FAM65C Gene
protein-coding GIFtS: 40
GCID: GC20M049202 (predicted)
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family with sequence similarity 65, member C(Previous names: chromosome 20 open reading frame 175, chromosome 20 open...)
(Previous symbols: C20orf175, C20orf176)
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Aliases
for FAM65C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Family With Sequence Similarity 65, Member C1 2 | | DJ530I15.31 | | C20orf1751 2 3 | | Chromosome 20 Open Reading Frame 1751 | | C20orf1761 2 | | Chromosome 20 Open Reading Frame 1761 | | DJ530I15.21 | | Protein FAM65C2 |
Export aliases for FAM65C gene to outside databasesPrevious GC identifers: GC20M048637 GC20M045952 |
Summaries
for FAM65C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for FAM65C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM65C gene promoter:
LHX3b/Lhx3b AP-1 NF-kappaB CREB FOXJ2 (long isoform) deltaCREB LHX3a/Lhx3a FOXJ2 NF-kappaB1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM65C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM65C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.13FAM65C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M049202: view genomic region
(about GC identifiers)
Start:
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49,202,645 bp from pter |
End:
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49,308,065 bp from pter |
Size:
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105,421 bases |
Orientation:
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minus strand |
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Proteins
for FAM65C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: FA65C_HUMAN, Q96MK2 (See
protein sequence)Recommended Name: Protein FAM65C Size: 946 amino acids; 105290 Da
Secondary accessions: Q5QPB6 Q9NQQ2Alternative splicing: 2 isoforms: Q96MK2-1 Q96MK2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM65C: NX_Q96MK2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MK2
FAM65C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543019.2
ENSEMBL proteins: ENSP00000332663 ENSP00000439802 ENSP00000045083
Human Recombinant Protein Products:
FAM65C Antibody Products:
Assay Products for FAM65C: |
Protein
Domains /
Families
for FAM65C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM65C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96MK2ProtoNet protein and cluster: Q96MK2 UniProtKB/Swiss-Prot: FA65C_HUMAN, Q96MK2Similarity: Belongs to the FAM65 family |
Function
for FAM65C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM65C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM65C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM65C (NM_080829) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM65C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM65C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM65C |
1 GenomeRNAi human phenotype for FAM65C:
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Pathways & Interactions
for FAM65C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM65C
|
Drugs & Compounds
for FAM65C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM65C
Search CenterWatch for drugs/clinical trials and news about FAM65C / FA65C
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Transcripts
for FAM65C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for FAM65C gene: NM_080829.2 Unigene Cluster for FAM65C: Family with sequence similarity 65, member C Hs.372578 [show with all ESTs]Unigene Representative Sequence: NM_0808297 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000327979(uc010zyt.2) ENST00000462842 ENST00000488529 ENST00000482129
ENST00000462493(uc002xvn.1) ENST00000535356(uc010zyu.1) ENST00000045083(uc002xvm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM65C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM65C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM65C (NM_080829) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM65C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM65C |
Additional cDNA sequence: AK056792.1 AK124347.1 AK130652.1 AK295781.1 AK299337.1 BC131485.1 9 DOTS entries: DT.111567 DT.70104763 DT.99929314 DT.91916700 DT.100746700 DT.120811161 DT.97804580 DT.100644322 DT.97803433 24/67 AceView cDNA sequences (see all 67): AW025449 AW593763 AI279714 CA389799 AA258384 AW445044 AI761954 AI151129 AA437074 AW057583 BQ446237 BX495517 AI261200 AL042920 AI206264 AI056877 AW269606 NM_080829 AW243363 BF688656 AI499082 AW189031 AK124347 AW193098
GeneLoc Exon Structure
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Expression
for FAM65C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM65C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTGAGATG
About this image
See FAM65C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM65C
SOURCE GeneReport for Unigene cluster: Hs.372578
SABiosciences Custom PCR Arrays for FAM65C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM65C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM65C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM65C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM65C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM65C |
Orthologs
for FAM65C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for FAM65C gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for FAM65C (if available)
TreeFam Gene Tree for FAM65C (if available) |
Paralogs
for FAM65C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM65C gene
- FAM65A2 FAM65B2
2 SIMAP similar genes for FAM65C using alignment to 2 protein entries: FA65C_HUMAN (see all proteins):FLJ00360 FAM65B
FAM65C for paralogs About GeneDecksing
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Genomic Variants
for FAM65C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FAM65C (49202645 - 49308065 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM65C
1 CNV: 5141 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM65C |
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Disorders
/ Diseases
for FAM65C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM65C for disorders About GeneDecksing
1  disease for FAM65C: About MalaCardschoroiditis
Human Genome Epidemiology (HuGE) Navigator: FAM65C (1 document)
Export disorders for FAM65C gene to outside databases
|
Publications
for FAM65C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM65C gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM65C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- A transcript finishing initiative for closing gaps in the human transcriptome. (PubMed id 15197164)1 Sogayar M.C....Zanette D.L. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410)1 Wistow G.... Peterson K. (2002)
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External Searches for FAM65C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FAM65C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing FAM65C gene
(According to HUGE)
About This Section
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Specialized Databases showing FAM65C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for FAM65C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAM65C gene:
Search GeneIP for patents involving FAM65C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM65C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM65C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM65C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM65C | | | OriGene Protein Over-expression Lysate for FAM65C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM65C | | OriGene 3'-UTR Clone for FAM65C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM65C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM65C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM65C | | OriGene Custom Protein Services for FAM65C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM65C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM65C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM65C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM65C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM65C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM65C |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM65C |
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 | | | FAM65C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM65C |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM65C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM65C |
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