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FAM71A Gene

protein-coding   GIFtS: 41
GCID: GC01P212798

Family With Sequence Similarity 71, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 71, Member A1 2
Protein FAM71A2

External Ids:    HGNC: 265411   Entrez Gene: 1496472   Ensembl: ENSG000001627717   UniProtKB: Q8IYT13   

Export aliases for FAM71A gene to outside databases

Previous GC identifers: GC01P209187 GC01P210865 GC01P183474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM71A Gene:
FAM71A (family with sequence similarity 71, member A) is a protein-coding gene. An important paralog of this gene is FAM71E2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM71A gene promoter:
         AhR   CREB   deltaCREB   Pax-2   CUTL1   E4BP4   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM71A promoter sequence
   Search Chromatin IP Primers for FAM71A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM71A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

FAM71A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM71A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212798:  view genomic region     (about GC identifiers)

Start:
212,797,789 bp from pter      End:
212,800,120 bp from pter
Size:
2,332 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA71A_HUMAN, Q8IYT1 (See protein sequence)
Recommended Name: Protein FAM71A  
Size: 594 amino acids; 63177 Da
Secondary accessions: Q5VTZ1

Explore the universe of human proteins at neXtProt for FAM71A: NX_Q8IYT1

Explore proteomics data for FAM71A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM71A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_705834.2  
    ENSEMBL proteins: 
     ENSP00000294829  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022168 DUF3699

    Graphical View of Domain Structure for InterPro Entry Q8IYT1

    ProtoNet protein and cluster: Q8IYT1

    UniProtKB/Swiss-Prot: FA71A_HUMAN, Q8IYT1
    Similarity: Belongs to the FAM71 family


    Find genes that share domains with FAM71A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM71A:
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM71A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM71A
    Interactions:

        Search GeneGlobe Interaction Network for FAM71A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM71A (FA71A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM71A gene: 
    NM_153606.3  

    Unigene Cluster for FAM71A:

    Family with sequence similarity 71, member A
    Hs.129293  [show with all ESTs]
    Unigene Representative Sequence: NM_153606
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000294829(uc001hjk.3)
    miRNA
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    Additional mRNA sequence: 

    AK057358.1 AK097437.1 AK301981.1 AK315021.1 BC035007.1 

    1 DOTS entry:

    DT.100009943 

    17 AceView cDNA sequences:

    BI830794 AA934001 BI828923 AK057358 BP370869 BI460556 BI459111 BI828703 
    BX100134 BI830818 BI828361 BI827261 BC035007 NM_153606 AA991839 BM554538 
    BE465999 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM71A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACAGTGA
    FAM71A Expression
    About this image

    FAM71A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM71A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129293
        Custom PCR Arrays for FAM71A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM71A gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam71a1 , 5 family with sequence similarity 71, member A1, 5 68.82(n)1
    54.68(a)1
      1 (96.28 cM)5
    6192881  NM_001109759.11  NP_001103229.11 
     1911625845 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    50(a)
    44(a)
    many ↔ many
    many ↔ many
    6(71330920-71334054)
    6(71352843-71360031)


    ENSEMBL Gene Tree for FAM71A (if available)
    TreeFam Gene Tree for FAM71A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM71A gene
    FAM71E22  FAM71E12  FAM71B2  FAM71D2  FAM71F22  FAM71C2  ENSG000002677062  FAM71F12  
    2 SIMAP similar genes for FAM71A using alignment to 2 protein entries:     FA71A_HUMAN (see all proteins):
    FAM71C    FAM71B

    Find genes that share paralogs with FAM71A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FAM71A
    PGOHUM00000248906 PGOHUM00000240705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM71A (see all 217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440772821,2
    Cuntested1212798492(+) CGACCA/GGCCAC 2 P syn10--------
    rs612109001,2
    F--212795920(+) AGGACT/CGTTGA 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs2014226161,2
    C--212795950(+) CTAACA/GTTTAT 1 -- us2k10--------
    rs1451751741,2
    --212795968(+) GACAAC/TACACT 1 -- us2k10--------
    rs1479780081,2
    C--212796008(+) TCCTC-/ACAACAAC 1 -- us2k10--------
    rs115715671,2
    F--212796015(+) ACAAC-/AACTGCTA 1 -- cds11Minor allele frequency- AAC:0.05NS 174
    rs1468374421,2
    --212796021(+) TGCTAC/TCCCCA 1 -- us2k10--------
    rs762725201,2
    C,F--212796065(+) TTGCTC/TGAGGT 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1158207491,2
    F--212796100(+) GAAGCC/GTATGC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1397405211,2
    C--212796148(+) ACATT-/TGTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM71A (212797789 - 212800120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM71A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv178e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FAM71A
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FAM71A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM71A           About GenesLikeMe


    Export disorders for FAM71A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM71A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM71A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 149647 HGNC: 26541 AceView: FLJ32796 Ensembl:ENSG00000162771 euGenes: HUgn149647
    ECgene: FAM71A H-InvDB: FAM71A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM71A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM71A gene:
    Search GeneIP for patents involving FAM71A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM71A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM71A
     SwitchGear Promoter luciferase reporter plasmids for FAM71A
     Search ThermoFisher Antibodies for FAM71A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM71A
     Browse compounds at ApexBio
     Search Addgene for plasmids for FAM71A
      Search eBioscience for proteins for FAM71A
      Search eBioscience for elisas for FAM71A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAM71A
     antibodies-online antibodies for FAM71A (19 products)
     antibodies-online kits for FAM71A (2 products)
     antibodies-online peptides for FAM71A
     antibodies-online proteins for FAM71A (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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