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Aliases for FAM53A Gene

Aliases for FAM53A Gene

  • Family With Sequence Similarity 53, Member A 2 3
  • Dorsal Neural-Tube Nuclear Protein 3 4
  • Protein FAM53A 3
  • DNTNP 3

External Ids for FAM53A Gene

Summaries for FAM53A Gene

GeneCards Summary for FAM53A Gene

FAM53A (Family With Sequence Similarity 53, Member A) is a Protein Coding gene. An important paralog of this gene is FAM53B.

UniProtKB/Swiss-Prot for FAM53A Gene

  • May play an important role in neural development; the dorsomedial roof of the third ventricle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM53A Gene

Genomics for FAM53A Gene

Regulatory Elements for FAM53A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM53A Gene

1,617,915 bp from pter
1,684,302 bp from pter
66,388 bases
Minus strand

Genomic View for FAM53A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM53A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM53A Gene

Proteins for FAM53A Gene

  • Protein details for FAM53A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM53A
    Protein Accession:
    Secondary Accessions:
    • Q6ZUL5

    Protein attributes for FAM53A Gene

    398 amino acids
    Molecular mass:
    42585 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM53A Gene

Proteomics data for FAM53A Gene at MOPED

Post-translational modifications for FAM53A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM53A

No data available for DME Specific Peptides for FAM53A Gene

Domains for FAM53A Gene

Protein Domains for FAM53A Gene


Suggested Antigen Peptide Sequences for FAM53A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM53 family.
  • Belongs to the FAM53 family.
genes like me logo Genes that share domains with FAM53A: view

No data available for Gene Families for FAM53A Gene

Function for FAM53A Gene

Molecular function for FAM53A Gene

UniProtKB/Swiss-Prot Function:
May play an important role in neural development; the dorsomedial roof of the third ventricle.

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM53A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM53A Gene

Localization for FAM53A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM53A Gene

Nucleus. Note=Subnuclear distribution. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FAM53A Gene COMPARTMENTS Subcellular localization image for FAM53A gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FAM53A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FAM53A: view

Pathways for FAM53A Gene

SuperPathways for FAM53A Gene

No Data Available

Interacting Proteins for FAM53A Gene

Gene Ontology (GO) - Biological Process for FAM53A Gene


No data available for Pathways by source for FAM53A Gene

Transcripts for FAM53A Gene

Unigene Clusters for FAM53A Gene

Family with sequence similarity 53, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM53A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM53A Gene

No ASD Table

Relevant External Links for FAM53A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM53A Gene

mRNA expression in normal human tissues for FAM53A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM53A Gene

This gene is overexpressed in Testis (12.0).

Protein differential expression in normal tissues for FAM53A Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM53A Gene

SOURCE GeneReport for Unigene cluster for FAM53A Gene Hs.143314

genes like me logo Genes that share expressions with FAM53A: view

Expression partners for FAM53A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM53A Gene

Orthologs for FAM53A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM53A Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Fam53a 35
  • 75.49 (n)
  • 68.12 (a)
Fam53a 16
Fam53a 36
  • 62 (a)
(Pan troglodytes)
Mammalia FAM53A 35
  • 97.74 (n)
  • 95.98 (a)
FAM53A 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam53a 35
  • 75.24 (n)
  • 69.15 (a)
(Canis familiaris)
Mammalia FAM53A 36
  • 57 (a)
(Monodelphis domestica)
Mammalia FAM53A 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia FAM53A 36
  • 52 (a)
(Gallus gallus)
Aves FAM53A 35
  • 62.53 (n)
  • 59.17 (a)
FAM53A 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam53a 35
  • 60.6 (n)
  • 56.73 (a)
Species with no ortholog for FAM53A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM53A Gene

Gene Tree for FAM53A (if available)
Gene Tree for FAM53A (if available)

Paralogs for FAM53A Gene

Paralogs for FAM53A Gene

genes like me logo Genes that share paralogs with FAM53A: view

Variants for FAM53A Gene

Sequence variations from dbSNP and Humsavar for FAM53A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs798714 -- 1,685,859(+) CCGGG(A/G)CGAGG upstream-variant-2KB
rs798725 -- 1,683,614(-) TTAAA(C/T)TCAAA intron-variant, utr-variant-5-prime
rs798726 -- 1,683,484(-) AGTCC(A/G)TTACA intron-variant, utr-variant-5-prime
rs798727 -- 1,683,410(-) AAACA(A/G)AAAAG intron-variant, utr-variant-5-prime
rs798728 -- 1,682,907(-) ATTGT(C/T)CCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM53A Gene

Variant ID Type Subtype PubMed ID
nsv878328 CNV Loss 21882294
nsv878347 CNV Loss 21882294
dgv5407n71 CNV Loss 21882294
dgv5408n71 CNV Loss 21882294
nsv822437 CNV Loss 20364138
dgv5409n71 CNV Loss 21882294
nsv878368 CNV Loss 21882294
nsv878369 CNV Gain 21882294
nsv470000 CNV Loss 18288195
dgv5410n71 CNV Loss 21882294
dgv5411n71 CNV Loss 21882294
dgv5412n71 CNV Loss 21882294
dgv5413n71 CNV Loss 21882294
dgv5414n71 CNV Loss 21882294
nsv878390 CNV Loss 21882294
dgv1565e1 CNV Complex 17122850
nsv428434 CNV Gain 18775914
nsv508989 CNV Insertion 20534489
nsv878391 CNV Loss 21882294
esv2726825 CNV Deletion 23290073
esv2726826 CNV Deletion 23290073
esv1776644 CNV Insertion 17803354
esv2726827 CNV Deletion 23290073
esv1444353 CNV Insertion 17803354
esv23460 CNV Loss 19812545
esv2726828 CNV Deletion 23290073
esv1210969 CNV Insertion 17803354
esv1465412 CNV Insertion 17803354
esv2726830 CNV Deletion 23290073
esv2726831 CNV Deletion 23290073

Relevant External Links for FAM53A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM53A Gene

Disorders for FAM53A Gene

No disorders were found for FAM53A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM53A Gene

Publications for FAM53A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Isolation of DNTNP, which encodes a potential nuclear protein that is expressed in the developing, dorsal neural tube. (PMID: 11984880) Jun L. … Bergemann A.D. (Dev. Dyn. 2002) 3

Products for FAM53A Gene

Sources for FAM53A Gene

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