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Aliases for FAM57B Gene

Aliases for FAM57B Gene

  • Family With Sequence Similarity 57 Member B 2 3 5
  • Family With Sequence Similarity 57, Member B 2 3
  • FP1188 3

External Ids for FAM57B Gene

Previous GeneCards Identifiers for FAM57B Gene

  • GC16M029944
  • GC16M027697

Summaries for FAM57B Gene

Entrez Gene Summary for FAM57B Gene

  • This gene encodes a transmembrane protein, which may be a likely target of peroxisome proliferator-activated receptor gamma (PPAR-gamma). The product of the orthologous gene in mouse is related to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for FAM57B Gene

FAM57B (Family With Sequence Similarity 57 Member B) is a Protein Coding gene. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is FAM57A.

UniProtKB/Swiss-Prot for FAM57B Gene

  • Involved in ceramide synthesis.

Gene Wiki entry for FAM57B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM57B Gene

Genomics for FAM57B Gene

Regulatory Elements for FAM57B Gene

Enhancers for FAM57B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM57B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM57B Gene

30,024,427 bp from pter
30,053,012 bp from pter
28,586 bases
Minus strand

Genomic View for FAM57B Gene

Genes around FAM57B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM57B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM57B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM57B Gene

Proteins for FAM57B Gene

  • Protein details for FAM57B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM57B
    Protein Accession:
    Secondary Accessions:
    • Q9H0J1

    Protein attributes for FAM57B Gene

    274 amino acids
    Molecular mass:
    30629 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM57B Gene


neXtProt entry for FAM57B Gene

Proteomics data for FAM57B Gene at MOPED

Post-translational modifications for FAM57B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM57B Gene

No data available for DME Specific Peptides for FAM57B Gene

Domains & Families for FAM57B Gene

Protein Domains for FAM57B Gene


Suggested Antigen Peptide Sequences for FAM57B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with FAM57B: view

No data available for Gene Families for FAM57B Gene

Function for FAM57B Gene

Molecular function for FAM57B Gene

UniProtKB/Swiss-Prot Function:
Involved in ceramide synthesis.
genes like me logo Genes that share phenotypes with FAM57B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM57B Gene

Localization for FAM57B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM57B Gene

Isoform 1: Golgi apparatus membrane; Multi-pass membrane protein.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM57B Gene COMPARTMENTS Subcellular localization image for FAM57B gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for FAM57B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with FAM57B: view

Pathways & Interactions for FAM57B Gene

SuperPathways for FAM57B Gene

No Data Available

Interacting Proteins for FAM57B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369863 Q71RH2-FA57B_HUMAN for FAM57B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM57B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM57B Gene

Drugs & Compounds for FAM57B Gene

No Compound Related Data Available

Transcripts for FAM57B Gene

Unigene Clusters for FAM57B Gene

Family with sequence similarity 57, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM57B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b

Relevant External Links for FAM57B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM57B Gene

mRNA expression in normal human tissues for FAM57B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM57B Gene

This gene is overexpressed in Testis (x9.6), Brain - Cerebellum (x7.3), Brain - Cerebellar Hemisphere (x6.7), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for FAM57B Gene

This gene is overexpressed in Retina (42.5), Ovary (13.7), and Fetal Brain (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM57B Gene

SOURCE GeneReport for Unigene cluster for FAM57B Gene Hs.558560

genes like me logo Genes that share expression patterns with FAM57B: view

Protein tissue co-expression partners for FAM57B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM57B Gene

Orthologs for FAM57B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM57B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM57B 35
  • 91 (n)
  • 95.26 (a)
FAM57B 36
  • 96 (a)
(Mus musculus)
Mammalia Fam57b 35
  • 89.54 (n)
  • 95.26 (a)
Fam57b 16
Fam57b 36
  • 95 (a)
(Pan troglodytes)
Mammalia FAM57B 35
  • 98.42 (n)
  • 97.81 (a)
FAM57B 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam57b 35
  • 89.29 (n)
  • 94.89 (a)
(Monodelphis domestica)
Mammalia FAM57B 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia FAM57B 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FAM57B 36
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32611 35
(Danio rerio)
Actinopterygii fam57ba 35
  • 67.93 (n)
  • 68.72 (a)
wufb95d07 35
fam57ba 36
  • 60 (a)
fam57bb 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011200 35
  • 51.68 (n)
  • 37.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17841 35
  • 51.26 (n)
  • 37.05 (a)
CG17841 36
  • 18 (a)
Species with no ortholog for FAM57B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM57B Gene

Gene Tree for FAM57B (if available)
Gene Tree for FAM57B (if available)

Paralogs for FAM57B Gene

Paralogs for FAM57B Gene

(1) SIMAP similar genes for FAM57B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM57B: view

Variants for FAM57B Gene

Sequence variations from dbSNP and Humsavar for FAM57B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4238959 -- 30,027,326(-) AAGGC(C/T)ATGCA intron-variant
rs4238960 -- 30,027,327(-) TAAGG(C/G)TATGC intron-variant
rs9929454 -- 30,041,198(+) TTGAG(C/G)AATGG intron-variant
rs4787492 -- 30,044,228(+) ccgac(C/T)tcaag intron-variant
rs4788214 -- 30,030,129(+) CCGCA(A/T)GCTGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM57B Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294

Variation tolerance for FAM57B Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM57B Gene

Disorders for FAM57B Gene

Relevant External Links for FAM57B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM57B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM57B Gene

Publications for FAM57B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor I^ target gene that regulates adipogenesis through ceramide synthesis. (PMID: 23275342) Yamashita-Sugahara Y. … Okazaki Y. (J. Biol. Chem. 2013) 2 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for FAM57B Gene

Sources for FAM57B Gene