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Aliases for FAM76A Gene

Aliases for FAM76A Gene

  • Family With Sequence Similarity 76 Member A 2 3 5
  • Family With Sequence Similarity 76, Member A 2

External Ids for FAM76A Gene

Previous GeneCards Identifiers for FAM76A Gene

  • GC01P027925
  • GC01P028052
  • GC01P026308

Summaries for FAM76A Gene

GeneCards Summary for FAM76A Gene

FAM76A (Family With Sequence Similarity 76 Member A) is a Protein Coding gene. An important paralog of this gene is FAM76B.

Additional gene information for FAM76A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM76A Gene

Genomics for FAM76A Gene

GeneHancer (GH) Regulatory Elements for FAM76A Gene

Promoters and enhancers for FAM76A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I027724 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 572.8 0.0 -3 3.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FAM76A GMEB1 ACTG1P20 SNHG12 TRNAU1AP GPN2 RCC1 PTAFR NPM1P39 TMEM222
GH01I027487 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67 -235.3 -235283 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 MCM3 WASF2 ARID1A ACTG1P20 GPN2 FAM76A PHACTR4 NPM1P39 MAP3K6 ENSG00000231344 LOC101928728
GH01I027151 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 57.6 -571.9 -571933 4.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC SLC9A1 ARID1A ACTG1P20 FAM76A HMGN2 GPN2 ENSG00000231344 EYA3 LOC101928324 LOC101928728
GH01I028647 Promoter/Enhancer 1.7 Ensembl ENCODE 76.5 +922.5 922466 2.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC01P028672 RNU11 GC01P028671 GC01P028670 GC01P028669 GC01P028651 ENSG00000270103 SRSF4 GMEB1 TRNAU1AP
GH01I027516 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 35.2 -202.2 -202166 13.7 ZFP64 DMAP1 YY1 ZNF548 ZNF263 MCM3 SP3 MEF2D SSRP1 GLIS1 LOC105376892 ARID1A ACTG1P20 MAP3K6 FAM76A PHACTR4 NPM1P39 EYA3 WASF2 GPN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM76A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM76A gene promoter:

Genomic Locations for FAM76A Gene

Genomic Locations for FAM76A Gene
chr1:27,725,979-27,763,122
(GRCh38/hg38)
Size:
37,144 bases
Orientation:
Plus strand
chr1:28,052,490-28,089,633
(GRCh37/hg19)

Genomic View for FAM76A Gene

Genes around FAM76A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM76A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM76A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM76A Gene

Proteins for FAM76A Gene

  • Protein details for FAM76A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAV0-FA76A_HUMAN
    Recommended name:
    Protein FAM76A
    Protein Accession:
    Q8TAV0
    Secondary Accessions:
    • B4DWT3
    • O95565
    • O95566
    • Q8N7J5

    Protein attributes for FAM76A Gene

    Size:
    307 amino acids
    Molecular mass:
    35049 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM76A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM76A Gene

Post-translational modifications for FAM76A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM76A Gene

Domains & Families for FAM76A Gene

Gene Families for FAM76A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM76A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TAV0

UniProtKB/Swiss-Prot:

FA76A_HUMAN :
  • Belongs to the FAM76 family.
Family:
  • Belongs to the FAM76 family.
genes like me logo Genes that share domains with FAM76A: view

Function for FAM76A Gene

Phenotypes From GWAS Catalog for FAM76A Gene

Phenotypes for FAM76A Gene

genes like me logo Genes that share phenotypes with FAM76A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM76A Gene

Localization for FAM76A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM76A gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM76A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 19266028
genes like me logo Genes that share ontologies with FAM76A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM76A Gene

Pathways & Interactions for FAM76A Gene

SuperPathways for FAM76A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM76A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM76A Gene

Drugs & Compounds for FAM76A Gene

No Compound Related Data Available

Transcripts for FAM76A Gene

Unigene Clusters for FAM76A Gene

Family with sequence similarity 76, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM76A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for FAM76A Gene

GeneLoc Exon Structure for
FAM76A
ECgene alternative splicing isoforms for
FAM76A

Expression for FAM76A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM76A Gene

Protein differential expression in normal tissues from HIPED for FAM76A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.1), Adipocyte (11.7), and NK cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM76A Gene



Protein tissue co-expression partners for FAM76A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM76A Gene:

FAM76A

SOURCE GeneReport for Unigene cluster for FAM76A Gene:

Hs.469359

Evidence on tissue expression from TISSUES for FAM76A Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with FAM76A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM76A Gene

Orthologs for FAM76A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM76A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM76A 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia FAM76A 33 34
  • 94.88 (n)
cow
(Bos Taurus)
Mammalia FAM76A 33 34
  • 94.57 (n)
mouse
(Mus musculus)
Mammalia Fam76a 33 16 34
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Fam76a 33
  • 90.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM76A 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM76A 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM76A 33 34
  • 82.63 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005928 33
  • 52.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4452 33 34
  • 52.45 (n)
worm
(Caenorhabditis elegans)
Secernentea K04F10.7 33 34
  • 48.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for FAM76A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FAM76A Gene

ENSEMBL:
Gene Tree for FAM76A (if available)
TreeFam:
Gene Tree for FAM76A (if available)

Paralogs for FAM76A Gene

Paralogs for FAM76A Gene

(1) SIMAP similar genes for FAM76A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM76A Gene

genes like me logo Genes that share paralogs with FAM76A: view

Variants for FAM76A Gene

Sequence variations from dbSNP and Humsavar for FAM76A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000133444 -- 27,752,143(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000174589 -- 27,724,396(+) T/A/G upstream_transcript_variant
rs1000213501 -- 27,749,394(+) G/T intron_variant
rs1000265108 -- 27,743,361(+) C/T intron_variant
rs1000337701 -- 27,743,654(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM76A Gene

Variant ID Type Subtype PubMed ID
nsv1126986 CNV deletion 24896259

Variation tolerance for FAM76A Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM76A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM76A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM76A Gene

Disorders for FAM76A Gene

Additional Disease Information for FAM76A

No disorders were found for FAM76A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM76A Gene

Publications for FAM76A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E … de la Luna S (PLoS genetics 2009) 3 58

Products for FAM76A Gene

Sources for FAM76A Gene

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