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FAM50A Gene

protein-coding   GIFtS: 53
GCID: GC0XP153672

Family With Sequence Similarity 50, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 50, Member A1 2     DNA Segment On Chromosome X (Unique) 9928 Expressed Sequence1
DXS9928E2 3 5     9F2
HXC262 3 5     HXC-262
Protein XAP-52 3     Protein FAM50A2
XAP52 3     Protein HXC-263

External Ids:    HGNC: 187861   Entrez Gene: 91302   Ensembl: ENSG000000718597   OMIM: 3004535   UniProtKB: Q143203   

Export aliases for FAM50A gene to outside databases

Previous GC identifers: GC0XP153236 GC0XP153325 GC0XP142251


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAM50A Gene:
This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across
different species. It is a basic protein containing a nuclear localization signal, and may function as a
DNA-binding protein or a transcriptional factor. (provided by RefSeq, Sep 2009)

GeneCards Summary for FAM50A Gene:
FAM50A (family with sequence similarity 50, member A) is a protein-coding gene. An important paralog of this gene is FAM50B.

UniProtKB/Swiss-Prot: FA50A_HUMAN, Q14320
Function: May be a DNA-binding protein or transcriptional factor

Gene Wiki entry for FAM50A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM50A gene promoter:
         Pax-5   NF-kappaB   YY1   CREB   PPAR-alpha   deltaCREB   SEF-1 (1)   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM50A promoter sequence
   Search Chromatin IP Primers for FAM50A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM50A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

FAM50A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM50A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153672:  view genomic region     (about GC identifiers)

Start:
153,672,473 bp from pter      End:
153,679,002 bp from pter
Size:
6,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA50A_HUMAN, Q14320 (See protein sequence)
Recommended Name: Protein FAM50A  
Size: 339 amino acids; 40242 Da
Secondary accessions: A8KAQ4 B2R997 Q5HY37

Explore the universe of human proteins at neXtProt for FAM50A: NX_Q14320

Explore proteomics data for FAM50A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys271, Lys305
  • Modification sites at PhosphoSitePlus

  • See FAM50A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004690.1  
    ENSEMBL proteins: 
     ENSP00000377225   ENSP00000158526  

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    antibodies-online proteins for FAM50A (6 products) 

     
    antibodies-online peptides for FAM50A

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    antibodies-online antibodies for FAM50A (47 products) 

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    antibodies-online kits for FAM50A (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007005 XAP5

    Graphical View of Domain Structure for InterPro Entry Q14320

    ProtoNet protein and cluster: Q14320

    UniProtKB/Swiss-Prot: FA50A_HUMAN, Q14320
    Similarity: Belongs to the FAM50 family


    Find genes that share domains with FAM50A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA50A_HUMAN, Q14320
    Function: May be a DNA-binding protein or transcriptional factor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FAM50A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM50A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM50A

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    miRTarBase miRNAs that target FAM50A:
    hsa-mir-93-3p (MIRT038815), hsa-mir-193b-3p (MIRT041512)

    Block miRNA regulation of human, mouse, rat FAM50A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAM50A
    SwitchGear 3'UTR luciferase reporter plasmidFAM50A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA50A_HUMAN, Q14320: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9339379

    Find genes that share ontologies with FAM50A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM50A
    Interactions:

        Search GeneGlobe Interaction Network for FAM50A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for FAM50A (Q143203 ENSP000003772254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEF2AQ020783I2D: score=2 
    PRKCHP247233I2D: score=2 
    FOSP011003I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis NAS10534398

    Find genes that share ontologies with FAM50A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM50A (FA50A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM50A gene: 
    NM_004699.3  

    Unigene Cluster for FAM50A:

    Family with sequence similarity 50, member A
    Hs.54277  [show with all ESTs]
    Unigene Representative Sequence: NM_004699
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393600(uc004fll.4) ENST00000464419 ENST00000481619 ENST00000158526
    ENST00000490480 ENST00000478509 ENST00000494278
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM50A
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    Primer
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    OriGene qPCR primer pairs and template standards for FAM50A
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM50A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM50A
      QuantiFast Probe-based Assays in human, mouse, rat FAM50A

    Additional mRNA sequence: 

    AD001530.1 AK293119.1 AK313697.1 AL365368.1 BC000028.2 BC015499.2 D83260.1 X74611.1 
    X87199.1 

    16 DOTS entries:

    DT.92456597  DT.95215373  DT.91973850  DT.100779487  DT.121294379  DT.121294442  DT.95215370  DT.102827647 
    DT.95215364  DT.86860005  DT.92456559  DT.97862236  DT.80101838  DT.91686647  DT.438887  DT.92473287 

    Selected AceView cDNA sequences (see all 273):

    BQ012716 BM792979 BU626465 BM424218 AD001530 BQ684693 BF222716 BU166419 
    BM915519 BE902329 BU630801 CF127416 CR623814 BM703087 CF127981 AW236816 
    BE326208 CR597867 BM704719 CR619686 CD365890 CR614465 BF448075 BM476117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM50A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGCACGC
    FAM50A Expression
    About this image


    FAM50A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FAM50A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM50A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.54277

    UniProtKB/Swiss-Prot: FA50A_HUMAN, Q14320
    Tissue specificity: Expressed in all tissues examined. Mostly abundant in fetal brain, liver and kidney; in the
    adult, high levels were also observed in heart, skeletal muscle, spleen, thymus, prostate and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM50A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAM50A gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam50a1 , 5 family with sequence similarity 50, member A1, 5 88.2(n)1
    98.23(a)1
      X (37.98 cM)5
    1081601  NM_138607.31  NP_613073.21 
     743130335 
    lizard
    (Anolis carolinensis)
    Reptilia FAM50A6
    family with sequence similarity 50, member A
    92(a)
    1 ↔ 1
    1(204532396-204552128)
    African clawed frog
    (Xenopus laevis)
    Amphibia mgdb03h09-prov2 hypothetical protein MGC52848 79.26(n)    BC041272.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI673823.12   -- 78.98(n)   326956  BI673823.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122591 CG12259 70.34(n)
    64.88(a)
      43347  NM_143338.3  NP_651595.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C47E8.46
    Protein C47E8.4, isoform b
    45(a)
    1 → many
    V(14683671-14685528) WBGene00008143
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XCT1 XCT 55.14(n)
    48.77(a)
      816650  NM_127685.3  NP_179711.2 
    rice
    (Oryza sativa)
    Liliopsida Os.114342 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.22(n)    AK071211.1 


    ENSEMBL Gene Tree for FAM50A (if available)
    TreeFam Gene Tree for FAM50A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM50A gene
    FAM50B2  
    1 SIMAP similar gene for FAM50A using alignment to 3 protein entries:     FA50A_HUMAN (see all proteins):
    FAM50B

    Find genes that share paralogs with FAM50A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM50A (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013308291,2
    C--153538931(+) CCCAGC/TAGCTG 1 -- us2k10--------
    rs1850406851,2
    C--153539069(+) CAGCTC/TGTCCC 1 -- us2k10--------
    rs2004075691,2
    --153539094(+) GGCTGC/TCCGCC 1 -- us2k10--------
    rs765781391,2
    C--153539203(+) TGCAAC/TGACAT 1 -- us2k10--------
    rs557369381,2
    C--153539320(+) CCAGCC/TCCTGC 1 -- us2k10--------
    rs1902190271,2
    C--153539348(+) GTTCTC/TCTCGA 1 -- us2k10--------
    rs70590131,2
    C,F,H--153539350(+) TCTCCT/CCGAGG 1 -- us2k16Minor allele frequency- C:0.04NS NA 794
    rs1832162901,2
    --153539534(+) CCCCCC/GACCCC 1 -- us2k10--------
    rs115493031,2
    C--153539745(-) GCTCAG/AAAAGG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1114317991,2
    C--153540041(+) CCCCAC/GCCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM50A (153672473 - 153679002 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FAM50A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): FAM50A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM50A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM50A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300453    OMIM disorders: --


    Find genes that share disorders with FAM50A           About GenesLikeMe

    Genetic Association Database (GAD): FAM50A
    Human Genome Epidemiology (HuGE) Navigator: FAM50A (3 documents)

    Export disorders for FAM50A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM50A gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FAM50A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of XAP5, a candidate disease gene. (PubMed id 9339379)1, 2, 3, 9 Mazzarella R.... Schlessinger D. (Genomics 1997)
    2. Isolation and analysis of a novel gene, HXC-26, adjacent to the rab GDP dissociation inhibitor gene located at human chromosome Xq28 region. (PubMed id 9039504)1, 2, 3 Toyoda A.... Maeda H. (DNA Res. 1996)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (Hum. Mol. Genet. 1996)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9130 HGNC: 18786 AceView: FAM50A Ensembl:ENSG00000071859 euGenes: HUgn9130
    ECgene: FAM50A H-InvDB: FAM50A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM50A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM50A gene:
    Search GeneIP for patents involving FAM50A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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