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Aliases for FAM71E2 Gene

Aliases for FAM71E2 Gene

  • Family With Sequence Similarity 71, Member E2 2 3
  • C19orf16 3 4
  • Chromosome 19 Open Reading Frame 16 2
  • Putative Protein FAM71E2 3
  • Protein FAM71E2 3

External Ids for FAM71E2 Gene

Previous HGNC Symbols for FAM71E2 Gene

  • C19orf16

Previous GeneCards Identifiers for FAM71E2 Gene

  • GC19M060569
  • GC19M060570
  • GC19M060571
  • GC19M060573
  • GC19M060574
  • GC19M055866
  • GC19M052190

Summaries for FAM71E2 Gene

GeneCards Summary for FAM71E2 Gene

FAM71E2 (Family With Sequence Similarity 71, Member E2) is a Protein Coding gene. An important paralog of this gene is FAM71F1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM71E2 Gene

Genomics for FAM71E2 Gene

Regulatory Elements for FAM71E2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM71E2 Gene

Start:
55,354,908 bp from pter
End:
55,363,260 bp from pter
Size:
8,353 bases
Orientation:
Minus strand

Genomic View for FAM71E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM71E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM71E2 Gene

Proteins for FAM71E2 Gene

  • Protein details for FAM71E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Q1-F71E2_HUMAN
    Recommended name:
    Protein FAM71E2
    Protein Accession:
    Q8N5Q1
    Secondary Accessions:
    • Q8ND99

    Protein attributes for FAM71E2 Gene

    Size:
    922 amino acids
    Molecular mass:
    99915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31875.1; Type=Frameshift; Positions=198; Evidence={ECO:0000305}; Sequence=AAH31875.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAD38986.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM71E2 Gene

Proteomics data for FAM71E2 Gene at MOPED

Post-translational modifications for FAM71E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM71E2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM71E2 Gene

Domains for FAM71E2 Gene

Protein Domains for FAM71E2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM71E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5Q1

UniProtKB/Swiss-Prot:

F71E2_HUMAN :
  • Q8N5Q1
Family:
  • Belongs to the FAM71 family.
genes like me logo Genes that share domains with FAM71E2: view

No data available for Gene Families for FAM71E2 Gene

Function for FAM71E2 Gene

Phenotypes for FAM71E2 Gene

GenomeRNAi human phenotypes for FAM71E2:
genes like me logo Genes that share phenotypes with FAM71E2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM71E2 Gene

Localization for FAM71E2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM71E2 Gene COMPARTMENTS Subcellular localization image for FAM71E2 gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM71E2 Gene

Pathways for FAM71E2 Gene

SuperPathways for FAM71E2 Gene

No Data Available

Interacting Proteins for FAM71E2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000398617%0d%0a9606.ENSP00000392057%0d%0a9606.ENSP00000354929%0d%0a
Selected Interacting proteins: ENSP00000398617 for FAM71E2 Gene via STRING

Gene Ontology (GO) - Biological Process for FAM71E2 Gene

None

No data available for Pathways by source for FAM71E2 Gene

Transcripts for FAM71E2 Gene

mRNA/cDNA for FAM71E2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM71E2 Gene

Family with sequence similarity 71, member E2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM71E2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAM71E2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM71E2 Gene

No ASD Table

Relevant External Links for FAM71E2 Gene

GeneLoc Exon Structure for
FAM71E2
ECgene alternative splicing isoforms for
FAM71E2

Expression for FAM71E2 Gene

mRNA expression in normal human tissues for FAM71E2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM71E2 Gene

This gene is overexpressed in Testis (51.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM71E2 Gene

SOURCE GeneReport for Unigene cluster for FAM71E2 Gene Hs.528319

genes like me logo Genes that share expressions with FAM71E2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM71E2 Gene

Orthologs for FAM71E2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM71E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM71E2 36
  • 95 (a)
OneToOne
LOC749035 35
  • 94.66 (n)
  • 92.35 (a)
cow
(Bos Taurus)
Mammalia FAM71E2 35
  • 71.09 (n)
  • 55.4 (a)
FAM71E2 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM71E2 35
  • 69.02 (n)
  • 51.99 (a)
mouse
(Mus musculus)
Mammalia Fam71e2 35
  • 64.97 (n)
  • 48.94 (a)
Fam71e2 16
Fam71e2 36
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
ManyToMany
-- 36
  • 10 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fam71e2 35
  • 62.44 (n)
  • 45.61 (a)
Species with no ortholog for FAM71E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM71E2 Gene

ENSEMBL:
Gene Tree for FAM71E2 (if available)
TreeFam:
Gene Tree for FAM71E2 (if available)

Paralogs for FAM71E2 Gene

Selected SIMAP similar genes for FAM71E2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM71E2: view

Variants for FAM71E2 Gene

Sequence variations from dbSNP and Humsavar for FAM71E2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs897799 -- 55,360,823(+) ACACT(A/G)TGGCA intron-variant
rs2124918 -- 55,361,029(+) ACGTC(A/G)GCATG synonymous-codon, reference
rs2124919 -- 55,361,198(+) TGAGC(A/G)GCCAC synonymous-codon, reference
rs2124920 -- 55,361,223(+) AGTTG(C/T)GCTCA missense, reference
rs4007155 -- 55,360,093(-) ggagg(A/G)gctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM71E2 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680
nsv912466 CNV Loss 21882294
nsv912467 CNV Loss 21882294
esv1487088 CNV Insertion 17803354
esv2718961 CNV Deletion 23290073
dgv4018n71 CNV Loss 21882294
dgv4019n71 CNV Loss 21882294
dgv4020n71 CNV Loss 21882294
esv2718963 CNV Deletion 23290073
esv5326 CNV Deletion 18987735
esv1695561 CNV Deletion 17803354
esv2718964 CNV Deletion 23290073
nsv912471 CNV Loss 21882294

Relevant External Links for FAM71E2 Gene

HapMap Linkage Disequilibrium report
FAM71E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71E2 Gene

Disorders for FAM71E2 Gene

Relevant External Links for FAM71E2

Genetic Association Database (GAD)
FAM71E2
Human Genome Epidemiology (HuGE) Navigator
FAM71E2
genes like me logo Genes that share disorders with FAM71E2: view

No data available for UniProtKB/Swiss-Prot for FAM71E2 Gene

Publications for FAM71E2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for FAM71E2 Gene

Sources for FAM71E2 Gene

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