Gene

Publications for FAM76B Gene

  1. Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B. (PMID: 27018871) Zheng X. … Mao Q. (PLoS ONE 2016) 2 3 64
  2. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E. … de la Luna S. (PLoS Genet. 2009) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM76B Gene

Sources for FAM76B Gene

Loading form....