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Aliases for FAM58A Gene

Aliases for FAM58A Gene

  • Family With Sequence Similarity 58, Member A 2 3
  • CDK10-Activating Cyclin 3 4
  • Cyclin M 2 3
  • StAR 3 6
  • Cyclin-Related Protein FAM58A 3
  • Cyclin-M 4

External Ids for FAM58A Gene

Summaries for FAM58A Gene

Entrez Gene Summary for FAM58A Gene

  • Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for FAM58A Gene

FAM58A (Family With Sequence Similarity 58, Member A) is a Protein Coding gene. Diseases associated with FAM58A include star syndrome and syndactyly. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for FAM58A Gene

  • Activating cyclin for the cyclin-associated kinase CDK10.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM58A Gene

Genomics for FAM58A Gene

Genomic Location for FAM58A Gene

Start:
153,587,919 bp from pter
End:
153,600,045 bp from pter
Size:
12,127 bases
Orientation:
Minus strand

Genomic View for FAM58A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM58A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM58A Gene

Regulatory Elements for FAM58A Gene

Proteins for FAM58A Gene

  • Protein details for FAM58A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1B3-FA58A_HUMAN
    Recommended name:
    Cyclin-related protein FAM58A
    Protein Accession:
    Q8N1B3
    Secondary Accessions:
    • Q2I380
    • Q330J9
    • Q96IU5
    • Q9BUU1

    Protein attributes for FAM58A Gene

    Size:
    248 amino acids
    Molecular mass:
    28369 Da
    Quaternary structure:
    • Associates with CDK10 to promote its kinase activity. Interacts with SALL1.
    Miscellaneous:
    • Silencing with siRNAs phenocopies CDK10 silencing in increasing c-Raf and in conferring tamoxifen resistance to breast cancer cells
    SequenceCaution:
    • Sequence=AAH01909.4; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07232.4; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH32121.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH71851.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM58A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM58A Gene

Proteomics data for FAM58A Gene at MOPED

Post-translational modifications for FAM58A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM58A Gene

Domains for FAM58A Gene

Protein Domains for FAM58A Gene

Suggested Antigen Peptide Sequences for FAM58A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1B3

UniProtKB/Swiss-Prot:

FA58A_HUMAN
Family:
  • Belongs to the cyclin family. Cyclin-like FAM58 subfamily.:
    • Q8N1B3
genes like me logo Genes that share domains with FAM58A: view

No data available for Gene Families for FAM58A Gene

Function for FAM58A Gene

Molecular function for FAM58A Gene

UniProtKB/Swiss-Prot Function: Activating cyclin for the cyclin-associated kinase CDK10.

Gene Ontology (GO) - Molecular Function for FAM58A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18297069
GO:0019901 protein kinase binding IEA --
GO:0030295 protein kinase activator activity IEA --
genes like me logo Genes that share ontologies with FAM58A: view

miRNA for FAM58A Gene

miRTarBase miRNAs that target FAM58A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM58A Gene

Localization for FAM58A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM58A Gene COMPARTMENTS Subcellular localization image for FAM58A gene
Compartment Confidence
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM58A Gene

Pathways for FAM58A Gene

genes like me logo Genes that share pathways with FAM58A: view

Pathways by source for FAM58A Gene

1 GeneGo (Thomson Reuters) pathway for FAM58A Gene
1 Cell Signaling Technology pathway for FAM58A Gene
1 BioSystems pathway for FAM58A Gene

Interacting Proteins for FAM58A Gene

Gene Ontology (GO) - Biological Process for FAM58A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043410 positive regulation of MAPK cascade IEA --
GO:0045860 positive regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with FAM58A: view

Transcripts for FAM58A Gene

Unigene Clusters for FAM58A Gene

Family with sequence similarity 58, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM58A Gene

No ASD Table

Relevant External Links for FAM58A Gene

GeneLoc Exon Structure for
FAM58A
ECgene alternative splicing isoforms for
FAM58A

Expression for FAM58A Gene

mRNA expression in normal human tissues for FAM58A Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM58A Gene

SOURCE GeneReport for Unigene cluster for FAM58A Gene Hs.496943

genes like me logo Genes that share expressions with FAM58A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM58A Gene

Orthologs for FAM58A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM58A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM58A 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FAM58A 35
  • 86.86 (n)
  • 87.71 (a)
dog
(Canis familiaris)
Mammalia FAM58A 35
  • 90.52 (n)
  • 90.05 (a)
mouse
(Mus musculus)
Mammalia Fam58b 35
  • 86.64 (n)
  • 91.81 (a)
rat
(Rattus norvegicus)
Mammalia Fam58b 35
  • 85.2 (n)
  • 90.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32944 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam58a 35
  • 68.3 (n)
  • 75.11 (a)
Str.6402 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13923 35
zebrafish
(Danio rerio)
Actinopterygii fam58a 35
  • 64.7 (n)
  • 64.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005056 35
  • 51.15 (n)
  • 42.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta koko 35
  • 54.09 (n)
  • 38.21 (a)
Species with no ortholog for FAM58A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM58A Gene

ENSEMBL:
Gene Tree for FAM58A (if available)
TreeFam:
Gene Tree for FAM58A (if available)

Paralogs for FAM58A Gene

Selected SIMAP similar genes for FAM58A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FAM58A Gene

genes like me logo Genes that share paralogs with FAM58A: view

No data available for Paralogs for FAM58A Gene

Variants for FAM58A Gene

Sequence variations from dbSNP and Humsavar for FAM58A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1048916 -- 153,599,660(+) AAGAC(A/G)GCGGC upstream-variant-2KB
rs2280924 -- 153,592,235(+) AAAGC(A/G)GTTCT intron-variant
rs2280925 -- 153,592,362(+) CCATC(A/G)CAACA intron-variant
rs2294103 -- 153,594,184(+) GGGGA(C/T)GGGGA intron-variant
rs2294104 -- 153,595,932(+) GGCAG(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM58A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407

Relevant External Links for FAM58A Gene

HapMap Linkage Disequilibrium report
FAM58A
Human Gene Mutation Database (HGMD)
FAM58A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM58A Gene

Disorders for FAM58A Gene

(1) OMIM Diseases for FAM58A Gene (300708)

UniProtKB/Swiss-Prot

FA58A_HUMAN
  • Toe syndactyly, telecanthus, and anogenital and renal malformations (STAR) [MIM:300707]: A syndrome characterized by anal, genital and renal tract anomalies, facial dysmorphism and syndactyly. Features include anal stenosis, a rectovaginal fistula, clitoral hypertrophy, a pelvic right kidney, toe syndactyly, and telecanthus. {ECO:0000269 PubMed:18297069}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) MalaCards Diseases for FAM58A Gene

Search for FAM58A Gene in MalaCards »

(2) University of Copenhagen DISEASES for FAM58A Gene

genes like me logo Genes that share disorders with FAM58A: view

Publications for FAM58A Gene

  1. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PMID: 24218572) Guen V.J. … Colas P. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3 4
  2. Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations. (PMID: 18297069) Unger S. … Kohlhase J. (Nat. Genet. 2008) 2 3 4
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. (PMID: 22961080) Li H. … Lin X. (Diabetes 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for FAM58A Gene

Sources for FAM58A Gene

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