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Aliases for FAM76B Gene

Aliases for FAM76B Gene

  • Family With Sequence Similarity 76, Member B 2 3

External Ids for FAM76B Gene

Previous GeneCards Identifiers for FAM76B Gene

  • GC11M095142
  • GC11M095502
  • GC11M091567

Summaries for FAM76B Gene

GeneCards Summary for FAM76B Gene

FAM76B (Family With Sequence Similarity 76, Member B) is a Protein Coding gene. An important paralog of this gene is FAM76A.

Gene Wiki entry for FAM76B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM76B Gene

Genomics for FAM76B Gene

Regulatory Elements for FAM76B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM76B Gene

Start:
95,768,942 bp from pter
End:
95,790,409 bp from pter
Size:
21,468 bases
Orientation:
Minus strand

Genomic View for FAM76B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM76B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM76B Gene

Proteins for FAM76B Gene

  • Protein details for FAM76B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYJ3-FA76B_HUMAN
    Recommended name:
    Protein FAM76B
    Protein Accession:
    Q5HYJ3
    Secondary Accessions:
    • B2R9C2
    • Q6PIU3
    • Q8TC53

    Protein attributes for FAM76B Gene

    Size:
    339 amino acids
    Molecular mass:
    38708 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM76B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM76B Gene

Proteomics data for FAM76B Gene at MOPED

Post-translational modifications for FAM76B Gene

No data available for DME Specific Peptides for FAM76B Gene

Domains for FAM76B Gene

Protein Domains for FAM76B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM76B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYJ3

UniProtKB/Swiss-Prot:

FA76B_HUMAN :
  • Q5HYJ3
Domain:
  • The polyhistidine repeat acts as a targeting signal to nuclear speckles.
Family:
  • Belongs to the FAM76 family.
genes like me logo Genes that share domains with FAM76B: view

No data available for Gene Families for FAM76B Gene

Function for FAM76B Gene

Gene Ontology (GO) - Molecular Function for FAM76B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019784 NEDD8-specific protease activity IBA --
genes like me logo Genes that share ontologies with FAM76B: view

Phenotypes for FAM76B Gene

GenomeRNAi human phenotypes for FAM76B:
genes like me logo Genes that share phenotypes with FAM76B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM76B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM76B Gene

Localization for FAM76B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM76B Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM76B Gene COMPARTMENTS Subcellular localization image for FAM76B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM76B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0016607 nuclear speck IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FAM76B: view

Pathways for FAM76B Gene

SuperPathways for FAM76B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM76B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000338 protein deneddylation IBA --
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with FAM76B: view

No data available for Pathways by source for FAM76B Gene

Transcripts for FAM76B Gene

Unigene Clusters for FAM76B Gene

Family with sequence similarity 76, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM76B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM76B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: -
SP9:
SP10: -

Relevant External Links for FAM76B Gene

GeneLoc Exon Structure for
FAM76B
ECgene alternative splicing isoforms for
FAM76B

Expression for FAM76B Gene

mRNA expression in normal human tissues for FAM76B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FAM76B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.7), Lung (11.9), Fetal Brain (8.8), and Lymph node (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM76B Gene

SOURCE GeneReport for Unigene cluster for FAM76B Gene Hs.288304

genes like me logo Genes that share expressions with FAM76B: view

Expression partners for FAM76B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM76B Gene

Orthologs for FAM76B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM76B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM76B 35
  • 94.79 (n)
  • 99.12 (a)
FAM76B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM76B 35
  • 96.66 (n)
  • 99.12 (a)
FAM76B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam76b 35
  • 91.45 (n)
  • 97.64 (a)
Fam76b 16
Fam76b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM76B 35
  • 99.71 (n)
  • 99.71 (a)
FAM76B 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM76B 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM76B 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM76B 35
  • 84.57 (n)
  • 97.92 (a)
FAM76B 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM76B 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam76b 35
  • 83.13 (n)
  • 95.24 (a)
Str.6497 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5406 35
zebrafish
(Danio rerio)
Actinopterygii fam76b 35
  • 75.43 (n)
  • 88.99 (a)
wufa11h02 35
fam76b 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9806 35
fruit fly
(Drosophila melanogaster)
Insecta CG4452 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K04F10.7 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for FAM76B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM76B Gene

ENSEMBL:
Gene Tree for FAM76B (if available)
TreeFam:
Gene Tree for FAM76B (if available)

Paralogs for FAM76B Gene

Paralogs for FAM76B Gene

Selected SIMAP similar genes for FAM76B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM76B: view

Variants for FAM76B Gene

Sequence variations from dbSNP and Humsavar for FAM76B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1106318 -- 95,781,092(+) TTTTT(C/T)CCCAC intron-variant
rs1129081 -- 95,768,975(-) ATTTC(A/C)CAATA utr-variant-3-prime, nc-transcript-variant
rs1150358 -- 95,774,053(-) GAGTG(C/G)CATCT intron-variant
rs1150359 -- 95,774,460(-) TGTGT(G/T)TTGGT intron-variant
rs1150360 -- 95,778,896(+) TTTCA(A/C/G/T)TTGAC missense, synonymous-codon, reference, utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM76B Gene

Variant ID Type Subtype PubMed ID
nsv832235 CNV Gain 17160897

Relevant External Links for FAM76B Gene

HapMap Linkage Disequilibrium report
FAM76B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM76B Gene

Disorders for FAM76B Gene

Relevant External Links for FAM76B

Genetic Association Database (GAD)
FAM76B
Human Genome Epidemiology (HuGE) Navigator
FAM76B

No disorders were found for FAM76B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM76B Gene

Publications for FAM76B Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PMID: 17203973) Vasilescu J. … Figeys D. (J. Proteome Res. 2007) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FAM76B Gene

Sources for FAM76B Gene

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