Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM60A Gene

Aliases for FAM60A Gene

  • Family With Sequence Similarity 60 Member A 2 3 5
  • Tera Protein Homolog 3 4
  • C12orf14 3 4
  • Family With Sequence Similarity 60, Member A 2
  • Chromosome 12 Open Reading Frame 14 2
  • Protein FAM60A 3
  • TERA 3
  • L4 3

External Ids for FAM60A Gene

Previous HGNC Symbols for FAM60A Gene

  • C12orf14

Previous GeneCards Identifiers for FAM60A Gene

  • GC12M031325
  • GC12M031433
  • GC12M031186

Summaries for FAM60A Gene

GeneCards Summary for FAM60A Gene

FAM60A (Family With Sequence Similarity 60 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM60A Gene

  • Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.

Gene Wiki entry for FAM60A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM60A Gene

Genomics for FAM60A Gene

Regulatory Elements for FAM60A Gene

Enhancers for FAM60A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G031361 1.4 Ensembl ENCODE dbSUPER 18.6 -36.0 -35981 2.4 HDGF PKNOX1 ATF1 FOXA2 WRNIP1 ARID4B ZNF48 ZNF121 GLIS2 SP5 FAM60A RNU6-618P FLJ13224 AK4P3 DDX11 DENND5B ENSG00000283256 GC12P031343
GH12G031730 1.4 ENCODE dbSUPER 14.1 -406.1 -406078 5.0 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF207 FOS KLF13 FAM60A FLJ13224 BICD1 AMN1 GC12M031770
GH12G031121 1 Ensembl ENCODE 18.9 +208.5 208540 0.6 ATF1 ZNF792 ZIC2 ZEB1 HIC1 ZFHX2 GLIS2 PATZ1 ZNF600 PRDM10 FAM60A FLJ13224 IPO8 DDX11 GC12P031123 PIR58939 LOC101060058
GH12G031714 1.8 VISTA Ensembl ENCODE dbSUPER 9.8 -388.6 -388644 3.0 HDGF PKNOX1 FOXA2 ARNT YY1 ZNF766 CBX5 ZNF207 FOS ZHX2 H3F3C FLJ13224 KIAA1551 FAM60A GC12P031714 STMN1P1
GH12G031316 1.7 Ensembl ENCODE dbSUPER 10.1 +5.0 5003 10.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 SIN3A ARID4B DMAP1 FLJ13224 H3F3C IPO8 FAM60A KIAA1551 DENND5B DENND5B-AS1 RNU5F-4P ENSG00000256176
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM60A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FAM60A gene promoter:

Genomic Location for FAM60A Gene

Chromosome:
12
Start:
31,280,422 bp from pter
End:
31,327,058 bp from pter
Size:
46,637 bases
Orientation:
Minus strand

Genomic View for FAM60A Gene

Genes around FAM60A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM60A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM60A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM60A Gene

Proteins for FAM60A Gene

  • Protein details for FAM60A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP50-FA60A_HUMAN
    Recommended name:
    Protein FAM60A
    Protein Accession:
    Q9NP50
    Secondary Accessions:
    • D3DUV8
    • Q9BSZ8

    Protein attributes for FAM60A Gene

    Size:
    221 amino acids
    Molecular mass:
    24852 Da
    Quaternary structure:
    • Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1.

    Alternative splice isoforms for FAM60A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM60A Gene

Post-translational modifications for FAM60A Gene

  • Ubiquitination at Lys168, isoforms=2171, isoforms=2179, and isoforms=2200
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM60A Gene

Domains & Families for FAM60A Gene

Protein Domains for FAM60A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM60A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP50

UniProtKB/Swiss-Prot:

FA60A_HUMAN :
  • Belongs to the FAM60 family.
Family:
  • Belongs to the FAM60 family.
genes like me logo Genes that share domains with FAM60A: view

No data available for Gene Families for FAM60A Gene

Function for FAM60A Gene

Molecular function for FAM60A Gene

UniProtKB/Swiss-Prot Function:
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.
UniProtKB/Swiss-Prot Induction:
Peaks during G1 and S phases of the cell cycle in U2OS cells. Up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors.

Gene Ontology (GO) - Molecular Function for FAM60A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23752268
genes like me logo Genes that share ontologies with FAM60A: view
genes like me logo Genes that share phenotypes with FAM60A: view

Animal Model Products

CRISPR Products

miRNA for FAM60A Gene

miRTarBase miRNAs that target FAM60A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM60A Gene

Localization for FAM60A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM60A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM60A gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM60A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016580 Sin3 complex IDA 22984288
genes like me logo Genes that share ontologies with FAM60A: view

Pathways & Interactions for FAM60A Gene

SuperPathways for FAM60A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM60A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030336 negative regulation of cell migration IMP 22984288
genes like me logo Genes that share ontologies with FAM60A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM60A Gene

Drugs & Compounds for FAM60A Gene

No Compound Related Data Available

Transcripts for FAM60A Gene

Unigene Clusters for FAM60A Gene

Family with sequence similarity 60, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM60A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for FAM60A Gene

GeneLoc Exon Structure for
FAM60A
ECgene alternative splicing isoforms for
FAM60A

Expression for FAM60A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM60A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM60A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM60A Gene:

FAM60A

SOURCE GeneReport for Unigene cluster for FAM60A Gene:

Hs.505154

Evidence on tissue expression from TISSUES for FAM60A Gene

  • Lung(4.6)
  • Bone marrow(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with FAM60A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM60A Gene

Orthologs for FAM60A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM60A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM60A 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia FAM60A 34 35
  • 96.08 (n)
cow
(Bos Taurus)
Mammalia FAM60A 34 35
  • 95.32 (n)
mouse
(Mus musculus)
Mammalia Fam60a 34 16 35
  • 92.61 (n)
rat
(Rattus norvegicus)
Mammalia Fam60a 34
  • 90.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM60A 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM60A 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM60A 34 35
  • 83.64 (n)
lizard
(Anolis carolinensis)
Reptilia FAM60A 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497969 34
  • 66.19 (n)
Str.11785 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6697 34
zebrafish
(Danio rerio)
Actinopterygii fam60a 34 35
  • 73.78 (n)
zgc66459 34
fruit fly
(Drosophila melanogaster)
Insecta CG4068 35
  • 16 (a)
OneToOne
Species where no ortholog for FAM60A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM60A Gene

ENSEMBL:
Gene Tree for FAM60A (if available)
TreeFam:
Gene Tree for FAM60A (if available)

Paralogs for FAM60A Gene

genes like me logo Genes that share paralogs with FAM60A: view

No data available for Paralogs for FAM60A Gene

Variants for FAM60A Gene

Sequence variations from dbSNP and Humsavar for FAM60A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000025004 -- 31,296,187(+) GGTGA(A/G)CAGGA intron-variant
rs1000163207 -- 31,310,976(+) GCAAT(A/T)CTCCT intron-variant
rs1000200274 -- 31,280,324(+) ATGCC(C/T)ATAGA downstream-variant-500B
rs1000228297 -- 31,302,398(+) ATATT(A/T)AAAAA intron-variant
rs1000272261 -- 31,282,924(+) AGGAA(C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM60A Gene

Variant ID Type Subtype PubMed ID
dgv63e55 CNV gain 17911159
esv2422447 CNV duplication 17116639
esv2751043 CNV gain 17911159
esv2751046 CNV gain 17911159
esv2759890 CNV gain+loss 17122850
nsv1045497 CNV gain 25217958
nsv428276 CNV gain 18775914
nsv515974 CNV gain+loss 19592680
nsv524737 CNV gain 19592680
nsv661 CNV insertion 18451855
nsv832364 CNV loss 17160897
nsv973050 CNV duplication 23825009

Variation tolerance for FAM60A Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM60A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM60A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM60A Gene

Disorders for FAM60A Gene

Relevant External Links for FAM60A

Genetic Association Database (GAD)
FAM60A
Human Genome Epidemiology (HuGE) Navigator
FAM60A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM60A

No disorders were found for FAM60A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM60A Gene

Publications for FAM60A Gene

  1. Family with sequence similarity 60A (FAM60A) protein is a cell cycle- fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. (PMID: 22865885) Munoz I.M. … Rouse J. (J. Biol. Chem. 2012) 2 3 4 64
  2. Functional characterization of the human FAM60A protein: a new subunit of the Sin3 deacetylase complex. (PMID: 22984288) Smith K.T. … Workman J.L. (Mol. Cell. Proteomics 2012) 2 3 4 64
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4 64

Products for FAM60A Gene

Sources for FAM60A Gene

Content
Loading form....