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Aliases for FAM69A Gene

Aliases for FAM69A Gene

  • Family With Sequence Similarity 69, Member A 2 3

External Ids for FAM69A Gene

Previous GeneCards Identifiers for FAM69A Gene

  • GC01M093021
  • GC01M093071
  • GC01M093307
  • GC01M091428

Summaries for FAM69A Gene

Entrez Gene Summary for FAM69A Gene

  • This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM69A Gene

FAM69A (Family With Sequence Similarity 69, Member A) is a Protein Coding gene. An important paralog of this gene is FAM69B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM69A Gene

Genomics for FAM69A Gene

Regulatory Elements for FAM69A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM69A Gene

92,832,729 bp from pter
92,961,522 bp from pter
128,794 bases
Minus strand

Genomic View for FAM69A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM69A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM69A Gene

Proteins for FAM69A Gene

  • Protein details for FAM69A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM69A
    Protein Accession:
    Secondary Accessions:
    • Q6IRV2

    Protein attributes for FAM69A Gene

    428 amino acids
    Molecular mass:
    49024 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM69A Gene


neXtProt entry for FAM69A Gene

Proteomics data for FAM69A Gene at MOPED

Post-translational modifications for FAM69A Gene

  • Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.
  • Glycosylation at Thr 141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM69A Gene

Domains & Families for FAM69A Gene

Protein Domains for FAM69A Gene


Suggested Antigen Peptide Sequences for FAM69A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM69 family.
  • Belongs to the FAM69 family.
genes like me logo Genes that share domains with FAM69A: view

No data available for Gene Families for FAM69A Gene

Function for FAM69A Gene

Gene Ontology (GO) - Molecular Function for FAM69A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FAM69A: view

Phenotypes for FAM69A Gene

GenomeRNAi human phenotypes for FAM69A:
genes like me logo Genes that share phenotypes with FAM69A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM69A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM69A Gene

Localization for FAM69A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM69A Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for FAM69A Gene COMPARTMENTS Subcellular localization image for FAM69A gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for FAM69A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM69A: view

Pathways & Interactions for FAM69A Gene

SuperPathways for FAM69A Gene

No Data Available

Interacting Proteins for FAM69A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359333 Q5T7M9-FA69A_HUMAN for FAM69A Gene via STRING MINT I2D

Gene Ontology (GO) - Biological Process for FAM69A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM69A Gene

Drugs & Compounds for FAM69A Gene

No Compound Related Data Available

Transcripts for FAM69A Gene

Unigene Clusters for FAM69A Gene

Family with sequence similarity 69, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM69A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM69A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for FAM69A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM69A Gene

mRNA expression in normal human tissues for FAM69A Gene

Protein differential expression in normal tissues from HIPED for FAM69A Gene

This gene is overexpressed in Heart (33.1), Placenta (29.8), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM69A Gene

SOURCE GeneReport for Unigene cluster for FAM69A Gene Hs.180946

genes like me logo Genes that share expression patterns with FAM69A: view

Protein tissue co-expression partners for FAM69A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM69A Gene

Orthologs for FAM69A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM69A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM69A 35
  • 95.17 (n)
  • 99.53 (a)
MGC143035 36
  • 100 (a)
(Canis familiaris)
Mammalia FAM69A 35
  • 95.17 (n)
  • 98.55 (a)
FAM69A 36
  • 97 (a)
(Mus musculus)
Mammalia Fam69a 35
  • 91.36 (n)
  • 96.96 (a)
Fam69a 16
Fam69a 36
  • 97 (a)
(Pan troglodytes)
Mammalia FAM69A 35
  • 99.92 (n)
  • 100 (a)
FAM69A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam69a 35
  • 89.25 (n)
  • 96.03 (a)
(Monodelphis domestica)
Mammalia FAM69A 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia FAM69A 36
  • 92 (a)
(Gallus gallus)
Aves FAM69A 35
  • 80.74 (n)
  • 86.67 (a)
FAM69A 36
  • 85 (a)
(Anolis carolinensis)
Reptilia FAM69A 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam69a 35
  • 72.05 (n)
  • 76.71 (a)
(Danio rerio)
Actinopterygii fam69a 35
  • 62.85 (n)
  • 66.12 (a)
fam69a 36
  • 66 (a)
FAM69A (1 of 2) 36
  • 60 (a)
Species with no ortholog for FAM69A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM69A Gene

Gene Tree for FAM69A (if available)
Gene Tree for FAM69A (if available)

Paralogs for FAM69A Gene

Paralogs for FAM69A Gene

(1) SIMAP similar genes for FAM69A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM69A: view

Variants for FAM69A Gene

Sequence variations from dbSNP and Humsavar for FAM69A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs945629 -- 92,961,309(-) CGCGC(A/G)GGACT intron-variant
rs945630 -- 92,960,784(-) ACACC(A/C)AAGAT intron-variant
rs945631 -- 92,960,610(-) TTTCC(C/T)GTTCC intron-variant
rs949915 -- 92,904,217(+) CTGAG(A/G)CTATT intron-variant
rs950672 -- 92,854,468(-) TACAG(G/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM69A Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv508393 CNV Loss 20534489
nsv506946 CNV Insertion 20534489
esv2714873 CNV Deletion 23290073

Variation tolerance for FAM69A Gene

Gene Damage Index Score: 1.34; 26.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM69A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM69A Gene

Disorders for FAM69A Gene

Relevant External Links for FAM69A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM69A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM69A Gene

Publications for FAM69A Gene

  1. Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins. (PMID: 21334309) Tennant-Eyles A.J. … Roberts R.G. (Biochem. Biophys. Res. Commun. 2011) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 67
  4. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. (PMID: 20087403) Alcina A. … Matesanz F. (Eur. J. Hum. Genet. 2010) 67
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 67

Products for FAM69A Gene

Sources for FAM69A Gene

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