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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM76A Gene

protein-coding   GIFtS: 43
GCID: GC01P028052

Family With Sequence Similarity 76, Member A

  Search for FAM76A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 76, Member A1 2
Protein FAM76A2

External Ids:    HGNC: 285301   Entrez Gene: 1998702   Ensembl: ENSG000000097807   UniProtKB: Q8TAV03   

Export aliases for FAM76A gene to outside databases

Previous GC identifers: GC01P027737 GC01P027925 GC01P026308


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM76A Gene: 
FAM76A (family with sequence similarity 76, member A) is a protein-coding gene. An important paralog of this gene is FAM76B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM76A gene promoter:
         N-Myc   CREB   USF1   USF-1   deltaCREB   p300   Egr-1   USF2   USF-1:USF-2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM76A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM76A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM76A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

FAM76A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM76A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028052:  view genomic region     (about GC identifiers)

Start:
28,052,490 bp from pter      End:
28,089,633 bp from pter
Size:
37,144 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FA76A_HUMAN, Q8TAV0 (See protein sequence)
Recommended Name: Protein FAM76A  
Size: 307 amino acids; 35049 Da
Secondary accessions: B4DWT3 O95565 O95566 Q8N7J5
Alternative splicing: 5 isoforms:  Q8TAV0-1   Q8TAV0-2   Q8TAV0-3   Q8TAV0-4   Q8TAV0-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM76A: NX_Q8TAV0

Explore proteomics data for FAM76A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAV0

  • FAM76A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM76A Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001137384.1  NP_001137385.1  NP_001137386.1  NP_001137387.1  NP_689873.1  

    ENSEMBL proteins: 
     ENSP00000363065   ENSP00000395150   ENSP00000436176   ENSP00000234549   ENSP00000363060  
     ENSP00000010299   ENSP00000393171  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8TAV0

    UniProtKB/Swiss-Prot: FA76A_HUMAN, Q8TAV0
    Similarity: Belongs to the FAM76 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for FAM76A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM76A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM76A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM76A 
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    SwitchGear 3'UTR luciferase reporter plasmidFAM76A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM76A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM76A (ENSP000000102994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM76A (FA76A)

    Search CenterWatch for drugs/clinical trials and news about FAM76A / FA76A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM76A gene (5 alternative transcripts): 
    NM_001143912.1  NM_001143913.1  NM_001143914.1  NM_001143915.1  NM_152660.2  

    Unigene Cluster for FAM76A:

    Family with sequence similarity 76, member A
    Hs.469359  [show with all ESTs]
    Unigene Representative Sequence: NM_001143912
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373954 ENST00000419687 ENST00000530324(uc009vtb.3) ENST00000234549
    ENST00000373949(uc001bor.3 uc001boq.3 uc001bos.3 uc001bot.3 uc010ofm.2)
    ENST00000010299 ENST00000446647
    miRNA
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    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM76A (see all 54):
    hsa-miR-549 hsa-miR-607 hsa-miR-4328 hsa-miR-938 hsa-miR-485-3p hsa-miR-449a hsa-miR-374a* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidFAM76A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM76A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM76A
    Clone
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    OriGene clones in human, mouse for FAM76A (see all 26)
    OriGene ORF clones in mouse, rat for FAM76A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FAM76A (NM_001143915)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM76A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM76A
    Sirion Biotech Customized lentivirus for stable overexpression of FAM76A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM76A 
    Primer
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    OriGene qPCR primer pairs and template standards for FAM76A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM76A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM76A

    Additional mRNA sequence: 

    AK098318.1 AK123940.1 AK290120.1 AK301672.1 AK310165.1 AL035307.1 AL035309.1 BC025768.1 

    5 DOTS entries:

    DT.97766911  DT.100683411  DT.91954508  DT.100009669  DT.121417312 

    24/70 AceView cDNA sequences (see all 70):

    BC025768 AA676651 AI821696 AI935980 AL035309 AA770394 AA826504 AA292538 
    AA631135 AA284410 AA972353 AL035307 NM_152660 AI791889 AA405008 AI334343 
    AK123940 AI631053 CA439236 BI518602 CB218009 BQ084260 BQ429633 BU155520 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM76A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                            
    SP2:                                      -                     


    ECgene alternative splicing isoforms for FAM76A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM76A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGAGTA
    FAM76A Expression
    About this image


    See FAM76A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM76A

    SOURCE GeneReport for Unigene cluster: Hs.469359
        SABiosciences Custom PCR Arrays for FAM76A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM76A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAM76A gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam76a1 , 5 family with sequence similarity 76, member A1, 5 91.53(n)1
    98.05(a)1
      4 (66.01 cM)5
    2307891  NM_145553.21  NP_663528.11 
     1328992135 
    chicken
    (Gallus gallus)
    Aves FAM76A1 family with sequence similarity 76, member A 82.63(n)
    93.81(a)
      426384  NM_001031377.1  NP_001026548.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44521 CG4452 50.84(n)
    43.14(a)
      39069  NM_140046.3  NP_648303.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K04F10.76
    Protein K04F10.7
    25(a)
    1 → many
    I(6366361-6368079)


    ENSEMBL Gene Tree for FAM76A (if available)
    TreeFam Gene Tree for FAM76A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM76A gene
    FAM76B2  
    1 SIMAP similar gene for FAM76A using alignment to 3 protein entries:     FA76A_HUMAN (see all proteins):
    FAM76B

    FAM76A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FAM76A
    PGOHUM00000258050 PGOHUM00000237778


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/722 SNPs in FAM76A are shown (see all 722)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728728041,2
    C,F--28050597(+) CTCAGG/AGCAGC 5 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1409659021,2
    C--28050900(+) ACCACA/GCCCGG 5 -- us2k10--------
    rs1874335881,2
    --28050938(+) GGTTTA/GACCTT 5 -- us2k10--------
    rs1930028511,2
    --28050944(+) ACCTTG/TTTGGT 5 -- us2k10--------
    rs745450411,2
    C,F--28051052(+) CCGGCC/TGACCC 5 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1388879751,2
    C--28051087(+) CAAGTG/TATCCT 5 -- us2k10--------
    rs790343111,2
    F--28051145(+) CGCCCC/GGACTC 5 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1829531531,2
    --28051236(+) AAGGTC/TATGTA 5 -- us2k10--------
    rs1887934231,2
    --28051241(+) CATGTA/CGTTAG 5 -- us2k10--------
    rs1126592001,2
    C--28051354(+) GTAAAT/-TTTTT 5 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for FAM76A (28052490 - 28089633 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM76A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM76A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM76A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM76A for disorders           About MalaCards

    FAM76A for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM76A

    Export disorders for FAM76A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM76A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM76A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199870 HGNC: 28530 AceView: MGC34648 Ensembl:ENSG00000009780 euGenes: HUgn199870
    ECgene: FAM76A H-InvDB: FAM76A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM76A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM76A gene:
    Search GeneIP for patents involving FAM76A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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