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Aliases for FAM72D Gene

Aliases for FAM72D Gene

  • Family With Sequence Similarity 72 Member D 2 3 5
  • Gastric Cancer Up-Regulated Protein 2 3 4
  • GCUD2 3 4
  • Family With Sequence Similarity 72, Member D 2
  • Family With Sequence Similarity 72 Member 3
  • Gastric Cancer Up-Regulated-2 3
  • Protein FAM72D 3

External Ids for FAM72D Gene

Previous GeneCards Identifiers for FAM72D Gene

  • GC01M142618
  • GC01M143896

Summaries for FAM72D Gene

GeneCards Summary for FAM72D Gene

FAM72D (Family With Sequence Similarity 72 Member D) is a Protein Coding gene. An important paralog of this gene is FAM72C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72D Gene

Genomics for FAM72D Gene

Regulatory Elements for FAM72D Gene

Enhancers for FAM72D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F145015 1.3 FANTOM5 Ensembl ENCODE 0.2 -76.2 -76198 5.2 STAT2 PRDM10 ZNF600 STAT1 ZNF362 NR2F1 CEBPB ZEB2 ATF2 ZNF623 ENSG00000271644 FAM72D
GH01F145007 1.1 Ensembl ENCODE 0.2 -84.2 -84198 5.2 BCOR HDAC1 LEF1 TAL1 PYGO2 ZNF316 NCOR1 NFE2 TRIM24 SMARCE1 ENSG00000271644 FAM72D
GH01F145089 0.2 Ensembl 0.8 -4.7 -4698 0.2 FAM72D ENSG00000271644
GH01F144997 1.4 Ensembl ENCODE 0.1 -94.3 -94295 4.2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF302 ZNF548 FOS ZNF263 POLR3C PFN1P6 NBPF25P ENSG00000224363 NUDT17 ENSG00000271644 FAM72D
GH01F144994 1.2 Ensembl ENCODE 0.1 -98.1 -98117 2.7 PKNOX1 INSM2 FEZF1 RAD21 ZNF48 ZNF366 SCRT2 FOS ZNF548 SMARCC1 POLR3C PFN1P6 ENSG00000271644 FAM72D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM72D on UCSC Golden Path with GeneCards custom track

Promoters for FAM72D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001749587 1502 5000

Genomic Location for FAM72D Gene

Chromosome:
1
Start:
145,093,798 bp from pter
End:
145,112,696 bp from pter
Size:
18,899 bases
Orientation:
Plus strand

Genomic View for FAM72D Gene

Genes around FAM72D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM72D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM72D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM72D Gene

Proteins for FAM72D Gene

  • Protein details for FAM72D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L9T8-FA72D_HUMAN
    Recommended name:
    Protein FAM72D
    Protein Accession:
    Q6L9T8

    Protein attributes for FAM72D Gene

    Size:
    149 amino acids
    Molecular mass:
    16688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM72D Gene

Post-translational modifications for FAM72D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM72D Gene

No data available for DME Specific Peptides for FAM72D Gene

Domains & Families for FAM72D Gene

Protein Domains for FAM72D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM72D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L9T8

UniProtKB/Swiss-Prot:

FA72D_HUMAN :
  • Belongs to the FAM72 family.
Family:
  • Belongs to the FAM72 family.
genes like me logo Genes that share domains with FAM72D: view

No data available for Gene Families for FAM72D Gene

Function for FAM72D Gene

Molecular function for FAM72D Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in gastric cancer.

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM72D Gene

Localization for FAM72D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM72D gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM72D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM72D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM72D Gene

Pathways & Interactions for FAM72D Gene

SuperPathways for FAM72D Gene

No Data Available

Interacting Proteins for FAM72D Gene

Selected Interacting proteins: Q6L9T8-FA72D_HUMAN for FAM72D Gene via IID

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for FAM72D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM72D Gene

Transcripts for FAM72D Gene

mRNA/cDNA for FAM72D Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM72D Gene

Family with sequence similarity 72, member D:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72D Gene

No ASD Table

Relevant External Links for FAM72D Gene

GeneLoc Exon Structure for
FAM72D
ECgene alternative splicing isoforms for
FAM72D

Expression for FAM72D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM72D Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM72D Gene:

FAM72D

SOURCE GeneReport for Unigene cluster for FAM72D Gene:

Hs.535577
genes like me logo Genes that share expression patterns with FAM72D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM72D Gene

Orthologs for FAM72D Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam72a 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM72A 35
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAM72B 35
  • 62 (a)
OneToMany
Species where no ortholog for FAM72D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72D Gene

ENSEMBL:
Gene Tree for FAM72D (if available)
TreeFam:
Gene Tree for FAM72D (if available)

Paralogs for FAM72D Gene

Paralogs for FAM72D Gene

(3) SIMAP similar genes for FAM72D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM72D: view

Variants for FAM72D Gene

Sequence variations from dbSNP and Humsavar for FAM72D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10081803 -- 145,100,426(+) GTTAC(A/C)AGGGC intron-variant
rs1077771 -- 145,109,712(+) atact(C/G)tccag intron-variant
rs111453274 -- 145,102,734(-) GTTTT(C/G)CTCTT intron-variant
rs111489598 -- 145,099,634(-) AATAA(A/T)AAACT intron-variant
rs111640514 -- 145,103,707(-) TTATT(A/G)TGGTG intron-variant

Variation tolerance for FAM72D Gene

Gene Damage Index Score: 5.10; 69.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM72D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM72D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM72D Gene

Disorders for FAM72D Gene

Relevant External Links for FAM72D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM72D

No disorders were found for FAM72D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72D Gene

Publications for FAM72D Gene

  1. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A. … Heese K. (Genomics 2015) 2 3 64
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM72D Gene

Sources for FAM72D Gene

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