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FAM72B Gene

protein-coding   GIFtS: 36
GCID: GC01P120837

Family With Sequence Similarity 72, Member B

  Search for FAM72B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 72, Member B1 2
RP11-439A17.62
Amyloid-Beta Peptide-Induced Protein P172
p172
Protein FAM72B2

External Ids:    HGNC: 248051   Entrez Gene: 6538202   Ensembl: ENSG000001886107   OMIM: 6147115   UniProtKB: Q86X603   
ORGUL members:         

Export aliases for FAM72B gene to outside databases

Previous GC identifers: GC01U901174 GC01P120641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM72B Gene:
FAM72B (family with sequence similarity 72, member B) is a protein-coding gene. An important paralog of this gene is FAM72C.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM72B gene promoter:
         AREB6   Sox5   CBF-A   GCNF-1   GCNF   FOXO4   Nkx2-2   GCNF-2   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM72B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM72B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p11.2   Ensembl cytogenetic band:  1p11.2   HGNC cytogenetic band: 1p12

FAM72B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM72B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P120837:  view genomic region     (about GC identifiers)

Start:
120,837,756 bp from pter      End:
120,855,681 bp from pter
Size:
17,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA72B_HUMAN, Q86X60 (See protein sequence)
Recommended Name: Protein FAM72B  
Size: 149 amino acids; 16617 Da
Miscellaneous: Highly homologous to GCUD2 but localized to a distinct locus
Secondary accessions: B2RPQ5 Q5QP15
Alternative splicing: 2 isoforms:  Q86X60-1   Q86X60-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM72B: NX_Q86X60

Explore proteomics data for FAM72B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9

  • See FAM72B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001094380.1  
    ENSEMBL proteins: 
     ENSP00000358397   ENSP00000392882   ENSP00000347368  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026768 FAM72

    Graphical View of Domain Structure for InterPro Entry Q86X60

    ProtoNet protein and cluster: Q86X60

    UniProtKB/Swiss-Prot: FA72B_HUMAN, Q86X60
    Similarity: Belongs to the FAM72 family


    Find genes that share domains with FAM72B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM72B:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM72B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM72B
    Interactions:

        Search GeneGlobe Interaction Network for FAM72B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM72B (ENSP000003583974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM107BENSP000001817964STRING: ENSP00000181796
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM72B (FA72B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM72B gene: 
    NM_001100910.1  

    Unigene Cluster for FAM72B:

    Family with sequence similarity 72, member B
    Hs.339665  [show with all ESTs]
    Unigene Representative Sequence: NM_001100910
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480765 ENST00000471903 ENST00000369390(uc009whp.3 uc001ein.4)
    ENST00000468129 ENST00000452190 ENST00000355228
    miRNA
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FAM72B

    Additional mRNA sequence: 

    BC046199.1 BC137546.1 DQ786235.1 

    13 DOTS entries:

    DT.443462  DT.99970592  DT.100815765  DT.121436032  DT.121435821  DT.121440207  DT.87011017  DT.98081773 
    DT.121440216  DT.91982635  DT.121372985  DT.121440200  DT.121450097 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM72B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM72B Expression
    About this image

    FAM72B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM72B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.339665
        Custom PCR Arrays for FAM72B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM72B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM72B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    72(a)
    1 → many
    26(2325314-2330088)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    72(a)
    1 → many
    GL343228.1(1047981-1078730)
    zebrafish
    (Danio rerio)
    Actinopterygii FAM72B6
    family with sequence similarity 72, member B
    63(a)
    1 → many
    11(22419536-22431726) ENSDARG00000070621
            Species with no ortholog for FAM72B

    ENSEMBL Gene Tree for FAM72B (if available)
    TreeFam Gene Tree for FAM72B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM72B gene
    FAM72C2  FAM72A2  FAM72D2  
    3 SIMAP similar genes for FAM72B using alignment to 3 protein entries:     FA72B_HUMAN (see all proteins):
    FAM72A    FAM72D    FAM72C

    Find genes that share paralogs with FAM72B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM72B (see all 81)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285407001,2
    C--120843860(+) CAAGTG/AATCCA 1 -- int12Minor allele frequency- A:0.00WA NA 4
    rs618031041,2
    C--120843942(+) TTTTGC/TTTTGA 1 -- int10--------
    rs1503224571,2
    C--120843963(+) TGCTCA/TGTTGC 1 -- int10--------
    rs2009423621,2
    C--120844052(+) CCTCCC/TGAGTA 1 -- int10--------
    rs2016365351,2
    C--120844223(+) GCACCC/TGAAGA 1 -- int10--------
    rs2005432211,2
    C--120845739(+) TAATA-/AA    
       T
    /ATA
    GCAAA
    2 -- cds10--------
    rs796110301,2
    C--120846033(-) AGGAAC/TTACAT 2 N S mis10--------
    rs1997805721,2
    C,F--120846060(+) CAACGG/AACACT 2 /E /G mis11Minor allele frequency- A:0.03EU 1323
    rs1453938641,2
    --120846507(+) CAATGA/GGAGTT 1 -- int10--------
    rs2006192201,2
    C--120846806(+) AATAGC/TAGGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM72B (120837756 - 120855681 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FAM72B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv338n71CNV Gain21882294
    dgv337n71CNV Gain21882294
    nsv831237CNV Gain17160897
    nsv872191CNV Gain21882294
    dgv336n71CNV Gain21882294
    nsv524681CNV Gain19592680
    nsv872181CNV Gain21882294
    esv26241CNV Gain+Loss19812545
    dgv97e1CNV Complex17122850
    dgv94e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FAM72B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM72B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614711    OMIM disorders: --


    Find genes that share disorders with FAM72B           About GenesLikeMe


    Export disorders for FAM72B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM72B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM72B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    2. Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. (PubMed id 19755123)1 Nehar S.... Heese K. (FEBS Lett. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653820 HGNC: 24805 Ensembl:ENSG00000188610 euGenes: HUgn653820 ECgene: FAM72B
    H-InvDB: FAM72B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM72B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM72B gene:
    Search GeneIP for patents involving FAM72B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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