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Aliases for FAM71E2 Gene

Aliases for FAM71E2 Gene

  • Family With Sequence Similarity 71 Member E2 2 3 5
  • C19orf16 3 4
  • Family With Sequence Similarity 71, Member E2 2
  • Chromosome 19 Open Reading Frame 16 2
  • Putative Protein FAM71E2 3
  • Protein FAM71E2 3

External Ids for FAM71E2 Gene

Previous HGNC Symbols for FAM71E2 Gene

  • C19orf16

Previous GeneCards Identifiers for FAM71E2 Gene

  • GC19M060569
  • GC19M060570
  • GC19M060571
  • GC19M060573
  • GC19M060574
  • GC19M055866
  • GC19M052190

Summaries for FAM71E2 Gene

GeneCards Summary for FAM71E2 Gene

FAM71E2 (Family With Sequence Similarity 71 Member E2) is a Protein Coding gene. An important paralog of this gene is ENSG00000267706.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM71E2 Gene

Genomics for FAM71E2 Gene

Regulatory Elements for FAM71E2 Gene

Enhancers for FAM71E2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055291 1.1 Ensembl ENCODE 11.7 +71.2 71227 1.0 ELF3 TBP HDAC1 PKNOX1 ARNT ARID4B SIN3A RAD21 RFX5 GTF3C2 ZNF581 U2AF2 ENSG00000267523 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF628 PPP6R1 MIR6805 RPL28
GH19F055319 1.2 FANTOM5 Ensembl ENCODE 11.6 +41.6 41583 4.0 SUZ12 CREB3L1 ZNF76 DEAF1 ZNF384 CEBPG ZNF644 ETS1 ZNF316 ELK1 FCAR CDC42EP5 TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 MIR6805
GH19F055382 1.1 ENCODE 11.4 -23.6 -23604 8.2 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 PAF1 ZNF263 SP3 RPL28 RFPL4AP1 RPL13P13 MIR6805 ZNF581 U2AF2 COX6B2 BRSK1 FAM71E2 SHISA7
GH19F055306 0.4 ENCODE 10.8 +57.1 57133 0.2 HCFC1 ZBTB11 ZNF143 SIX5 THAP11 CDC42EP5 TMEM150B KMT5C BRSK1 HSPBP1 PPP6R1 MIR6805 RPL28 TMEM238 UBE2S
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM71E2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM71E2 Gene

55,354,908 bp from pter
55,363,260 bp from pter
8,353 bases
Minus strand

Genomic View for FAM71E2 Gene

Genes around FAM71E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM71E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM71E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM71E2 Gene

Proteins for FAM71E2 Gene

  • Protein details for FAM71E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM71E2
    Protein Accession:
    Secondary Accessions:
    • Q8ND99

    Protein attributes for FAM71E2 Gene

    922 amino acids
    Molecular mass:
    99915 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31875.1; Type=Frameshift; Positions=198; Evidence={ECO:0000305}; Sequence=AAH31875.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAD38986.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM71E2 Gene

Post-translational modifications for FAM71E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM71E2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM71E2 Gene

Domains & Families for FAM71E2 Gene

Protein Domains for FAM71E2 Gene


Suggested Antigen Peptide Sequences for FAM71E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM71 family.
  • Belongs to the FAM71 family.
genes like me logo Genes that share domains with FAM71E2: view

No data available for Gene Families for FAM71E2 Gene

Function for FAM71E2 Gene

Phenotypes for FAM71E2 Gene

GenomeRNAi human phenotypes for FAM71E2:
genes like me logo Genes that share phenotypes with FAM71E2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM71E2 Gene

Localization for FAM71E2 Gene

Subcellular locations from

Jensen Localization Image for FAM71E2 Gene COMPARTMENTS Subcellular localization image for FAM71E2 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM71E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FAM71E2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM71E2 Gene

Pathways & Interactions for FAM71E2 Gene

SuperPathways for FAM71E2 Gene

No Data Available

Interacting Proteins for FAM71E2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8N5Q1-F71E2_HUMAN ENSP00000398617 for FAM71E2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM71E2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM71E2 Gene

Transcripts for FAM71E2 Gene

mRNA/cDNA for FAM71E2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM71E2 Gene

Family with sequence similarity 71, member E2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM71E2 Gene

No ASD Table

Relevant External Links for FAM71E2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM71E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM71E2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM71E2 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for FAM71E2 Gene

This gene is overexpressed in Liver (48.1) and Peripheral blood mononuclear cells (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM71E2 Gene

Protein tissue co-expression partners for FAM71E2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM71E2 Gene:


SOURCE GeneReport for Unigene cluster for FAM71E2 Gene:

genes like me logo Genes that share expression patterns with FAM71E2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM71E2 Gene

Orthologs for FAM71E2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM71E2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM71E2 35
  • 95 (a)
LOC749035 34
  • 94.66 (n)
(Bos Taurus)
Mammalia FAM71E2 34 35
  • 71.09 (n)
(Canis familiaris)
Mammalia FAM71E2 34
  • 69.02 (n)
(Mus musculus)
Mammalia Fam71e2 34 16 35
  • 64.97 (n)
(Rattus norvegicus)
Mammalia Fam71e2 34
  • 62.44 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 27 (a)
-- 35
  • 19 (a)
-- 35
  • 19 (a)
-- 35
  • 10 (a)
Species where no ortholog for FAM71E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM71E2 Gene

Gene Tree for FAM71E2 (if available)
Gene Tree for FAM71E2 (if available)

Paralogs for FAM71E2 Gene

(2) SIMAP similar genes for FAM71E2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM71E2: view

Variants for FAM71E2 Gene

Sequence variations from dbSNP and Humsavar for FAM71E2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10422372 -- 55,355,669(+) TTGTT(C/T)ACACT intron-variant, upstream-variant-2KB
rs11084397 -- 55,361,163(+) CACCC(C/G)GCCGG intron-variant
rs11084398 -- 55,361,926(+) ccagg(A/C)cccca intron-variant
rs111341155 -- 55,356,742(+) TTTGT(A/G)TCACC intron-variant, upstream-variant-2KB
rs111342881 -- 55,363,522(+) AGTGC(A/G)GGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM71E2 Gene

Variant ID Type Subtype PubMed ID
esv1487088 CNV insertion 17803354
esv1695561 CNV deletion 17803354
esv2718961 CNV deletion 23290073
esv2718963 CNV deletion 23290073
esv2718964 CNV deletion 23290073
esv3556648 CNV deletion 23714750
esv5326 CNV loss 18987735
nsv1071551 CNV deletion 25765185
nsv1071552 CNV deletion 25765185
nsv1110729 CNV insertion 24896259
nsv1125679 CNV tandem duplication 24896259
nsv1135855 CNV deletion 24896259
nsv1142803 CNV deletion 24896259
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for FAM71E2 Gene

Gene Damage Index Score: 7.19; 80.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM71E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71E2 Gene

Disorders for FAM71E2 Gene

Relevant External Links for FAM71E2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM71E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM71E2 Gene

Publications for FAM71E2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 3 64

Products for FAM71E2 Gene

Sources for FAM71E2 Gene

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