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Aliases for FAM71F1 Gene

Aliases for FAM71F1 Gene

  • Family With Sequence Similarity 71 Member F1 2 3 5
  • Family With Sequence Similarity 137, Member A 2 3
  • Testis Development Protein NYD-SP18 3 4
  • FAM137A 3 4
  • Family With Sequence Similarity 71, Member F1 2
  • Testes Development-Related NYD-SP18 3
  • Testicular Tissue Protein Li 67 3
  • Protein FAM71F1 3
  • Protein FAM137A 4
  • NYD-SP18 3

External Ids for FAM71F1 Gene

Previous HGNC Symbols for FAM71F1 Gene

  • FAM137A

Previous GeneCards Identifiers for FAM71F1 Gene

  • GC07P128143
  • GC07P128350
  • GC07P122716
  • GC07P128352
  • GC07P128391
  • GC07P128446
  • GC07P128498

Summaries for FAM71F1 Gene

GeneCards Summary for FAM71F1 Gene

FAM71F1 (Family With Sequence Similarity 71 Member F1) is a Protein Coding gene. An important paralog of this gene is FAM71F2.

Additional gene information for FAM71F1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM71F1 Gene

Genomics for FAM71F1 Gene

Regulatory Elements for FAM71F1 Gene

Enhancers for FAM71F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H128737 1.6 Ensembl ENCODE dbSUPER 10.9 +31.6 31642 6 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ENSG00000243302 ENSG00000230715 ENSG00000243679 OPN1SW ENSG00000242588 TNPO3 RPS10P15 NRF1 CALU ENSG00000242162
GH07H128754 0.9 ENCODE dbSUPER 10.9 +46.9 46898 3 ZNF362 ZSCAN4 JUND ZNF316 POLR2A RCOR1 FOS FOXP2 OPN1SW CALU CCDC136 IMP3P2 FAM71F2 ENSG00000241493 FLNC FAM71F1 RN7SL81P
GH07H128812 0.9 Ensembl 10.4 +103.9 103940 0 HDAC1 ATF1 RB1 TCF12 GATA2 ATF7 ETV6 CREM CEBPB REST OPN1SW FLNC-AS1 ATP6V1F IMP3P2 FAM71F2 ENSG00000241493 FAM71F1 PIR31734 GC07P128904 CCDC136
GH07H128814 0.8 ENCODE dbSUPER 10.4 +105.8 105836 1 HDGF CTBP1 POLR2A HLF ZNF24 CCDC136 OPN1SW FLNC-AS1 ATP6V1F IMP3P2 ENSG00000241493 FAM71F2 FAM71F1 CALU PIR31734
GH07H128897 0.3 FANTOM5 20.8 +188.1 188127 0 FAM71F2 FAM71F1 LOC100130705 ATP6V1F FLNC-AS1 FLNC TSPAN33 OPN1SW ENSG00000243230 AHCYL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM71F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM71F1 Gene

Chromosome:
7
Start:
128,709,061 bp from pter
End:
128,731,743 bp from pter
Size:
22,683 bases
Orientation:
Plus strand

Genomic View for FAM71F1 Gene

Genes around FAM71F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM71F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM71F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM71F1 Gene

Proteins for FAM71F1 Gene

  • Protein details for FAM71F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KD3-F71F1_HUMAN
    Recommended name:
    Protein FAM71F1
    Protein Accession:
    Q96KD3
    Secondary Accessions:
    • Q8IY75
    • Q8NA48

    Protein attributes for FAM71F1 Gene

    Size:
    344 amino acids
    Molecular mass:
    38946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM71F1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM71F1 Gene

Post-translational modifications for FAM71F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM71F1 Gene

Domains & Families for FAM71F1 Gene

Gene Families for FAM71F1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM71F1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM71F1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96KD3

UniProtKB/Swiss-Prot:

F71F1_HUMAN :
  • Belongs to the FAM71 family.
Family:
  • Belongs to the FAM71 family.
genes like me logo Genes that share domains with FAM71F1: view

Function for FAM71F1 Gene

Phenotypes for FAM71F1 Gene

genes like me logo Genes that share phenotypes with FAM71F1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM71F1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM71F1 Gene

Localization for FAM71F1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM71F1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM71F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FAM71F1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM71F1 Gene

Pathways & Interactions for FAM71F1 Gene

SuperPathways for FAM71F1 Gene

No Data Available

Interacting Proteins for FAM71F1 Gene

Selected Interacting proteins: Q96KD3-F71F1_HUMAN for FAM71F1 Gene via IID

Gene Ontology (GO) - Biological Process for FAM71F1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM71F1 Gene

Drugs & Compounds for FAM71F1 Gene

No Compound Related Data Available

Transcripts for FAM71F1 Gene

Unigene Clusters for FAM71F1 Gene

Family with sequence similarity 71, member F1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM71F1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM71F1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - -
SP9: -

Relevant External Links for FAM71F1 Gene

GeneLoc Exon Structure for
FAM71F1
ECgene alternative splicing isoforms for
FAM71F1

Expression for FAM71F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM71F1 Gene

mRNA differential expression in normal tissues according to GTEx for FAM71F1 Gene

This gene is overexpressed in Testis (x48.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM71F1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM71F1 Gene:

FAM71F1

SOURCE GeneReport for Unigene cluster for FAM71F1 Gene:

Hs.732440

Evidence on tissue expression from TISSUES for FAM71F1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with FAM71F1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM71F1 Gene

Orthologs for FAM71F1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM71F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM71F1 33 34
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia FAM71F1 33 34
  • 88.08 (n)
dog
(Canis familiaris)
Mammalia FAM71F1 33 34
  • 87.89 (n)
mouse
(Mus musculus)
Mammalia Fam71f1 33 16 34
  • 82.99 (n)
rat
(Rattus norvegicus)
Mammalia Fam71f1 33
  • 82.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
OneToMany
Species where no ortholog for FAM71F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM71F1 Gene

ENSEMBL:
Gene Tree for FAM71F1 (if available)
TreeFam:
Gene Tree for FAM71F1 (if available)

Paralogs for FAM71F1 Gene

(1) SIMAP similar genes for FAM71F1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM71F1: view

Variants for FAM71F1 Gene

Sequence variations from dbSNP and Humsavar for FAM71F1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000021805 -- 128,724,924(+) CTGCA(A/C)CCTTG intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000307300 -- 128,731,583(+) ATCTA(A/C)TTTAA nc-transcript-variant, utr-variant-3-prime
rs1000450517 -- 128,724,963(+) TCAGA(C/T)CTGTA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000495811 -- 128,718,424(+) CAAAA(C/T)TTTGC intron-variant
rs1000588943 -- 128,713,329(+) AGAAA(C/G)AGAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM71F1 Gene

Variant ID Type Subtype PubMed ID
esv2670312 CNV deletion 23128226
esv2673978 CNV deletion 23128226
esv2735137 CNV deletion 23290073

Variation tolerance for FAM71F1 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.86; 94.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM71F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM71F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71F1 Gene

Disorders for FAM71F1 Gene

Relevant External Links for FAM71F1

Genetic Association Database (GAD)
FAM71F1
Human Genome Epidemiology (HuGE) Navigator
FAM71F1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM71F1

No disorders were found for FAM71F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM71F1 Gene

Publications for FAM71F1 Gene

  1. NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. (PMID: 18317470) Wilk JB … Myers RH (International journal of obesity (2005) 2008) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T … Xu J (Neurobiology of aging 2015) 3 60
  5. Strong gender-specific additive effects of the NYD-SP18 and FTO variants on BMI values. (PMID: 26680676) Hubacek JA … Adamkova V (Physiological research 2015) 3 60

Products for FAM71F1 Gene

Sources for FAM71F1 Gene

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