FAM5C Gene
protein-coding GIFtS : 47
GCID: GC01 M190066
family with sequence similarity 5, member C
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Aliasesfor FAM5C gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 5, Member C 1 2 DBCCR1L1 2 3 DBCCR1L11 2 3 BRINP31 2 DBCCR1-Like Protein 12 3 Protein FAM5C2
Export aliases for FAM5C gene to outside databases Previous GC identifers: GC01M186799 GC01M188333 GC01M161301
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Summariesfor FAM5C gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor FAM5C gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM5C gene promoter: LHX3b/Lhx3b POU3F1 HNF-3beta Nkx6-1 POU2F1 POU2F1a LHX3a/Lhx3a POU2F1c Other transcription factors Search SABiosciences Chromatin IP Primers for FAM5C Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM5C
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q31.1 Ensembl cytogenetic band: 1q31.1 HGNC cytogenetic band: 1q31.1 FAM5C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M190066: view genomic region
(about GC identifiers )
Start:
190,066,792 bp from pter
End:
190,446,759 bp from pter
Size:
379,968 bases
Orientation:
minus strand
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Proteinsfor FAM5C gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FAM5C_HUMAN, Q76B58 (See
protein sequence )Recommended Name: Protein FAM5C precursor Size : 766 amino acids; 88445 Da
Subcellular location : Secreted (Potential)
Secondary accessions : B3KVP1 O95726 Q2M330Explore the universe of human proteins at neXtProt for FAM5C: NX_Q76B58 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q76B58 FAM5C Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_950252.1 ENSEMBL proteins: ENSP00000356432 ENSP00000393441 ENSP00000438022 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
FAM5C for ontologies About GeneDecksing FAM5C Antibody Products: Assay Products for FAM5C:
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Protein
Domains / Familiesfor FAM5C gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM5C for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q76B58 ProtoNet protein and cluster: Q76B58
UniProtKB/Swiss-Prot: FAM5C_HUMAN, Q76B58 Similarity : Belongs to the FAM5 familySimilarity : Contains 1 MACPF domain
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Functionfor FAM5C gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM5C (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM5COriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM5C (NM_199051 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM5C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM5C
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM5C
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Pathways & Interactionsfor FAM5C gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM5C STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for FAM5C (Q76B58 3 ENSP00000356432 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007399 nervous system development
IEA -- GO:0045786 negative regulation of cell cycle
IEA --
FAM5C for ontologies About GeneDecksing
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Drugs & Compoundsfor FAM5C gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM5C Search CenterWatch for drugs/clinical trials and news about FAM5C
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Transcriptsfor FAM5C gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM5C gene: NM_199051.1 Unigene Cluster for FAM5C:
Family with sequence similarity 5, member C Hs.65765 [show with all ESTs ] Unigene Representative Sequence: AB111893 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367462 (uc001gse.1 ) ENST00000484105 ENST00000463404 ENST00000445957 ENST00000534846 (uc010pot.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM5C (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM5COriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM5C (NM_199051 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM5C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM5C
Additional cDNA sequence: AB111893.1 AK123024.1 AK123637.1 AK294365.1 BC105052.1 BC105054.1 U67037.1
4 DOTS entries : DT.409284 DT.121407127
DT.95176785 DT.95211313 24/28 AceView cDNA sequences (see all 28 ):
AA953423 AB111893 AI934620 CA489081 NM_199051 AI214732 AK123637 R44837 BF589529 CB120579 BM991433 CB122074 AK123024 AI918244 R52543 U64597 R18898 U67037 U72943 CB121944 R20022 R61404 BI754453 T09353 GeneLoc Exon Structure
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Expression for FAM5C gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM5C expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AACTTGCTGA
About this image FAM5C expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Neural Tube Metencephalon Neural Tube Neural Tube Telencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM5C Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM5C SOURCE GeneReport for Unigene cluster: Hs.65765 SABiosciences Custom PCR Arrays for FAM5C Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM5CBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM5C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM5C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM5C In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM5C
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Orthologsfor FAM5C gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM5C gene from 3/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for FAM5C (if available)TreeFam Gene Tree for FAM5C (if available)
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Paralogsfor FAM5C gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM5C gene FAM5B 2 DBC1 2 2 SIMAP similar genes for FAM5C using alignment to 3 protein entries: FAM5C_HUMAN (see all proteins ):FAM5B DBC1
FAM5C for paralogs About GeneDecksing
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Genomic Variantsfor FAM5C gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM5C (190066792 - 190316792 bp, first 250kb of FAM5C)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for FAM5C 2 CNVs : 53440 65473
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM5C
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Disorders
/ Diseasesfor FAM5C gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM5C for disorders About GeneDecksing 8 diseases for FAM5C : About MalaCards oligoastrocytoma aggressive periodontitis pituitary adenoma myocardial infarction periodontitis oligodendroglioma noma adenoma 1 disease from the University of Copenhagen DISEASES database for FAM5C :Aggressive periodontitis Human Genome Epidemiology (HuGE) Navigator: FAM5C (4 documents) Export disorders for FAM5C gene to outside databases
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Publicationsfor FAM5C gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM5C gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with FAM5C) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (PubMed id 16018821) 1 , 3 Liang Y....Gupta N. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Hypermethylated FAM5C and MYLK in serum as diagnosis a nd pre-warning markers for gastric cancer. (PubMed id 22377736) 1 Chen L....Liu B. (2012) A preliminary study on the FAM5C expression in general ized chronic periodontitis. (PubMed id 22355820) 1 Ribeiro F.V....Duarte P.M. (2012) A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266) 1 Shi Y....Qin J. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536) 1 Barber M.J....Krauss R.M. (2010) FAM5C contributes to aggressive periodontitis. (PubMed id 20383335) 1 Carvalho F.M....Vieira A.R. (2010) Expression of the FAM5C in tongue squamous cell carci noma. (PubMed id 19787213) 1 Kuroiwa T....Shibahara T. (2009)
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External Searches for FAM5C gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM5C gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM5C gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM5C gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM5C Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM5C gene: Search GeneIP for patents involving FAM5C GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM5C gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM5C OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM5C OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM5C Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM5C OriGene 3'-UTR Clone for FAM5C OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM5C OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM5C Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM5C OriGene Custom Protein Services for FAM5C OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM5C QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM5C QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM5C QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM5C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM5C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM5C
Search Tocris compounds for FAM5C
FAM5C Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM5C
ThermoFisher Antibodies for FAM5C
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM5C
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Aliases for FAM5C
Databases for FAM5C
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