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Aliases for FAM64A Gene

Aliases for FAM64A Gene

  • Family With Sequence Similarity 64, Member A 2 3
  • CALM Interacting Protein Expressed In Thymus And Spleen 2 3
  • CALM-Interactor Expressed In Thymus And Spleen 3 4
  • Regulator Of Chromosome Segregation Protein 1 3 4
  • CATS 3 4
  • RCS1 3 4
  • Regulator Of Chromosome Segregation 1 3
  • Protein FAM64A 3

External Ids for FAM64A Gene

Previous GeneCards Identifiers for FAM64A Gene

  • GC17P006289

Summaries for FAM64A Gene

GeneCards Summary for FAM64A Gene

FAM64A (Family With Sequence Similarity 64, Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM64A Gene

  • During mitosis, may play a role in the control of metaphase-to-anaphase transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM64A Gene

Genomics for FAM64A Gene

Regulatory Elements for FAM64A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM64A Gene

6,444,415 bp from pter
6,451,469 bp from pter
7,055 bases
Plus strand

Genomic View for FAM64A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM64A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM64A Gene

Proteins for FAM64A Gene

  • Protein details for FAM64A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM64A
    Protein Accession:
    Secondary Accessions:
    • Q96CT4
    • Q9NVV1
    • Q9NWB5

    Protein attributes for FAM64A Gene

    248 amino acids
    Molecular mass:
    27480 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with PICALM; this interaction may target PICALM to the nucleus. During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase

    Alternative splice isoforms for FAM64A Gene


neXtProt entry for FAM64A Gene

Proteomics data for FAM64A Gene at MOPED

Post-translational modifications for FAM64A Gene

  • Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for FAM64A Gene

Domains for FAM64A Gene

Protein Domains for FAM64A Gene


Suggested Antigen Peptide Sequences for FAM64A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BSJ6
  • The N-terminal destruction box 2 (D-box 2) is required for APC/C ubiquitination and proteasomal degradation.
genes like me logo Genes that share domains with FAM64A: view

No data available for Gene Families for FAM64A Gene

Function for FAM64A Gene

Molecular function for FAM64A Gene

UniProtKB/Swiss-Prot Function:
During mitosis, may play a role in the control of metaphase-to-anaphase transition.

Gene Ontology (GO) - Molecular Function for FAM64A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16491119
genes like me logo Genes that share ontologies with FAM64A: view

Phenotypes for FAM64A Gene

GenomeRNAi human phenotypes for FAM64A:
genes like me logo Genes that share phenotypes with FAM64A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM64A Gene

Localization for FAM64A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM64A Gene

Nucleus. Nucleus, nucleolus. Note=Partially localizes to the nucleolus.

Subcellular locations from

Jensen Localization Image for FAM64A Gene COMPARTMENTS Subcellular localization image for FAM64A gene
Compartment Confidence
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM64A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FAM64A: view

Pathways for FAM64A Gene

SuperPathways for FAM64A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM64A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FAM64A: view

No data available for Pathways by source for FAM64A Gene

Transcripts for FAM64A Gene

Unigene Clusters for FAM64A Gene

Family with sequence similarity 64, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM64A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM64A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - -
SP10: - - -
SP11: - -

Relevant External Links for FAM64A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM64A Gene

mRNA expression in normal human tissues for FAM64A Gene

mRNA differential expression in normal tissues according to GTEx for FAM64A Gene

This gene is overexpressed in Spleen (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM64A Gene

SOURCE GeneReport for Unigene cluster for FAM64A Gene Hs.592116

mRNA Expression by UniProt/SwissProt for FAM64A Gene

Tissue specificity: Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines.
genes like me logo Genes that share expressions with FAM64A: view

Expression partners for FAM64A Gene

In Situ Assay Products

No data available for Protein differential expression in normal tissues for FAM64A Gene

Orthologs for FAM64A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM64A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM64A 35
  • 85.85 (n)
  • 83.19 (a)
FAM64A 36
  • 80 (a)
(Canis familiaris)
Mammalia FAM64A 35
  • 81.18 (n)
  • 73.28 (a)
FAM64A 36
  • 70 (a)
(Mus musculus)
Mammalia Fam64a 35
  • 77.54 (n)
  • 74.78 (a)
Fam64a 16
Fam64a 36
  • 72 (a)
(Pan troglodytes)
Mammalia FAM64A 35
  • 98.6 (n)
  • 96.64 (a)
FAM64A 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam64a 35
  • 79.15 (n)
  • 76.65 (a)
(Gallus gallus)
Aves FAM64A 36
  • 22 (a)
Species with no ortholog for FAM64A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM64A Gene

Gene Tree for FAM64A (if available)
Gene Tree for FAM64A (if available)

Paralogs for FAM64A Gene Pseudogenes for FAM64A Gene

genes like me logo Genes that share paralogs with FAM64A: view

No data available for Paralogs for FAM64A Gene

Variants for FAM64A Gene

Sequence variations from dbSNP and Humsavar for FAM64A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1051443 -- 6,450,713(+) TAGCT(C/G)TGTAC utr-variant-3-prime
rs2280110 -- 6,446,694(-) CTGAC(C/T)GTGAC intron-variant
rs2280111 -- 6,446,657(-) GCTTC(C/T)TGTTG intron-variant
rs4796495 -- 6,443,449(+) ACCTG(C/T)GCATA upstream-variant-2KB
rs4796496 -- 6,443,692(+) GGCTG(A/C)ATTTG upstream-variant-2KB

Relevant External Links for FAM64A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM64A Gene

Disorders for FAM64A Gene

No disorders were found for FAM64A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM64A Gene

Publications for FAM64A Gene

  1. The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. (PMID: 16491119) Archangelo L.F. … Bohlander S.K. (Oncogene 2006) 2 3 4
  2. The CALM and CALM/AF10 interactor CATS is a marker for proliferation. (PMID: 19383357) Archangelo L.F. … Bohlander S.K. (Mol. Oncol. 2008) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The CATS (FAM64A) protein is a substrate of the kinase interacting stathmin (KIS). (PMID: 23419774) Archangelo L.F. … Saad S.T. (Biochim. Biophys. Acta 2013) 3 4

Products for FAM64A Gene

Sources for FAM64A Gene

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