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Aliases for FAM63A Gene

Aliases for FAM63A Gene

  • Family With Sequence Similarity 63 Member A 2 3 5
  • Deubiquitinating Enzyme MINDY-1 3 4
  • Protein FAM63A 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase MINDY-1 3
  • Family With Sequence Similarity 63, Member A 2
  • EC 3.4.19.12 4
  • KIAA1390 4
  • MINDY-1 3

External Ids for FAM63A Gene

Previous GeneCards Identifiers for FAM63A Gene

  • GC01M147782
  • GC01M149232
  • GC01M150965
  • GC01M122346

Summaries for FAM63A Gene

GeneCards Summary for FAM63A Gene

FAM63A (Family With Sequence Similarity 63 Member A) is a Protein Coding gene. An important paralog of this gene is FAM63B.

UniProtKB/Swiss-Prot for FAM63A Gene

  • Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM63A Gene

Genomics for FAM63A Gene

Regulatory Elements for FAM63A Gene

Enhancers for FAM63A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F151308 1.8 FANTOM5 Ensembl ENCODE 10.8 -303.6 -303559 6.1 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GABPB2 SETDB1 MRPL9 GOLPH3L ZNF687 PRPF3 ADAMTSL4 RFX5 VPS72 UBE2D3P3
GH01F150925 1.1 ENCODE 10.6 +82.1 82099 2.4 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 HORMAD1 UBE2D3P3 PRPF3 SETDB1 CTSK GOLPH3L GABPB2 SF3B4 VPS45 MRPL9
GH01F150484 0.9 Ensembl ENCODE 9.4 +523.4 523426 0.9 CTCF TAL1 REST RAD21 ARID1B JUND NCOR1 SMC3 HMBOX1 CUX1 ADAMTSL4 ECM1 LOC100289061 ADAMTSL4-AS1 PRPF3 APH1A C1orf54 CA14 UBE2D3P3 CTSK
GH01F150969 1.6 FANTOM5 ENCODE 5.1 +33.4 33421 10.6 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HORMAD1 ANXA9 GOLPH3L ARNT MCL1 GABPB2 MRPL9 CDC42SE1 ZNF687 CTSS
GH01F151099 0.7 ENCODE 10.9 -91.6 -91602 0.2 CTCF KLF1 ZNF654 TRIM22 ZNF384 REST RAD21 RFX5 ZNF664 SCRT2 TNFAIP8L2 SEMA6C GABPB2 FAM63A PRUNE1 TMOD4 SCNM1 LYSMD1 PIP5K1A VPS72
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM63A on UCSC Golden Path with GeneCards custom track

Promoters for FAM63A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001524686 -422 1601 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for FAM63A Gene

Chromosome:
1
Start:
150,996,086 bp from pter
End:
151,008,378 bp from pter
Size:
12,293 bases
Orientation:
Minus strand

Genomic View for FAM63A Gene

Genes around FAM63A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM63A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM63A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM63A Gene

Proteins for FAM63A Gene

  • Protein details for FAM63A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5J2-FA63A_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase MINDY-1
    Protein Accession:
    Q8N5J2
    Secondary Accessions:
    • B3KWP4
    • B3KWV8
    • B4DXF2
    • B4E1S4
    • D3DV09
    • J3KP53
    • Q5SZF0
    • Q9NUL9
    • Q9P2F7

    Protein attributes for FAM63A Gene

    Size:
    469 amino acids
    Molecular mass:
    51778 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAM63A Gene

    Alternative splice isoforms for FAM63A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM63A Gene

Post-translational modifications for FAM63A Gene

  • Ubiquitination at Lys 255
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM63A Gene

Domains & Families for FAM63A Gene

Protein Domains for FAM63A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM63A Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5J2

UniProtKB/Swiss-Prot:

FA63A_HUMAN :
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM63 subfamily.
genes like me logo Genes that share domains with FAM63A: view

No data available for Gene Families for FAM63A Gene

Function for FAM63A Gene

Molecular function for FAM63A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Enzyme Numbers (IUBMB) for FAM63A Gene

Gene Ontology (GO) - Molecular Function for FAM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with FAM63A: view
genes like me logo Genes that share phenotypes with FAM63A: view

Animal Models for FAM63A Gene

MGI Knock Outs for FAM63A:

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM63A Gene

Localization for FAM63A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM63A gene
Compartment Confidence
extracellular 5
nucleus 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM63A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM63A Gene

Pathways & Interactions for FAM63A Gene

SuperPathways for FAM63A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with FAM63A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM63A Gene

Transcripts for FAM63A Gene

Unigene Clusters for FAM63A Gene

Family with sequence similarity 63, member A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM63A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: - -
SP6: -
SP7:
SP8:

Relevant External Links for FAM63A Gene

GeneLoc Exon Structure for
FAM63A
ECgene alternative splicing isoforms for
FAM63A

Expression for FAM63A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM63A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM63A Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for FAM63A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.3), Platelet (15.6), and Spinal cord (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM63A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM63A Gene:

FAM63A

SOURCE GeneReport for Unigene cluster for FAM63A Gene:

Hs.743952
genes like me logo Genes that share expression patterns with FAM63A: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM63A Gene

Orthologs for FAM63A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM63A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM63A 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia FAM63A 34 35
  • 87.73 (n)
cow
(Bos Taurus)
Mammalia FAM63A 34 35
  • 85.65 (n)
mouse
(Mus musculus)
Mammalia Fam63a 34 16 35
  • 84.01 (n)
rat
(Rattus norvegicus)
Mammalia Fam63a 34
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM63A 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100857795 34
  • 73.25 (n)
FAM63A 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM63A 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63a 34
  • 69.21 (n)
zebrafish
(Danio rerio)
Actinopterygii fam63a 34 35
  • 66.07 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.877 34
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 25 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 37
rice
(Oryza sativa)
Liliopsida Os.20605 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 35
  • 49 (a)
OneToMany
Species where no ortholog for FAM63A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM63A Gene

ENSEMBL:
Gene Tree for FAM63A (if available)
TreeFam:
Gene Tree for FAM63A (if available)

Paralogs for FAM63A Gene

Paralogs for FAM63A Gene

(1) SIMAP similar genes for FAM63A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM63A: view

Variants for FAM63A Gene

Sequence variations from dbSNP and Humsavar for FAM63A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111232945 -- 151,008,725(+) GAAGG(A/T)CGAAG intron-variant, upstream-variant-2KB
rs111348012 -- 151,007,474(+) ACTCC(A/G)GCCTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111360728 -- 151,003,648(+) CCAAG(A/C)AATCC intron-variant
rs111584878 -- 150,998,768(+) GTGGC(A/T)TGGAG intron-variant
rs111642464 -- 151,001,737(+) GGCCA(A/C/T)GAGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM63A Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV gain 19592680
nsv522317 CNV loss 19592680
nsv1008496 CNV gain 25217958

Variation tolerance for FAM63A Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM63A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM63A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM63A Gene

Disorders for FAM63A Gene

Relevant External Links for FAM63A

Genetic Association Database (GAD)
FAM63A
Human Genome Epidemiology (HuGE) Navigator
FAM63A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM63A

No disorders were found for FAM63A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM63A Gene

Publications for FAM63A Gene

  1. MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. (PMID: 27292798) Abdul Rehman S.A. … Kulathu Y. (Mol. Cell 2016) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FAM63A Gene

Sources for FAM63A Gene

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