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Aliases for FAM63B Gene

Aliases for FAM63B Gene

  • Family With Sequence Similarity 63, Member B 2 3
  • KIAA1164 4

External Ids for FAM63B Gene

Previous GeneCards Identifiers for FAM63B Gene

  • GC15P056851
  • GC15P059063
  • GC15P035885

Summaries for FAM63B Gene

GeneCards Summary for FAM63B Gene

FAM63B (Family With Sequence Similarity 63, Member B) is a Protein Coding gene. An important paralog of this gene is FAM63A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM63B Gene

Genomics for FAM63B Gene

Regulatory Elements for FAM63B Gene

Genomic Location for FAM63B Gene

Start:
58,771,192 bp from pter
End:
58,861,900 bp from pter
Size:
90,709 bases
Orientation:
Plus strand

Genomic View for FAM63B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM63B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM63B Gene

Proteins for FAM63B Gene

  • Protein details for FAM63B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBR6-FA63B_HUMAN
    Recommended name:
    Protein FAM63B
    Protein Accession:
    Q8NBR6
    Secondary Accessions:
    • B2RTT8
    • Q9ULQ6

    Protein attributes for FAM63B Gene

    Size:
    621 amino acids
    Molecular mass:
    67106 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW77545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM63B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM63B Gene

Proteomics data for FAM63B Gene at MOPED

Post-translational modifications for FAM63B Gene

  • Ubiquitination at Lys234 and Lys309
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM63B Gene

No data available for DME Specific Peptides for FAM63B Gene

Domains for FAM63B Gene

Protein Domains for FAM63B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM63B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBR6

UniProtKB/Swiss-Prot:

FA63B_HUMAN :
  • Q8NBR6
Family:
  • Belongs to the FAM63 family.
genes like me logo Genes that share domains with FAM63B: view

No data available for Gene Families for FAM63B Gene

Function for FAM63B Gene

Gene Ontology (GO) - Molecular Function for FAM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM63B: view

miRNA for FAM63B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM63B Gene

Localization for FAM63B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM63B Gene COMPARTMENTS Subcellular localization image for FAM63B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FAM63B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM63B Gene

Pathways for FAM63B Gene

SuperPathways for FAM63B Gene

No Data Available

Interacting Proteins for FAM63B Gene

Gene Ontology (GO) - Biological Process for FAM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM63B: view

No data available for Pathways by source for FAM63B Gene

Transcripts for FAM63B Gene

Unigene Clusters for FAM63B Gene

Family with sequence similarity 63, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM63B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for FAM63B Gene

GeneLoc Exon Structure for
FAM63B
ECgene alternative splicing isoforms for
FAM63B

Expression for FAM63B Gene

mRNA expression in normal human tissues for FAM63B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM63B Gene

SOURCE GeneReport for Unigene cluster for FAM63B Gene Hs.591122

genes like me logo Genes that share expressions with FAM63B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM63B Gene

Orthologs for FAM63B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAM63B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM63B 35
  • 99.79 (n)
  • 99.84 (a)
FAM63B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM63B 35
  • 91.41 (n)
  • 91.3 (a)
FAM63B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM63B 35
  • 92.35 (n)
  • 91.97 (a)
FAM63B 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam63b 35
  • 84.39 (n)
  • 85.28 (a)
Fam63b 16
Fam63b 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM63B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM63B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam63b 35
  • 83.61 (n)
  • 84.4 (a)
chicken
(Gallus gallus)
Aves FAM63B 35
  • 78.27 (n)
  • 85.05 (a)
FAM63B 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM63B 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63b 35
  • 73.2 (n)
  • 80.87 (a)
zebrafish
(Danio rerio)
Actinopterygii fam63b 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 35
  • 49.04 (n)
  • 38.31 (a)
Y55F3AM.9 36
  • 31 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL071C 35
  • 45.98 (n)
  • 35.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 25 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 38
YGL082W 35
  • 47.49 (n)
  • 36.99 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19273g 35
  • 47.57 (n)
  • 40.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 36
  • 52 (a)
OneToMany
Species with no ortholog for FAM63B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM63B Gene

ENSEMBL:
Gene Tree for FAM63B (if available)
TreeFam:
Gene Tree for FAM63B (if available)

Paralogs for FAM63B Gene

Paralogs for FAM63B Gene

Selected SIMAP similar genes for FAM63B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM63B: view

Variants for FAM63B Gene

Sequence variations from dbSNP and Humsavar for FAM63B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs193224 -- 58,814,591(-) gacca(C/G)cctga intron-variant
rs347111 -- 58,848,629(-) agctg(C/G)gacta intron-variant
rs347112 -- 58,813,579(+) atatc(A/G)taGtt intron-variant
rs347113 -- 58,816,078(-) ttatg(C/T)gccag intron-variant
rs347114 -- 58,832,606(-) gttgc(G/T)gtgaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM63B Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
esv34110 CNV Loss 18971310
esv2669121 CNV Deletion 23128226
esv2656587 CNV Deletion 23128226
nsv527307 CNV Gain 19592680
nsv904270 CNV Loss 21882294

Relevant External Links for FAM63B Gene

HapMap Linkage Disequilibrium report
FAM63B
Human Gene Mutation Database (HGMD)
FAM63B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM63B Gene

Disorders for FAM63B Gene

Relevant External Links for FAM63B

Genetic Association Database (GAD)
FAM63B
genes like me logo Genes that share disorders with FAM63B: view

No data available for UniProtKB/Swiss-Prot for FAM63B Gene

Publications for FAM63B Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for FAM63B Gene

Sources for FAM63B Gene

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