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Aliases for FAM72B Gene

Aliases for FAM72B Gene

  • Family With Sequence Similarity 72 Member B 2 3 5
  • Family With Sequence Similarity 72, Member B 2
  • Amyloid-Beta Peptide-Induced Protein P17 3
  • Protein FAM72B 3
  • RP11-439A17.6 3
  • P17 3

External Ids for FAM72B Gene

Previous GeneCards Identifiers for FAM72B Gene

  • GC01U901174
  • GC01P120641
  • GC01P120837

Summaries for FAM72B Gene

GeneCards Summary for FAM72B Gene

FAM72B (Family With Sequence Similarity 72 Member B) is a Protein Coding gene. An important paralog of this gene is FAM72A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72B Gene

Genomics for FAM72B Gene

Regulatory Elements for FAM72B Gene

Enhancers for FAM72B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G121201 0.8 Ensembl 0.4 -15.2 -15205 1.8 INSM2 KLF17 ZNF2 ZEB1 ZNF366 ZNF398 ZNF843 ZFP69B PRDM6 ZNF610 FAM72B GC01M121262
GH01G121260 1 Ensembl dbSUPER 0.2 -73.4 -73405 0.2 ZBTB21 CEBPG PATZ1 ZNF600 CREM MAZ CEBPB NCOA1 ZEB2 ZNF398 GC01M121262 FAM72B
GH01G121206 0.2 Ensembl 0.4 -19.5 -19505 0.4 FAM72B GC01M121262
GH01G121215 0.2 Ensembl 0.3 -29.1 -29105 0.4 FAM72B GC01M121262
GH01G121214 0.2 Ensembl 0.3 -28.1 -28105 0.8 FAM72B GC01M121262
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM72B on UCSC Golden Path with GeneCards custom track

Promoters for FAM72B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012566 1596 4201

Genomic Location for FAM72B Gene

Chromosome:
1
Start:
121,167,646 bp from pter
End:
121,186,896 bp from pter
Size:
19,251 bases
Orientation:
Minus strand

Genomic View for FAM72B Gene

Genes around FAM72B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM72B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM72B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM72B Gene

Proteins for FAM72B Gene

  • Protein details for FAM72B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X60-FA72B_HUMAN
    Recommended name:
    Protein FAM72B
    Protein Accession:
    Q86X60
    Secondary Accessions:
    • B2RPQ5
    • Q5QP15

    Protein attributes for FAM72B Gene

    Size:
    149 amino acids
    Molecular mass:
    16617 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Highly homologous to GCUD2 but localized to a distinct locus.

    Alternative splice isoforms for FAM72B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM72B Gene

Post-translational modifications for FAM72B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM72B Gene

No data available for DME Specific Peptides for FAM72B Gene

Domains & Families for FAM72B Gene

Protein Domains for FAM72B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM72B Gene

Graphical View of Domain Structure for InterPro Entry

Q86X60

UniProtKB/Swiss-Prot:

FA72B_HUMAN :
  • Belongs to the FAM72 family.
Family:
  • Belongs to the FAM72 family.
genes like me logo Genes that share domains with FAM72B: view

No data available for Gene Families for FAM72B Gene

Function for FAM72B Gene

Phenotypes for FAM72B Gene

GenomeRNAi human phenotypes for FAM72B:
genes like me logo Genes that share phenotypes with FAM72B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM72B Gene

Localization for FAM72B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM72B gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM72B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM72B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM72B Gene

Pathways & Interactions for FAM72B Gene

SuperPathways for FAM72B Gene

No Data Available

Interacting Proteins for FAM72B Gene

Gene Ontology (GO) - Biological Process for FAM72B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM72B Gene

Drugs & Compounds for FAM72B Gene

No Compound Related Data Available

Transcripts for FAM72B Gene

mRNA/cDNA for FAM72B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM72B Gene

Family with sequence similarity 72, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72B Gene

No ASD Table

Relevant External Links for FAM72B Gene

GeneLoc Exon Structure for
FAM72B
ECgene alternative splicing isoforms for
FAM72B

Expression for FAM72B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM72B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM72B Gene:

FAM72B

SOURCE GeneReport for Unigene cluster for FAM72B Gene:

Hs.339665

Evidence on tissue expression from TISSUES for FAM72B Gene

  • Skin(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with FAM72B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM72B Gene

Orthologs for FAM72B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam72a 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM72A 35
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAM72B 35
  • 63 (a)
OneToMany
Species where no ortholog for FAM72B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72B Gene

ENSEMBL:
Gene Tree for FAM72B (if available)
TreeFam:
Gene Tree for FAM72B (if available)

Paralogs for FAM72B Gene

Paralogs for FAM72B Gene

(3) SIMAP similar genes for FAM72B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM72B: view

Variants for FAM72B Gene

Sequence variations from dbSNP and Humsavar for FAM72B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111297482 -- 121,173,568(-) AAAAG(A/G)TTGAA intron-variant
rs112282289 -- 121,170,582(-) TAACA(C/T)GGATT intron-variant
rs112987898 -- 121,180,214(-) TTTAC(C/T)TTATC intron-variant
rs115943512 -- 121,171,886(+) AAATC(C/T)TCCAA intron-variant
rs1260179 -- 121,173,458(+) ataga(C/T)actgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM72B Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV gain 19592680

Variation tolerance for FAM72B Gene

Gene Damage Index Score: 4.43; 63.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM72B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM72B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM72B Gene

Disorders for FAM72B Gene

Relevant External Links for FAM72B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM72B

No disorders were found for FAM72B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72B Gene

Publications for FAM72B Gene

  1. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A. … Heese K. (Genomics 2015) 2 3 64
  2. Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. (PMID: 19755123) Nehar S. … Heese K. (FEBS Lett. 2009) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM72B Gene

Sources for FAM72B Gene

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