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Aliases for FAM60A Gene

Aliases for FAM60A Gene

  • Family With Sequence Similarity 60, Member A 2 3
  • Tera Protein Homolog 3 4
  • C12orf14 3 4
  • Chromosome 12 Open Reading Frame 14 2
  • Protein FAM60A 3
  • TERA 3
  • L4 3

External Ids for FAM60A Gene

Previous HGNC Symbols for FAM60A Gene

  • C12orf14

Previous GeneCards Identifiers for FAM60A Gene

  • GC12M031325
  • GC12M031433
  • GC12M031186

Summaries for FAM60A Gene

GeneCards Summary for FAM60A Gene

FAM60A (Family With Sequence Similarity 60, Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM60A Gene

  • Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.

Gene Wiki entry for FAM60A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM60A Gene

Genomics for FAM60A Gene

Regulatory Elements for FAM60A Gene

Transcription factor binding sites by QIAGEN in the FAM60A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM60A Gene

Start:
31,280,422 bp from pter
End:
31,327,058 bp from pter
Size:
46,637 bases
Orientation:
Minus strand

Genomic View for FAM60A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM60A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM60A Gene

Proteins for FAM60A Gene

  • Protein details for FAM60A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP50-FA60A_HUMAN
    Recommended name:
    Protein FAM60A
    Protein Accession:
    Q9NP50
    Secondary Accessions:
    • D3DUV8
    • Q9BSZ8

    Protein attributes for FAM60A Gene

    Size:
    221 amino acids
    Molecular mass:
    24852 Da
    Quaternary structure:
    • Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1.

    Alternative splice isoforms for FAM60A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM60A Gene

Proteomics data for FAM60A Gene at MOPED

Post-translational modifications for FAM60A Gene

  • Ubiquitination at Lys168, Lys171, Lys179, and Lys200
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM60A Gene

Domains for FAM60A Gene

Protein Domains for FAM60A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM60A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP50

UniProtKB/Swiss-Prot:

FA60A_HUMAN :
  • Q9NP50
Family:
  • Belongs to the FAM60 family.
genes like me logo Genes that share domains with FAM60A: view

No data available for Gene Families for FAM60A Gene

Function for FAM60A Gene

Molecular function for FAM60A Gene

UniProtKB/Swiss-Prot Function: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.
UniProtKB/Swiss-Prot Induction: Peaks during G1 and S phases of the cell cycle in U2OS cells. Up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors.

Gene Ontology (GO) - Molecular Function for FAM60A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23752268
genes like me logo Genes that share ontologies with FAM60A: view

Phenotypes for FAM60A Gene

genes like me logo Genes that share phenotypes with FAM60A: view

Animal Model Products

CRISPR Products

miRNA for FAM60A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM60A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM60A Gene

Localization for FAM60A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM60A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM60A Gene COMPARTMENTS Subcellular localization image for FAM60A gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM60A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016580 Sin3 complex IDA 22984288
genes like me logo Genes that share ontologies with FAM60A: view

Pathways for FAM60A Gene

SuperPathways for FAM60A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM60A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030336 negative regulation of cell migration IMP 22984288
genes like me logo Genes that share ontologies with FAM60A: view

No data available for Pathways by source for FAM60A Gene

Transcripts for FAM60A Gene

Unigene Clusters for FAM60A Gene

Family with sequence similarity 60, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM60A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM60A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for FAM60A Gene

GeneLoc Exon Structure for
FAM60A
ECgene alternative splicing isoforms for
FAM60A

Expression for FAM60A Gene

mRNA expression in normal human tissues for FAM60A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM60A Gene

SOURCE GeneReport for Unigene cluster for FAM60A Gene Hs.505154

genes like me logo Genes that share expressions with FAM60A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM60A Gene

Orthologs for FAM60A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM60A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM60A 35
  • 99.7 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FAM60A 35
  • 95.32 (n)
  • 100 (a)
FAM60A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM60A 35
  • 96.08 (n)
  • 100 (a)
FAM60A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam60a 35
  • 92.61 (n)
  • 97.74 (a)
Fam60a 16
Fam60a 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM60A 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM60A 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam60a 35
  • 90.5 (n)
  • 96.83 (a)
chicken
(Gallus gallus)
Aves FAM60A 35
  • 83.64 (n)
  • 91.82 (a)
FAM60A 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM60A 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6697 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497969 35
  • 66.19 (n)
  • 63.51 (a)
Str.11785 35
zebrafish
(Danio rerio)
Actinopterygii fam60a 35
  • 73.78 (n)
  • 80.57 (a)
fam60a 36
  • 70 (a)
OneToOne
zgc66459 35
fruit fly
(Drosophila melanogaster)
Insecta CG4068 36
  • 16 (a)
OneToOne
Species with no ortholog for FAM60A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM60A Gene

ENSEMBL:
Gene Tree for FAM60A (if available)
TreeFam:
Gene Tree for FAM60A (if available)

Paralogs for FAM60A Gene

genes like me logo Genes that share paralogs with FAM60A: view

No data available for Paralogs for FAM60A Gene

Variants for FAM60A Gene

Sequence variations from dbSNP and Humsavar for FAM60A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs607205 -- 31,302,583(+) TCCAA(C/T)AGGTT intron-variant
rs1150962 -- 31,285,935(+) acacc(A/C)ctgca intron-variant
rs1258712 -- 31,313,616(-) TACAC(A/C)CAGAT intron-variant
rs1873676 -- 31,310,939(-) TGAGC(G/T)GAGAT intron-variant
rs1992066 -- 31,297,289(+) tagct(A/T)ggact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM60A Gene

Variant ID Type Subtype PubMed ID
esv2422447 CNV Duplication 17116639
dgv489e1 CNV Complex 17122850
nsv428276 CNV Gain 18775914
esv2751043 CNV Gain 17911159
esv2751046 CNV Gain 17911159
nsv515974 CNV Gain+Loss 19592680
dgv63e55 CNV Gain 17911159
dgv490e1 CNV Complex 17122850
dgv493e1 CNV Complex 17122850
nsv524737 CNV Gain 19592680
nsv832364 CNV Loss 17160897
nsv661 CNV Insertion 18451855

Relevant External Links for FAM60A Gene

HapMap Linkage Disequilibrium report
FAM60A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM60A Gene

Disorders for FAM60A Gene

Relevant External Links for FAM60A

Genetic Association Database (GAD)
FAM60A
Human Genome Epidemiology (HuGE) Navigator
FAM60A
genes like me logo Genes that share disorders with FAM60A: view

No data available for UniProtKB/Swiss-Prot for FAM60A Gene

Publications for FAM60A Gene

  1. Family with sequence similarity 60A (FAM60A) protein is a cell cycle- fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. (PMID: 22865885) Munoz I.M. … Rouse J. (J. Biol. Chem. 2012) 2 3 4
  2. Functional characterization of the human FAM60A protein: a new subunit of the Sin3 deacetylase complex. (PMID: 22984288) Smith K.T. … Workman J.L. (Mol. Cell. Proteomics 2012) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4

Products for FAM60A Gene

Sources for FAM60A Gene

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