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Aliases for FAM73B Gene

Aliases for FAM73B Gene

  • Family With Sequence Similarity 73, Member B 2 3
  • C9orf54 3 4
  • Chromosome 9 Open Reading Frame 54 2
  • Protein FAM73B 3

External Ids for FAM73B Gene

Previous HGNC Symbols for FAM73B Gene

  • C9orf54

Previous GeneCards Identifiers for FAM73B Gene

  • GC09P128879
  • GC09P130838
  • GC09P131798
  • GC09P101406

Summaries for FAM73B Gene

GeneCards Summary for FAM73B Gene

FAM73B (Family With Sequence Similarity 73, Member B) is a Protein Coding gene. An important paralog of this gene is FAM73A.

Gene Wiki entry for FAM73B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM73B Gene

Genomics for FAM73B Gene

Regulatory Elements for FAM73B Gene

Genomic Location for FAM73B Gene

Start:
129,036,620 bp from pter
End:
129,072,082 bp from pter
Size:
35,463 bases
Orientation:
Plus strand

Genomic View for FAM73B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM73B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM73B Gene

Proteins for FAM73B Gene

  • Protein details for FAM73B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L4E1-FA73B_HUMAN
    Recommended name:
    Protein FAM73B
    Protein Accession:
    Q7L4E1
    Secondary Accessions:
    • Q8NBM3
    • Q8TEJ6
    • Q969E6

    Protein attributes for FAM73B Gene

    Size:
    593 amino acids
    Molecular mass:
    65531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW87861.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM73B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM73B Gene

Proteomics data for FAM73B Gene at MOPED

Post-translational modifications for FAM73B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM73B Gene

No data available for DME Specific Peptides for FAM73B Gene

Domains for FAM73B Gene

Protein Domains for FAM73B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM73B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L4E1

UniProtKB/Swiss-Prot:

FA73B_HUMAN :
  • Q7L4E1
Family:
  • Belongs to the FAM73 family.
genes like me logo Genes that share domains with FAM73B: view

No data available for Gene Families for FAM73B Gene

Function for FAM73B Gene

genes like me logo Genes that share phenotypes with FAM73B: view

miRNA for FAM73B Gene

miRTarBase miRNAs that target FAM73B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM73B Gene

Localization for FAM73B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM73B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM73B Gene COMPARTMENTS Subcellular localization image for FAM73B gene
Compartment Confidence
endoplasmic reticulum 2
plasma membrane 2
cytosol 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM73B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM73B: view

Pathways for FAM73B Gene

SuperPathways for FAM73B Gene

No Data Available

Interacting Proteins for FAM73B Gene

Selected Interacting proteins: Q7L4E1-FA73B_HUMAN for FAM73B Gene via I2D

Symbol External ID(s) Details
STAMBP

Gene Ontology (GO) - Biological Process for FAM73B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with FAM73B: view

No data available for Pathways by source for FAM73B Gene

Transcripts for FAM73B Gene

Unigene Clusters for FAM73B Gene

Family with sequence similarity 73, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM73B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6:
SP7: - - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - - -
SP11: - -
SP12: -
SP13: - -
SP14: - - - - -
SP15:
SP16:
SP17:
SP18:

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: - -
SP17:
SP18:

Relevant External Links for FAM73B Gene

GeneLoc Exon Structure for
FAM73B
ECgene alternative splicing isoforms for
FAM73B

Expression for FAM73B Gene

mRNA expression in normal human tissues for FAM73B Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM73B Gene

SOURCE GeneReport for Unigene cluster for FAM73B Gene Hs.632693

genes like me logo Genes that share expressions with FAM73B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM73B Gene

Orthologs for FAM73B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM73B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM73B 35
  • 99.38 (n)
  • 99.83 (a)
FAM73B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM73B 35
  • 90.67 (n)
  • 94.27 (a)
FAM73B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM73B 35
  • 89.09 (n)
  • 92.92 (a)
FAM73B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam73b 35
  • 86.68 (n)
  • 92.58 (a)
Fam73b 16
Fam73b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM73B 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam73b 35
  • 86.04 (n)
  • 90.61 (a)
chicken
(Gallus gallus)
Aves FAM73B 35
  • 74.48 (n)
  • 80.65 (a)
FAM73B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM73B 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73b 35
  • 66.37 (n)
  • 68.75 (a)
Str.11456 35
zebrafish
(Danio rerio)
Actinopterygii fam73b 35
  • 62.9 (n)
  • 63.83 (a)
fam73b 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011689 35
  • 52.97 (n)
  • 42.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12125 35
  • 49.81 (n)
  • 39.05 (a)
CG12125 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K01D12.6 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for FAM73B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM73B Gene

ENSEMBL:
Gene Tree for FAM73B (if available)
TreeFam:
Gene Tree for FAM73B (if available)

Paralogs for FAM73B Gene

Paralogs for FAM73B Gene

Selected SIMAP similar genes for FAM73B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM73B: view

Variants for FAM73B Gene

Sequence variations from dbSNP and Humsavar for FAM73B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1048355 -- 129,071,684(+) TGATG(C/T)TGGGT utr-variant-3-prime
rs3814495 -- 129,059,953(-) CAGAT(A/T)CCTCC intron-variant
rs3814496 -- 129,059,952(-) AGATT(C/T)CTCCA intron-variant
rs3814497 -- 129,059,765(-) GGTCC(A/G)AAGAG intron-variant
rs4282673 -- 129,062,097(+) atagg(C/G)tggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM73B Gene

Variant ID Type Subtype PubMed ID
nsv893902 CNV Gain 21882294
dgv8297n71 CNV Loss 21882294
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
nsv818725 CNV Gain 17921354
esv2665493 CNV Deletion 23128226

Relevant External Links for FAM73B Gene

HapMap Linkage Disequilibrium report
FAM73B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM73B Gene

Disorders for FAM73B Gene

No disorders were found for FAM73B Gene.

No data available for UniProtKB/Swiss-Prot for FAM73B Gene

Publications for FAM73B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for FAM73B Gene

Sources for FAM73B Gene

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