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Aliases for FAM72A Gene

Aliases for FAM72A Gene

  • Family With Sequence Similarity 72, Member A 2 3
  • Ugene 3 4 6
  • LMPIP 3 4 6
  • Latent Membrane Protein 1-Induced Protein 3 4
  • LMP1-Induced Protein 3 4
  • Protein FAM72A 3
  • RP11-312O7.1 3

External Ids for FAM72A Gene

Summaries for FAM72A Gene

GeneCards Summary for FAM72A Gene

FAM72A (Family With Sequence Similarity 72, Member A) is a Protein Coding gene. An important paralog of this gene is FAM72B.

UniProtKB/Swiss-Prot for FAM72A Gene

  • May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72A Gene

Genomics for FAM72A Gene

Genomic Location for FAM72A Gene

Start:
206,186,179 bp from pter
End:
206,204,414 bp from pter
Size:
18,236 bases
Orientation:
Minus strand

Genomic View for FAM72A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM72A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM72A Gene

Regulatory Elements for FAM72A Gene

Proteins for FAM72A Gene

  • Protein details for FAM72A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TYM5-FA72A_HUMAN
    Recommended name:
    Protein FAM72A
    Protein Accession:
    Q5TYM5
    Secondary Accessions:
    • B2RV15
    • Q5TYM4

    Protein attributes for FAM72A Gene

    Size:
    149 amino acids
    Molecular mass:
    16619 Da
    Quaternary structure:
    • Interacts with UNG.
    Miscellaneous:
    • Highly homologous to GCUD2 but localized to a distinct locus

    Alternative splice isoforms for FAM72A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM72A Gene

Proteomics data for FAM72A Gene at MOPED

Post-translational modifications for FAM72A Gene

Other Protein References for FAM72A Gene

No data available for DME Specific Peptides for FAM72A Gene

Domains for FAM72A Gene

Protein Domains for FAM72A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FA72A_HUMAN
Family:
  • Belongs to the FAM72 family.:
    • Q5TYM5
genes like me logo Genes that share domains with FAM72A: view

No data available for Gene Families for FAM72A Gene

Function for FAM72A Gene

Molecular function for FAM72A Gene

UniProtKB/Swiss-Prot Function: May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.
UniProtKB/Swiss-Prot Induction: Up-regulated in peripheral blood mononuclear cells following Epstein-Barr virus (EBV) infection or following transfection with EBV LMP1 protein.

Gene Ontology (GO) - Molecular Function for FAM72A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM72A: view

miRNA for FAM72A Gene

miRTarBase miRNAs that target FAM72A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM72A Gene

Localization for FAM72A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM72A Gene

Cytoplasm. Mitochondrion. Note=A V5 epitope-tagged construct has been shown to localize to the nucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926). {ECO:0000269 PubMed:18676834, ECO:0000269 PubMed:21317926}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM72A Gene COMPARTMENTS Subcellular localization image for FAM72A gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM72A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with FAM72A: view

Pathways for FAM72A Gene

SuperPathways for FAM72A Gene

No Data Available

Interacting Proteins for FAM72A Gene

Selected Interacting proteins: Q5TYM5-FA72A_HUMAN for FAM72A Gene via UniProtKB

Symbol External ID(s) Details
MPPED2

Gene Ontology (GO) - Biological Process for FAM72A Gene

None

No data available for Pathways by source for FAM72A Gene

Transcripts for FAM72A Gene

mRNA/cDNA for FAM72A Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM72A Gene

Family with sequence similarity 72, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - - -
SP2:
SP3: -
SP4: -

Relevant External Links for FAM72A Gene

GeneLoc Exon Structure for
FAM72A
ECgene alternative splicing isoforms for
FAM72A

Expression for FAM72A Gene

mRNA expression in normal human tissues for FAM72A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM72A Gene

SOURCE GeneReport for Unigene cluster for FAM72A Gene Hs.661924

mRNA Expression by UniProt/SwissProt for FAM72A Gene

Q5TYM5-FA72A_HUMAN
Tissue specificity: May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas. Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary.
genes like me logo Genes that share expressions with FAM72A: view

Orthologs for FAM72A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
FAM72A 36
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FAM72A 36
  • 94.63 (n)
  • 91.95 (a)
FAM72A 37
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 79 (a)
OneToMany
FAM72A 36
  • 92.62 (n)
  • 94.63 (a)
mouse
(Mus musculus)
Mammalia Fam72a 36
  • 90.16 (n)
  • 89.93 (a)
Fam72a 16
Fam72a 37
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam72a 36
  • 89.04 (n)
  • 89.26 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 74 (a)
OneToMany
FAM72A 36
  • 74.27 (n)
  • 76.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam72a 36
  • 64.35 (n)
  • 64.58 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM72B 37
  • 63 (a)
OneToMany
zgc:101564 36
  • 66.67 (n)
  • 66.67 (a)
Species with no ortholog for FAM72A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72A Gene

ENSEMBL:
Gene Tree for FAM72A (if available)
TreeFam:
Gene Tree for FAM72A (if available)

Paralogs for FAM72A Gene

Paralogs for FAM72A Gene

Selected SIMAP similar genes for FAM72A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FAM72A Gene

genes like me logo Genes that share paralogs with FAM72A: view

Variants for FAM72A Gene

Sequence variations from dbSNP and Humsavar for FAM72A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1260182 -- 206,193,244(+) gagtt(C/T)cactc intron-variant
rs2144660 -- 206,193,164(+) cgcct(C/T)ggcct intron-variant
rs9331194 -- 206,191,172(-) aggtg(C/T)gcacc intron-variant
rs61815509 -- 206,191,292(-) AGATG(A/G)AGTCA intron-variant
rs61815528 -- 206,186,053(-) AACTG(G/T)TAAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM72A Gene

Variant ID Type Subtype PubMed ID
esv26345 CNV Gain+Loss 19812545

Relevant External Links for FAM72A Gene

HapMap Linkage Disequilibrium report
FAM72A

Disorders for FAM72A Gene

No disorders were found for FAM72A Gene.

No data available for UniProtKB/Swiss-Prot for FAM72A Gene

Publications for FAM72A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. (PMID: 18676834) Guo C. … Markowitz S.D. (Cancer Res. 2008) 3 4
  4. Functional interaction of Ugene and EBV infection mediates tumorigenic effects. (PMID: 21317926) Wang L.T. … Hsu S.H. (Oncogene 2011) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for FAM72A Gene

Sources for FAM72A Gene

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