Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM76A Gene

Aliases for FAM76A Gene

  • Family With Sequence Similarity 76 Member A 2 3 5
  • Family With Sequence Similarity 76, Member A 2

External Ids for FAM76A Gene

Previous GeneCards Identifiers for FAM76A Gene

  • GC01P027925
  • GC01P028052
  • GC01P026308

Summaries for FAM76A Gene

GeneCards Summary for FAM76A Gene

FAM76A (Family With Sequence Similarity 76 Member A) is a Protein Coding gene. An important paralog of this gene is FAM76B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM76A Gene

Genomics for FAM76A Gene

Regulatory Elements for FAM76A Gene

Enhancers for FAM76A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027614 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -100.1 -100142 23.4 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 MCM3 FGR ACTG1P20 THEMIS2 ENSG00000225886 XKR8 FAM76A TMEM222 RNU6-48P TRNAU1AP RPA2
GH01G027655 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -70.0 -69978 2.0 HDGF HDAC1 PKNOX1 CBX3 PTBP1 ZNF2 EGR1 ZSCAN5C IKZF2 EGR2 FGR AHDC1 FAM76A RNU6-1245P PPP1R8 SCARNA1 THEMIS2 NUDC STX12 EYA3
GH01G027685 1.4 FANTOM5 Ensembl ENCODE 11.8 -37.9 -37877 6.0 TBP SIN3A RAD21 ZNF366 RELB RCOR1 IKZF2 CBFB GATAD2B NR2F2 FAM76A STX12 RNU6-1245P PPP1R8 SCARNA1 TMEM222 ACTG1P20 RNU6-48P ENSG00000270605 PTAFR
GH01G027771 1.4 FANTOM5 ENCODE 11.6 +47.4 47387 3.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A ZNF2 YY1 RNU6-1245P PPP1R8 SCARNA1 FAM76A STX12 SESN2 PTAFR FGR EYA3 ENSG00000269971
GH01G027979 1.6 FANTOM5 Ensembl ENCODE 9.6 +253.7 253675 1.1 HDGF PKNOX1 ATF1 FOXA2 ARNT TCF12 GATA2 NCOA1 JUNB REST EYA3 PTAFR THEMIS2 SMPDL3B RPA2 SCARNA1 PPP1R8 RNU6-1245P FAM76A ENSG00000270605
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM76A on UCSC Golden Path with GeneCards custom track

Promoters for FAM76A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003774 321 1801 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for FAM76A Gene

Chromosome:
1
Start:
27,725,979 bp from pter
End:
27,763,122 bp from pter
Size:
37,144 bases
Orientation:
Plus strand

Genomic View for FAM76A Gene

Genes around FAM76A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM76A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM76A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM76A Gene

Proteins for FAM76A Gene

  • Protein details for FAM76A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAV0-FA76A_HUMAN
    Recommended name:
    Protein FAM76A
    Protein Accession:
    Q8TAV0
    Secondary Accessions:
    • B4DWT3
    • O95565
    • O95566
    • Q8N7J5

    Protein attributes for FAM76A Gene

    Size:
    307 amino acids
    Molecular mass:
    35049 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM76A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM76A Gene

Post-translational modifications for FAM76A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM76A Gene

Domains & Families for FAM76A Gene

Protein Domains for FAM76A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TAV0

UniProtKB/Swiss-Prot:

FA76A_HUMAN :
  • Belongs to the FAM76 family.
Family:
  • Belongs to the FAM76 family.
genes like me logo Genes that share domains with FAM76A: view

No data available for Gene Families for FAM76A Gene

Function for FAM76A Gene

Phenotypes for FAM76A Gene

genes like me logo Genes that share phenotypes with FAM76A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM76A Gene

Localization for FAM76A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM76A gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM76A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 19266028
genes like me logo Genes that share ontologies with FAM76A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM76A Gene

Pathways & Interactions for FAM76A Gene

SuperPathways for FAM76A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM76A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM76A Gene

Drugs & Compounds for FAM76A Gene

No Compound Related Data Available

Transcripts for FAM76A Gene

Unigene Clusters for FAM76A Gene

Family with sequence similarity 76, member A:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM76A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for FAM76A Gene

GeneLoc Exon Structure for
FAM76A
ECgene alternative splicing isoforms for
FAM76A

Expression for FAM76A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM76A Gene

Protein differential expression in normal tissues from HIPED for FAM76A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.1), Adipocyte (11.7), and NK cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM76A Gene



Protein tissue co-expression partners for FAM76A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM76A Gene:

FAM76A

SOURCE GeneReport for Unigene cluster for FAM76A Gene:

Hs.469359

Evidence on tissue expression from TISSUES for FAM76A Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with FAM76A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM76A Gene

Orthologs for FAM76A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM76A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM76A 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia FAM76A 34 35
  • 94.88 (n)
cow
(Bos Taurus)
Mammalia FAM76A 34 35
  • 94.57 (n)
mouse
(Mus musculus)
Mammalia Fam76a 34 16 35
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Fam76a 34
  • 90.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM76A 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM76A 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM76A 34 35
  • 82.63 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005928 34
  • 52.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4452 34 35
  • 52.45 (n)
worm
(Caenorhabditis elegans)
Secernentea K04F10.7 34 35
  • 48.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for FAM76A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FAM76A Gene

ENSEMBL:
Gene Tree for FAM76A (if available)
TreeFam:
Gene Tree for FAM76A (if available)

Paralogs for FAM76A Gene

Paralogs for FAM76A Gene

(1) SIMAP similar genes for FAM76A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM76A Gene

genes like me logo Genes that share paralogs with FAM76A: view

Variants for FAM76A Gene

Sequence variations from dbSNP and Humsavar for FAM76A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000133444 -- 27,752,143(+) CTGCA(A/G)GTTGC intron-variant
rs1000174589 -- 27,724,396(+) CCGGG(A/G/T)AATTT upstream-variant-2KB
rs1000213501 -- 27,749,394(+) AGACA(G/T)TCTCA intron-variant
rs1000265108 -- 27,743,361(+) ATTGC(C/T)CCGAG intron-variant
rs1000337701 -- 27,743,654(+) CAGCT(A/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM76A Gene

Variant ID Type Subtype PubMed ID
nsv1126986 CNV deletion 24896259

Variation tolerance for FAM76A Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM76A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM76A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM76A Gene

Disorders for FAM76A Gene

Relevant External Links for FAM76A

Genetic Association Database (GAD)
FAM76A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM76A

No disorders were found for FAM76A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM76A Gene

Publications for FAM76A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E. … de la Luna S. (PLoS Genet. 2009) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for FAM76A Gene

Sources for FAM76A Gene

Content
Loading form....