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Aliases for FAM65C Gene

Aliases for FAM65C Gene

  • Family With Sequence Similarity 65, Member C 2 3
  • C20orf175 3 4
  • Chromosome 20 Open Reading Frame 175 2
  • Chromosome 20 Open Reading Frame 176 2
  • Protein FAM65C 3
  • C20orf176 3

External Ids for FAM65C Gene

Previous Symbols for FAM65C Gene

  • C20orf175
  • C20orf176

Summaries for FAM65C Gene

GeneCards Summary for FAM65C Gene

FAM65C (Family With Sequence Similarity 65, Member C) is a Protein Coding gene. An important paralog of this gene is FAM65A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM65C Gene

Genomics for FAM65C Gene

Genomic Location for FAM65C Gene

Start:
50,586,108 bp from pter
End:
50,692,004 bp from pter
Size:
105,897 bases
Orientation:
Minus strand

Genomic View for FAM65C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM65C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM65C Gene

Proteins for FAM65C Gene

  • Protein details for FAM65C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MK2-FA65C_HUMAN
    Recommended name:
    Protein FAM65C
    Protein Accession:
    Q96MK2
    Secondary Accessions:
    • Q5QPB6
    • Q9NQQ2

    Protein attributes for FAM65C Gene

    Size:
    946 amino acids
    Molecular mass:
    105290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM65C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM65C Gene

Proteomics data for FAM65C Gene at MOPED

Post-translational modifications for FAM65C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM65C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM65C Gene

Domains for FAM65C Gene

Protein Domains for FAM65C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM65C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MK2

UniProtKB/Swiss-Prot:

FA65C_HUMAN
Family:
  • Belongs to the FAM65 family.:
    • Q96MK2
genes like me logo Genes that share domains with FAM65C: view

No data available for Gene Families for FAM65C Gene

Function for FAM65C Gene

Gene Ontology (GO) - Molecular Function for FAM65C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0008009 chemokine activity --
genes like me logo Genes that share ontologies with FAM65C: view

Phenotypes for FAM65C Gene

GenomeRNAi human phenotypes for FAM65C:
genes like me logo Genes that share phenotypes with FAM65C: view

miRNA for FAM65C Gene

miRTarBase miRNAs that target FAM65C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM65C Gene

Localization for FAM65C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM65C Gene COMPARTMENTS Subcellular localization image for FAM65C gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM65C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
genes like me logo Genes that share ontologies with FAM65C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM65C Gene

Pathways for FAM65C Gene

SuperPathways for FAM65C Gene

No Data Available

Interacting Proteins for FAM65C Gene

Gene Ontology (GO) - Biological Process for FAM65C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response --
genes like me logo Genes that share ontologies with FAM65C: view

No data available for Pathways by source for FAM65C Gene

Transcripts for FAM65C Gene

Unigene Clusters for FAM65C Gene

Family with sequence similarity 65, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM65C Gene

No ASD Table

Relevant External Links for FAM65C Gene

GeneLoc Exon Structure for
FAM65C
ECgene alternative splicing isoforms for
FAM65C

Expression for FAM65C Gene

mRNA expression in normal human tissues for FAM65C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM65C Gene

SOURCE GeneReport for Unigene cluster for FAM65C Gene Hs.372578

genes like me logo Genes that share expressions with FAM65C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM65C Gene

Orthologs for FAM65C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM65C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM65C 35
  • 99.15 (n)
  • 98.84 (a)
FAM65C 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM65C 35
  • 84.81 (n)
  • 83.83 (a)
FAM65C 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM65C 35
  • 87.6 (n)
  • 87.21 (a)
FAM65C 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam65c 35
  • 79.07 (n)
  • 76.65 (a)
Fam65c 16
Fam65c 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM65C 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM65C 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam65c 35
  • 79.82 (n)
  • 76.97 (a)
chicken
(Gallus gallus)
Aves FAM65C 35
  • 59.96 (n)
  • 57.27 (a)
FAM65C 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM65C 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam65c 35
  • 61.83 (n)
  • 56.79 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM65C 36
  • 35 (a)
OneToOne
zgc:113070 35
  • 52.05 (n)
  • 42.12 (a)
worm
(Caenorhabditis elegans)
Secernentea C27H2.2 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for FAM65C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM65C Gene

ENSEMBL:
Gene Tree for FAM65C (if available)
TreeFam:
Gene Tree for FAM65C (if available)

Paralogs for FAM65C Gene

Paralogs for FAM65C Gene

Selected SIMAP similar genes for FAM65C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM65C: view

Variants for FAM65C Gene

Sequence variations from dbSNP and Humsavar for FAM65C Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs179635 -- 50,640,502(-) GAGCT(A/G)AGCCT intron-variant
rs179636 -- 50,640,585(+) CTGGA(A/G)TGAAC intron-variant
rs231564 -- 50,638,198(+) CCTGA(C/T)GGATA intron-variant, upstream-variant-2KB
rs231568 -- 50,639,731(+) CTTGT(A/G)TATAG intron-variant
rs231569 -- 50,639,872(+) TGTAA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM65C Gene

Variant ID Type Subtype PubMed ID
esv1002485 CNV Deletion 20482838
esv2722503 CNV Deletion 23290073
esv2667883 CNV Deletion 23128226
nsv834001 CNV Loss 17160897

Relevant External Links for FAM65C Gene

HapMap Linkage Disequilibrium report
FAM65C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM65C Gene

Disorders for FAM65C Gene

Relevant External Links for FAM65C

Genetic Association Database (GAD)
FAM65C
Human Genome Epidemiology (HuGE) Navigator
FAM65C
genes like me logo Genes that share disorders with FAM65C: view

No data available for UniProtKB/Swiss-Prot for FAM65C Gene

Publications for FAM65C Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. A transcript finishing initiative for closing gaps in the human transcriptome. (PMID: 15197164) Sogayar M.C. … Zanette D.L. (Genome Res. 2004) 3

Products for FAM65C Gene

Sources for FAM65C Gene

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