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Aliases for FAM73A Gene

Aliases for FAM73A Gene

  • Family With Sequence Similarity 73, Member A 2 3

External Ids for FAM73A Gene

Previous GeneCards Identifiers for FAM73A Gene

  • GC01P077960
  • GC01P077963
  • GC01P078246
  • GC01P076376

Summaries for FAM73A Gene

GeneCards Summary for FAM73A Gene

FAM73A (Family With Sequence Similarity 73, Member A) is a Protein Coding gene. An important paralog of this gene is FAM73B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM73A Gene

Genomics for FAM73A Gene

Regulatory Elements for FAM73A Gene

Genomic Location for FAM73A Gene

77,779,622 bp from pter
77,879,540 bp from pter
99,919 bases
Plus strand

Genomic View for FAM73A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM73A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM73A Gene

Proteins for FAM73A Gene

  • Protein details for FAM73A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM73A
    Protein Accession:
    Secondary Accessions:
    • Q6MZG0

    Protein attributes for FAM73A Gene

    632 amino acids
    Molecular mass:
    71006 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM73A Gene


neXtProt entry for FAM73A Gene

Proteomics data for FAM73A Gene at MOPED

Post-translational modifications for FAM73A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM73A Gene

No data available for DME Specific Peptides for FAM73A Gene

Domains & Families for FAM73A Gene

Protein Domains for FAM73A Gene


Suggested Antigen Peptide Sequences for FAM73A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM73 family.
  • Belongs to the FAM73 family.
genes like me logo Genes that share domains with FAM73A: view

No data available for Gene Families for FAM73A Gene

Function for FAM73A Gene

Phenotypes for FAM73A Gene

genes like me logo Genes that share phenotypes with FAM73A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM73A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM73A Gene

Localization for FAM73A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM73A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM73A Gene COMPARTMENTS Subcellular localization image for FAM73A gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FAM73A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM73A: view

Pathways & Interactions for FAM73A Gene

SuperPathways for FAM73A Gene

No Data Available

Interacting Proteins for FAM73A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359827 for FAM73A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM73A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM73A Gene

Drugs & Compounds for FAM73A Gene

No Compound Related Data Available

Transcripts for FAM73A Gene

Unigene Clusters for FAM73A Gene

Family with sequence similarity 73, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM73A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM73A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP5: -

Relevant External Links for FAM73A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM73A Gene

mRNA expression in normal human tissues for FAM73A Gene

Protein differential expression in normal tissues from HIPED for FAM73A Gene

This gene is overexpressed in Liver (60.6) and Monocytes (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM73A Gene

SOURCE GeneReport for Unigene cluster for FAM73A Gene Hs.437755

genes like me logo Genes that share expression patterns with FAM73A: view

Protein tissue co-expression partners for FAM73A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM73A Gene

Orthologs for FAM73A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM73A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM73A 35
  • 92.22 (n)
  • 93 (a)
FAM73A 36
  • 93 (a)
(Canis familiaris)
Mammalia FAM73A 35
  • 92.57 (n)
  • 95.08 (a)
FAM73A 36
  • 87 (a)
(Mus musculus)
Mammalia Fam73a 35
  • 84.06 (n)
  • 84.83 (a)
Fam73a 16
Fam73a 36
  • 85 (a)
(Pan troglodytes)
Mammalia FAM73A 35
  • 99.58 (n)
  • 99.68 (a)
FAM73A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam73a 35
  • 81.13 (n)
  • 81.57 (a)
(Monodelphis domestica)
Mammalia FAM73A 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia FAM73A 36
  • 86 (a)
(Gallus gallus)
Aves FAM73A 35
  • 80.3 (n)
  • 86.42 (a)
FAM73A 36
  • 80 (a)
(Anolis carolinensis)
Reptilia FAM73A 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73a 35
  • 69.38 (n)
  • 70.32 (a)
(Danio rerio)
Actinopterygii Dr.18613 35
fam73a 35
  • 63.32 (n)
  • 62.24 (a)
fam73a 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1985 35
fruit fly
(Drosophila melanogaster)
Insecta CG12125 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea K01D12.6 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for FAM73A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM73A Gene

Gene Tree for FAM73A (if available)
Gene Tree for FAM73A (if available)

Paralogs for FAM73A Gene

Paralogs for FAM73A Gene

(1) SIMAP similar genes for FAM73A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM73A: view

Variants for FAM73A Gene

Sequence variations from dbSNP and Humsavar for FAM73A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1047939 -- 77,879,246(+) ATGTA(A/T)GTGAA utr-variant-3-prime
rs1166584 -- 77,796,140(-) ctcca(C/T)ctcaa intron-variant
rs1166585 -- 77,794,036(-) tgagg(C/T)gggca intron-variant
rs1166586 -- 77,791,419(-) tggta(C/T)atcca intron-variant
rs1166587 -- 77,791,262(-) tgttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM73A Gene

Variant ID Type Subtype PubMed ID
nsv470719 CNV Gain 18288195
nsv830303 CNV Loss 17160897
esv2674622 CNV Deletion 23128226

Variation tolerance for FAM73A Gene

Residual Variation Intolerance Score: 17.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM73A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM73A Gene

Disorders for FAM73A Gene

Relevant External Links for FAM73A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM73A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM73A Gene

Publications for FAM73A Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for FAM73A Gene

Sources for FAM73A Gene

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