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Aliases for FAM69A Gene

Aliases for FAM69A Gene

  • Family With Sequence Similarity 69 Member A 2 3 5
  • Family With Sequence Similarity 69, Member A 2

External Ids for FAM69A Gene

Previous GeneCards Identifiers for FAM69A Gene

  • GC01M093021
  • GC01M093071
  • GC01M093307
  • GC01M091428

Summaries for FAM69A Gene

Entrez Gene Summary for FAM69A Gene

  • This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM69A Gene

FAM69A (Family With Sequence Similarity 69 Member A) is a Protein Coding gene. An important paralog of this gene is FAM69B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM69A Gene

Genomics for FAM69A Gene

Regulatory Elements for FAM69A Gene

Enhancers for FAM69A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F092933 0.8 Ensembl ENCODE 38 +26.5 26522 3.2 INSM2 SIN3A ZNF48 ZNF2 RAD21 RARA ZNF121 ZNF366 SCRT2 ZNF391 FAM69A EVI5 CCDC18-AS1 GC01P092939 LOC100127934
GH01F092949 1.1 Ensembl ENCODE 36.5 +9.5 9522 5.2 HDGF ATF1 ZNF133 ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 MIER2 FAM69A EVI5 SNORA66 SNORD21 RPL5 GC01P092958 GC01P092939
GH01F092503 1.1 Ensembl ENCODE 28.9 +456.5 456453 2.6 ELF3 TBP THRB RAD21 RARA YY1 GATA4 SCRT2 CREM MIXL1 FAM69A EVI5 GC01P092511 GFI1
GH01F092482 0.9 FANTOM5 ENCODE 28.8 +476.6 476638 5.3 HDGF SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 SP5 FAM69A EVI5 CCDC18-AS1 SNORA66 SNORD21 BTBD8 GFI1 GC01P092471
GH01F092853 1 Ensembl ENCODE 18.4 +107.2 107150 1.1 RFX1 SMARCA4 POLR2A NRF1 NFE2 IRF1 FAM69A EVI5 RPL5 RNU6-970P GC01M092852 LOC100127934
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM69A on UCSC Golden Path with GeneCards custom track

Promoters for FAM69A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM69A Gene

92,832,729 bp from pter
92,961,522 bp from pter
128,794 bases
Minus strand

Genomic View for FAM69A Gene

Genes around FAM69A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM69A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM69A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM69A Gene

Proteins for FAM69A Gene

  • Protein details for FAM69A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM69A
    Protein Accession:
    Secondary Accessions:
    • Q6IRV2

    Protein attributes for FAM69A Gene

    428 amino acids
    Molecular mass:
    49024 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM69A Gene


neXtProt entry for FAM69A Gene

Post-translational modifications for FAM69A Gene

  • Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.
  • Glycosylation at Thr 141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM69A Gene

Domains & Families for FAM69A Gene

Protein Domains for FAM69A Gene


Suggested Antigen Peptide Sequences for FAM69A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM69 family.
  • Belongs to the FAM69 family.
genes like me logo Genes that share domains with FAM69A: view

No data available for Gene Families for FAM69A Gene

Function for FAM69A Gene

Phenotypes for FAM69A Gene

genes like me logo Genes that share phenotypes with FAM69A: view

Animal Models for FAM69A Gene

MGI Knock Outs for FAM69A:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM69A Gene

Localization for FAM69A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM69A Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for FAM69A Gene COMPARTMENTS Subcellular localization image for FAM69A gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
golgi apparatus 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM69A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM69A: view

Pathways & Interactions for FAM69A Gene

SuperPathways for FAM69A Gene

No Data Available

Interacting Proteins for FAM69A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5T7M9-FA69A_HUMAN ENSP00000359333 for FAM69A Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for FAM69A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM69A Gene

Transcripts for FAM69A Gene

Unigene Clusters for FAM69A Gene

Family with sequence similarity 69, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM69A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for FAM69A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM69A Gene

mRNA expression in normal human tissues for FAM69A Gene

Protein differential expression in normal tissues from HIPED for FAM69A Gene

This gene is overexpressed in Heart (33.1), Placenta (29.8), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM69A Gene

Protein tissue co-expression partners for FAM69A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM69A Gene:


SOURCE GeneReport for Unigene cluster for FAM69A Gene:

genes like me logo Genes that share expression patterns with FAM69A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM69A Gene

Orthologs for FAM69A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM69A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MGC143035 35
  • 100 (a)
FAM69A 34
  • 95.17 (n)
(Pan troglodytes)
Mammalia FAM69A 34 35
  • 99.92 (n)
(Canis familiaris)
Mammalia FAM69A 34 35
  • 95.17 (n)
(Ornithorhynchus anatinus)
Mammalia FAM69A 35
  • 92 (a)
(Mus musculus)
Mammalia Fam69a 34 16 35
  • 91.36 (n)
(Rattus norvegicus)
Mammalia Fam69a 34
  • 89.25 (n)
(Monodelphis domestica)
Mammalia FAM69A 35
  • 81 (a)
(Gallus gallus)
Aves FAM69A 34 35
  • 80.74 (n)
(Anolis carolinensis)
Reptilia FAM69A 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam69a 34
  • 72.05 (n)
(Danio rerio)
Actinopterygii fam69a 34 35
  • 62.85 (n)
FAM69A (1 of 2) 35
  • 60 (a)
Species where no ortholog for FAM69A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM69A Gene

Gene Tree for FAM69A (if available)
Gene Tree for FAM69A (if available)

Paralogs for FAM69A Gene

Paralogs for FAM69A Gene

(1) SIMAP similar genes for FAM69A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM69A: view

Variants for FAM69A Gene

Sequence variations from dbSNP and Humsavar for FAM69A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs121434405 Pathogenic 92,833,452(+) GAAGA(C/T)GACGA intron-variant, reference, stop-gained
rs121434406 Pathogenic 92,836,283(+) AGCCA(A/G)GTGCC intron-variant, upstream-variant-2KB, reference, missense
rs587777117 Pathogenic 92,834,833(+) CACAC(G/T)AACTG intron-variant, reference, stop-gained
rs587777118 Pathogenic 92,837,592(+) AGAAA(C/T)AGTTC intron-variant, downstream-variant-500B, reference, stop-gained
rs878854146 Uncertain significance 92,836,191(+) ATAGC(C/T)TCTCA intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM69A Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
esv2714873 CNV deletion 23290073
esv3586822 CNV loss 21293372
nsv1008602 CNV gain 25217958
nsv1137783 CNV deletion 24896259
nsv506946 OTHER sequence alteration 20534489
nsv508393 CNV deletion 20534489
nsv946076 CNV duplication 23825009
nsv946077 CNV duplication 23825009
nsv946078 CNV duplication 23825009
nsv946079 CNV duplication 23825009

Variation tolerance for FAM69A Gene

Gene Damage Index Score: 1.34; 26.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM69A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM69A Gene

Disorders for FAM69A Gene

Relevant External Links for FAM69A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM69A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM69A Gene

Publications for FAM69A Gene

  1. A novel predicted calcium-regulated kinase family implicated in neurological disorders. (PMID: 23840464) Dudkiewicz M. … PawA8owski K. (PLoS ONE 2013) 2 3 64
  2. Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins. (PMID: 21334309) Tennant-Eyles A.J. … Roberts R.G. (Biochem. Biophys. Res. Commun. 2011) 2 3 64
  3. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. (PMID: 20087403) Alcina A. … Matesanz F. (Eur. J. Hum. Genet. 2010) 3 46 64
  4. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3 46 64
  5. Risk alleles for multiple sclerosis in multiplex families. (PMID: 19506219) D'Netto M.J. … Ebers G.C. (Neurology 2009) 3 46 64

Products for FAM69A Gene

Sources for FAM69A Gene

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