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Aliases for FAM72A Gene

Aliases for FAM72A Gene

  • Family With Sequence Similarity 72, Member A 2 3
  • Latent Membrane Protein 1-Induced Protein 3 4
  • LMP1-Induced Protein 3 4
  • Ugene 3 4
  • LMPIP 3 4
  • RP11-312O7.1 3

External Ids for FAM72A Gene

Previous GeneCards Identifiers for FAM72A Gene

  • GC01P120553
  • GC01P7M0094
  • GC01P204300
  • GC01P206136

Summaries for FAM72A Gene

GeneCards Summary for FAM72A Gene

FAM72A (Family With Sequence Similarity 72, Member A) is a Protein Coding gene. An important paralog of this gene is FAM72B.

UniProtKB/Swiss-Prot for FAM72A Gene

  • May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72A Gene

Genomics for FAM72A Gene

Regulatory Elements for FAM72A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM72A Gene

206,186,179 bp from pter
206,204,919 bp from pter
18,741 bases
Minus strand

Genomic View for FAM72A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FAM72A Gene

Proteins for FAM72A Gene

  • Protein details for FAM72A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM72A
    Protein Accession:
    Secondary Accessions:
    • B2RV15
    • Q5TYM4

    Protein attributes for FAM72A Gene

    149 amino acids
    Molecular mass:
    16619 Da
    Quaternary structure:
    • Interacts with UNG.
    • Highly homologous to GCUD2 but localized to a distinct locus

    Alternative splice isoforms for FAM72A Gene


neXtProt entry for FAM72A Gene

Proteomics data for FAM72A Gene at MOPED

Post-translational modifications for FAM72A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM72A Gene

No data available for DME Specific Peptides for FAM72A Gene

Domains & Families for FAM72A Gene

Protein Domains for FAM72A Gene


Suggested Antigen Peptide Sequences for FAM72A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM72 family.
  • Belongs to the FAM72 family.
genes like me logo Genes that share domains with FAM72A: view

No data available for Gene Families for FAM72A Gene

Function for FAM72A Gene

Molecular function for FAM72A Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood mononuclear cells following Epstein-Barr virus (EBV) infection or following transfection with EBV LMP1 protein.

Gene Ontology (GO) - Molecular Function for FAM72A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM72A: view

Animal Model Products

CRISPR Products

miRNA for FAM72A Gene

miRTarBase miRNAs that target FAM72A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM72A Gene

Localization for FAM72A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM72A Gene

Cytoplasm. Mitochondrion. Note=A V5 epitope-tagged construct has been shown to localize to the nucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926). {ECO:0000269 PubMed:18676834, ECO:0000269 PubMed:21317926}.

Gene Ontology (GO) - Cellular Components for FAM72A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with FAM72A: view

No data available for Subcellular locations from COMPARTMENTS for FAM72A Gene

Pathways & Interactions for FAM72A Gene

SuperPathways for FAM72A Gene

No Data Available

Interacting Proteins for FAM72A Gene

Selected Interacting proteins: Q5TYM5-FA72A_HUMAN for FAM72A Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM72A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM72A Gene

Drugs & Compounds for FAM72A Gene

No Compound Related Data Available

Transcripts for FAM72A Gene

mRNA/cDNA for FAM72A Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM72A Gene

Family with sequence similarity 72, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM72A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - - -
SP3: -
SP4: -

Relevant External Links for FAM72A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM72A Gene

mRNA expression in normal human tissues for FAM72A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM72A Gene

This gene is overexpressed in Kidney (35.0) and Colon (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM72A Gene

SOURCE GeneReport for Unigene cluster for FAM72A Gene Hs.661924

mRNA Expression by UniProt/SwissProt for FAM72A Gene

Tissue specificity: May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas. Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary.
genes like me logo Genes that share expression patterns with FAM72A: view

Protein tissue co-expression partners for FAM72A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM72A Gene

Orthologs for FAM72A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM72A 35
  • 94.63 (n)
  • 91.95 (a)
FAM72A 36
  • 89 (a)
(Canis familiaris)
Mammalia FAM72A 35
  • 92.62 (n)
  • 94.63 (a)
-- 36
  • 79 (a)
(Mus musculus)
Mammalia Fam72a 35
  • 90.16 (n)
  • 89.93 (a)
Fam72a 16
Fam72a 36
  • 90 (a)
(Pan troglodytes)
Mammalia FAM72A 35
  • 100 (n)
  • 100 (a)
-- 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam72a 35
  • 89.04 (n)
  • 89.26 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
(Gallus gallus)
Aves FAM72A 35
  • 74.27 (n)
  • 76.51 (a)
-- 36
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam72a 35
  • 64.35 (n)
  • 64.58 (a)
(Danio rerio)
Actinopterygii zgc:101564 35
  • 66.67 (n)
  • 66.67 (a)
FAM72B 36
  • 63 (a)
Species with no ortholog for FAM72A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72A Gene

Gene Tree for FAM72A (if available)
Gene Tree for FAM72A (if available)

Paralogs for FAM72A Gene

Paralogs for FAM72A Gene

(3) SIMAP similar genes for FAM72A Gene using alignment to 5 proteins: Pseudogenes for FAM72A Gene

genes like me logo Genes that share paralogs with FAM72A: view

Variants for FAM72A Gene

Sequence variations from dbSNP and Humsavar for FAM72A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1260182 -- 206,193,244(+) gagtt(C/T)cactc intron-variant, downstream-variant-500B
rs2144660 -- 206,193,164(+) cgcct(C/T)ggcct intron-variant, downstream-variant-500B
rs9331194 -- 206,191,172(-) aggtg(C/T)gcacc intron-variant
rs61815509 -- 206,191,292(-) AGATG(A/G)AGTCA intron-variant
rs61815528 -- 206,186,053(-) AACTG(G/T)TAAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM72A Gene

Variant ID Type Subtype PubMed ID
esv26345 CNV Gain+Loss 19812545

Variation tolerance for FAM72A Gene

Gene Damage Index Score: 0.01; 0.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM72A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM72A Gene

Disorders for FAM72A Gene

Relevant External Links for FAM72A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM72A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72A Gene

Publications for FAM72A Gene

  1. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A. … Heese K. (Genomics 2015) 67
  2. Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17). (PMID: 25234718) Pramanik S. … Heese K. (Tumour Biol. 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. The protein p17 signaling pathways in cancer. (PMID: 23900679) Heese K. (Tumour Biol. 2013) 67
  5. Functional interaction of Ugene and EBV infection mediates tumorigenic effects. (PMID: 21317926) Wang L.T. … Hsu S.H. (Oncogene 2011) 67

Products for FAM72A Gene

Sources for FAM72A Gene

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