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Aliases for FAM69C Gene

Aliases for FAM69C Gene

  • Family With Sequence Similarity 69 Member C 2 3 5
  • C18orf51 3 4
  • Family With Sequence Similarity 69, Member C 2
  • Chromosome 18 Open Reading Frame 51 2
  • Protein FAM69C 3

External Ids for FAM69C Gene

Previous HGNC Symbols for FAM69C Gene

  • C18orf51

Previous GeneCards Identifiers for FAM69C Gene

  • GC18M070254
  • GC18M072102
  • GC18M068835

Summaries for FAM69C Gene

Entrez Gene Summary for FAM69C Gene

  • This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM69C Gene

FAM69C (Family With Sequence Similarity 69 Member C) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups.

Additional gene information for FAM69C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM69C Gene

Genomics for FAM69C Gene

Regulatory Elements for FAM69C Gene

Enhancers for FAM69C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H074468 0.9 FANTOM5 ENCODE dbSUPER 11.9 -4.1 -4106 0 FAM69C CNDP1 FBXO15 CNDP2
GH18H074459 0.7 ENCODE dbSUPER 8.6 +4.3 4323 1 CTCF ZNF366 ZNF24 CNDP2 FAM69C GC18M074426
GH18H074540 1.5 FANTOM5 ENCODE dbSUPER 1.4 -77.7 -77723 3 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS ATF7 SP5 CNDP1 FAM69C ENSG00000264340
GH18H074078 0.3 FANTOM5 3.6 +385.8 385828 0 TIMM21 LINC00909 FAM69C CNDP1 FBXO15 ENSG00000263655
GH18H074480 1.5 FANTOM5 Ensembl ENCODE 0.4 -15.9 -15862 2 HDAC1 ELF3 PKNOX1 ATF1 FOXA2 ARNT RAD21 YY1 TCF12 ZNF766 CNDP2 FAM69C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM69C on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM69C Gene

Chromosome:
18
Start:
74,434,099 bp from pter
End:
74,464,715 bp from pter
Size:
30,617 bases
Orientation:
Minus strand

Genomic View for FAM69C Gene

Genes around FAM69C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM69C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM69C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM69C Gene

Proteins for FAM69C Gene

  • Protein details for FAM69C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P6D2-FA69C_HUMAN
    Recommended name:
    Protein FAM69C
    Protein Accession:
    Q0P6D2

    Protein attributes for FAM69C Gene

    Size:
    419 amino acids
    Molecular mass:
    46420 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM69C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM69C Gene

Post-translational modifications for FAM69C Gene

  • Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.

Other Protein References for FAM69C Gene

No data available for DME Specific Peptides for FAM69C Gene

Domains & Families for FAM69C Gene

Gene Families for FAM69C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM69C Gene

Suggested Antigen Peptide Sequences for FAM69C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0P6D2

UniProtKB/Swiss-Prot:

FA69C_HUMAN :
  • Belongs to the FAM69 family.
Family:
  • Belongs to the FAM69 family.
genes like me logo Genes that share domains with FAM69C: view

Function for FAM69C Gene

Phenotypes From GWAS Catalog for FAM69C Gene

Phenotypes for FAM69C Gene

GenomeRNAi human phenotypes for FAM69C:
genes like me logo Genes that share phenotypes with FAM69C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM69C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM69C Gene

Localization for FAM69C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM69C Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM69C gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
plasma membrane 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM69C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM69C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM69C Gene

Pathways & Interactions for FAM69C Gene

SuperPathways for FAM69C Gene

No Data Available

Interacting Proteins for FAM69C Gene

Gene Ontology (GO) - Biological Process for FAM69C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM69C Gene

Drugs & Compounds for FAM69C Gene

No Compound Related Data Available

Transcripts for FAM69C Gene

mRNA/cDNA for FAM69C Gene

Unigene Clusters for FAM69C Gene

Family with sequence similarity 69, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM69C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM69C Gene

No ASD Table

Relevant External Links for FAM69C Gene

GeneLoc Exon Structure for
FAM69C
ECgene alternative splicing isoforms for
FAM69C

Expression for FAM69C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM69C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM69C Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.8), Brain - Caudate (basal ganglia) (x5.7), Brain - Amygdala (x5.4), Brain - Substantia nigra (x4.2), Brain - Hippocampus (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for FAM69C Gene

This gene is overexpressed in Placenta (55.5) and Vitreous humor (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM69C Gene



Protein tissue co-expression partners for FAM69C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM69C Gene:

FAM69C

SOURCE GeneReport for Unigene cluster for FAM69C Gene:

Hs.371690
genes like me logo Genes that share expression patterns with FAM69C: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM69C Gene

Orthologs for FAM69C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM69C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM69C 33 34
  • 99.05 (n)
rat
(Rattus norvegicus)
Mammalia Fam69c 33
  • 81.66 (n)
cow
(Bos Taurus)
Mammalia FAM69C 33 34
  • 80.22 (n)
mouse
(Mus musculus)
Mammalia Fam69c 33 16 34
  • 79.67 (n)
dog
(Canis familiaris)
Mammalia FAM69C 33 34
  • 76.08 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM69C 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM69C 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM69C 33 34
  • 69.47 (n)
lizard
(Anolis carolinensis)
Reptilia FAM69C 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam69c 33
  • 60.19 (n)
Str.12002 33
zebrafish
(Danio rerio)
Actinopterygii fam69c 33 34
  • 60.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12038 34
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C53D5.1 34
  • 20 (a)
OneToOne
Species where no ortholog for FAM69C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM69C Gene

ENSEMBL:
Gene Tree for FAM69C (if available)
TreeFam:
Gene Tree for FAM69C (if available)

Paralogs for FAM69C Gene

No data available for Paralogs for FAM69C Gene

Variants for FAM69C Gene

Sequence variations from dbSNP and Humsavar for FAM69C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000138632 -- 74,454,623(+) TTTAT(C/T)ATTAC intron-variant
rs1000188925 -- 74,461,721(+) AGGTC(-/T)TCAGA intron-variant
rs1000382808 -- 74,456,124(+) AGGAA(-/T)ATGAA intron-variant
rs1000480262 -- 74,435,127(+) GCTGC(A/G)GGCCA utr-variant-3-prime
rs1000520901 -- 74,457,462(+) AGCAC(C/T)CACTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM69C Gene

Variant ID Type Subtype PubMed ID
dgv3401n100 CNV gain 25217958
esv1000434 CNV deletion 20482838
esv3643115 CNV loss 21293372
esv3643117 CNV loss 21293372
esv3643118 CNV gain 21293372
nsv1057441 CNV gain 25217958
nsv1064324 CNV gain 25217958
nsv1067091 CNV loss 25217958
nsv458298 CNV gain 19166990
nsv527671 CNV gain 19592680
nsv577652 CNV gain 21841781
nsv577653 CNV gain 21841781
nsv577654 CNV gain 21841781

Variation tolerance for FAM69C Gene

Gene Damage Index Score: 4.64; 65.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM69C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM69C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM69C Gene

Disorders for FAM69C Gene

Relevant External Links for FAM69C

Genetic Association Database (GAD)
FAM69C
Human Genome Epidemiology (HuGE) Navigator
FAM69C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM69C

No disorders were found for FAM69C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM69C Gene

Publications for FAM69C Gene

  1. A novel predicted calcium-regulated kinase family implicated in neurological disorders. (PMID: 23840464) Dudkiewicz M … Pawłowski K (PloS one 2013) 2 3 60
  2. Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins. (PMID: 21334309) Tennant-Eyles AJ … Roberts RG (Biochemical and biophysical research communications 2011) 2 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for FAM69C Gene

Sources for FAM69C Gene

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