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Aliases for FAM73A Gene

Aliases for FAM73A Gene

  • Family With Sequence Similarity 73, Member A 2 3

External Ids for FAM73A Gene

Previous GeneCards Identifiers for FAM73A Gene

  • GC01P077960
  • GC01P077963
  • GC01P078246
  • GC01P076376

Summaries for FAM73A Gene

GeneCards Summary for FAM73A Gene

FAM73A (Family With Sequence Similarity 73, Member A) is a Protein Coding gene. An important paralog of this gene is FAM73B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM73A Gene

Genomics for FAM73A Gene

Regulatory Elements for FAM73A Gene

Genomic Location for FAM73A Gene

Start:
77,779,624 bp from pter
End:
77,879,540 bp from pter
Size:
99,917 bases
Orientation:
Plus strand

Genomic View for FAM73A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM73A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM73A Gene

Proteins for FAM73A Gene

  • Protein details for FAM73A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAN2-FA73A_HUMAN
    Recommended name:
    Protein FAM73A
    Protein Accession:
    Q8NAN2
    Secondary Accessions:
    • Q6MZG0

    Protein attributes for FAM73A Gene

    Size:
    632 amino acids
    Molecular mass:
    71006 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM73A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM73A Gene

Proteomics data for FAM73A Gene at MOPED

Post-translational modifications for FAM73A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM73A Gene

No data available for DME Specific Peptides for FAM73A Gene

Domains for FAM73A Gene

Protein Domains for FAM73A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM73A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAN2

UniProtKB/Swiss-Prot:

FA73A_HUMAN :
  • Q8NAN2
Family:
  • Belongs to the FAM73 family.
genes like me logo Genes that share domains with FAM73A: view

No data available for Gene Families for FAM73A Gene

Function for FAM73A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM73A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM73A Gene

Localization for FAM73A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM73A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM73A Gene COMPARTMENTS Subcellular localization image for FAM73A gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM73A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM73A: view

Pathways for FAM73A Gene

SuperPathways for FAM73A Gene

No Data Available

Interacting Proteins for FAM73A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359827%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000359827 for FAM73A Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for FAM73A Gene

None

No data available for Pathways by source for FAM73A Gene

Transcripts for FAM73A Gene

Unigene Clusters for FAM73A Gene

Family with sequence similarity 73, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM73A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM73A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -

Relevant External Links for FAM73A Gene

GeneLoc Exon Structure for
FAM73A
ECgene alternative splicing isoforms for
FAM73A

Expression for FAM73A Gene

mRNA expression in normal human tissues for FAM73A Gene

Protein differential expression in normal tissues for FAM73A Gene

This gene is overexpressed in Liver (60.6) and Monocytes (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM73A Gene

SOURCE GeneReport for Unigene cluster for FAM73A Gene Hs.437755

genes like me logo Genes that share expressions with FAM73A: view

Expression partners for FAM73A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM73A Gene

Orthologs for FAM73A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM73A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM73A 35
  • 92.22 (n)
  • 93 (a)
FAM73A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM73A 35
  • 92.57 (n)
  • 95.08 (a)
FAM73A 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam73a 35
  • 84.06 (n)
  • 84.83 (a)
Fam73a 16
Fam73a 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM73A 35
  • 99.58 (n)
  • 99.68 (a)
FAM73A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam73a 35
  • 81.13 (n)
  • 81.57 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM73A 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM73A 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM73A 35
  • 80.3 (n)
  • 86.42 (a)
FAM73A 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM73A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73a 35
  • 69.38 (n)
  • 70.32 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18613 35
fam73a 35
  • 63.32 (n)
  • 62.24 (a)
fam73a 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1985 35
fruit fly
(Drosophila melanogaster)
Insecta CG12125 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K01D12.6 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for FAM73A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM73A Gene

ENSEMBL:
Gene Tree for FAM73A (if available)
TreeFam:
Gene Tree for FAM73A (if available)

Paralogs for FAM73A Gene

Paralogs for FAM73A Gene

Selected SIMAP similar genes for FAM73A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM73A: view

Variants for FAM73A Gene

Sequence variations from dbSNP and Humsavar for FAM73A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1047939 -- 77,879,246(+) ATGTA(A/T)GTGAA utr-variant-3-prime
rs1166584 -- 77,796,140(-) ctcca(C/T)ctcaa intron-variant
rs1166585 -- 77,794,036(-) tgagg(C/T)gggca intron-variant
rs1166586 -- 77,791,419(-) tggta(C/T)atcca intron-variant
rs1166587 -- 77,791,262(-) tgttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM73A Gene

Variant ID Type Subtype PubMed ID
nsv470719 CNV Gain 18288195
nsv830303 CNV Loss 17160897
esv2674622 CNV Deletion 23128226

Relevant External Links for FAM73A Gene

HapMap Linkage Disequilibrium report
FAM73A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM73A Gene

Disorders for FAM73A Gene

No disorders were found for FAM73A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM73A Gene

Publications for FAM73A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for FAM73A Gene

Sources for FAM73A Gene

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