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Aliases for FAM72A Gene

Aliases for FAM72A Gene

  • Family With Sequence Similarity 72 Member A 2 3 5
  • Latent Membrane Protein 1-Induced Protein 3 4
  • LMP1-Induced Protein 3 4
  • Ugene 3 4
  • LMPIP 3 4
  • Family With Sequence Similarity 72, Member A 2
  • Protein FAM72A 3

External Ids for FAM72A Gene

Previous GeneCards Identifiers for FAM72A Gene

  • GC01P120553
  • GC01P7M0094
  • GC01P204300
  • GC01P206136

Summaries for FAM72A Gene

GeneCards Summary for FAM72A Gene

FAM72A (Family With Sequence Similarity 72 Member A) is a Protein Coding gene. An important paralog of this gene is FAM72B.

UniProtKB/Swiss-Prot for FAM72A Gene

  • May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM72A Gene

Genomics for FAM72A Gene

Regulatory Elements for FAM72A Gene

Enhancers for FAM72A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F206202 0.9 ENCODE 0.8 +1.1 1091 2.4 HDGF ATF1 PKNOX1 SIN3A RFX5 GLIS2 ZNF366 RCOR1 FOS SP3 FAM72A SRGAP2
GH01F206238 0.9 Ensembl ENCODE 0.3 -35.3 -35282 2.8 CTCF PKNOX1 CEBPB MAFG FOXK2 IKZF1 PBX2 NFE2 ZNF600 MAFK PIR37211 FAM72A
GH01F206224 0.8 Ensembl 0.3 -19.9 -19882 1.2 HDAC1 PKNOX1 INSM2 ZNF335 ZFHX2 ZNF366 PRDM10 ZNF600 KLF8 EZH2 FAM72A PIR37211
GH01F206232 0.8 Ensembl 0.3 -29.1 -29082 2.8 CTCF ESRRA ARID4B FEZF1 RAD21 POLR2A ZNF143 SMC3 PRDM10 MAFK PIR37211 FAM72A
GH01F206218 0.7 Ensembl 0.3 -15.2 -15182 3.4 CBX3 RNF2 CEBPB CEBPG DPF2 ZNF664 GATA3 CTBP1 RCOR1 CUX1 FAM72A PIR37211
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM72A on UCSC Golden Path with GeneCards custom track

Promoters for FAM72A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000288646 1119 4801 HDGF ATF1 PKNOX1 SIN3A RFX5 GLIS2 ZNF366 RCOR1 FOS EGR2

Genomic Location for FAM72A Gene

Chromosome:
1
Start:
206,186,179 bp from pter
End:
206,204,919 bp from pter
Size:
18,741 bases
Orientation:
Minus strand

Genomic View for FAM72A Gene

Genes around FAM72A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM72A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM72A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM72A Gene

Proteins for FAM72A Gene

  • Protein details for FAM72A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TYM5-FA72A_HUMAN
    Recommended name:
    Protein FAM72A
    Protein Accession:
    Q5TYM5
    Secondary Accessions:
    • B2RV15
    • Q5TYM4

    Protein attributes for FAM72A Gene

    Size:
    149 amino acids
    Molecular mass:
    16619 Da
    Quaternary structure:
    • Interacts with UNG.
    Miscellaneous:
    • Highly homologous to GCUD2 but localized to a distinct locus.

    Alternative splice isoforms for FAM72A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM72A Gene

Post-translational modifications for FAM72A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM72A Gene

Domains & Families for FAM72A Gene

Protein Domains for FAM72A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM72A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TYM5

UniProtKB/Swiss-Prot:

FA72A_HUMAN :
  • Belongs to the FAM72 family.
Family:
  • Belongs to the FAM72 family.
genes like me logo Genes that share domains with FAM72A: view

No data available for Gene Families for FAM72A Gene

Function for FAM72A Gene

Molecular function for FAM72A Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood mononuclear cells following Epstein-Barr virus (EBV) infection or following transfection with EBV LMP1 protein.

Gene Ontology (GO) - Molecular Function for FAM72A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM72A: view

Phenotypes for FAM72A Gene

GenomeRNAi human phenotypes for FAM72A:
genes like me logo Genes that share phenotypes with FAM72A: view

Animal Model Products

miRNA for FAM72A Gene

miRTarBase miRNAs that target FAM72A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM72A Gene

Localization for FAM72A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM72A Gene

Cytoplasm. Mitochondrion. Note=A V5 epitope-tagged construct has been shown to localize to the nucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926). {ECO:0000269 PubMed:18676834, ECO:0000269 PubMed:21317926}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM72A gene
Compartment Confidence
mitochondrion 5
cytosol 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM72A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM72A: view

Pathways & Interactions for FAM72A Gene

SuperPathways for FAM72A Gene

No Data Available

Interacting Proteins for FAM72A Gene

Selected Interacting proteins: Q5TYM5-FA72A_HUMAN for FAM72A Gene via UniProtKB IID

Symbol External ID(s) Details
MPPED2

Gene Ontology (GO) - Biological Process for FAM72A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM72A Gene

Transcripts for FAM72A Gene

mRNA/cDNA for FAM72A Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM72A Gene

Family with sequence similarity 72, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - - -
SP2:
SP3: -
SP4: -

Relevant External Links for FAM72A Gene

GeneLoc Exon Structure for
FAM72A
ECgene alternative splicing isoforms for
FAM72A

Expression for FAM72A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM72A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM72A Gene

This gene is overexpressed in Kidney (35.0) and Colon (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM72A Gene



Protein tissue co-expression partners for FAM72A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM72A Gene:

FAM72A

SOURCE GeneReport for Unigene cluster for FAM72A Gene:

Hs.661924

mRNA Expression by UniProt/SwissProt for FAM72A Gene:

Q5TYM5-FA72A_HUMAN
Tissue specificity: May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas. Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary.
genes like me logo Genes that share expression patterns with FAM72A: view

Primer Products

No data available for mRNA differential expression in normal tissues for FAM72A Gene

Orthologs for FAM72A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM72A 34
  • 100 (n)
-- 35
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM72A 34 35
  • 94.63 (n)
dog
(Canis familiaris)
Mammalia FAM72A 34
  • 92.62 (n)
-- 35
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam72a 34 16 35
  • 90.16 (n)
rat
(Rattus norvegicus)
Mammalia Fam72a 34
  • 89.04 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM72A 34
  • 74.27 (n)
-- 35
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam72a 34
  • 64.35 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:101564 34
  • 66.67 (n)
FAM72B 35
  • 63 (a)
OneToMany
Species where no ortholog for FAM72A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72A Gene

ENSEMBL:
Gene Tree for FAM72A (if available)
TreeFam:
Gene Tree for FAM72A (if available)

Paralogs for FAM72A Gene

Paralogs for FAM72A Gene

(3) SIMAP similar genes for FAM72A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FAM72A Gene

genes like me logo Genes that share paralogs with FAM72A: view

Variants for FAM72A Gene

Sequence variations from dbSNP and Humsavar for FAM72A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1077770 -- 206,189,142(+) aatga(A/G)cgaaa intron-variant
rs111756773 -- 206,192,917(-) AAAAA(A/G)AAAAG intron-variant
rs111793857 -- 206,188,443(-) CTTTT(A/T)ACTAA intron-variant
rs112419596 -- 206,198,602(-) AAATT(C/T)TCTCA intron-variant
rs112424008 -- 206,205,979(-) GCTGG(A/G)GACGT upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM72A Gene

Variant ID Type Subtype PubMed ID
nsv946611 CNV duplication 23825009
nsv1148900 CNV duplication 26484159
nsv1115377 CNV duplication 24896259
esv26345 CNV gain+loss 19812545

Variation tolerance for FAM72A Gene

Gene Damage Index Score: 0.01; 0.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM72A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM72A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM72A Gene

Disorders for FAM72A Gene

Relevant External Links for FAM72A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM72A

No disorders were found for FAM72A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72A Gene

Publications for FAM72A Gene

  1. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A. … Heese K. (Genomics 2015) 2 3 64
  2. Functional interaction of Ugene and EBV infection mediates tumorigenic effects. (PMID: 21317926) Wang L.T. … Hsu S.H. (Oncogene 2011) 3 4 64
  3. Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. (PMID: 18676834) Guo C. … Markowitz S.D. (Cancer Res. 2008) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM72A Gene

Sources for FAM72A Gene

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