Aliases for FAM76B Gene
Aliases for FAM76B Gene
External Ids for FAM76B Gene
- HGNC: 28492
- Entrez Gene: 143684
- Ensembl: ENSG00000077458
- UniProtKB: Q5HYJ3
Previous GeneCards Identifiers for FAM76B Gene
- GC11M095142
- GC11M095502
- GC11M091567
Summaries for FAM76B Gene
GeneCards Summary for FAM76B Gene
FAM76B (Family With Sequence Similarity 76 Member B) is a Protein Coding gene. GO annotations related to this gene include NEDD8-specific protease activity. An important paralog of this gene is FAM76A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM76B Gene
Genomics for FAM76B Gene
Regulatory Elements for FAM76B Gene
Enhancers for FAM76B Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM76B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM76B gene promoter:
Regulatory Element Products
Genomic Location for FAM76B Gene
- Chromosome:
- 11
- Start:
- 95,768,942 bp from pter
- End:
- 95,790,409 bp from pter
- Size:
- 21,468 bases
- Orientation:
- Minus strand
Genomic View for FAM76B Gene
Genes around FAM76B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q21 by Ensembl
- 11q21 by Entrez Gene
- 11q21 by HGNC
FAM76B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM76B Gene
Proteins for FAM76B Gene
-
Protein details for FAM76B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5HYJ3-FA76B_HUMAN
- Recommended name:
- Protein FAM76B
- Protein Accession:
- Q5HYJ3
- B2R9C2
- Q6PIU3
- Q8TC53
Protein attributes for FAM76B Gene
- Size:
- 339 amino acids
- Molecular mass:
- 38708 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM76B Gene
Post-translational modifications for FAM76B Gene
Other Protein References for FAM76B Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM76B
- Novus Biologicals Antibodies for FAM76B
-
Abcam antibodies for FAM76B
- Invitrogen Antibodies for FAM76B
- GeneTex FAM76B antibody for FAM76B
Protein Products
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- Search GeneTex for Proteins for FAM76B
Assay Products
No data available for DME Specific Peptides for FAM76B Gene
Domains & Families for FAM76B Gene
Suggested Antigen Peptide Sequences for FAM76B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5HYJ3UniProtKB/Swiss-Prot:
FA76B_HUMAN :- The polyhistidine repeat acts as a targeting signal to nuclear speckles.
- Belongs to the FAM76 family.
- Domain:
-
- The polyhistidine repeat acts as a targeting signal to nuclear speckles.
- Family:
-
- Belongs to the FAM76 family.
No data available for Gene Families for FAM76B Gene
Function for FAM76B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for FAM76B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM76B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM76B gene
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CRISPR Products
-
OriGene CRISPR knockouts for FAM76B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM76B
- GenScript: Design CRISPR guide RNA sequences for FAM76B
miRNA for FAM76B Gene
- miRTarBase miRNAs that target FAM76B
miRNA Products
- Search ViGene Biosciences for FAM76B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM76B
- Browse OriGene Inhibitory RNA Products For FAM76B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM76B gene
Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM76B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM76B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM76B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM76B gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM76B Gene
Localization for FAM76B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FAM76B Gene
- Nucleus speckle.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| cytosol | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016607 | nuclear speck | IEA,IDA | 19266028 |
Pathways & Interactions for FAM76B Gene
No Data Available
Interacting Proteins for FAM76B Gene
Selected Interacting proteins:
Q5HYJ3-FA76B_HUMAN
ENSP00000351631
for FAM76B Gene via
MINT
STRING
IID
UniProtKB
| Symbol | External ID(s) | Details |
|---|---|---|
| KRTAP10-11 | ||
| KRTAP9-2 | ||
| ADO | ||
| IDI2 | ||
| KRTAP10-5 |
No data available for Pathways by source and SIGNOR curated interactions for FAM76B Gene
Transcripts for FAM76B Gene
mRNA/cDNA for FAM76B Gene
- (8) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (84) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM76B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM76B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM76B
- GenScript: Design CRISPR guide RNA sequences for FAM76B
miRNA Products
- Search ViGene Biosciences for FAM76B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM76B
- Browse OriGene Inhibitory RNA Products For FAM76B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM76B gene
Clone Products
-
OriGene ORF clones in human for FAM76B
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- Sino Biological Human cDNA Clone for FAM76B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - |
Expression for FAM76B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (21.7), Lung (11.9), Fetal Brain (8.8), and Lymph node (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM76B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FAM76B Gene:
FAM76BSOURCE GeneReport for Unigene cluster for FAM76B Gene:
Hs.288304Evidence on tissue expression from TISSUES for FAM76B Gene
- Skin(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for FAM76B
-
OriGene qPCR primer pairs and template standards for FAM76B
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM76B Gene
Orthologs for FAM76B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM76B 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM76B 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FAM76B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM76B 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM76B 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fam76b 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | FAM76B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FAM76B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam76b 34 |
|
||
| Str.6497 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5406 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam76b 34 35 |
|
||
| wufa11h02 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9806 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4452 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | K04F10.7 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FAM76B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FAM76B Gene
(1) SIMAP similar genes for FAM76B Gene using alignment to 6 proteins:
Variants for FAM76B Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs878854985 | Uncertain significance | 95,790,702(+) | AGATG(A/G)CGGCG | nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime | |
| rs1000024325 | -- | 95,773,529(+) | AGACA(C/T)GTTGG | intron-variant | |
| rs1000116560 | -- | 95,785,659(+) | GAATT(A/G)TCACA | intron-variant | |
| rs1000246363 | -- | 95,770,932(+) | ACATT(G/T)TACCT | nc-transcript-variant, utr-variant-3-prime | |
| rs1000416925 | -- | 95,789,934(+) | TCAGC(G/T)CGCGA | intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime |
Residual Variation Intolerance Score:
33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.61;
13.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM76B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM76B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM76B Gene
Disorders for FAM76B Gene
Relevant External Links for FAM76B
No disorders were found for FAM76B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM76B Gene
Publications for FAM76B Gene
- Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B. (PMID: 27018871) Zheng X. … Mao Q. (PLoS ONE 2016) 2 3 64
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E. … de la Luna S. (PLoS Genet. 2009) 3 4 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for FAM76B Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for FAM76B
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- OriGene qPCR primer pairs and template standards for FAM76B
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- GenScript: Design CRISPR guide RNA sequences for FAM76B
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- Novus Biologicals Antibodies for FAM76B
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- VectorBuilder custom plasmid, inducible vectors for FAM76B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM76B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM76B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer