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Aliases for FAM65C Gene

Aliases for FAM65C Gene

  • Family With Sequence Similarity 65 Member C 2 3 5
  • C20orf175 3 4
  • Family With Sequence Similarity 65, Member C 2
  • Chromosome 20 Open Reading Frame 175 2
  • Chromosome 20 Open Reading Frame 176 2
  • Protein FAM65C 3
  • C20orf176 3

External Ids for FAM65C Gene

Previous HGNC Symbols for FAM65C Gene

  • C20orf175
  • C20orf176

Previous GeneCards Identifiers for FAM65C Gene

  • GC20M048637
  • GC20M049202
  • GC20M045952

Summaries for FAM65C Gene

GeneCards Summary for FAM65C Gene

FAM65C (Family With Sequence Similarity 65 Member C) is a Protein Coding gene. GO annotations related to this gene include binding and chemokine activity. An important paralog of this gene is FAM65B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM65C Gene

Genomics for FAM65C Gene

Regulatory Elements for FAM65C Gene

Enhancers for FAM65C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM65C on UCSC Golden Path with GeneCards custom track

Promoters for FAM65C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM65C Gene

50,586,108 bp from pter
50,692,004 bp from pter
105,897 bases
Minus strand

Genomic View for FAM65C Gene

Genes around FAM65C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM65C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM65C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM65C Gene

Proteins for FAM65C Gene

  • Protein details for FAM65C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM65C
    Protein Accession:
    Secondary Accessions:
    • Q5QPB6
    • Q9NQQ2

    Protein attributes for FAM65C Gene

    946 amino acids
    Molecular mass:
    105290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM65C Gene


neXtProt entry for FAM65C Gene

Post-translational modifications for FAM65C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM65C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM65C Gene

Domains & Families for FAM65C Gene

Protein Domains for FAM65C Gene


Suggested Antigen Peptide Sequences for FAM65C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM65 family.
  • Belongs to the FAM65 family.
genes like me logo Genes that share domains with FAM65C: view

No data available for Gene Families for FAM65C Gene

Function for FAM65C Gene

genes like me logo Genes that share phenotypes with FAM65C: view

Animal Model Products

CRISPR Products

miRNA for FAM65C Gene

miRTarBase miRNAs that target FAM65C

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM65C Gene

Localization for FAM65C Gene

Subcellular locations from

Jensen Localization Image for FAM65C Gene COMPARTMENTS Subcellular localization image for FAM65C gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM65C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with FAM65C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM65C Gene

Pathways & Interactions for FAM65C Gene

SuperPathways for FAM65C Gene

No Data Available

Interacting Proteins for FAM65C Gene

Gene Ontology (GO) - Biological Process for FAM65C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM65C Gene

Drugs & Compounds for FAM65C Gene

No Compound Related Data Available

Transcripts for FAM65C Gene

Unigene Clusters for FAM65C Gene

Family with sequence similarity 65, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM65C Gene

No ASD Table

Relevant External Links for FAM65C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM65C Gene

mRNA expression in normal human tissues for FAM65C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM65C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.8), Platelet (10.2), Adrenal (9.0), and Pancreatic juice (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM65C Gene

Protein tissue co-expression partners for FAM65C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM65C Gene:


SOURCE GeneReport for Unigene cluster for FAM65C Gene:

genes like me logo Genes that share expression patterns with FAM65C: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM65C Gene

Orthologs for FAM65C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM65C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM65C 34
  • 84.81 (n)
  • 83.83 (a)
FAM65C 35
  • 83 (a)
(Canis familiaris)
Mammalia FAM65C 34
  • 87.6 (n)
  • 87.21 (a)
FAM65C 35
  • 86 (a)
(Mus musculus)
Mammalia Fam65c 34
  • 79.07 (n)
  • 76.65 (a)
Fam65c 16
Fam65c 35
  • 76 (a)
(Pan troglodytes)
Mammalia FAM65C 34
  • 99.15 (n)
  • 98.84 (a)
FAM65C 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam65c 34
  • 79.82 (n)
  • 76.97 (a)
(Monodelphis domestica)
Mammalia FAM65C 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia FAM65C 35
  • 67 (a)
(Gallus gallus)
Aves FAM65C 34
  • 59.96 (n)
  • 57.27 (a)
FAM65C 35
  • 54 (a)
(Anolis carolinensis)
Reptilia FAM65C 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam65c 34
  • 61.83 (n)
  • 56.79 (a)
(Danio rerio)
Actinopterygii zgc:113070 34
  • 52.05 (n)
  • 42.12 (a)
FAM65C 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C27H2.2 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
Species where no ortholog for FAM65C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM65C Gene

Gene Tree for FAM65C (if available)
Gene Tree for FAM65C (if available)

Paralogs for FAM65C Gene

Paralogs for FAM65C Gene

(2) SIMAP similar genes for FAM65C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM65C: view

Variants for FAM65C Gene

Sequence variations from dbSNP and Humsavar for FAM65C Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6020624 - 50,597,619(+) CATCC(A/C/G)GGGCG nc-transcript-variant, reference, missense
rs35965508 - 50,597,661(-) GGAGT(C/G)CATCC nc-transcript-variant, reference, missense
rs179635 -- 50,640,502(-) GAGCT(A/G)AGCCT intron-variant
rs179636 -- 50,640,585(+) CTGGA(A/G)TGAAC intron-variant
rs401303 -- 50,639,688(+) ACACC(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM65C Gene

Variant ID Type Subtype PubMed ID
esv1002485 CNV deletion 20482838
esv1006667 CNV deletion 20482838
esv1383548 CNV insertion 17803354
esv2667883 CNV deletion 23128226
esv2722503 CNV deletion 23290073
esv3646045 CNV loss 21293372
nsv1124835 CNV duplication 24896259
nsv1131595 CNV deletion 24896259
nsv834001 CNV loss 17160897
nsv979439 CNV duplication 23825009

Variation tolerance for FAM65C Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM65C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM65C Gene

Disorders for FAM65C Gene

Relevant External Links for FAM65C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM65C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM65C Gene

Publications for FAM65C Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 65

Products for FAM65C Gene

Sources for FAM65C Gene

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