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Aliases for FAM65A Gene

Aliases for FAM65A Gene

  • Family With Sequence Similarity 65 Member A 2 3 5
  • Family With Sequence Similarity 65, Member A 2
  • KIAA1930 4

External Ids for FAM65A Gene

Previous GeneCards Identifiers for FAM65A Gene

  • GC16P066121
  • GC16P067562
  • GC16P053436

Summaries for FAM65A Gene

GeneCards Summary for FAM65A Gene

FAM65A (Family With Sequence Similarity 65 Member A) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ENSG00000283332.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM65A Gene

Genomics for FAM65A Gene

Regulatory Elements for FAM65A Gene

Enhancers for FAM65A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F067479 1.1 FANTOM5 ENCODE 13.7 -36.4 -36366 5.0 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ATP6V0D1 ZDHHC1 ACD FAM65A SLC7A6OS CARMIL2 C16orf86 ENKD1 ENSG00000259797 HSD11B2
GH16F067545 1.5 FANTOM5 Ensembl ENCODE 12.4 +29.7 29671 5.3 HDGF WRNIP1 ARID4B ZNF2 YY1 ZNF121 ZNF143 SP5 MIER2 REST HSD11B2 CARMIL2 E2F4 RANBP10 ATP6V0D1 FAM65A THAP11 ACD PARD6A ENSG00000262514
GH16F067550 1.1 Ensembl ENCODE 12.4 +35.7 35716 6.3 ZFP64 ZNF493 ZNF121 KLF7 FOS ZNF202 ZNF263 REST ZNF518A ZNF623 ZDHHC1 ENSG00000260465 CENPT E2F4 ENKD1 ENSG00000263276 ACD ENSG00000270165 FBXL8 KIAA0895L
GH16F067493 0.6 Ensembl ENCODE 12.1 -24.3 -24318 1.0 ARID4B DMAP1 THRB RAD21 ZNF48 YY1 ZNF121 GLIS2 ZNF143 THAP11 FAM65A CARMIL2 HSD11B2 ENSG00000237718 ACD PARD6A ZDHHC1 DPEP2 GC16M067502 AGRP
GH16F067486 1.1 Ensembl ENCODE 12.1 -28.6 -28608 6.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ATP6V0D1 DPEP2 FAM65A LRRC36 CARMIL2 ZDHHC1 HSD11B2 ENSG00000237718 ACD PARD6A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM65A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM65A Gene

Chromosome:
16
Start:
67,518,418 bp from pter
End:
67,546,788 bp from pter
Size:
28,371 bases
Orientation:
Plus strand

Genomic View for FAM65A Gene

Genes around FAM65A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM65A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM65A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM65A Gene

Proteins for FAM65A Gene

  • Protein details for FAM65A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS17-FA65A_HUMAN
    Recommended name:
    Protein FAM65A
    Protein Accession:
    Q6ZS17
    Secondary Accessions:
    • B4DEQ9
    • B4DIM2
    • E9PBS3
    • Q4G0A4
    • Q7Z5R7
    • Q8NDA4
    • Q96J39
    • Q96PV8
    • Q9H8D9

    Protein attributes for FAM65A Gene

    Size:
    1223 amino acids
    Molecular mass:
    132308 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14678.1; Type=Erroneous termination; Positions=256; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAB67823.1; Type=Frameshift; Positions=579; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM65A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM65A Gene

Post-translational modifications for FAM65A Gene

  • Ubiquitination at Lys 916
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM65A Gene

Domains & Families for FAM65A Gene

Protein Domains for FAM65A Gene

Suggested Antigen Peptide Sequences for FAM65A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS17

UniProtKB/Swiss-Prot:

FA65A_HUMAN :
  • Belongs to the FAM65 family.
Family:
  • Belongs to the FAM65 family.
genes like me logo Genes that share domains with FAM65A: view

No data available for Gene Families for FAM65A Gene

Function for FAM65A Gene

Gene Ontology (GO) - Molecular Function for FAM65A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM65A: view
genes like me logo Genes that share phenotypes with FAM65A: view

Animal Model Products

miRNA for FAM65A Gene

miRTarBase miRNAs that target FAM65A

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM65A Gene

Localization for FAM65A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM65A Gene

Cytoplasm. Note=Localizes to the podocyte major processes and cell body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM65A Gene COMPARTMENTS Subcellular localization image for FAM65A gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM65A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FAM65A: view

Pathways & Interactions for FAM65A Gene

SuperPathways for FAM65A Gene

No Data Available

Interacting Proteins for FAM65A Gene

Gene Ontology (GO) - Biological Process for FAM65A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM65A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM65A Gene

Transcripts for FAM65A Gene

Unigene Clusters for FAM65A Gene

Family with sequence similarity 65, member A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM65A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - -
SP14:
SP15: - - -

ExUns: 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14:
SP15:

Relevant External Links for FAM65A Gene

GeneLoc Exon Structure for
FAM65A
ECgene alternative splicing isoforms for
FAM65A

Expression for FAM65A Gene

mRNA expression in normal human tissues for FAM65A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM65A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.8), Fetal Brain (7.5), Heart (6.9), and Spleen (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM65A Gene



Protein tissue co-expression partners for FAM65A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM65A Gene:

FAM65A

SOURCE GeneReport for Unigene cluster for FAM65A Gene:

Hs.152717
genes like me logo Genes that share expression patterns with FAM65A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM65A Gene

Orthologs for FAM65A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM65A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM65A 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia FAM65A 34 35
  • 87.34 (n)
cow
(Bos Taurus)
Mammalia FAM65A 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam65a 34
  • 83.01 (n)
mouse
(Mus musculus)
Mammalia Fam65a 34 16 35
  • 82.77 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM65A 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM65A 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM65A 34 35
  • 70.68 (n)
lizard
(Anolis carolinensis)
Reptilia FAM65A 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam65a 34
  • 61.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20882 34
zebrafish
(Danio rerio)
Actinopterygii fam65a 34 35
  • 63.99 (n)
worm
(Caenorhabditis elegans)
Secernentea C27H2.2 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for FAM65A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM65A Gene

ENSEMBL:
Gene Tree for FAM65A (if available)
TreeFam:
Gene Tree for FAM65A (if available)

Paralogs for FAM65A Gene

Paralogs for FAM65A Gene

(1) SIMAP similar genes for FAM65A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with FAM65A: view

Variants for FAM65A Gene

Sequence variations from dbSNP and Humsavar for FAM65A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1106516 -- 67,537,493(+) GAGCC(C/G)GGAGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111574912 -- 67,531,672(+) AGCAG(A/G)GGACT intron-variant
rs111681103 -- 67,538,934(+) CACCC(C/T)GGGCA intron-variant
rs112273315 -- 67,534,843(+) TTTTT(C/T)TTTTT intron-variant
rs112474768 -- 67,528,987(+) CCCCC(C/G)CCGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM65A Gene

Variant ID Type Subtype PubMed ID
esv29734 CNV loss 19812545
esv3329286 CNV insertion 20981092
esv3638889 CNV loss 21293372
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv827711 CNV gain 20364138
nsv833266 CNV loss 17160897

Variation tolerance for FAM65A Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM65A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM65A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM65A Gene

Disorders for FAM65A Gene

Relevant External Links for FAM65A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM65A

No disorders were found for FAM65A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM65A Gene

Publications for FAM65A Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for FAM65A Gene

Sources for FAM65A Gene

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