Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM65A Gene

Aliases for FAM65A Gene

  • Family With Sequence Similarity 65 Member A 2 3 5
  • Family With Sequence Similarity 65, Member A 2
  • KIAA1930 4

External Ids for FAM65A Gene

Previous GeneCards Identifiers for FAM65A Gene

  • GC16P066121
  • GC16P053436

Summaries for FAM65A Gene

GeneCards Summary for FAM65A Gene

FAM65A (Family With Sequence Similarity 65 Member A) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is FAM65B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM65A Gene

Genomics for FAM65A Gene

Regulatory Elements for FAM65A Gene

Enhancers for FAM65A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM65A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM65A Gene

67,518,418 bp from pter
67,546,788 bp from pter
28,371 bases
Plus strand

Genomic View for FAM65A Gene

Genes around FAM65A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM65A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM65A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM65A Gene

Proteins for FAM65A Gene

  • Protein details for FAM65A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM65A
    Protein Accession:
    Secondary Accessions:
    • B4DEQ9
    • B4DIM2
    • E9PBS3
    • Q4G0A4
    • Q7Z5R7
    • Q8NDA4
    • Q96J39
    • Q96PV8
    • Q9H8D9

    Protein attributes for FAM65A Gene

    1223 amino acids
    Molecular mass:
    132308 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14678.1; Type=Erroneous termination; Positions=256; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAB67823.1; Type=Frameshift; Positions=579; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM65A Gene


neXtProt entry for FAM65A Gene

Proteomics data for FAM65A Gene at MOPED

Post-translational modifications for FAM65A Gene

  • Ubiquitination at Lys 916
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM65A Gene

Domains & Families for FAM65A Gene

Protein Domains for FAM65A Gene

Suggested Antigen Peptide Sequences for FAM65A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM65 family.
  • Belongs to the FAM65 family.
genes like me logo Genes that share domains with FAM65A: view

No data available for Gene Families for FAM65A Gene

Function for FAM65A Gene

genes like me logo Genes that share phenotypes with FAM65A: view

Animal Model Products

CRISPR Products

miRNA for FAM65A Gene

miRTarBase miRNAs that target FAM65A

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM65A Gene

Localization for FAM65A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM65A Gene

Cytoplasm. Note=Localizes to the podocyte major processes and cell body. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FAM65A Gene COMPARTMENTS Subcellular localization image for FAM65A gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM65A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with FAM65A: view

Pathways & Interactions for FAM65A Gene

SuperPathways for FAM65A Gene

No Data Available

Interacting Proteins for FAM65A Gene

Gene Ontology (GO) - Biological Process for FAM65A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM65A Gene

Drugs & Compounds for FAM65A Gene

No Compound Related Data Available

Transcripts for FAM65A Gene

Unigene Clusters for FAM65A Gene

Family with sequence similarity 65, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM65A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP13: - - - - - -
SP15: - - -

ExUns: 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP8: -
SP12: - -

Relevant External Links for FAM65A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM65A Gene

mRNA expression in normal human tissues for FAM65A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM65A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.8), Fetal Brain (7.5), Heart (6.9), and Spleen (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM65A Gene

SOURCE GeneReport for Unigene cluster for FAM65A Gene Hs.152717

genes like me logo Genes that share expression patterns with FAM65A: view

Protein tissue co-expression partners for FAM65A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM65A Gene

Orthologs for FAM65A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM65A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM65A 35
  • 87.34 (n)
  • 86.77 (a)
FAM65A 36
  • 84 (a)
(Mus musculus)
Mammalia Fam65a 35
  • 82.77 (n)
  • 82.24 (a)
Fam65a 16
Fam65a 36
  • 80 (a)
(Pan troglodytes)
Mammalia FAM65A 35
  • 99.54 (n)
  • 99.43 (a)
FAM65A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam65a 35
  • 83.01 (n)
  • 81.18 (a)
(Bos Taurus)
Mammalia FAM65A 36
  • 84 (a)
(Monodelphis domestica)
Mammalia FAM65A 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia FAM65A 36
  • 59 (a)
(Gallus gallus)
Aves FAM65A 35
  • 70.68 (n)
  • 69.09 (a)
FAM65A 36
  • 58 (a)
(Anolis carolinensis)
Reptilia FAM65A 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam65a 35
  • 61.72 (n)
  • 62.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20882 35
(Danio rerio)
Actinopterygii fam65a 35
  • 63.99 (n)
  • 63.65 (a)
fam65a 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea C27H2.2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for FAM65A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM65A Gene

Gene Tree for FAM65A (if available)
Gene Tree for FAM65A (if available)

Paralogs for FAM65A Gene

Paralogs for FAM65A Gene

(1) SIMAP similar genes for FAM65A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with FAM65A: view

Variants for FAM65A Gene

Sequence variations from dbSNP and Humsavar for FAM65A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4329916 -- 67,537,844(+) GGAGG(A/G)CGCCG intron-variant
rs9924509 -- 67,539,393(+) CTTCC(C/T)GGAGG intron-variant
rs61690248 -- 67,534,158(+) AGAAA(A/G)AATCT intron-variant
rs9929024 -- 67,532,338(+) gttca(A/C)ggctg intron-variant
rs61744916 -- 67,544,354(+) GTGCC(C/T)GCCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM65A Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv833266 CNV Loss 17160897
nsv906807 CNV Loss 21882294
esv29734 CNV Loss 19812545
nsv827711 CNV Gain 20364138
esv270767 CNV Insertion 20981092

Variation tolerance for FAM65A Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM65A Gene

Disorders for FAM65A Gene

Relevant External Links for FAM65A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM65A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM65A Gene

Publications for FAM65A Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for FAM65A Gene

Sources for FAM65A Gene