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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM72D Gene

protein-coding GIFtS: 34
GCID: GC01M143896 (predicted)

family with sequence similarity 72, member D

Explore 1 disease affiliated with
FAM72D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 72, Member D¹ ²
Gastric Cancer Up-Regulated Protein 2² ³
GCUD2² ³
Family With Sequence Similarity 72 Member²
Gastric Cancer Up-Regulated-2²
Protein FAM72D²

External Ids:	HGNC: 33593¹	Entrez Gene: 728833²	Ensembl: ENSG00000215784⁷	OMIM: 614712⁵	UniProtKB: Q6L9T8³

Export aliases for FAM72D gene to outside databases

Previous GC identifer: GC01M142618

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_079485.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM72D gene promoter:
Sox5 GCNF AREB6 CBF-B CBF-A FOXO4 GCNF-1 GCNF-2 CBF(2)
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FAM72D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM72D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

FAM72D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM72D gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M143896: view genomic region (about GC identifiers)

Start:	143,896,452 bp from pter	End:	143,913,143 bp from pter
Size:	16,692 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA72D_HUMAN, Q6L9T8 (See protein sequence)

Recommended Name: Protein FAM72D

Size: 149 amino acids; 16688 Da

Explore the universe of human proteins at neXtProt for FAM72D: NX_Q6L9T8

FAM72D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997301.2

ENSEMBL proteins:

ENSP00000383682

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM72D for domains About GeneDecksing

1 InterPro domain/family:

IPR026768 FAM72

Graphical View of Domain Structure for InterPro Entry Q6L9T8

ProtoNet protein and cluster: Q6L9T8

UniProtKB/Swiss-Prot: FA72D_HUMAN, Q6L9T8

Similarity: Belongs to the FAM72 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FA72D_HUMAN, Q6L9T8

Induction: Up-regulated in gastric cancer

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM72D

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

4 Interacting proteins for FAM72D (Q6L9T8³ ENSP00000383682⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF6	P56537³	I2D: score=1
MAGEB2	O15479³	I2D: score=1
TSC22D1	Q15714³	I2D: score=1
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM72D
Search CenterWatch for drugs/clinical trials and news about FAM72D / FA72D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM72D gene:

NM_207418.2

Unigene Cluster for FAM72D:

Family with sequence similarity 72, member D

Hs.535577 [show with all ESTs]

Unigene Representative Sequence: NM_207418

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000400889(uc002qvn.1 uc010evy.1)

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Additional cDNA sequence:

AB096683.1 AK307197.1

10 DOTS entries:

DT.99970592 DT.91982635 DT.87011017 DT.443462 DT.91750430 DT.100815765 DT.121436032 DT.121372985

DT.121440216 DT.97859228

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM72D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FAM72D expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Adult human kidney epithelial cells (Primary Cell)

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM72D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM72D

SOURCE GeneReport for Unigene cluster: Hs.535577

SABiosciences Custom PCR Arrays for FAM72D

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM72D gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	75(a)	1 → many	26(2194370-2198076)
lizard (Anolis carolinensis)	Reptilia	--	--	74(a)	1 → many	GL343228.1(1050929-1075871)
zebrafish (Danio rerio)	Actinopterygii	zgc:101564⁶	zgc:101564	65(a)	1 → many	11(22419536-22431726)

ENSEMBL Gene Tree for FAM72D (if available)
TreeFam Gene Tree for FAM72D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM72D gene

FAM72C² FAM72A² FAM72B²

3 SIMAP similar genes for FAM72D using alignment to 1 protein entry: FA72D_HUMAN:

FAM72C FAM72A FAM72B

FAM72D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200296078^1,2		--	143901888(+)	`AAAAA-/GAAAAA`	1	--	int¹		0	--	--	--	--
rs180786030^1,2		--	143901955(+)	`TTTTTA/TAAAAG`	1	--	int¹		0	--	--	--	--
rs184948401^1,2		--	143903462(+)	`GCCACC/TGCGCC`	1	--	int¹		0	--	--	--	--
rs200256929^1,2		--	143903482(+)	`ATTCC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs190790581^1,2		--	143904970(+)	`GCAATA/CAAGCA`	1	--	int¹		0	--	--	--	--
rs201508121^1,2		--	143907064(+)	`TCACA-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs181117049^1,2		--	143908052(+)	`GGTGGA/CATGTG`	1	--	int¹		0	--	--	--	--
rs9697686^1,2	C,	--	143908346(-)	`cacccA/Ggctaa`	1	--	int¹		0	--	--	--	--
rs140348205^1,2		--	143908347(+)	`TAGCCA/GGGTGG`	1	--	int¹		0	--	--	--	--
rs201662922^1,2		--	143910179(+)	`AAAAAA/GACAGT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM72D (143896452 - 143913143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM72D
2 CNVs: 64778 64777

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM72D for disorders           About GeneDecksing

OMIM gene information: 614712    OMIM disorders: --

1 disease for FAM72D:    About MalaCards

gastric cancer

Export disorders for FAM72D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM72D gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM72D)

Utopia: connect your pdf to the dynamic
world of online information

Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 728833	HGNC: 33593	Ensembl:ENSG00000215784	euGenes: HUgn728833	ECgene: FAM72D
H-InvDB: FAM72D

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM72D	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM72D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM72D gene:
Search GeneIP for patents involving FAM72D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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FAM72D Gene

family with sequence similarity 72, member D

Aliases
for FAM72D gene

Summaries
for FAM72D gene

Genomic Views
for FAM72D gene

Proteins
for FAM72D gene

Protein Domains /
Families
for FAM72D gene

Function
for FAM72D gene

Pathways & Interactions
for FAM72D gene

Drugs & Compounds
for FAM72D gene

Transcripts
for FAM72D gene

Expression
for FAM72D gene

Orthologs
for FAM72D gene

Paralogs
for FAM72D gene

Genomic Variants
for FAM72D gene

Disorders / Diseases
for FAM72D gene

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for FAM72D gene

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Genome Databases showing FAM72D gene

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FAM72D Gene

family with sequence similarity 72, member D

Aliasesfor FAM72D gene

Summariesfor FAM72D gene

Genomic Viewsfor FAM72D gene

Proteinsfor FAM72D gene

Protein Domains /Familiesfor FAM72D gene

Functionfor FAM72D gene

Pathways & Interactionsfor FAM72D gene

Drugs & Compoundsfor FAM72D gene

Transcriptsfor FAM72D gene

Expression for FAM72D gene

Orthologsfor FAM72D gene

Paralogsfor FAM72D gene

Genomic Variantsfor FAM72D gene

Disorders / Diseasesfor FAM72D gene

Publicationsfor FAM72D gene

External Searches for FAM72D gene

Genome Databases showing FAM72D gene

Other Databases showing FAM72D gene

Specialized Databases showing FAM72D gene

Intellectual Propertyfor FAM72D gene

Productsfor FAM72D gene

View Random Gene

Aliases
for FAM72D gene

Summaries
for FAM72D gene

Genomic Views
for FAM72D gene

Proteins
for FAM72D gene

Protein Domains /
Families
for FAM72D gene

Function
for FAM72D gene

Pathways & Interactions
for FAM72D gene

Drugs & Compounds
for FAM72D gene

Transcripts
for FAM72D gene

Expression
for FAM72D gene

Orthologs
for FAM72D gene

Paralogs
for FAM72D gene

Genomic Variants
for FAM72D gene

Disorders / Diseases
for FAM72D gene

Publications
for FAM72D gene

Intellectual Property
for FAM72D gene

Products
for FAM72D gene