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Aliases for FAM53C Gene

Aliases for FAM53C Gene

  • Family With Sequence Similarity 53 Member C 2 3 5
  • Family With Sequence Similarity 53, Member C 2 3
  • C5orf6 3 4
  • Chromosome 5 Open Reading Frame 6 2
  • Putative Nuclear Protein 3

External Ids for FAM53C Gene

Previous HGNC Symbols for FAM53C Gene

  • C5orf6

Previous GeneCards Identifiers for FAM53C Gene

  • GC05P137702
  • GC05P137703
  • GC05P137673
  • GC05P132864

Summaries for FAM53C Gene

GeneCards Summary for FAM53C Gene

FAM53C (Family With Sequence Similarity 53 Member C) is a Protein Coding gene. An important paralog of this gene is FAM53A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM53C Gene

Genomics for FAM53C Gene

Regulatory Elements for FAM53C Gene

Promoters for FAM53C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM53C on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM53C Gene

138,331,935 bp from pter
138,349,729 bp from pter
17,795 bases
Plus strand

Genomic View for FAM53C Gene

Genes around FAM53C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM53C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM53C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM53C Gene

Proteins for FAM53C Gene

  • Protein details for FAM53C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM53C
    Protein Accession:
    Secondary Accessions:
    • B2RDJ5
    • D3DQB9

    Protein attributes for FAM53C Gene

    392 amino acids
    Molecular mass:
    43091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM53C Gene

Proteomics data for FAM53C Gene at MOPED

Post-translational modifications for FAM53C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM53C Gene

No data available for DME Specific Peptides for FAM53C Gene

Domains & Families for FAM53C Gene

Protein Domains for FAM53C Gene


Suggested Antigen Peptide Sequences for FAM53C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM53 family.
  • Belongs to the FAM53 family.
genes like me logo Genes that share domains with FAM53C: view

No data available for Gene Families for FAM53C Gene

Function for FAM53C Gene

Phenotypes for FAM53C Gene

genes like me logo Genes that share phenotypes with FAM53C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM53C Gene

Localization for FAM53C Gene

Subcellular locations from

Jensen Localization Image for FAM53C Gene COMPARTMENTS Subcellular localization image for FAM53C gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM53C Gene

Pathways & Interactions for FAM53C Gene

SuperPathways for FAM53C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM53C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM53C Gene

Drugs & Compounds for FAM53C Gene

No Compound Related Data Available

Transcripts for FAM53C Gene

Unigene Clusters for FAM53C Gene

Family with sequence similarity 53, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM53C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: - - -
SP9: - - - -

Relevant External Links for FAM53C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM53C Gene

mRNA expression in normal human tissues for FAM53C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM53C Gene

This gene is overexpressed in Whole Blood (x8.4).

Protein differential expression in normal tissues from HIPED for FAM53C Gene

This gene is overexpressed in Fetal heart (35.2) and Testis (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM53C Gene

SOURCE GeneReport for Unigene cluster for FAM53C Gene Hs.54056

genes like me logo Genes that share expression patterns with FAM53C: view

Protein tissue co-expression partners for FAM53C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM53C Gene

Orthologs for FAM53C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM53C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM53C 35
  • 94.98 (n)
  • 96.68 (a)
FAM53C 36
  • 97 (a)
(Canis familiaris)
Mammalia FAM53C 35
  • 94.98 (n)
  • 96.17 (a)
FAM53C 36
  • 96 (a)
(Mus musculus)
Mammalia Fam53c 35
  • 93.11 (n)
  • 94.64 (a)
Fam53c 16
Fam53c 36
  • 94 (a)
(Pan troglodytes)
Mammalia FAM53C 35
  • 99.49 (n)
  • 98.98 (a)
FAM53C 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam53c 35
  • 93.33 (n)
  • 94.87 (a)
(Monodelphis domestica)
Mammalia FAM53C 36
  • 79 (a)
(Anolis carolinensis)
Reptilia FAM53C 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam53c 35
  • 58.29 (n)
  • 54.32 (a)
(Danio rerio)
Actinopterygii LOC100002393 35
  • 50.87 (n)
  • 42.16 (a)
FAM53C 36
  • 32 (a)
Species with no ortholog for FAM53C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM53C Gene

Gene Tree for FAM53C (if available)
Gene Tree for FAM53C (if available)

Paralogs for FAM53C Gene

Paralogs for FAM53C Gene

genes like me logo Genes that share paralogs with FAM53C: view

Variants for FAM53C Gene

Sequence variations from dbSNP and Humsavar for FAM53C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35360938 - 138,341,396(+) GCACA(C/T)GCTTC intron-variant, reference, missense
rs16373 -- 138,347,855(+) GGCTC(-/AT/TA)CTCTC utr-variant-3-prime
rs740074 -- 138,348,641(+) CTCCT(C/G/T)GTCTC utr-variant-3-prime
rs1052648 -- 138,349,043(+) CCTTA(A/G)GGGAG utr-variant-3-prime
rs2269952 -- 138,347,616(-) GCTGT(A/G)CCCCA utr-variant-3-prime

Variation tolerance for FAM53C Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM53C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM53C Gene

Disorders for FAM53C Gene

Relevant External Links for FAM53C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM53C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM53C Gene

Publications for FAM53C Gene

  1. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. (PMID: 11087669) Lai F. … Le Beau M.M. (Genomics 2000) 2 3 4 67
  2. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). (PMID: 11161817) Lai F. … Le Beau M.M. (Genomics 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FAM53C Gene

Sources for FAM53C Gene

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