FAM72A Gene
protein-coding GIFtS : 39
GCID: GC01 P206136 (predicted)
family with sequence similarity 72, member A
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Aliasesfor FAM72A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 72, Member A 1 2 RP11-312O7.11 Latent Membrane Protein 1-Induced Protein2 3 Ugene2 LMPIP2 3 Protein FAM72A2 LMP1-Induced Protein2 3 UGENE3 MGC578271
Export aliases for FAM72A gene to outside databases Previous GC identifers: GC01P120553 GC01P7M0094 GC01P204300
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Summariesfor FAM72A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: FA72A_HUMAN, Q5TYM5 Function : May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cellgrowth regulation
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Genomic Viewsfor FAM72A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_086602.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM72A gene promoter: AREB6 Sox5 GCNF-1 GCNF Nkx2-2 FOXO4 MyoD GCNF-2 CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for FAM72A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM72A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1 FAM72A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P206136: view genomic region
(about GC identifiers )
Start:
206,136,916 bp from pter
End:
206,155,151 bp from pter
Size:
18,236 bases
Orientation:
plus strand
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Proteinsfor FAM72A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FA72A_HUMAN, Q5TYM5 (See
protein sequence )Recommended Name: Protein FAM72A Size : 149 amino acids; 16619 Da
Subunit : Interacts with UNG
Subcellular location : Cytoplasm. Mitochondrion. Note=A V5 epitope-tagged construct has been shown to localize to thenucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926)
Miscellaneous : Highly homologous to GCUD2 but localized to a distinct locus
Secondary accessions : B2RV15 Q5TYM4Alternative splicing : 2 isoforms : Q5TYM5-1 Q5TYM5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM72A: NX_Q5TYM5 FAM72A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001116640.1 ENSEMBL proteins: ENSP00000356097 ENSP00000356096 ENSP00000340661 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IEA --
FAM72A for ontologies About GeneDecksing FAM72A Antibody Products: Assay Products for FAM72A:
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Protein
Domains / Familiesfor FAM72A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM72A for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5TYM5 ProtoNet protein and cluster: Q5TYM5
UniProtKB/Swiss-Prot: FA72A_HUMAN, Q5TYM5 Similarity : Belongs to the FAM72 family
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Functionfor FAM72A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: FA72A_HUMAN, Q5TYM5 Function : May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cellgrowth regulation Induction : Up-regulated in peripheral blood mononuclear cells following Epstein-Barr virus (EBV) infection or followingtransfection with EBV LMP1 protein
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM72A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM72AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM72A (NM_001123168 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM72A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM72A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM72A
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Pathways & Interactionsfor FAM72A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM72A STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)5/12 Interacting proteins for FAM72A (ENSP00000356096 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 12 )About this table
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Drugs & Compoundsfor FAM72A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM72A Search CenterWatch for drugs/clinical trials and news about FAM72A / FA72A
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Transcriptsfor FAM72A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM72A gene: NM_001123168.1 Unigene Cluster for FAM72A:
Family with sequence similarity 72, member A Hs.661924 [show with all ESTs ] Unigene Representative Sequence: BC035696 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000470041 ENST00000468509 ENST00000367129 ENST00000367128 (uc001hdr.4 )ENST00000481737 ENST00000431655 ENST00000341209 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM72A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM72AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM72A (NM_001123168 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM72A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM72A
Additional cDNA sequence: BC035696.1 BC137545.1 BC146978.1 BC146992.1 DQ786198.1
6 DOTS entries : DT.99970592 DT.91982635
DT.98081773 DT.305991 DT.100737737 DT.121450097 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM72A About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c SP1 :   -   -   -   -   -             SP2 :                       SP3 :           -             SP4 :       -                
ECgene alternative splicing isoforms for FAM72A
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Expression for FAM72A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM72A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGTTAGATA
About this image FAM72A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Inner Nuclear Layer Mature Horizontal Cells Horizontal, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM72A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM72A SOURCE GeneReport for Unigene cluster: Hs.661924 UniProtKB/Swiss-Prot: FA72A_HUMAN, Q5TYM5 Tissue specificity : May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas.Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary SABiosciences Custom PCR Arrays for FAM72A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM72ABrowse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM72A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM72A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM72A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM72A
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Orthologsfor FAM72A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM72A gene from 4/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for FAM72A (if available)TreeFam Gene Tree for FAM72A (if available)
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Paralogsfor FAM72A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM72A gene FAM72C 2 FAM72D 2 FAM72B 2 3 SIMAP similar genes for FAM72A using alignment to 2 protein entries: FA72A_HUMAN (see all proteins ):FAM72B FAM72D FAM72C
FAM72A for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for FAM72A PGOHUM00000259477 PGOHUM00000244877
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Genomic Variantsfor FAM72A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM72A (206136916 - 206155151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for FAM72A 3 CNVs : 4268 84803 65718
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM72A
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Disorders
/ Diseasesfor FAM72A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM72A for disorders About MalaCards
FAM72A for disorders About GeneDecksing
OMIM gene information: 614710
OMIM disorders : --Export disorders for FAM72A gene to outside databases
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Publicationsfor FAM72A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM72A gene integrated from 9 sources : (articles sorted by number of sources associating them with FAM72A) Utopia : connect your pdf to the dynamic world of online information
Functional interaction of Ugene and EBV infection med iates tumorigenic effects. (PubMed id 21317926) 1 , 2 Wang L.T....Hsu S.H. (2011) Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. (PubMed id 18676834) 1 , 2 Guo C....Markowitz S.D. (2008) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450) 1 Fortna A....Sikela J.M. (2004)
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External Searches for FAM72A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM72A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM72A gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM72A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM72A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM72A gene: Search GeneIP for patents involving FAM72A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM72A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM72A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM72A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM72A OriGene Protein Over-expression Lysate for FAM72A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM72A Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM72A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM72A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM72A OriGene Custom Protein Services for FAM72A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM72A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM72A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM72A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM72A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM72A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM72A
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FAM72A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM72A
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM72A
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