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Aliases for FAM72D Gene

Aliases for FAM72D Gene

  • Family With Sequence Similarity 72 Member D 2 3 5
  • Gastric Cancer Up-Regulated Protein 2 3 4
  • GCUD2 3 4
  • Family With Sequence Similarity 72, Member D 2
  • Gastric Cancer Up-Regulated-2 3
  • Protein FAM72D 3

External Ids for FAM72D Gene

Previous GeneCards Identifiers for FAM72D Gene

  • GC01M142618
  • GC01M143896

Summaries for FAM72D Gene

GeneCards Summary for FAM72D Gene

FAM72D (Family With Sequence Similarity 72 Member D) is a Protein Coding gene. An important paralog of this gene is FAM72C.

Additional gene information for FAM72D Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72D Gene

Genomics for FAM72D Gene

GeneHancer (GH) Regulatory Elements for FAM72D Gene

Promoters and enhancers for FAM72D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I145092 Promoter 0.5 Ensembl 550.8 +1.1 1103 4.2 FAM72D SRGAP2B
GH01I144997 Enhancer 1.5 Ensembl ENCODE dbSUPER 0.2 -94.3 -94276 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF766 PIAS3 NBPF20 POLR3C PFN1P6 GPR89A NUDT17 LOC645166 LIX1L-AS1 GNRHR2 ENSG00000271644
GH01I145015 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.2 -76.1 -76097 5 HDGF ZBTB21 SIN3A CEBPG PRDM10 ZNF600 ATF7 IKZF2 ZNF362 MTA2 ENSG00000271644 FAM72D SRGAP2B
GH01I144994 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.2 -98.1 -98117 2.7 PKNOX1 FEZF1 ZNF48 ZNF213 ZNF548 FOS YY2 ZNF662 REST KAT8 PIAS3 POLR3C NBPF20 NUDT17 PFN1P6 GPR89A LOC645166 LIX1L-AS1 ENSG00000271644 FAM72D
GH01I145007 Enhancer 1 Ensembl ENCODE dbSUPER 0.2 -84.3 -84297 3.8 SMARCE1 ZNF362 ZBTB2 MAFG DPF2 ZBTB40 ZNF316 SMARCA4 IKZF1 NFE2 ENSG00000271644 FAM72D SRGAP2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM72D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM72D gene promoter:

Genomic Locations for FAM72D Gene

Genomic Locations for FAM72D Gene
chr1:145,093,798-145,112,696
(GRCh38/hg38)
Size:
18,899 bases
Orientation:
Plus strand
chr1:143,896,452-143,913,143
(GRCh37/hg19)

Genomic View for FAM72D Gene

Genes around FAM72D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM72D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM72D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM72D Gene

Proteins for FAM72D Gene

  • Protein details for FAM72D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L9T8-FA72D_HUMAN
    Recommended name:
    Protein FAM72D
    Protein Accession:
    Q6L9T8

    Protein attributes for FAM72D Gene

    Size:
    149 amino acids
    Molecular mass:
    16688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM72D Gene

Post-translational modifications for FAM72D Gene

No Post-translational modifications

Other Protein References for FAM72D Gene

No data available for DME Specific Peptides for FAM72D Gene

Domains & Families for FAM72D Gene

Gene Families for FAM72D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM72D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM72D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L9T8

UniProtKB/Swiss-Prot:

FA72D_HUMAN :
  • Belongs to the FAM72 family.
Family:
  • Belongs to the FAM72 family.
genes like me logo Genes that share domains with FAM72D: view

Function for FAM72D Gene

Molecular function for FAM72D Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in gastric cancer.

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM72D Gene

Localization for FAM72D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM72D gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM72D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM72D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM72D Gene

Pathways & Interactions for FAM72D Gene

SuperPathways for FAM72D Gene

No Data Available

Interacting Proteins for FAM72D Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383682%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q6L9T8-FA72D_HUMAN ENSP00000383682 for FAM72D Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM72D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM72D Gene

Drugs & Compounds for FAM72D Gene

No Compound Related Data Available

Transcripts for FAM72D Gene

mRNA/cDNA for FAM72D Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM72D Gene

Family with sequence similarity 72, member D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72D Gene

No ASD Table

Relevant External Links for FAM72D Gene

GeneLoc Exon Structure for
FAM72D
ECgene alternative splicing isoforms for
FAM72D

Expression for FAM72D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM72D Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM72D Gene:

FAM72D

SOURCE GeneReport for Unigene cluster for FAM72D Gene:

Hs.535577

Evidence on tissue expression from TISSUES for FAM72D Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with FAM72D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM72D Gene

Orthologs for FAM72D Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam72a 34
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM72A 34
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAM72B 34
  • 62 (a)
OneToMany
Species where no ortholog for FAM72D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72D Gene

ENSEMBL:
Gene Tree for FAM72D (if available)
TreeFam:
Gene Tree for FAM72D (if available)

Paralogs for FAM72D Gene

Paralogs for FAM72D Gene

(3) SIMAP similar genes for FAM72D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM72D: view

Variants for FAM72D Gene

Sequence variations from dbSNP and Humsavar for FAM72D Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs10081803 -- 145,100,426(+) A/C intron_variant
rs10465240 -- 145,100,045(+) C/T intron_variant
rs1077771 -- 145,109,712(+) C/G genic_downstream_transcript_variant, intron_variant
rs111453274 -- 145,102,734(+) C/G intron_variant
rs111489598 -- 145,099,634(+) T/A intron_variant

Variation tolerance for FAM72D Gene

Gene Damage Index Score: 5.10; 69.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM72D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM72D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM72D Gene

Disorders for FAM72D Gene

Additional Disease Information for FAM72D

No disorders were found for FAM72D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72D Gene

Publications for FAM72D Gene

  1. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A … Heese K (Genomics 2015) 2 3 58
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM72D Gene

Sources for FAM72D Gene

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