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Aliases for FAM69B Gene

Aliases for FAM69B Gene

  • Family With Sequence Similarity 69, Member B 2 3
  • C9orf136 3 4
  • Protein FAM69B 3
  • Pp6977 3

External Ids for FAM69B Gene

Previous GeneCards Identifiers for FAM69B Gene

  • GC09P136883
  • GC09P138726
  • GC09P139607
  • GC09P109066

Summaries for FAM69B Gene

Entrez Gene Summary for FAM69B Gene

  • This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM69B Gene

FAM69B (Family With Sequence Similarity 69, Member B) is a Protein Coding gene. An important paralog of this gene is FAM69A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM69B Gene

Genomics for FAM69B Gene

Regulatory Elements for FAM69B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM69B Gene

Start:
136,712,570 bp from pter
End:
136,724,718 bp from pter
Size:
12,149 bases
Orientation:
Plus strand

Genomic View for FAM69B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM69B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM69B Gene

Proteins for FAM69B Gene

  • Protein details for FAM69B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUD6-FA69B_HUMAN
    Recommended name:
    Protein FAM69B
    Protein Accession:
    Q5VUD6
    Secondary Accessions:
    • Q5VUD7
    • Q8N5N0
    • Q8WYU5

    Protein attributes for FAM69B Gene

    Size:
    431 amino acids
    Molecular mass:
    48583 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55862.1; Type=Frameshift; Positions=341, 393; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM69B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM69B Gene

Proteomics data for FAM69B Gene at MOPED

Post-translational modifications for FAM69B Gene

  • Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.
  • Glycosylation at Thr144
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM69B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM69B Gene

Domains for FAM69B Gene

Protein Domains for FAM69B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM69B Gene

Graphical View of Domain Structure for InterPro Entry

Q5VUD6

UniProtKB/Swiss-Prot:

FA69B_HUMAN :
  • Q5VUD6
Family:
  • Belongs to the FAM69 family.
genes like me logo Genes that share domains with FAM69B: view

No data available for Gene Families for FAM69B Gene

Function for FAM69B Gene

Gene Ontology (GO) - Molecular Function for FAM69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM69B: view

Animal Model Products

CRISPR Products

miRNA for FAM69B Gene

miRTarBase miRNAs that target FAM69B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM69B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM69B Gene

Localization for FAM69B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM69B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM69B Gene COMPARTMENTS Subcellular localization image for FAM69B gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM69B: view

Pathways for FAM69B Gene

SuperPathways for FAM69B Gene

No Data Available

Interacting Proteins for FAM69B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360757%0d%0a9606.ENSP00000368572%0d%0a9606.ENSP00000262031%0d%0a
Selected Interacting proteins: ENSP00000360757 Q5VUD6-FA69B_HUMAN for FAM69B Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for FAM69B Gene

None

No data available for Pathways by source for FAM69B Gene

Transcripts for FAM69B Gene

Unigene Clusters for FAM69B Gene

Family with sequence similarity 69, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM69B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM69B Gene

No ASD Table

Relevant External Links for FAM69B Gene

GeneLoc Exon Structure for
FAM69B
ECgene alternative splicing isoforms for
FAM69B

Expression for FAM69B Gene

mRNA expression in normal human tissues for FAM69B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM69B Gene

SOURCE GeneReport for Unigene cluster for FAM69B Gene Hs.741305

genes like me logo Genes that share expressions with FAM69B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM69B Gene

Orthologs for FAM69B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM69B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM69B 35
  • 98.72 (n)
  • 99.04 (a)
FAM69B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM69B 35
  • 86.29 (n)
  • 85.16 (a)
FAM69B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM69B 35
  • 87.36 (n)
  • 88.84 (a)
FAM69B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam69b 35
  • 85.54 (n)
  • 88.86 (a)
Fam69b 16
Fam69b 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM69B 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM69B 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam69b 35
  • 84.69 (n)
  • 88.4 (a)
chicken
(Gallus gallus)
Aves FAM69B 35
  • 70.92 (n)
  • 67.05 (a)
FAM69B 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM69B 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam69b 35
  • 71.77 (n)
  • 65.2 (a)
zebrafish
(Danio rerio)
Actinopterygii fam69b 35
  • 62.95 (n)
  • 62.09 (a)
fam69b 36
  • 62 (a)
OneToOne
Species with no ortholog for FAM69B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM69B Gene

ENSEMBL:
Gene Tree for FAM69B (if available)
TreeFam:
Gene Tree for FAM69B (if available)

Paralogs for FAM69B Gene

Paralogs for FAM69B Gene

Selected SIMAP similar genes for FAM69B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM69B: view

Variants for FAM69B Gene

Sequence variations from dbSNP and Humsavar for FAM69B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6873 -- 136,723,831(+) GTCCA(A/C/G/T)CCCTC utr-variant-3-prime
rs6874 -- 136,723,384(-) CCCAC(A/G)TTGGC reference, synonymous-codon
rs11849 -- 136,723,210(+) GCCCT(C/T)CCACC synonymous-codon, reference
rs883104 -- 136,722,491(-) ACCCT(C/T)GCCCC intron-variant
rs945384 - 136,722,290(-) GAAGC(C/T)GAGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM69B Gene

Variant ID Type Subtype PubMed ID
dgv8385n71 CNV Loss 21882294
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8400n71 CNV Loss 21882294
nsv894386 CNV Loss 21882294
nsv894387 CNV Gain 21882294
nsv8579 CNV Gain 18304495
nsv509334 CNV Insertion 20534489
dgv8404n71 CNV Loss 21882294
dgv2427e1 CNV Complex 17122850
esv2422220 CNV Deletion 17116639
dgv8408n71 CNV Loss 21882294
dgv957n27 CNV Loss 19166990
dgv8410n71 CNV Loss 21882294
dgv8411n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
nsv894446 CNV Loss 21882294
nsv7436 OTHER Inversion 18451855
nsv894447 CNV Loss 21882294
dgv8413n71 CNV Loss 21882294
dgv8414n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
esv2739383 CNV Deletion 23290073
esv2420501 CNV Deletion 18987734
esv4681 CNV Deletion 18987735
esv1004940 CNV Deletion 20482838
esv2671283 CNV Deletion 23128226
esv1163941 CNV Deletion 17803354
esv2739385 CNV Deletion 23290073
nsv6769 CNV Insertion 18451855

Relevant External Links for FAM69B Gene

HapMap Linkage Disequilibrium report
FAM69B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM69B Gene

Disorders for FAM69B Gene

No disorders were found for FAM69B Gene.

No data available for UniProtKB/Swiss-Prot for FAM69B Gene

Publications for FAM69B Gene

  1. Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins. (PMID: 21334309) Tennant-Eyles A.J. … Roberts R.G. (Biochem. Biophys. Res. Commun. 2011) 2 3
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4

Products for FAM69B Gene

Sources for FAM69B Gene

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