Aliases for FAM76A Gene
Aliases for FAM76A Gene
External Ids for FAM76A Gene
- HGNC: 28530
- Entrez Gene: 199870
- Ensembl: ENSG00000009780
- UniProtKB: Q8TAV0
Previous GeneCards Identifiers for FAM76A Gene
- GC01P027925
- GC01P028052
- GC01P026308
Summaries for FAM76A Gene
GeneCards Summary for FAM76A Gene
FAM76A (Family With Sequence Similarity 76 Member A) is a Protein Coding gene. An important paralog of this gene is FAM76B.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM76A Gene
Genomics for FAM76A Gene
Regulatory Elements for FAM76A Gene
Enhancers for FAM76A Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM76A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FAM76A gene promoter:
Regulatory Element Products
Genomic Location for FAM76A Gene
- Chromosome:
- 1
- Start:
- 27,725,979 bp from pter
- End:
- 27,763,122 bp from pter
- Size:
- 37,144 bases
- Orientation:
- Plus strand
Genomic View for FAM76A Gene
Genes around FAM76A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p35.3 by Ensembl
- 1p35.3 by Entrez Gene
- 1p35.3 by HGNC
FAM76A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM76A Gene
Proteins for FAM76A Gene
-
Protein details for FAM76A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TAV0-FA76A_HUMAN
- Recommended name:
- Protein FAM76A
- Protein Accession:
- Q8TAV0
- B4DWT3
- O95565
- O95566
- Q8N7J5
Protein attributes for FAM76A Gene
- Size:
- 307 amino acids
- Molecular mass:
- 35049 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM76A Gene
Post-translational modifications for FAM76A Gene
Other Protein References for FAM76A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FAM76A
-
Abcam antibodies for FAM76A
- Invitrogen Antibodies for FAM76A
- GeneTex FAM76A antibody for FAM76A
Protein Products
-
OriGene Purified Proteins for FAM76A
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM76A
- Origene Custom Protein Services for FAM76A
- Search GeneTex for Proteins for FAM76A
Assay Products
No data available for DME Specific Peptides for FAM76A Gene
Domains & Families for FAM76A Gene
Suggested Antigen Peptide Sequences for FAM76A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TAV0- Family:
-
- Belongs to the FAM76 family.
No data available for Gene Families for FAM76A Gene
Function for FAM76A Gene
Phenotypes for FAM76A Gene
- GenomeRNAi human phenotypes for FAM76A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for FAM76A
CRISPR Products
-
OriGene CRISPR knockouts for FAM76A
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM76A
- GenScript: Design CRISPR guide RNA sequences for FAM76A
miRNA for FAM76A Gene
- miRTarBase miRNAs that target FAM76A
-
- hsa-mir-374b-5p (MIRT016051)
- hsa-mir-124-3p (MIRT022497)
- hsa-mir-410-3p (MIRT188654)
- hsa-mir-3689a-5p (MIRT188656)
- hsa-mir-3689b-5p (MIRT188657)
- hsa-mir-3689e (MIRT188658)
- hsa-mir-3689f (MIRT188659)
- hsa-mir-5011-5p (MIRT188660)
- hsa-mir-548g-3p (MIRT384836)
- hsa-mir-155-5p (MIRT498288)
- hsa-mir-365b-3p (MIRT498289)
- hsa-mir-365a-3p (MIRT498290)
miRNA Products
- Search ViGene Biosciences for FAM76A
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FAM76A
- Browse OriGene Inhibitory RNA Products For FAM76A
Clone Products
-
OriGene ORF clones in human for FAM76A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM76A
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM76A Gene
Localization for FAM76A Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | 19266028 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM76A Gene
Pathways & Interactions for FAM76A Gene
No Data Available
Interacting Proteins for FAM76A Gene
No data available for Pathways by source and SIGNOR curated interactions for FAM76A Gene
Transcripts for FAM76A Gene
mRNA/cDNA for FAM76A Gene
- (6) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (70) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM76A Gene
- Family with sequence similarity 76, member A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FAM76A
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM76A
- GenScript: Design CRISPR guide RNA sequences for FAM76A
miRNA Products
- Search ViGene Biosciences for FAM76A
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FAM76A
- Browse OriGene Inhibitory RNA Products For FAM76A
Clone Products
-
OriGene ORF clones in human for FAM76A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | - |
Expression for FAM76A Gene
This gene is overexpressed in Peripheral blood mononuclear cells (37.1), Adipocyte (11.7), and NK cells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM76A Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM76A Gene:
FAM76ASOURCE GeneReport for Unigene cluster for FAM76A Gene:
Hs.469359Evidence on tissue expression from TISSUES for FAM76A Gene
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for FAM76A
-
OriGene qPCR primer pairs and template standards for FAM76A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM76A Gene
Orthologs for FAM76A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM76A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM76A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM76A 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam76a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam76a 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM76A 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FAM76A 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM76A 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005928 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4452 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | K04F10.7 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FAM76A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for FAM76A Gene
(1) SIMAP similar genes for FAM76A Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for FAM76A Gene
Variants for FAM76A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000133444 | -- | 27,752,143(+) | CTGCA(A/G)GTTGC | intron-variant | |
| rs1000174589 | -- | 27,724,396(+) | CCGGG(A/G/T)AATTT | upstream-variant-2KB | |
| rs1000213501 | -- | 27,749,394(+) | AGACA(G/T)TCTCA | intron-variant | |
| rs1000265108 | -- | 27,743,361(+) | ATTGC(C/T)CCGAG | intron-variant | |
| rs1000337701 | -- | 27,743,654(+) | CAGCT(A/G)TTCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1126986 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.64;
13.72% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM76A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM76A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM76A Gene
Disorders for FAM76A Gene
Relevant External Links for FAM76A
No disorders were found for FAM76A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM76A Gene
Publications for FAM76A Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E. … de la Luna S. (PLoS Genet. 2009) 3 64
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
Products for FAM76A Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FAM76A
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM76A
- Origene Custom Protein Services for FAM76A
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM76A
- Browse OriGene Inhibitory RNA Products For FAM76A
- OriGene qPCR primer pairs and template standards for FAM76A
- OriGene qPCR primer pairs for FAM76A
- OriGene CRISPR knockouts for FAM76A
- OriGene ORF clones in human for FAM76A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FAM76A
- GenScript: Next-day shipping cDNA ORF clone for FAM76A in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FAM76A
- GenScript Custom Assay Services for FAM76A
- GenScript Custom overexpressing Cell Line Services for FAM76A
- GenScript: Design CRISPR guide RNA sequences for FAM76A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FAM76A
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
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- Sino Biological qPCR Primers
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FAM76A
- Novus Biologicals proteins and lysates for FAM76A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM76A
- VectorBuilder custom plasmid, inducible vectors for FAM76A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM76A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM76A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer