Aliases for FAM72B Gene
Aliases for FAM72B Gene
External Ids for FAM72B Gene
- HGNC: 24805
- Entrez Gene: 653820
- Ensembl: ENSG00000188610
- OMIM: 614711
- UniProtKB: Q86X60
Previous GeneCards Identifiers for FAM72B Gene
- GC01U901174
- GC01P120641
- GC01P120837
Summaries for FAM72B Gene
GeneCards Summary for FAM72B Gene
FAM72B (Family With Sequence Similarity 72 Member B) is a Protein Coding gene. An important paralog of this gene is FAM72A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72B Gene
Genomics for FAM72B Gene
Regulatory Elements for FAM72B Gene
Enhancers for FAM72B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G121201 | 0.8 | Ensembl | 0.4 | -15.2 | -15205 | 1.8 | INSM2 KLF17 ZNF2 ZEB1 ZNF366 ZNF398 ZNF843 ZFP69B PRDM6 ZNF610 | FAM72B GC01M121262 |
| GH01G121260 | 1 | Ensembl dbSUPER | 0.2 | -73.4 | -73405 | 0.2 | ZBTB21 CEBPG PATZ1 ZNF600 CREM MAZ CEBPB NCOA1 ZEB2 ZNF398 | GC01M121262 FAM72B |
| GH01G121206 | 0.2 | Ensembl | 0.4 | -19.5 | -19505 | 0.4 | FAM72B GC01M121262 | |
| GH01G121214 | 0.2 | Ensembl | 0.3 | -28.1 | -28105 | 0.8 | FAM72B GC01M121262 | |
| GH01G121220 | 0.2 | Ensembl | 0.3 | -33.4 | -33405 | 0.2 | FAM72B GC01M121262 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM72B on UCSC Golden Path with GeneCards custom track
Promoters for FAM72B Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000012566 | 1596 | 4201 |
Regulatory Element Products
Genomic Location for FAM72B Gene
- Chromosome:
- 1
- Start:
- 121,167,646 bp from pter
- End:
- 121,186,896 bp from pter
- Size:
- 19,251 bases
- Orientation:
- Minus strand
Genomic View for FAM72B Gene
Genes around FAM72B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p11.2 by Ensembl
- 1p11.2 by Entrez Gene
- 1p11.2 by HGNC
FAM72B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM72B Gene
Proteins for FAM72B Gene
-
Protein details for FAM72B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86X60-FA72B_HUMAN
- Recommended name:
- Protein FAM72B
- Protein Accession:
- Q86X60
- B2RPQ5
- Q5QP15
Protein attributes for FAM72B Gene
- Size:
- 149 amino acids
- Molecular mass:
- 16617 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Highly homologous to GCUD2 but localized to a distinct locus.
Post-translational modifications for FAM72B Gene
Other Protein References for FAM72B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for FAM72B
Protein Products
-
OriGene Purified Proteins for FAM72B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM72B
- Origene Custom Protein Services for FAM72B
- Search GeneTex for Proteins for FAM72B
Assay Products
No data available for DME Specific Peptides for FAM72B Gene
Domains & Families for FAM72B Gene
Suggested Antigen Peptide Sequences for FAM72B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86X60- Family:
-
- Belongs to the FAM72 family.
No data available for Gene Families for FAM72B Gene
Function for FAM72B Gene
Phenotypes for FAM72B Gene
- GenomeRNAi human phenotypes for FAM72B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM72B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM72B gene
- Search ViGene Biosciences for FAM72B
CRISPR Products
-
OriGene CRISPR knockouts for FAM72B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM72B
- GenScript: Design CRISPR guide RNA sequences for FAM72B
miRNA Products
- Search ViGene Biosciences for FAM72B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM72B
- Browse OriGene Inhibitory RNA Products For FAM72B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM72B gene
Clone Products
-
OriGene ORF clones in human for FAM72B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM72B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM72B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM72B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM72B gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM72B Gene
Localization for FAM72B Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM72B Gene
Transcripts for FAM72B Gene
mRNA/cDNA for FAM72B Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM72B Gene
- Family with sequence similarity 72, member B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FAM72B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM72B
- GenScript: Design CRISPR guide RNA sequences for FAM72B
miRNA Products
- Search ViGene Biosciences for FAM72B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM72B
- Browse OriGene Inhibitory RNA Products For FAM72B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM72B gene
Clone Products
-
OriGene ORF clones in human for FAM72B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FAM72B Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM72B Gene:
FAM72BSOURCE GeneReport for Unigene cluster for FAM72B Gene:
Hs.339665Evidence on tissue expression from TISSUES for FAM72B Gene
- Skin(4.1)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs for FAM72B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM72B Gene
Orthologs for FAM72B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Fam72a 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | FAM72A 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | FAM72B 35 |
|
OneToMany |
- Species where no ortholog for FAM72B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM72B Gene
(3) SIMAP similar genes for FAM72B Gene using alignment to 3 proteins:
Variants for FAM72B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs111297482 | -- | 121,173,568(-) | AAAAG(A/G)TTGAA | intron-variant | |
| rs112282289 | -- | 121,170,582(-) | TAACA(C/T)GGATT | intron-variant | |
| rs112987898 | -- | 121,180,214(-) | TTTAC(C/T)TTATC | intron-variant | |
| rs115943512 | -- | 121,171,886(+) | AAATC(C/T)TCCAA | intron-variant | |
| rs1260179 | -- | 121,173,458(+) | ataga(C/T)actgg | intron-variant |
Gene Damage Index Score:
4.43;
63.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM72B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM72B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM72B Gene
Disorders for FAM72B Gene
Relevant External Links for FAM72B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM72B
No disorders were found for FAM72B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72B Gene
Publications for FAM72B Gene
- All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A. … Heese K. (Genomics 2015) 2 3 64
- Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. (PMID: 19755123) Nehar S. … Heese K. (FEBS Lett. 2009) 2 3 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for FAM72B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for FAM72B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM72B
- Origene Custom Protein Services for FAM72B
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM72B
- Browse OriGene Inhibitory RNA Products For FAM72B
- OriGene qPCR primer pairs for FAM72B
- OriGene CRISPR knockouts for FAM72B
- OriGene ORF clones in human for FAM72B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FAM72B
- GenScript: Next-day shipping cDNA ORF clone for FAM72B in any vector
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- GenScript: Design CRISPR guide RNA sequences for FAM72B
- Design optimal peptide antigens
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- Plasmid Preparation
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for FAM72B gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM72B gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM72B gene
- Search ViGene Biosciences for FAM72B
- Horizon Cell Lines for FAM72B
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM72B
- VectorBuilder custom plasmid, inducible vectors for FAM72B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM72B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM72B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer