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Aliases for FAM69C Gene

Aliases for FAM69C Gene

  • Family With Sequence Similarity 69, Member C 2 3
  • C18orf51 3 4
  • Chromosome 18 Open Reading Frame 51 2
  • Protein FAM69C 3

External Ids for FAM69C Gene

Previous HGNC Symbols for FAM69C Gene

  • C18orf51

Previous GeneCards Identifiers for FAM69C Gene

  • GC18M070254
  • GC18M072102
  • GC18M068835

Summaries for FAM69C Gene

Entrez Gene Summary for FAM69C Gene

  • This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM69C Gene

FAM69C (Family With Sequence Similarity 69, Member C) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM69C Gene

Genomics for FAM69C Gene

Genomic Location for FAM69C Gene

Start:
74,434,099 bp from pter
End:
74,457,944 bp from pter
Size:
23,846 bases
Orientation:
Minus strand

Genomic View for FAM69C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM69C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM69C Gene

No data available for Regulatory Elements for FAM69C Gene

Proteins for FAM69C Gene

  • Protein details for FAM69C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P6D2-FA69C_HUMAN
    Recommended name:
    Protein FAM69C
    Protein Accession:
    Q0P6D2
    Secondary Accessions:

    Protein attributes for FAM69C Gene

    Size:
    419 amino acids
    Molecular mass:
    46420 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM69C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM69C Gene

Proteomics data for FAM69C Gene at MOPED

Post-translational modifications for FAM69C Gene

  • Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.

Other Protein References for FAM69C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM69C Gene

Domains for FAM69C Gene

Protein Domains for FAM69C Gene

Suggested Antigen Peptide Sequences for FAM69C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0P6D2

UniProtKB/Swiss-Prot:

FA69C_HUMAN :
  • Q0P6D2
Family:
  • Belongs to the FAM69 family.
genes like me logo Genes that share domains with FAM69C: view

No data available for Gene Families for FAM69C Gene

Function for FAM69C Gene

Gene Ontology (GO) - Molecular Function for FAM69C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
genes like me logo Genes that share ontologies with FAM69C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM69C Gene

Localization for FAM69C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM69C Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM69C Gene COMPARTMENTS Subcellular localization image for FAM69C gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM69C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM69C: view

Pathways for FAM69C Gene

SuperPathways for FAM69C Gene

No Data Available

Interacting Proteins for FAM69C Gene

Gene Ontology (GO) - Biological Process for FAM69C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with FAM69C: view

No data available for Pathways by source for FAM69C Gene

Transcripts for FAM69C Gene

mRNA/cDNA for FAM69C Gene

Unigene Clusters for FAM69C Gene

Family with sequence similarity 69, member C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM69C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAM69C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM69C Gene

No ASD Table

Relevant External Links for FAM69C Gene

GeneLoc Exon Structure for
FAM69C
ECgene alternative splicing isoforms for
FAM69C

Expression for FAM69C Gene

mRNA expression in normal human tissues for FAM69C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM69C Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (6.8), Brain - Caudate (basal ganglia) (5.7), Brain - Amygdala (5.4), Brain - Substantia nigra (4.2), Brain - Hippocampus (4.1), and Brain - Nucleus accumbens (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM69C Gene

SOURCE GeneReport for Unigene cluster for FAM69C Gene Hs.371690

genes like me logo Genes that share expressions with FAM69C: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM69C Gene

Orthologs for FAM69C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM69C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM69C 35
  • 99.05 (n)
  • 98.09 (a)
FAM69C 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM69C 35
  • 80.22 (n)
  • 76.17 (a)
FAM69C 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM69C 35
  • 76.08 (n)
  • 72.73 (a)
FAM69C 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam69c 35
  • 79.67 (n)
  • 82.58 (a)
Fam69c 16
Fam69c 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM69C 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM69C 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam69c 35
  • 81.66 (n)
  • 82.78 (a)
chicken
(Gallus gallus)
Aves FAM69C 35
  • 69.47 (n)
  • 65.05 (a)
FAM69C 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM69C 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam69c 35
  • 60.19 (n)
  • 55.38 (a)
Str.12002 35
zebrafish
(Danio rerio)
Actinopterygii fam69c 35
  • 60.22 (n)
  • 56.86 (a)
fam69c 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12038 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C53D5.1 36
  • 20 (a)
OneToOne
Species with no ortholog for FAM69C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM69C Gene

ENSEMBL:
Gene Tree for FAM69C (if available)
TreeFam:
Gene Tree for FAM69C (if available)

Paralogs for FAM69C Gene

No data available for Paralogs for FAM69C Gene

Variants for FAM69C Gene

Sequence variations from dbSNP and Humsavar for FAM69C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs729605 -- 74,443,306(+) AAGCC(A/G)TTTAT intron-variant
rs729606 -- 74,443,362(+) TGGAG(C/T)CAGTG intron-variant
rs746230 -- 74,443,835(-) GAAAG(A/G)ATAGA intron-variant
rs746231 -- 74,443,623(-) TATTG(G/T)TTATC intron-variant
rs746232 -- 74,443,587(-) ATAAA(C/T)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM69C Gene

Variant ID Type Subtype PubMed ID
nsv909916 CNV Gain 21882294
nsv527671 CNV Gain 19592680
esv1000434 CNV Deletion 20482838
nsv458298 CNV Gain 19166990

Relevant External Links for FAM69C Gene

HapMap Linkage Disequilibrium report
FAM69C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM69C Gene

Disorders for FAM69C Gene

Relevant External Links for FAM69C

Genetic Association Database (GAD)
FAM69C
Human Genome Epidemiology (HuGE) Navigator
FAM69C
genes like me logo Genes that share disorders with FAM69C: view

No data available for UniProtKB/Swiss-Prot for FAM69C Gene

Publications for FAM69C Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins. (PMID: 21334309) Tennant-Eyles A.J. … Roberts R.G. (Biochem. Biophys. Res. Commun. 2011) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM69C Gene

Sources for FAM69C Gene

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