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FAM60A Gene

protein-coding   GIFtS: 50
GCID: GC12M031433

Family With Sequence Similarity 60, Member A

(Previous name: chromosome 12 open reading frame 14)
(Previous symbol: C12orf14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 60, Member A1 2
C12orf141 2 3
Tera Protein Homolog2 3
Chromosome 12 Open Reading Frame 141
TERA2
Protein FAM60A2

External Ids:    HGNC: 307021   Entrez Gene: 585162   Ensembl: ENSG000001391467   OMIM: 6150275   UniProtKB: Q9NP503   

Export aliases for FAM60A gene to outside databases

Previous GC identifers: GC12M031325 GC12M031186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM60A Gene:
FAM60A (family with sequence similarity 60, member A) is a protein-coding gene.

UniProtKB/Swiss-Prot: FA60A_HUMAN, Q9NP50
Function: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of
genes encoding components of the TGF-beta signaling pathway

Gene Wiki entry for FAM60A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NT_187587.1  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM60A gene promoter:
         Elk-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM60A promoter sequence
   Search Chromatin IP Primers for FAM60A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM60A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

FAM60A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM60A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M031433:  view genomic region     (about GC identifiers)

Start:
31,433,518 bp from pter      End:
31,479,992 bp from pter
Size:
46,475 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA60A_HUMAN, Q9NP50 (See protein sequence)
Recommended Name: Protein FAM60A  
Size: 221 amino acids; 24852 Da
Subunit: Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L
and HDAC1
Secondary accessions: D3DUV8 Q9BSZ8
Alternative splicing: 2 isoforms:  Q9NP50-1   Q9NP50-2   

Explore the universe of human proteins at neXtProt for FAM60A: NX_Q9NP50

Explore proteomics data for FAM60A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys168, Lys171, Lys179, Lys200
  • Modification sites at PhosphoSitePlus

  • See FAM60A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129283.1  NP_001129284.1  NP_067061.1  

    ENSEMBL proteins: 
     ENSP00000443697   ENSP00000337477   ENSP00000393279   ENSP00000443087   ENSP00000439952  
     ENSP00000443881   ENSP00000437363   ENSP00000379115  

    FAM60A Human Recombinant Protein Products:

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    Novus Biologicals FAM60A Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FAM60A

     
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    FAM60A Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026065 FAM60A

    Graphical View of Domain Structure for InterPro Entry Q9NP50

    ProtoNet protein and cluster: Q9NP50

    UniProtKB/Swiss-Prot: FA60A_HUMAN, Q9NP50
    Similarity: Belongs to the FAM60 family


    Find genes that share domains with FAM60A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA60A_HUMAN, Q9NP50
    Function: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of
    genes encoding components of the TGF-beta signaling pathway
    Induction: Peaks during G1 and S phases of the cell cycle in U2OS cells. Up-regulated in squamous cell carcinoma
    (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FAM60A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FAM60A:
     Decreased viability of wild-ty  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM60A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM60A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM60A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM60A

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM60A:
    hsa-mir-30d-5p (MIRT047776), hsa-mir-193b-3p (MIRT041352), hsa-mir-125b-5p (MIRT046021), hsa-mir-320a (MIRT044476), hsa-mir-98-5p (MIRT027679)

    Block miRNA regulation of human, mouse, rat FAM60A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM60A (see all 92):
    hsa-miR-640 hsa-miR-1321 hsa-miR-3194-5p hsa-miR-4272 hsa-miR-106a hsa-miR-199a-3p hsa-miR-15a hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM60A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM60A

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    Sino Biological Human cDNA Clone for FAM60A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM60A

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM60A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA60A_HUMAN, Q9NP50: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016580Sin3 complex IDA--

    Find genes that share ontologies with FAM60A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM60A
    Interactions:

        Search GeneGlobe Interaction Network for FAM60A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for FAM60A (Q9NP501, 2, 3 ENSP000003374774) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTPBP3Q969Y23, ENSP000003516444I2D: score=5 STRING: ENSP00000351644
    NMIQ132873I2D: score=1 
    HDAC1Q135471EBI-741906,EBI-301834
    PSMC2ENSP000002926444STRING: ENSP00000292644
    NDRG1ENSP000003199774STRING: ENSP00000319977
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030336negative regulation of cell migration IMP--

    Find genes that share ontologies with FAM60A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM60A (FA60A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM60A gene (3 alternative transcripts): 
    NM_001135811.1  NM_001135812.1  NM_021238.2  

    Unigene Cluster for FAM60A:

    Family with sequence similarity 60, member A
    Hs.505154  [show with all ESTs]
    Unigene Representative Sequence: NM_001135811
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448582(uc001rkc.3 uc010sjz.2) ENST00000539409 ENST00000337682(uc001rkd.3 uc010ska.2 uc001rke.3 uc010skb.2)
    ENST00000454658 ENST00000544921 ENST00000542983 ENST00000539004 ENST00000543615
    ENST00000536836 ENST00000395766
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM60A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM60A (see all 92):
    hsa-miR-640 hsa-miR-1321 hsa-miR-3194-5p hsa-miR-4272 hsa-miR-106a hsa-miR-199a-3p hsa-miR-15a hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM60A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM60A
    Clone
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    OriGene clones in human, mouse for FAM60A (see all 19)
    OriGene ORF clones in mouse, rat for FAM60A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAM60A (NM_001135811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM60A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM60A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM60A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM60A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM60A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM60A
      QuantiFast Probe-based Assays in human, mouse, rat FAM60A

    Additional mRNA sequence: 

    AF087885.1 AF212220.1 AK026932.1 AK027736.1 AK294457.1 AL157432.1 AY598323.1 BC000024.2 
    BC004462.1 BC071966.1 BX648630.1 

    Selected DOTS entries (see all 25):

    DT.117854  DT.100794304  DT.100673572  DT.100808260  DT.121126837  DT.100649258  DT.121126873  DT.95250842 
    DT.100794293  DT.121126879  DT.121126852  DT.121126816  DT.121126844  DT.75174382  DT.92448549  DT.100037389 
    DT.102843026  DT.121126853  DT.121077379  DT.121126817  DT.121126827  DT.121126836  DT.121126880  DT.85104497 

    Selected AceView cDNA sequences (see all 431):

    AY598323 AA147005 AW664891 BU170034 AI081326 BQ694160 BM461580 AK026932 
    AI886505 AW236963 BQ898350 BM509946 BM725339 BM472026 AI632849 AI611622 
    AA662918 BF446740 AA196525 AA976540 CK903854 AI493532 AA262652 BQ186363 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM60A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                      -                                       
    SP2:                          -     -     -                                       
    SP3:                          -           -                                       
    SP4:                                                                              
    SP5:                                -     -                                       


    ECgene alternative splicing isoforms for FAM60A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM60A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTTGTAT
    FAM60A Expression
    About this image

    FAM60A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM60A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505154
        Custom PCR Arrays for FAM60A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM60A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM60A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam60a1 , 5 family with sequence similarity 60, member A1, 5 92.61(n)1
    97.74(a)1
      6 (78.67 cM)5
    563061  NM_019643.31  NP_062617.21 
     1489210355 
    chicken
    (Gallus gallus)
    Aves FAM60A1 family with sequence similarity 60, member A 83.64(n)
    91.82(a)
      418140  NM_001030766.1  NP_001025937.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM60A6
    family with sequence similarity 60, member A
    89(a)
    1 ↔ 1
    5(10800643-10816706)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66972 Xenopus laevis transcribed sequence with weak similarity more 77.84(n)    BU901149.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc664592 zgc66459 76.82(n)   386721  BC055529.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40686
    --
    16(a)
    1 ↔ 1
    X(4820697-4832133)


    ENSEMBL Gene Tree for FAM60A (if available)
    TreeFam Gene Tree for FAM60A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM60A gene

    Find genes that share paralogs with FAM60A           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for FAM60A
    PGOHUM00000262878 PGOHUM00000262879 PGOHUM00000234904 PGOHUM00000234941 PGOHUM00000249270


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM60A (see all 901)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807360871,2
    C--31433039(+) TTTCCC/TAGGTA 3 -- int10--------
    rs1863185591,2
    C--31433042(+) CCCAGA/GTAATA 3 -- int10--------
    rs1435288971,2
    --31433116(+) AAGTAC/GATATT 3 -- int10--------
    rs1466519991,2
    C--31433191(+) CAACCA/CCTGAT 3 -- int10--------
    rs781635881,2
    C,F--31433219(+) TTTTAT/CAGTTT 3 -- int11Minor allele frequency- C:0.05EA 120
    rs1488271751,2
    --31433301(+) GGGAAC/GATTTT 3 -- int10--------
    rs1910223461,2
    --31433417(+) CCTTCA/TTGGCT 3 -- int10--------
    rs1831613781,2
    --31433803(+) AATCAC/TTTCAA 3 -- ut310--------
    rs1142205291,2
    C,F--31433844(+) TTTGTA/GATTCA 3 -- ut311Minor allele frequency- G:0.06WA 118
    rs1860506921,2
    --31434077(+) AAGGCA/TGGCAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM60A (31433518 - 31479992 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM60A (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422447CNV Duplication17116639
    nsv661CNV Insertion18451855
    nsv832364CNV Loss17160897
    nsv524737CNV Gain19592680
    esv2751043CNV Gain17911159
    nsv428276CNV Gain18775914
    dgv63e55CNV Gain17911159
    esv2751046CNV Gain17911159
    nsv515974CNV Gain+Loss19592680
    dgv490e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM60A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM60A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615027    OMIM disorders: --


    Find genes that share disorders with FAM60A           About GenesLikeMe

    Genetic Association Database (GAD): FAM60A
    Human Genome Epidemiology (HuGE) Navigator: FAM60A (1 document)

    Export disorders for FAM60A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM60A gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with FAM60A)
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    1. Family with sequence similarity 60A (FAM60A) protein is a cell cycle- fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. (PubMed id 22865885)1, 2, 3 Munoz I.M....Rouse J. (J. Biol. Chem. 2012)
    2. Functional characterization of the human FAM60A protein: a new subunit of the Sin3 deacetylase complex. (PubMed id 22984288)1, 2, 3 Smith K.T.... Workman J.L. (Mol. Cell. Proteomics 2012)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58516 HGNC: 30702 AceView: C12orf14 Ensembl:ENSG00000139146 euGenes: HUgn58516
    ECgene: FAM60A H-InvDB: FAM60A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM60A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM60A gene:
    Search GeneIP for patents involving FAM60A

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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