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Aliases for FAM63B Gene

Aliases for FAM63B Gene

  • Family With Sequence Similarity 63 Member B 2 3 5
  • Family With Sequence Similarity 63, Member B 2
  • Deubiquitinating Enzyme MINDY-2 4
  • Protein FAM63B 4
  • EC 3.4.19.12 4
  • KIAA1164 4

External Ids for FAM63B Gene

Previous GeneCards Identifiers for FAM63B Gene

  • GC15P056851
  • GC15P059063
  • GC15P035885

Summaries for FAM63B Gene

GeneCards Summary for FAM63B Gene

FAM63B (Family With Sequence Similarity 63 Member B) is a Protein Coding gene. An important paralog of this gene is FAM63A.

UniProtKB/Swiss-Prot for FAM63B Gene

  • Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. May play a regulatory role at the level of protein turnover.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM63B Gene

Genomics for FAM63B Gene

Regulatory Elements for FAM63B Gene

Enhancers for FAM63B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F058625 0.6 ENCODE 22.8 -143.5 -143505 4.2 ZFP64 ZBTB11 CEBPB ZNF623 ZNF781 ZNF518A MAFF SMARCA4 CEBPA IKZF1 FAM63B ADAM10 RNU3P1 LOC101928725 GC15P058674 HMGB1P51 ENSG00000259250
GH15F058723 0.9 FANTOM5 Ensembl ENCODE 19.7 -45.6 -45592 4.0 HDAC1 PKNOX1 MTA2 MAX ELF1 EBF1 TBX21 RFX5 IKZF1 PBX2 ADAM10 FAM63B RNU3P1 LOC101928725 ENSG00000278513 RN7SKP95
GH15F058736 1.4 FANTOM5 Ensembl ENCODE 16.8 -32.8 -32792 4.8 JUND JUN CEBPB EBF1 MYC FAM63B RNU3P1 LOC101928725 ENSG00000225798 SLTM RNF111 ADAM10 ENSG00000278513
GH15F058864 1.3 FANTOM5 ENCODE 16.8 +94.6 94555 3.3 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 BRCA1 SP5 ZHX2 MXD4 ZNF623 FAM63B BNIP2 SLTM ENSG00000225798 LOC101928725 RNU3P1 ENSG00000259353 RNF111 ADAM10 RPL21P14
GH15F058741 0.2 ENCODE 16.7 -28.5 -28471 1.9 SOX13 SAP130 JUN ARID4B ZNF48 RARA CBX5 HNF4G NR2F6 CREM FAM63B LOC101928725 ADAM10 ENSG00000278513
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM63B on UCSC Golden Path with GeneCards custom track

Promoters for FAM63B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000408745 1109 4600 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF263

Genomic Location for FAM63B Gene

Chromosome:
15
Start:
58,771,192 bp from pter
End:
58,861,900 bp from pter
Size:
90,709 bases
Orientation:
Plus strand

Genomic View for FAM63B Gene

Genes around FAM63B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM63B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM63B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM63B Gene

Proteins for FAM63B Gene

  • Protein details for FAM63B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBR6-FA63B_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase MINDY-2
    Protein Accession:
    Q8NBR6
    Secondary Accessions:
    • B2RTT8
    • Q9ULQ6

    Protein attributes for FAM63B Gene

    Size:
    621 amino acids
    Molecular mass:
    67106 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW77545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM63B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM63B Gene

Post-translational modifications for FAM63B Gene

  • Ubiquitination at Lys 234 and Lys 309
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM63B Gene

Domains & Families for FAM63B Gene

Protein Domains for FAM63B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM63B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBR6

UniProtKB/Swiss-Prot:

FA63B_HUMAN :
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
genes like me logo Genes that share domains with FAM63B: view

No data available for Gene Families for FAM63B Gene

Function for FAM63B Gene

Molecular function for FAM63B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. May play a regulatory role at the level of protein turnover.

Enzyme Numbers (IUBMB) for FAM63B Gene

Gene Ontology (GO) - Molecular Function for FAM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with FAM63B: view
genes like me logo Genes that share phenotypes with FAM63B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM63B Gene

Localization for FAM63B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM63B Gene COMPARTMENTS Subcellular localization image for FAM63B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FAM63B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM63B Gene

Pathways & Interactions for FAM63B Gene

SuperPathways for FAM63B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with FAM63B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM63B Gene

Transcripts for FAM63B Gene

Unigene Clusters for FAM63B Gene

Family with sequence similarity 63, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM63B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for FAM63B Gene

GeneLoc Exon Structure for
FAM63B
ECgene alternative splicing isoforms for
FAM63B

Expression for FAM63B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM63B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM63B Gene

This gene is overexpressed in Adrenal (39.1) and Retina (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM63B Gene



Protein tissue co-expression partners for FAM63B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM63B Gene:

FAM63B

SOURCE GeneReport for Unigene cluster for FAM63B Gene:

Hs.591122
genes like me logo Genes that share expression patterns with FAM63B: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM63B Gene

Orthologs for FAM63B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAM63B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM63B 34 35
  • 99.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM63B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM63B 34 35
  • 92.35 (n)
cow
(Bos Taurus)
Mammalia FAM63B 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Fam63b 34 16 35
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Fam63b 34
  • 83.61 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM63B 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM63B 34 35
  • 78.27 (n)
lizard
(Anolis carolinensis)
Reptilia FAM63B 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63b 34
  • 73.2 (n)
zebrafish
(Danio rerio)
Actinopterygii fam63b 35
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 34 35
  • 49.04 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19273g 34
  • 47.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGL082W 34
  • 47.49 (n)
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 37
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL071C 34
  • 45.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 35
  • 52 (a)
OneToMany
Species where no ortholog for FAM63B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM63B Gene

ENSEMBL:
Gene Tree for FAM63B (if available)
TreeFam:
Gene Tree for FAM63B (if available)

Paralogs for FAM63B Gene

Paralogs for FAM63B Gene

(2) SIMAP similar genes for FAM63B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM63B: view

Variants for FAM63B Gene

Sequence variations from dbSNP and Humsavar for FAM63B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1047390 -- 58,771,652(-) TCAAG(C/T)CCAAA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1053420 -- 58,861,609(+) AAACT(A/G)CTTAA utr-variant-3-prime
rs1054991 -- 58,857,201(+) CAATT(A/G)TATTA utr-variant-3-prime
rs10563818 -- 58,853,842(+) AAAAA(-/A)GTCTG intron-variant
rs10699783 -- 58,824,792(+) GCCTC(-/CT)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM63B Gene

Variant ID Type Subtype PubMed ID
esv2656587 CNV deletion 23128226
esv2669121 CNV deletion 23128226
esv34110 CNV loss 18971310
esv3636631 CNV loss 21293372
esv3636632 CNV loss 21293372
esv3636633 CNV loss 21293372
nsv1035640 CNV gain 25217958
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv977719 CNV duplication 23825009

Variation tolerance for FAM63B Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM63B Gene

Human Gene Mutation Database (HGMD)
FAM63B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM63B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM63B Gene

Disorders for FAM63B Gene

Relevant External Links for FAM63B

Genetic Association Database (GAD)
FAM63B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM63B

No disorders were found for FAM63B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM63B Gene

Publications for FAM63B Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. (PMID: 27292798) Abdul Rehman S.A. … Kulathu Y. (Mol. Cell 2016) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Hypomethylation of FAM63B in bipolar disorder patients. (PMID: 27175219) Starnawska A. … Nyegaard M. (Clin Epigenetics 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FAM63B Gene

Sources for FAM63B Gene

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