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FAM57B Gene

protein-coding   GIFtS: 47
GCID: GC16M030035

Family With Sequence Similarity 57, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 57, Member B1 2
Protein FAM57B2

External Ids:    HGNC: 252951   Entrez Gene: 837232   Ensembl: ENSG000001499267   OMIM: 6151755   UniProtKB: Q71RH23   

Export aliases for FAM57B gene to outside databases

Previous GC identifers: GC16M029944 GC16M027697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM57B Gene:
FAM57B (family with sequence similarity 57, member B) is a protein-coding gene. An important paralog of this gene is FAM57A.

UniProtKB/Swiss-Prot: FA57B_HUMAN, Q71RH2
Function: Involved in ceramide synthesis (By similarity)

Gene Wiki entry for FAM57B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM57B gene promoter:
         GR   MAZR   Sp1   GR-beta   MIF-1   Evi-1   YY1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM57B promoter sequence
   Search Chromatin IP Primers for FAM57B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM57B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

FAM57B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM57B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030035:  view genomic region     (about GC identifiers)

Start:
30,035,748 bp from pter      End:
30,064,299 bp from pter
Size:
28,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA57B_HUMAN, Q71RH2 (See protein sequence)
Recommended Name: Protein FAM57B  
Size: 274 amino acids; 30629 Da
Secondary accessions: Q9H0J1
Alternative promoter usage: 2 isoforms:  Q71RH2-1   Q71RH2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM57B: NX_Q71RH2

Explore proteomics data for FAM57B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM57B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113666.2  
    ENSEMBL proteins: 
     ENSP00000279389   ENSP00000369863   ENSP00000457769   ENSP00000457712   ENSP00000456854  
     ENSP00000458640  

    FAM57B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM57B

     
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    Search for Antibodies for FAM57B at Abcam
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    LSBio Antibodies in human, mouse, rat for FAM57B

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    Cloud-Clone Corp. ELISAs for FAM57B
    Cloud-Clone Corp. CLIAs for FAM57B
    Search eBioscience for ELISAs for FAM57B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q71RH2

    ProtoNet protein and cluster: Q71RH2

    1 Blocks protein domain: IPB006634 TRAM

    UniProtKB/Swiss-Prot: FA57B_HUMAN, Q71RH2
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    Find genes that share domains with FAM57B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA57B_HUMAN, Q71RH2
    Function: Involved in ceramide synthesis (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for FAM57B:

     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM57B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM57B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM57B

    miRNA
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    Block miRNA regulation of human, mouse, rat FAM57B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM57B (see all 10):
    hsa-miR-3163 hsa-miR-3607-3p hsa-miR-3065-3p hsa-miR-765 hsa-miR-29c hsa-miR-29a hsa-miR-3918 hsa-miR-145*
    SwitchGear 3'UTR luciferase reporter plasmidFAM57B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM57B

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    Sino Biological Human cDNA Clone for FAM57B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM57B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM57B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA57B_HUMAN, Q71RH2: Isoform 1: Golgi apparatus membrane; Multi-pass membrane protein (By similarity)
    FA57B_HUMAN, Q71RH2: Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM57B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM57B
    Interactions:

        Search GeneGlobe Interaction Network for FAM57B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for FAM57B (Q71RH23 ENSP000003698634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NF2P352403I2D: score=4 
    MAT2AP311533I2D: score=3 
    EXOC2ENSP000002304494STRING: ENSP00000230449
    ZNF598ENSP000004114094STRING: ENSP00000411409
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--

    Find genes that share ontologies with FAM57B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM57B (FA57B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM57B gene: 
    NM_031478.4  

    Unigene Cluster for FAM57B:

    Family with sequence similarity 57, member B
    Hs.558560  [show with all ESTs]
    Unigene Representative Sequence: NM_031478
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279389 ENST00000380495(uc002dvt.3) ENST00000564806 ENST00000569508
    ENST00000561666 ENST00000567037(uc002dvv.1) ENST00000571269
    miRNA
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    Block miRNA regulation of human, mouse, rat FAM57B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM57B (see all 10):
    hsa-miR-3163 hsa-miR-3607-3p hsa-miR-3065-3p hsa-miR-765 hsa-miR-29c hsa-miR-29a hsa-miR-3918 hsa-miR-145*
    SwitchGear 3'UTR luciferase reporter plasmidFAM57B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM57B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM57B
    Clone
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    GenScript: all cDNA clones in your preferred vector: FAM57B (NM_031478)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM57B
    Primer
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    OriGene qPCR primer pairs and template standards for FAM57B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM57B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM57B
      QuantiFast Probe-based Assays in human, mouse, rat FAM57B

    Additional mRNA sequence: 

    AB593089.1 AB593090.1 AF370365.1 AL136777.1 BC007892.2 

    9 DOTS entries:

    DT.409775  DT.99935515  DT.100675514  DT.100752028  DT.40227635  DT.91700114  DT.97846531  DT.100752027 
    DT.100752031 

    Selected AceView cDNA sequences (see all 102):

    BX089025 AL136777 BQ636792 NM_031478 AL565653 BU728829 F12595 BU729278 
    BC007892 CR604281 AI580815 CR615686 BM564876 BM674892 CR614964 BM664500 
    BQ638599 BQ635866 AA621278 BU192909 BU156485 BU728649 BM691788 AL565715 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM57B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for FAM57B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM57B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGTGC
    FAM57B Expression
    About this image


    FAM57B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
     
     Testis (Reproductive System)
     
     Eye (Sensory Organs)
    FAM57B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM57B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558560
        Custom PCR Arrays for FAM57B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM57B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM57B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam57b1 , 5 family with sequence similarity 57, member B1, 5 89.54(n)1
    95.26(a)1
      7 (69.25 cM)5
    689521  NM_029978.11  NP_084254.11 
     1268168855 
    lizard
    (Anolis carolinensis)
    Reptilia FAM57B6
    family with sequence similarity 57, member B
    69(a)
    1 ↔ 1
    GL343279.1(281561-294507)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.326112 Xenopus laevis transcribed sequences 76.11(n)    CB209529.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb95d072 wufb95d07 75.81(n)   323326  BC059567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178411 CG17841 51.26(n)
    37.05(a)
      31965  NM_132394.2  NP_572622.1 


    ENSEMBL Gene Tree for FAM57B (if available)
    TreeFam Gene Tree for FAM57B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM57B gene
    FAM57A2  
    1 SIMAP similar gene for FAM57B using alignment to 6 protein entries:     FA57B_HUMAN (see all proteins):
    FAM57A

    Find genes that share paralogs with FAM57B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM57B (see all 140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904501521,2
    --30036525(+) CAGGCC/TGGGGG 2 P syn10--------
    rs1381746281,2
    F--30036621(+) GCGCCC/TAGGTT 2 L syn11Minor allele frequency- T:0.00NA 2610
    rs2020842701,2
    --30036680(+) ATGGCA/GCCCGT 2 R C mis10--------
    rs1823292481,2
    --30036717(+) AGCACC/TCGGCA 2 R syn10--------
    rs2014725381,2
    --30036826(+) CAGAAA/GGGCTC 1 -- int10--------
    rs2004995001,2
    --30036831(+) GGGCTC/TGGCCC 1 -- int10--------
    rs1996597041,2
    C--30036832(+) GGCTCA/GGCCCC 1 -- int10--------
    rs1465964321,2
    C--30036855(+) CCCTGA/CCTCCC 1 -- int10--------
    rs1402945271,2
    --30036942(+) GGTGAG/TGGGGG 1 -- int10--------
    rs2012390381,2
    --30037053(+) TGGATA/GAGGAT 2 L syn10--------

    HapMap Linkage Disequilibrium report for FAM57B (30035748 - 30064299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM57B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2668n71CNV Loss21882294
    nsv905717CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM57B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM57B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615175    OMIM disorders: --


    Find genes that share disorders with FAM57B           About GenesLikeMe


    Export disorders for FAM57B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM57B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM57B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor I^ target gene that regulates adipogenesis through ceramide synthesis. (PubMed id 23275342)1, 3 Yamashita-Sugahara Y....Okazaki Y. (J. Biol. Chem. 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    10. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83723 HGNC: 25295 AceView: DKFZP434I2117 Ensembl:ENSG00000149926 euGenes: HUgn83723
    ECgene: FAM57B H-InvDB: FAM57B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM57B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM57B gene:
    Search GeneIP for patents involving FAM57B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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