FAM76A Gene
protein-coding GIFtS: 40
GCID: GC01P028052
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family with sequence similarity 76, member A
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Aliases
for FAM76A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 76, Member A1 2 | | MGC346481 | | Protein FAM76A2 |
Export aliases for FAM76A gene to outside databasesPrevious GC identifers: GC01P027737 GC01P027925 GC01P026308 |
Summaries
for FAM76A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM76A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM76A gene promoter:
N-Myc CREB USF1 USF-1 deltaCREB p300 Egr-1 USF2 USF-1:USF-2 Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM76A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM76A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.3FAM76A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P028052: view genomic region
(about GC identifiers)
Start:
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28,052,490 bp from pter |
End:
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28,089,426 bp from pter |
Size:
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36,937 bases |
Orientation:
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plus strand |
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Proteins
for FAM76A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA76A_HUMAN, Q8TAV0 (See
protein sequence)Recommended Name: Protein FAM76A Size: 307 amino acids; 35049 Da
Secondary accessions: B4DWT3 O95565 O95566 Q8N7J5Alternative splicing: 5 isoforms: Q8TAV0-1 Q8TAV0-2 Q8TAV0-3 Q8TAV0-4 Q8TAV0-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM76A: NX_Q8TAV0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAV0
FAM76A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001137384.1 NP_001137385.1 NP_001137386.1 NP_001137387.1 NP_689873.1
ENSEMBL proteins: ENSP00000363065 ENSP00000395150 ENSP00000436176 ENSP00000234549 ENSP00000363060 ENSP00000010299 ENSP00000393171
Human Recombinant Protein Products for FAM76A:
FAM76A Antibody Products:
Assay Products for FAM76A: |
Protein
Domains /
Families
for FAM76A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TAV0 UniProtKB/Swiss-Prot: FA76A_HUMAN, Q8TAV0Similarity: Belongs to the FAM76 family |
Function
for FAM76A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for FAM76A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM76A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM76A (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): FAM76A (NM_001143915) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM76A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM76A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM76A |
|
Pathways & Interactions
for FAM76A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM76A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM76A (ENSP000000102994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM76A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM76A
Search CenterWatch for drugs/clinical trials and news about FAM76A / FA76A
|
Transcripts
for FAM76A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM76A gene (5 alternative transcripts): NM_001143912.1 NM_001143913.1 NM_001143914.1 NM_001143915.1 NM_152660.2 Unigene Cluster for FAM76A: Family with sequence similarity 76, member A Hs.469359 [show with all ESTs]Unigene Representative Sequence: NM_0011439127 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373954 ENST00000419687 ENST00000530324(uc009vtb.3) ENST00000234549
ENST00000373949(uc001bor.3 uc001boq.3 uc001bos.3 uc001bot.3 uc010ofm.2)
ENST00000010299 ENST00000446647
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM76A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM76A (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): FAM76A (NM_001143915) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM76A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM76A |
Additional cDNA sequence: AK098318.1 AK123940.1 AK290120.1 AK301672.1 AK310165.1 AL035307.1 AL035309.1 BC025768.1 5 DOTS entries: DT.97766911 DT.100683411 DT.91954508 DT.100009669 DT.121417312 24/70 AceView cDNA sequences (see all 70): AA631135 AA826504 AI821696 BC025768 AA972353 AL035309 AA676651 AA284410 AI791889 AA405008 AA292538 AI935980 AA770394 AL035307 NM_152660 AI805069 AA973631 AV729264 AI825562 AA568176 BI518602 CB961617 BF970809 AK098318
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM76A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for FAM76A
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Expression
for FAM76A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM76A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGAGTA
About this image
See FAM76A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM76A
SOURCE GeneReport for Unigene cluster: Hs.469359
SABiosciences Custom PCR Arrays for FAM76A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM76A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM76A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM76A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM76A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM76A |
Orthologs
for FAM76A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM76A gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for FAM76A (if available)
TreeFam Gene Tree for FAM76A (if available) |
Paralogs
for FAM76A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM76A gene
- FAM76B2
1 SIMAP similar gene for FAM76A using alignment to 3 protein entries: FA76A_HUMAN (see all proteins):FAM76B
FAM76A for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FAM76A
PGOHUM00000258050 PGOHUM00000237778
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Genomic Variants
for FAM76A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM76A (28052490 - 28089426 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM76A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM76A |
|
Disorders
/ Diseases
for FAM76A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM76A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM76A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM76A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for FAM76A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM76A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM76A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM76A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM76A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM76A gene:
Search GeneIP for patents involving FAM76A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM76A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM76A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM76A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM76A | | | OriGene Protein Over-expression Lysate for FAM76A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM76A | | OriGene 3'-UTR Clone for FAM76A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM76A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM76A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM76A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM76A | | OriGene Custom Protein Services for FAM76A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM76A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM76A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM76A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM76A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM76A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM76A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM76A |
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 | | | FAM76A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM76A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM76A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM76A |
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