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Aliases for FAM63A Gene

Aliases for FAM63A Gene

  • Family With Sequence Similarity 63, Member A 2 3
  • KIAA1390 4

External Ids for FAM63A Gene

Previous GeneCards Identifiers for FAM63A Gene

  • GC01M147782
  • GC01M149232
  • GC01M150965
  • GC01M122346

Summaries for FAM63A Gene

GeneCards Summary for FAM63A Gene

FAM63A (Family With Sequence Similarity 63, Member A) is a Protein Coding gene. An important paralog of this gene is FAM63B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM63A Gene

Genomics for FAM63A Gene

Regulatory Elements for FAM63A Gene

Genomic Location for FAM63A Gene

Chromosome:
1
Start:
150,996,086 bp from pter
End:
151,008,378 bp from pter
Size:
12,293 bases
Orientation:
Minus strand

Genomic View for FAM63A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM63A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM63A Gene

Proteins for FAM63A Gene

  • Protein details for FAM63A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5J2-FA63A_HUMAN
    Recommended name:
    Protein FAM63A
    Protein Accession:
    Q8N5J2
    Secondary Accessions:
    • B3KWP4
    • B3KWV8
    • B4DXF2
    • B4E1S4
    • D3DV09
    • J3KP53
    • Q5SZF0
    • Q9NUL9
    • Q9P2F7

    Protein attributes for FAM63A Gene

    Size:
    469 amino acids
    Molecular mass:
    51778 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM63A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM63A Gene

Proteomics data for FAM63A Gene at MOPED

Post-translational modifications for FAM63A Gene

  • Ubiquitination at Lys 255
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM63A Gene

Domains & Families for FAM63A Gene

Protein Domains for FAM63A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM63A Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5J2

UniProtKB/Swiss-Prot:

FA63A_HUMAN :
  • Belongs to the FAM63 family.
Family:
  • Belongs to the FAM63 family.
genes like me logo Genes that share domains with FAM63A: view

No data available for Gene Families for FAM63A Gene

Function for FAM63A Gene

Gene Ontology (GO) - Molecular Function for FAM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM63A: view
genes like me logo Genes that share phenotypes with FAM63A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM63A Gene

Localization for FAM63A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM63A Gene COMPARTMENTS Subcellular localization image for FAM63A gene
Compartment Confidence
extracellular 5
nucleus 4

Gene Ontology (GO) - Cellular Components for FAM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM63A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM63A Gene

Pathways & Interactions for FAM63A Gene

SuperPathways for FAM63A Gene

No Data Available

Interacting Proteins for FAM63A Gene

Gene Ontology (GO) - Biological Process for FAM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM63A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM63A Gene

Drugs & Compounds for FAM63A Gene

No Compound Related Data Available

Transcripts for FAM63A Gene

Unigene Clusters for FAM63A Gene

Family with sequence similarity 63, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM63A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM63A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: - -
SP6: -
SP7:
SP8:

Relevant External Links for FAM63A Gene

GeneLoc Exon Structure for
FAM63A
ECgene alternative splicing isoforms for
FAM63A

Expression for FAM63A Gene

mRNA expression in normal human tissues for FAM63A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM63A Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for FAM63A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.3), Platelet (15.6), and Spinal cord (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM63A Gene



SOURCE GeneReport for Unigene cluster for FAM63A Gene Hs.743952

genes like me logo Genes that share expression patterns with FAM63A: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM63A Gene

Orthologs for FAM63A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM63A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM63A 35
  • 85.65 (n)
  • 85.87 (a)
FAM63A 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM63A 35
  • 87.73 (n)
  • 85.28 (a)
FAM63A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam63a 35
  • 84.01 (n)
  • 86.51 (a)
Fam63a 16
Fam63a 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM63A 35
  • 99.42 (n)
  • 98.84 (a)
FAM63A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam63a 35
  • 83.65 (n)
  • 84.58 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM63A 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100857795 35
  • 73.25 (n)
  • 77.5 (a)
FAM63A 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM63A 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam63a 35
  • 69.21 (n)
  • 72.24 (a)
zebrafish
(Danio rerio)
Actinopterygii fam63a 35
  • 66.07 (n)
  • 66.16 (a)
fam63a 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.877 35
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.9 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 22 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 38
rice
(Oryza sativa)
Liliopsida Os.20605 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1538 36
  • 49 (a)
OneToMany
Species with no ortholog for FAM63A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM63A Gene

ENSEMBL:
Gene Tree for FAM63A (if available)
TreeFam:
Gene Tree for FAM63A (if available)

Paralogs for FAM63A Gene

Paralogs for FAM63A Gene

(1) SIMAP similar genes for FAM63A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM63A: view

Variants for FAM63A Gene

Sequence variations from dbSNP and Humsavar for FAM63A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs708909 -- 151,000,062(+) ACCCT(A/G)TGATG intron-variant
rs771202 -- 150,997,091(+) CCTGG(A/G)TGGGA utr-variant-3-prime
rs771203 -- 151,001,038(+) CTCCC(A/G)CTTTG intron-variant
rs771204 -- 151,001,686(+) CTGGA(A/G)CCCCT intron-variant
rs771205 -- 151,002,632(+) GGACT(C/T)GGCTG intron-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM63A Gene

Variant ID Type Subtype PubMed ID
nsv522317 CNV Loss 19592680
nsv522840 CNV Gain 19592680

Variation tolerance for FAM63A Gene

Residual Variation Intolerance Score: 72.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM63A Gene

HapMap Linkage Disequilibrium report
FAM63A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM63A Gene

Disorders for FAM63A Gene

Relevant External Links for FAM63A

Genetic Association Database (GAD)
FAM63A
Human Genome Epidemiology (HuGE) Navigator
FAM63A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM63A
genes like me logo Genes that share disorders with FAM63A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM63A Gene

Publications for FAM63A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PMID: 23585552) Kirin M. … Mitry D. (Hum. Mol. Genet. 2013) 67

Products for FAM63A Gene

Sources for FAM63A Gene

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