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Aliases for FAM71D Gene

Aliases for FAM71D Gene

  • Family With Sequence Similarity 71 Member D 2 3 5
  • C14orf54 3 4
  • Family With Sequence Similarity 71, Member D 2
  • Chromosome 14 Open Reading Frame 54 2
  • Protein FAM71D 3

External Ids for FAM71D Gene

Previous HGNC Symbols for FAM71D Gene

  • C14orf54

Previous GeneCards Identifiers for FAM71D Gene

  • GC14P066726
  • GC14P067656
  • GC14P047825

Summaries for FAM71D Gene

GeneCards Summary for FAM71D Gene

FAM71D (Family With Sequence Similarity 71 Member D) is a Protein Coding gene. An important paralog of this gene is FAM71B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM71D Gene

Genomics for FAM71D Gene

Regulatory Elements for FAM71D Gene

Genomic Location for FAM71D Gene

67,189,393 bp from pter
67,228,550 bp from pter
39,158 bases
Plus strand

Genomic View for FAM71D Gene

Genes around FAM71D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM71D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM71D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM71D Gene

Proteins for FAM71D Gene

  • Protein details for FAM71D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM71D
    Protein Accession:
    Secondary Accessions:
    • Q86VN4

    Protein attributes for FAM71D Gene

    422 amino acids
    Molecular mass:
    47076 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM71D Gene


neXtProt entry for FAM71D Gene

Post-translational modifications for FAM71D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM71D Gene

Domains & Families for FAM71D Gene

Protein Domains for FAM71D Gene


Suggested Antigen Peptide Sequences for FAM71D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM71 family.
  • Belongs to the FAM71 family.
genes like me logo Genes that share domains with FAM71D: view

No data available for Gene Families for FAM71D Gene

Function for FAM71D Gene

genes like me logo Genes that share phenotypes with FAM71D: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM71D Gene

Localization for FAM71D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM71D gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM71D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FAM71D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM71D Gene

Pathways & Interactions for FAM71D Gene

SuperPathways for FAM71D Gene

No Data Available

Interacting Proteins for FAM71D Gene

Selected Interacting proteins: Q8N9W8-FA71D_HUMAN for FAM71D Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM71D Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM71D Gene

Transcripts for FAM71D Gene

Unigene Clusters for FAM71D Gene

Family with sequence similarity 71, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM71D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8

Relevant External Links for FAM71D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM71D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM71D Gene

mRNA differential expression in normal tissues according to GTEx for FAM71D Gene

This gene is overexpressed in Testis (x36.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM71D Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM71D Gene:


SOURCE GeneReport for Unigene cluster for FAM71D Gene:


Evidence on tissue expression from TISSUES for FAM71D Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM71D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM71D Gene

Orthologs for FAM71D Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM71D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM71D 34 35
  • 98.82 (n)
(Canis familiaris)
Mammalia FAM71D 34 35
  • 82.41 (n)
(Bos Taurus)
Mammalia FAM71D 34 35
  • 81.54 (n)
(Mus musculus)
Mammalia Fam71d 34 16 35
  • 74.77 (n)
(Rattus norvegicus)
Mammalia Fam71d 34
  • 73.61 (n)
(Ornithorhynchus anatinus)
Mammalia FAM71D 35
  • 54 (a)
(Gallus gallus)
Aves FAM71D 35
  • 32 (a)
(Anolis carolinensis)
Reptilia FAM71D 35
  • 48 (a)
Species where no ortholog for FAM71D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM71D Gene

Gene Tree for FAM71D (if available)
Gene Tree for FAM71D (if available)

Paralogs for FAM71D Gene

(1) SIMAP similar genes for FAM71D Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM71D: view

Variants for FAM71D Gene

Sequence variations from dbSNP and Humsavar for FAM71D Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000152798 -- 67,224,715(+) GAGAT(C/T)CAAGA intron-variant
rs1000245495 -- 67,211,997(+) TCTGC(A/C)AGGAG intron-variant
rs1000267006 -- 67,200,952(+) TGTCT(G/T)TGGCA intron-variant
rs1000308030 -- 67,209,853(+) AAGTA(A/T)AATAG intron-variant
rs1000310251 -- 67,207,780(+) TTGAC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM71D Gene

Variant ID Type Subtype PubMed ID
esv2751285 CNV gain 17911159
esv3581255 CNV loss 25503493
nsv1124992 CNV deletion 24896259
nsv832821 CNV gain 17160897
nsv977480 CNV duplication 23825009

Variation tolerance for FAM71D Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM71D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71D Gene

Disorders for FAM71D Gene

Relevant External Links for FAM71D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM71D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM71D Gene

Publications for FAM71D Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer. (PMID: 24488012) Teles Alves I. … Jenster G. (Oncogene 2015) 3 64
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for FAM71D Gene

Sources for FAM71D Gene

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