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Aliases for FAM60A Gene

Aliases for FAM60A Gene

  • Family With Sequence Similarity 60 Member A 2 3 5
  • Family With Sequence Similarity 60, Member A 2 3
  • Tera Protein Homolog 3 4
  • C12orf14 3 4
  • Chromosome 12 Open Reading Frame 14 2
  • TERA 3
  • L4 3

External Ids for FAM60A Gene

Previous HGNC Symbols for FAM60A Gene

  • C12orf14

Previous GeneCards Identifiers for FAM60A Gene

  • GC12M031325
  • GC12M031433
  • GC12M031186

Summaries for FAM60A Gene

GeneCards Summary for FAM60A Gene

FAM60A (Family With Sequence Similarity 60 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM60A Gene

  • Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.

Gene Wiki entry for FAM60A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM60A Gene

Genomics for FAM60A Gene

Regulatory Elements for FAM60A Gene

Enhancers for FAM60A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM60A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FAM60A gene promoter:

Genomic Location for FAM60A Gene

31,280,422 bp from pter
31,327,058 bp from pter
46,637 bases
Minus strand

Genomic View for FAM60A Gene

Genes around FAM60A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM60A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM60A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM60A Gene

Proteins for FAM60A Gene

  • Protein details for FAM60A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM60A
    Protein Accession:
    Secondary Accessions:
    • D3DUV8
    • Q9BSZ8

    Protein attributes for FAM60A Gene

    221 amino acids
    Molecular mass:
    24852 Da
    Quaternary structure:
    • Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1.

    Alternative splice isoforms for FAM60A Gene


neXtProt entry for FAM60A Gene

Proteomics data for FAM60A Gene at MOPED

Post-translational modifications for FAM60A Gene

  • Ubiquitination at Lys 168, Lys 171, Lys 179, and Lys 200
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM60A Gene

Domains & Families for FAM60A Gene

Protein Domains for FAM60A Gene


Suggested Antigen Peptide Sequences for FAM60A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM60 family.
  • Belongs to the FAM60 family.
genes like me logo Genes that share domains with FAM60A: view

No data available for Gene Families for FAM60A Gene

Function for FAM60A Gene

Molecular function for FAM60A Gene

UniProtKB/Swiss-Prot Function:
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.
UniProtKB/Swiss-Prot Induction:
Peaks during G1 and S phases of the cell cycle in U2OS cells. Up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors.
genes like me logo Genes that share phenotypes with FAM60A: view

Animal Model Products

miRNA for FAM60A Gene

miRTarBase miRNAs that target FAM60A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM60A Gene

Localization for FAM60A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM60A Gene

Subcellular locations from

Jensen Localization Image for FAM60A Gene COMPARTMENTS Subcellular localization image for FAM60A gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for FAM60A Gene

Pathways & Interactions for FAM60A Gene

SuperPathways for FAM60A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM60A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM60A Gene

Drugs & Compounds for FAM60A Gene

No Compound Related Data Available

Transcripts for FAM60A Gene

Unigene Clusters for FAM60A Gene

Family with sequence similarity 60, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM60A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - - -
SP3: - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for FAM60A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM60A Gene

mRNA expression in normal human tissues for FAM60A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM60A Gene

SOURCE GeneReport for Unigene cluster for FAM60A Gene Hs.505154

genes like me logo Genes that share expression patterns with FAM60A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM60A Gene

Orthologs for FAM60A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM60A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM60A 35
  • 95.32 (n)
  • 100 (a)
FAM60A 36
  • 100 (a)
(Canis familiaris)
Mammalia FAM60A 35
  • 96.08 (n)
  • 100 (a)
FAM60A 36
  • 97 (a)
(Mus musculus)
Mammalia Fam60a 35
  • 92.61 (n)
  • 97.74 (a)
Fam60a 16
Fam60a 36
  • 98 (a)
(Pan troglodytes)
Mammalia FAM60A 35
  • 99.7 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam60a 35
  • 90.5 (n)
  • 96.83 (a)
(Monodelphis domestica)
Mammalia FAM60A 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia FAM60A 36
  • 62 (a)
(Gallus gallus)
Aves FAM60A 35
  • 83.64 (n)
  • 91.82 (a)
FAM60A 36
  • 79 (a)
(Anolis carolinensis)
Reptilia FAM60A 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497969 35
  • 66.19 (n)
  • 63.51 (a)
Str.11785 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6697 35
(Danio rerio)
Actinopterygii fam60a 35
  • 73.78 (n)
  • 80.57 (a)
zgc66459 35
fam60a 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4068 36
  • 16 (a)
Species with no ortholog for FAM60A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM60A Gene

Gene Tree for FAM60A (if available)
Gene Tree for FAM60A (if available)

Paralogs for FAM60A Gene

genes like me logo Genes that share paralogs with FAM60A: view

No data available for Paralogs for FAM60A Gene

Variants for FAM60A Gene

Sequence variations from dbSNP and Humsavar for FAM60A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2304459 - 31,293,810(+) TATGA(C/T)GTTTA reference, missense
rs1992066 -- 31,297,289(+) tagct(A/T)ggact intron-variant
rs1992067 -- 31,297,619(+) AAGTG(C/T)GCACC intron-variant
rs7133432 -- 31,311,959(+) GGTGC(A/C)CCTGA intron-variant
rs7136605 -- 31,308,988(+) ccagg(G/T)gtggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM60A Gene

Variant ID Type Subtype PubMed ID
esv2422447 CNV Duplication 17116639
dgv489e1 CNV Complex 17122850
nsv428276 CNV Gain 18775914
esv2751043 CNV Gain 17911159
esv2751046 CNV Gain 17911159
nsv515974 CNV Gain+Loss 19592680
dgv63e55 CNV Gain 17911159
dgv490e1 CNV Complex 17122850
dgv493e1 CNV Complex 17122850
nsv524737 CNV Gain 19592680
nsv832364 CNV Loss 17160897
nsv661 CNV Insertion 18451855

Variation tolerance for FAM60A Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM60A Gene

Disorders for FAM60A Gene

Relevant External Links for FAM60A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM60A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM60A Gene

Publications for FAM60A Gene

  1. Family with sequence similarity 60A (FAM60A) protein is a cell cycle- fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. (PMID: 22865885) Munoz I.M. … Rouse J. (J. Biol. Chem. 2012) 2 3 4 67
  2. Functional characterization of the human FAM60A protein: a new subunit of the Sin3 deacetylase complex. (PMID: 22984288) Smith K.T. … Workman J.L. (Mol. Cell. Proteomics 2012) 2 3
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for FAM60A Gene

Sources for FAM60A Gene