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Aliases for FAM50B Gene

Aliases for FAM50B Gene

  • Family With Sequence Similarity 50, Member B 2 3
  • X5L 3 4 6
  • Protein XAP-5-Like 4
  • Protein FAM50B 3
  • D6S2654E 3
  • FAM60B 6

External Ids for FAM50B Gene

Previous GeneCards Identifiers for FAM50B Gene

  • GC06P003795
  • GC06P003726

Summaries for FAM50B Gene

GeneCards Summary for FAM50B Gene

FAM50B (Family With Sequence Similarity 50, Member B) is a Protein Coding gene. An important paralog of this gene is FAM50A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM50B Gene

Genomics for FAM50B Gene

Regulatory Elements for FAM50B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM50B Gene

Start:
3,849,386 bp from pter
End:
3,851,317 bp from pter
Size:
1,932 bases
Orientation:
Plus strand

Genomic View for FAM50B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM50B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM50B Gene

Proteins for FAM50B Gene

  • Protein details for FAM50B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y247-FA50B_HUMAN
    Recommended name:
    Protein FAM50B
    Protein Accession:
    Q9Y247
    Secondary Accessions:
    • Q5T2L6

    Protein attributes for FAM50B Gene

    Size:
    325 amino acids
    Molecular mass:
    38709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM50B Gene

Proteomics data for FAM50B Gene at MOPED

Post-translational modifications for FAM50B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM50B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM50B

No data available for DME Specific Peptides for FAM50B Gene

Domains for FAM50B Gene

Protein Domains for FAM50B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM50B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y247

UniProtKB/Swiss-Prot:

FA50B_HUMAN :
  • Q9Y247
Family:
  • Belongs to the FAM50 family.
genes like me logo Genes that share domains with FAM50B: view

No data available for Gene Families for FAM50B Gene

Function for FAM50B Gene

Molecular function for FAM50B Gene

UniProtKB/Swiss-Prot Induction:
Imprinted. Promoter methylation of the maternal allele may restrict expression to the paternal allele in placenta.

Gene Ontology (GO) - Molecular Function for FAM50B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM50B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM50B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM50B Gene

Localization for FAM50B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM50B Gene COMPARTMENTS Subcellular localization image for FAM50B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM50B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FAM50B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM50B Gene

Pathways for FAM50B Gene

SuperPathways for FAM50B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM50B Gene

None

No data available for Pathways by source for FAM50B Gene

Transcripts for FAM50B Gene

mRNA/cDNA for FAM50B Gene

(84) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM50B Gene

Family with sequence similarity 50, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM50B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM50B Gene

No ASD Table

Relevant External Links for FAM50B Gene

GeneLoc Exon Structure for
FAM50B
ECgene alternative splicing isoforms for
FAM50B

Expression for FAM50B Gene

mRNA expression in normal human tissues for FAM50B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FAM50B Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM50B Gene

SOURCE GeneReport for Unigene cluster for FAM50B Gene Hs.140944

mRNA Expression by UniProt/SwissProt for FAM50B Gene

Q9Y247-FA50B_HUMAN
Tissue specificity: Widely expressed. Mostly abundant in testis and adult and fetal brain
genes like me logo Genes that share expressions with FAM50B: view

Expression partners for FAM50B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM50B Gene

Orthologs for FAM50B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM50B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Fam50b 35
  • 85.74 (n)
  • 84.92 (a)
Fam50b 16
Fam50b 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM50B 35
  • 93.91 (n)
  • 91.51 (a)
FAM50B 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam50b 35
  • 85.23 (n)
  • 84.92 (a)
zebrafish
(Danio rerio)
Actinopterygii fam50a 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12259 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C47E8.4 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3121 36
  • 53 (a)
OneToMany
Species with no ortholog for FAM50B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM50B Gene

ENSEMBL:
Gene Tree for FAM50B (if available)
TreeFam:
Gene Tree for FAM50B (if available)

Paralogs for FAM50B Gene

Paralogs for FAM50B Gene

Selected SIMAP similar genes for FAM50B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM50B: view

Variants for FAM50B Gene

Sequence variations from dbSNP and Humsavar for FAM50B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2239713 -- 3,849,071(+) TACAG(C/T)TGGGC upstream-variant-2KB
rs2490035 -- 3,851,369(+) AGAAC(C/T)ATTTG downstream-variant-500B
rs3196512 -- 3,851,311(+) CTGTT(C/G)TTATT utr-variant-3-prime
rs6597007 -- 3,850,959(+) GGTTG(C/G)TTGGT utr-variant-3-prime
rs6908698 -- 3,851,694(+) ggctc(A/G)tgctt downstream-variant-500B

Relevant External Links for FAM50B Gene

HapMap Linkage Disequilibrium report
FAM50B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM50B Gene

Disorders for FAM50B Gene

(1) University of Copenhagen DISEASES for FAM50B Gene

genes like me logo Genes that share disorders with FAM50B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for FAM50B Gene

Publications for FAM50B Gene

  1. Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of an ancient functional retroposon differentially expressed in testis. (PMID: 10534398) Sedlack Z. … Poustka A. (Genomics 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. XAP5 CIRCADIAN TIMEKEEPER coordinates light signals for proper timing of photomorphogenesis and the circadian clock in Arabidopsis. (PMID: 18515502) Martin-Tryon E.L. … Harmer S.L. (Plant Cell 2008) 3

Products for FAM50B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FAM50B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FAM50B
    • Block miRNA regulation of FAM50B using miScript Target Protectors

    Sources for FAM50B Gene

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