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Aliases for FAM63B Gene

Aliases for FAM63B Gene

  • Family With Sequence Similarity 63 Member B 2 3 5
  • Family With Sequence Similarity 63, Member B 2
  • KIAA1164 4

External Ids for FAM63B Gene

Previous GeneCards Identifiers for FAM63B Gene

  • GC15P056851
  • GC15P059063
  • GC15P035885

Summaries for FAM63B Gene

GeneCards Summary for FAM63B Gene

FAM63B (Family With Sequence Similarity 63 Member B) is a Protein Coding gene. An important paralog of this gene is FAM63A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM63B Gene

Genomics for FAM63B Gene

Regulatory Elements for FAM63B Gene

Enhancers for FAM63B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM63B on UCSC Golden Path with GeneCards custom track

Promoters for FAM63B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM63B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM63B Gene

58,771,192 bp from pter
58,861,900 bp from pter
90,709 bases
Plus strand

Genomic View for FAM63B Gene

Genes around FAM63B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM63B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM63B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM63B Gene

Proteins for FAM63B Gene

  • Protein details for FAM63B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM63B
    Protein Accession:
    Secondary Accessions:
    • B2RTT8
    • Q9ULQ6

    Protein attributes for FAM63B Gene

    621 amino acids
    Molecular mass:
    67106 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW77545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM63B Gene


neXtProt entry for FAM63B Gene

Proteomics data for FAM63B Gene at MOPED

Post-translational modifications for FAM63B Gene

  • Ubiquitination at Lys 234 and Lys 309
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM63B Gene

No data available for DME Specific Peptides for FAM63B Gene

Domains & Families for FAM63B Gene

Protein Domains for FAM63B Gene


Suggested Antigen Peptide Sequences for FAM63B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM63 family.
  • Belongs to the FAM63 family.
genes like me logo Genes that share domains with FAM63B: view

No data available for Gene Families for FAM63B Gene

Function for FAM63B Gene

genes like me logo Genes that share phenotypes with FAM63B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM63B Gene

Localization for FAM63B Gene

Subcellular locations from

Jensen Localization Image for FAM63B Gene COMPARTMENTS Subcellular localization image for FAM63B gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM63B Gene

Pathways & Interactions for FAM63B Gene

SuperPathways for FAM63B Gene

No Data Available

Interacting Proteins for FAM63B Gene

Gene Ontology (GO) - Biological Process for FAM63B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM63B Gene

Drugs & Compounds for FAM63B Gene

No Compound Related Data Available

Transcripts for FAM63B Gene

Unigene Clusters for FAM63B Gene

Family with sequence similarity 63, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM63B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -

Relevant External Links for FAM63B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM63B Gene

mRNA expression in normal human tissues for FAM63B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM63B Gene

This gene is overexpressed in Adrenal (39.1) and Retina (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM63B Gene

SOURCE GeneReport for Unigene cluster for FAM63B Gene Hs.591122

genes like me logo Genes that share expression patterns with FAM63B: view

Protein tissue co-expression partners for FAM63B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM63B Gene

Orthologs for FAM63B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAM63B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM63B 35
  • 91.41 (n)
  • 91.3 (a)
FAM63B 36
  • 90 (a)
(Canis familiaris)
Mammalia FAM63B 35
  • 92.35 (n)
  • 91.97 (a)
FAM63B 36
  • 83 (a)
(Mus musculus)
Mammalia Fam63b 35
  • 84.39 (n)
  • 85.28 (a)
Fam63b 16
Fam63b 36
  • 85 (a)
(Pan troglodytes)
Mammalia FAM63B 35
  • 99.79 (n)
  • 99.84 (a)
FAM63B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam63b 35
  • 83.61 (n)
  • 84.4 (a)
(Monodelphis domestica)
Mammalia FAM63B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FAM63B 36
  • 96 (a)
(Gallus gallus)
Aves FAM63B 35
  • 78.27 (n)
  • 85.05 (a)
FAM63B 36
  • 94 (a)
(Anolis carolinensis)
Reptilia FAM63B 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63b 35
  • 73.2 (n)
  • 80.87 (a)
(Danio rerio)
Actinopterygii fam63b 36
  • 59 (a)
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 35
  • 49.04 (n)
  • 38.31 (a)
Y55F3AM.9 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL071C 35
  • 45.98 (n)
  • 35.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19273g 35
  • 47.57 (n)
  • 40.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGL082W 35
  • 47.49 (n)
  • 36.99 (a)
-- 36
  • 25 (a)
-- 36
  • 29 (a)
-- 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 36
  • 52 (a)
Species with no ortholog for FAM63B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM63B Gene

Gene Tree for FAM63B (if available)
Gene Tree for FAM63B (if available)

Paralogs for FAM63B Gene

Paralogs for FAM63B Gene

(2) SIMAP similar genes for FAM63B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM63B: view

Variants for FAM63B Gene

Sequence variations from dbSNP and Humsavar for FAM63B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs193224 -- 58,814,591(-) gacca(C/G)cctga intron-variant
rs5812950 -- 58,773,136(+) AAAAA(-/A)CAAAA intron-variant
rs5812951 -- 58,787,737(+) GTCTC(-/A)AAAAA intron-variant
rs347111 -- 58,848,629(-) agctg(C/G)gacta intron-variant
rs347112 -- 58,813,579(+) atatc(A/G)taGtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM63B Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
esv34110 CNV Loss 18971310
esv2669121 CNV Deletion 23128226
esv2656587 CNV Deletion 23128226
nsv527307 CNV Gain 19592680
nsv904270 CNV Loss 21882294

Variation tolerance for FAM63B Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM63B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM63B Gene

Disorders for FAM63B Gene

Relevant External Links for FAM63B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM63B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM63B Gene

Publications for FAM63B Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. (PMID: 21915095) Dodding M.P. … Way M. (EMBO J. 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM63B Gene

Sources for FAM63B Gene