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Aliases for FAM53B Gene

Aliases for FAM53B Gene

  • Family With Sequence Similarity 53, Member B 2 3
  • KIAA0140 2 3 4
  • Simplet Homolog (Zebrafish) 2
  • Simplet Homolog 3
  • Protein FAM53B 3
  • BA12J10.2 3
  • Smp 3

External Ids for FAM53B Gene

Previous Symbols for FAM53B Gene

  • KIAA0140

Summaries for FAM53B Gene

GeneCards Summary for FAM53B Gene

FAM53B (Family With Sequence Similarity 53, Member B) is a Protein Coding gene. An important paralog of this gene is FAM53A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM53B Gene

Genomics for FAM53B Gene

Genomic Location for FAM53B Gene

Start:
124,619,292 bp from pter
End:
124,744,361 bp from pter
Size:
125,070 bases
Orientation:
Minus strand

Genomic View for FAM53B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM53B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM53B Gene

Regulatory Elements for FAM53B Gene

Proteins for FAM53B Gene

  • Protein details for FAM53B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14153-FA53B_HUMAN
    Recommended name:
    Protein FAM53B
    Protein Accession:
    Q14153
    Secondary Accessions:
    • D3DRF1
    • Q5VUW1
    • Q5VUW2
    • Q8N5S6

    Protein attributes for FAM53B Gene

    Size:
    422 amino acids
    Molecular mass:
    45768 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09489.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM53B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM53B Gene

Proteomics data for FAM53B Gene at MOPED

Post-translational modifications for FAM53B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM53B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM53B Gene

Domains for FAM53B Gene

Protein Domains for FAM53B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FA53B_HUMAN
Family:
  • Belongs to the FAM53 family.:
    • Q14153
genes like me logo Genes that share domains with FAM53B: view

No data available for Gene Families for FAM53B Gene

Function for FAM53B Gene

Gene Ontology (GO) - Molecular Function for FAM53B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM53B: view

Phenotypes for FAM53B Gene

GenomeRNAi human phenotypes for FAM53B:
genes like me logo Genes that share phenotypes with FAM53B: view

miRNA for FAM53B Gene

miRTarBase miRNAs that target FAM53B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM53B Gene

Localization for FAM53B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM53B Gene COMPARTMENTS Subcellular localization image for FAM53B gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM53B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with FAM53B: view

Pathways for FAM53B Gene

SuperPathways for FAM53B Gene

No Data Available

Interacting Proteins for FAM53B Gene

Selected Interacting proteins: Q14153-FA53B_HUMAN for FAM53B Gene via MINT I2D

Symbol External ID(s) Details
SFN

Gene Ontology (GO) - Biological Process for FAM53B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM53B: view

No data available for Pathways by source for FAM53B Gene

Transcripts for FAM53B Gene

mRNA/cDNA for FAM53B Gene

Unigene Clusters for FAM53B Gene

Family with sequence similarity 53, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM53B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - -
SP7: - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12: - - - -
SP13: - - - -
SP14: - -

ExUns: 15b · 15c ^ 16 ^ 17 ^ 18
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for FAM53B Gene

GeneLoc Exon Structure for
FAM53B
ECgene alternative splicing isoforms for
FAM53B

Expression for FAM53B Gene

mRNA expression in normal human tissues for FAM53B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM53B Gene

SOURCE GeneReport for Unigene cluster for FAM53B Gene Hs.129195

mRNA Expression by UniProt/SwissProt for FAM53B Gene

Q14153-FA53B_HUMAN
Tissue specificity: Detected in skeletal muscle, kidney, spleen, thyroid, testis, ovary, small intestine, colon and peripheral blood.
genes like me logo Genes that share expressions with FAM53B: view

Orthologs for FAM53B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM53B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM53B 36
  • 99.84 (n)
  • 100 (a)
FAM53B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM53B 36
  • 82.88 (n)
  • 81.39 (a)
FAM53B 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM53B 36
  • 88.47 (n)
  • 87.44 (a)
FAM53B 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam53b 36
  • 85.79 (n)
  • 85.95 (a)
Fam53b 16
Fam53b 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM53B 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam53b 36
  • 85 (n)
  • 85.24 (a)
chicken
(Gallus gallus)
Aves FAM53B 36
  • 72.77 (n)
  • 69.07 (a)
FAM53B 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM53B 37
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam53b 36
  • 54.84 (n)
  • 48.88 (a)
fam53b 37
  • 41 (a)
OneToOne
wufj93e03 36
Species with no ortholog for FAM53B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM53B Gene

ENSEMBL:
Gene Tree for FAM53B (if available)
TreeFam:
Gene Tree for FAM53B (if available)

Paralogs for FAM53B Gene

Paralogs for FAM53B Gene

genes like me logo Genes that share paralogs with FAM53B: view

Variants for FAM53B Gene

Sequence variations from dbSNP and Humsavar for FAM53B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11554 -- 124,619,376(-) GCTGT(A/G)GCTTG utr-variant-3-prime
rs748129 -- 124,631,031(-) GCATA(C/T)CTGGC intron-variant
rs751513 -- 124,678,291(+) CACTG(A/G)GGGGA intron-variant
rs751514 -- 124,678,362(+) ACATA(C/T)ATAAA intron-variant
rs869303 -- 124,725,883(-) AGGCT(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM53B Gene

Variant ID Type Subtype PubMed ID
dgv833n71 CNV Loss 21882294
nsv521161 CNV Gain+Loss 19592680
nsv832013 CNV Loss 17160897
dgv835n71 CNV Loss 21882294
nsv7589 CNV Insertion 18451855
nsv467473 CNV Loss 19166990
nsv896077 CNV Loss 21882294
nsv470973 CNV Loss 18288195
esv2742739 CNV Deletion 23290073
nsv832014 CNV Loss 17160897
esv1000820 CNV Deletion 20482838
nsv825604 CNV Gain 20364138

Relevant External Links for FAM53B Gene

HapMap Linkage Disequilibrium report
FAM53B

Disorders for FAM53B Gene

Relevant External Links for FAM53B

Genetic Association Database (GAD)
FAM53B
genes like me logo Genes that share disorders with FAM53B: view

No data available for UniProtKB/Swiss-Prot for FAM53B Gene

Publications for FAM53B Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes controlling cell proliferation. (PMID: 16611694) Thermes V. … Joly J.S. (Development 2006) 2 3
  5. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. (PMID: 19727342) Geisert E.E. … Williams R.W. (Mol. Vis. 2009) 3

Products for FAM53B Gene

Sources for FAM53B Gene

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